{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:57:35Z","timestamp":1790269055820,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s00277-020-03984-w","type":"journal-article","created":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T17:02:32Z","timestamp":1587315752000},"page":"1251-1255","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Clinical characteristics and outcomes of oligosecretory and non-secretory multiple myeloma"],"prefix":"10.1007","volume":"99","author":[{"given":"Magdalini","family":"Migkou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irit","family":"Avivi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gavriatopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael C.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Fotiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kanellias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Ziogas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Eleutherakis-Papaiakovou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Terpos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Roussou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Kastritis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios A.","family":"Dimopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"issue":"8","key":"3984_CR1","doi-asserted-by":"publisher","first-page":"e328","DOI":"10.1016\/S1470-2045(16)30206-6","volume":"17","author":"S Kumar","year":"2016","unstructured":"Kumar S, Paiva B, Anderson KC, Durie B, Landgren O, Moreau P, Munshi N, Lonial S, Blade J, Mateos MV, Dimopoulos M, Kastritis E, Boccadoro M, Orlowski R, Goldschmidt H, Spencer A, Hou J, Chng WJ, Usmani SZ, Zamagni E, Shimizu K, Jagannath S, Johnsen HE, Terpos E, Reiman A, Kyle RA, Sonneveld P, Richardson PG, McCarthy P, Ludwig H, Chen W, Cavo M, Harousseau JL, Lentzsch S, Hillengass J, Palumbo A, Orfao A, Rajkumar SV, Miguel JS, Avet-Loiseau H (2016) International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. Lancet Oncol 17(8):e328\u2013e346. https:\/\/doi.org\/10.1016\/S1470-2045(16)30206-6","journal-title":"Lancet Oncol"},{"issue":"6","key":"3984_CR2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.0954-6820.1978.tb08472.x","volume":"204","author":"I Turesson","year":"1978","unstructured":"Turesson I, Grubb A (1978) Non-secretory or low-secretory myeloma with intracellular kappa chains. Report of six cases and review of the literature. Acta Med Scand 204(6):445\u2013451","journal-title":"Acta Med Scand"},{"issue":"4","key":"3984_CR3","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/j.1365-2141.1979.tb03788.x","volume":"43","author":"MV Joyner","year":"1979","unstructured":"Joyner MV, Cassuto JP, Dujardin P, Schneider M, Ziegler G, Euller L, Masseyeff R (1979) Non-excretory multiple myeloma. Br J Haematol 43(4):559\u2013566","journal-title":"Br J Haematol"},{"issue":"5","key":"3984_CR4","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1046\/j.1365-2141.1998.00930.x","volume":"102","author":"J Blade","year":"1998","unstructured":"Blade J, Samson D, Reece D, Apperley J, Bjorkstrand B, Gahrton G, Gertz M, Giralt S, Jagannath S, Vesole D (1998) Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. Br J Haematol 102(5):1115\u20131123","journal-title":"Br J Haematol"},{"issue":"9","key":"3984_CR5","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1182\/blood.V97.9.2900","volume":"97","author":"M Drayson","year":"2001","unstructured":"Drayson M, Tang LX, Drew R, Mead GP, Carr-Smith H, Bradwell AR (2001) Serum free light-chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma. Blood 97(9):2900\u20132902","journal-title":"Blood"},{"issue":"2","key":"3984_CR6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/leu.2008.307","volume":"23","author":"A Dispenzieri","year":"2009","unstructured":"Dispenzieri A, Kyle R, Merlini G, Miguel JS, Ludwig H, Hajek R, Palumbo A, Jagannath S, Blade J, Lonial S, Dimopoulos M, Comenzo R, Einsele H, Barlogie B, Anderson K, Gertz M, Harousseau JL, Attal M, Tosi P, Sonneveld P, Boccadoro M, Morgan G, Richardson P, Sezer O, Mateos MV, Cavo M, Joshua D, Turesson I, Chen W, Shimizu K, Powles R, Rajkumar SV, Durie BG (2009) International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia 23(2):215\u2013224. https:\/\/doi.org\/10.1038\/leu.2008.307","journal-title":"Leukemia"},{"issue":"3","key":"3984_CR7","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1182\/blood-2004-02-0477","volume":"104","author":"D Coriu","year":"2004","unstructured":"Coriu D, Weaver K, Schell M, Eulitz M, Murphy CL, Weiss DT, Solomon A (2004) A molecular basis for nonsecretory myeloma. Blood 104(3):829\u2013831. https:\/\/doi.org\/10.1182\/blood-2004-02-0477","journal-title":"Blood"},{"issue":"9","key":"3984_CR8","first-page":"932","volume":"27","author":"R Fonseca","year":"2013","unstructured":"Fonseca R (2013) Non-secretory myeloma: clinical and biologic implications. Oncology 27(9):932\u2013933","journal-title":"Oncology"},{"issue":"9","key":"3984_CR9","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1038\/sj.leu.2404284","volume":"20","author":"BG Durie","year":"2006","unstructured":"Durie BG, Harousseau JL, Miguel JS, Blade J, Barlogie B, Anderson K, Gertz M, Dimopoulos M, Westin J, Sonneveld P, Ludwig H, Gahrton G, Beksac M, Crowley J, Belch A, Boccadaro M, Cavo M, Turesson I, Joshua D, Vesole D, Kyle R, Alexanian R, Tricot G, Attal M, Merlini G, Powles R, Richardson P, Shimizu K, Tosi P, Morgan G, Rajkumar SV (2006) International uniform response criteria for multiple myeloma. Leukemia 20(9):1467\u20131473. https:\/\/doi.org\/10.1038\/sj.leu.2404284","journal-title":"Leukemia"},{"issue":"6","key":"3984_CR10","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1056\/NEJMc1206740","volume":"367","author":"D Larson","year":"2012","unstructured":"Larson D, Kyle RA, Rajkumar SV (2012) Prevalence and monitoring of oligosecretory myeloma. N Engl J Med 367(6):580\u2013581. https:\/\/doi.org\/10.1056\/NEJMc1206740","journal-title":"N Engl J Med"},{"issue":"3","key":"3984_CR11","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1189\/jlb.0803382","volume":"76","author":"C Decourt","year":"2004","unstructured":"Decourt C, Galea HR, Sirac C, Cogne M (2004) Immunologic basis for the rare occurrence of true nonsecretory plasma cell dyscrasias. J Leukoc Biol 76(3):528\u2013536. https:\/\/doi.org\/10.1189\/jlb.0803382","journal-title":"J Leukoc Biol"},{"issue":"1","key":"3984_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0092-8674(83)90336-7","volume":"33","author":"GE Wu","year":"1983","unstructured":"Wu GE, Hozumi N, Murialdo H (1983) Secretion of a lambda 2 immunoglobulin chain is prevented by a single amino acid substitution in its variable region. Cell 33(1):77\u201383","journal-title":"Cell"},{"issue":"20","key":"3984_CR13","doi-asserted-by":"publisher","first-page":"8135","DOI":"10.1073\/pnas.87.20.8135","volume":"87","author":"JL Dul","year":"1990","unstructured":"Dul JL, Argon Y (1990) A single amino acid substitution in the variable region of the light chain specifically blocks immunoglobulin secretion. Proc Natl Acad Sci U S A 87(20):8135\u20138139","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"3984_CR14","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/eji.1830090609","volume":"9","author":"SL Morrison","year":"1979","unstructured":"Morrison SL, Scharff MD (1979) A mouse myeloma variant with a defect in light chain synthesis. Eur J Immunol 9(6):461\u2013465. https:\/\/doi.org\/10.1002\/eji.1830090609","journal-title":"Eur J Immunol"},{"issue":"4","key":"3984_CR15","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1073\/pnas.77.4.2197","volume":"77","author":"G Kohler","year":"1980","unstructured":"Kohler G (1980) Immunoglobulin chain loss in hybridoma lines. Proc Natl Acad Sci U S A 77(4):2197\u20132199","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"22","key":"3984_CR16","doi-asserted-by":"publisher","first-page":"7185","DOI":"10.1073\/pnas.81.22.7185","volume":"81","author":"IG Haas","year":"1984","unstructured":"Haas IG, Wabl MR (1984) Immunoglobulin heavy chain toxicity in plasma cells is neutralized by fusion to pre-B cells. Proc Natl Acad Sci U S A 81(22):7185\u20137188","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"3984_CR17","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/BF01233529","volume":"19","author":"CL Chou","year":"1993","unstructured":"Chou CL, Morrison SL (1993) An insertion-deletion event in murine immunoglobulin kappa gene resembles mutations at heavy-chain disease loci. Somat Cell Mol Genet 19(2):131\u2013139","journal-title":"Somat Cell Mol Genet"},{"key":"3984_CR18","doi-asserted-by":"publisher","unstructured":"Chawla SS, Kumar SK, Dispenzieri A, Greenberg AJ, Larson DR, Kyle RA, Lacy MQ, Gertz MA, Rajkumar SV (2015) Clinical course and prognosis of non-secretory multiple myeloma. Eur J Haematol. https:\/\/doi.org\/10.1111\/ejh.12534","DOI":"10.1111\/ejh.12534"},{"issue":"2","key":"3984_CR19","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/bjh.14753","volume":"178","author":"JLJ Heaney","year":"2017","unstructured":"Heaney JLJ, Campbell JP, Griffin AE, Birtwistle J, Shemar M, Child JA, Gregory WM, Cairns DA, Morgan G, Jackson G, Drayson MT (2017) Diagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests. Br J Haematol 178(2):220\u2013230. https:\/\/doi.org\/10.1111\/bjh.14753","journal-title":"Br J Haematol"},{"issue":"6","key":"3984_CR20","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1182\/blood-2006-03-008953","volume":"108","author":"M Drayson","year":"2006","unstructured":"Drayson M, Begum G, Basu S, Makkuni S, Dunn J, Barth N, Child JA (2006) Effects of paraprotein heavy and light chain types and free light chain load on survival in myeloma: an analysis of patients receiving conventional-dose chemotherapy in Medical Research Council UK multiple myeloma trials. Blood 108(6):2013\u20132019. https:\/\/doi.org\/10.1182\/blood-2006-03-008953","journal-title":"Blood"},{"issue":"10","key":"3984_CR21","doi-asserted-by":"publisher","first-page":"4908","DOI":"10.1182\/blood-2008-02-138602","volume":"111","author":"A Dispenzieri","year":"2008","unstructured":"Dispenzieri A, Zhang L, Katzmann JA, Snyder M, Blood E, Degoey R, Henderson K, Kyle RA, Oken MM, Bradwell AR, Greipp PR (2008) Appraisal of immunoglobulin free light chain as a marker of response. Blood 111(10):4908\u20134915. https:\/\/doi.org\/10.1182\/blood-2008-02-138602","journal-title":"Blood"},{"issue":"1","key":"3984_CR22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1093\/ajcp\/aqw079","volume":"146","author":"S Mahmood","year":"2016","unstructured":"Mahmood S, Wassef NL, Salter SJ, Sachchithanantham S, Lane T, Foard D, Whelan CJ, Lachmann HJ, Gillmore JD, Hawkins PN, Wechalekar AD (2016) Comparison of free light chain assays: Freelite and N latex in diagnosis, monitoring, and predicting survival in light chain amyloidosis. Am J Clin Pathol 146(1):78\u201385. https:\/\/doi.org\/10.1093\/ajcp\/aqw079","journal-title":"Am J Clin Pathol"},{"issue":"11","key":"3984_CR23","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1515\/cclm-2016-1024","volume":"55","author":"G Palladini","year":"2017","unstructured":"Palladini G, Jaccard A, Milani P, Lavergne D, Foli A, Bender S, Lavatelli F, Bosoni T, Valentini V, Pirolini L, Ferraro G, Basset M, Russo F, Nuvolone M, Albertini R, Cogne M, Merlini G (2017) Circulating free light chain measurement in the diagnosis, prognostic assessment and evaluation of response of AL amyloidosis: comparison of Freelite and N latex FLC assays. Clin Chem Lab Med 55(11):1734\u20131743. https:\/\/doi.org\/10.1515\/cclm-2016-1024","journal-title":"Clin Chem Lab Med"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-020-03984-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-020-03984-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-020-03984-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T03:31:15Z","timestamp":1696044675000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-020-03984-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,19]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["3984"],"URL":"https:\/\/doi.org\/10.1007\/s00277-020-03984-w","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,19]]},"assertion":[{"value":"19 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}