{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:55:41Z","timestamp":1793368541746,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s00277-020-04083-6","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T21:02:21Z","timestamp":1590094941000},"page":"2095-2104","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["A comprehensive analysis of adult patients with secondary hemophagocytic lymphohistiocytosis: a prospective cohort study"],"prefix":"10.1007","volume":"99","author":[{"given":"Sang Eun","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonghee","family":"Eun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungmin","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Ryang","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Young","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duck","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hyeh","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seog","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"4083_CR1","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1182\/blood-2002-01-0172","volume":"100","author":"JI Henter","year":"2002","unstructured":"Henter JI, Samuelsson-Horne A, Arico M et al (2002) Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation. Blood 100:2367\u20132373","journal-title":"Blood"},{"key":"4083_CR2","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1309\/AJCP4ZDKJ4ICOUAT","volume":"139","author":"FGN Rosado","year":"2013","unstructured":"Rosado FGN, Kim AS (2013) Hemophagocytic lymphohistiocytosis: an update on diagnosis and pathogenesis. Am J Clin Pathol 139:713\u2013727","journal-title":"Am J Clin Pathol"},{"key":"4083_CR3","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/S0140-6736(13)61048-X","volume":"383","author":"M Ramos-Casals","year":"2014","unstructured":"Ramos-Casals M, Brito-Zeron P, Lopez-Guillermo A et al (2014) Adult haemophagocytic syndrome. Lancet 383:1503\u20131516","journal-title":"Lancet"},{"key":"4083_CR4","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/pbc.21039","volume":"48","author":"JI Henter","year":"2007","unstructured":"Henter JI, Horne A, Arico M et al (2007) HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 48:124\u2013131","journal-title":"Pediatr Blood Cancer"},{"key":"4083_CR5","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.mayocp.2013.12.012","volume":"89","author":"SA Parikh","year":"2014","unstructured":"Parikh SA, Kapoor P, Letendre L, Kumar S, Wolanskyj AP (2014) Prognostic factors and outcomes of adults with hemophagocytic lymphohistiocytosis. Mayo Clin Proc 89:484\u2013492","journal-title":"Mayo Clin Proc"},{"key":"4083_CR6","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.transci.2018.10.001","volume":"57","author":"BC Prokesch","year":"2018","unstructured":"Prokesch BC, Nagalla S, Ezzati F, Tujios SR, Dominguez A, Chen W, Kershaw C, Patel P, de la Flor C, Foster J, Martin AA, de la Morena MT, Wysocki CA (2018) What\u2019s in a name? The heterogeneous clinical spectrum and prognostic factors in a cohort of adults with hemophagocytic lymphohistiocytosis. Transfus Apher Sci 57:779\u2013784","journal-title":"Transfus Apher Sci"},{"key":"4083_CR7","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1002\/art.38690","volume":"66","author":"L Fardet","year":"2014","unstructured":"Fardet L, Galicier L, Lambotte O, Marzac C, Aumont C, Chahwan D, Coppo P, Hejblum G (2014) Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheum 66:2613\u20132620","journal-title":"Arthritis Rheum"},{"key":"4083_CR8","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1093\/ajcp\/aqw076","volume":"145","author":"F Debaugnies","year":"2016","unstructured":"Debaugnies F, Mahadeb B, Ferster A, Meuleman N, Rozen L, Demulder A, Corazza F (2016) Performances of the H-score for diagnosis of hemophagocytic lymphohistiocytosis in adult and pediatric patients. Am J Clin Pathol 145:862\u2013870","journal-title":"Am J Clin Pathol"},{"key":"4083_CR9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00277-015-2523-8","volume":"95","author":"SH Lim","year":"2016","unstructured":"Lim SH, Park S, Jang JH, Kim K, Kim HJ, Kim SH, Kang CI, Chung DR, Peck KR, Lee J, Cha HS, Koh EM, Ko YH, Kim WS, Jung CW, Kim SJ (2016) Clinical significance of bone marrow hemophagocytosis in adult patients with malignancy and non-malignancy-induced hemophagocytic lymphohistiocytosis. Ann Hematol 95:325\u2013335","journal-title":"Ann Hematol"},{"key":"4083_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0925-5710(97)00584-7","volume":"66","author":"S Imashuku","year":"1997","unstructured":"Imashuku S (1997) Differential diagnosis of hemophagocytic syndrome: underlying disorders and selection of the most effective treatment. Int J Hematol 66:135\u2013151","journal-title":"Int J Hematol"},{"key":"4083_CR11","doi-asserted-by":"crossref","unstructured":"Gualdoni GA, Hofmann GA, Wohlfarth P et al (2019) Prevalence and outcome of secondary hemophagocytic lymphohistiocytosis among SIRS patients: results from a prospective cohort study. J Clin Med 8","DOI":"10.3390\/jcm8040541"},{"key":"4083_CR12","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1182\/bloodadvances.2017012310","volume":"1","author":"A Hayden","year":"2017","unstructured":"Hayden A, Lin M, Park S, Pudek M, Schneider M, Jordan MB, Mattman A, Chen LYC (2017) Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH. Blood Adv 1:2529\u20132534","journal-title":"Blood Adv"},{"key":"4083_CR13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1182\/asheducation-2015.1.177","volume":"2015","author":"CE Allen","year":"2015","unstructured":"Allen CE, McClain KL (2015) Pathophysiology and epidemiology of hemophagocytic lymphohistiocytosis. Hematology 2015:177\u2013182","journal-title":"Hematology"},{"key":"4083_CR14","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3324\/haematol.2018.198655","volume":"104","author":"JH Yoon","year":"2019","unstructured":"Yoon JH, Park SS, Jeon YW, Lee SE, Cho BS, Eom KS, Kim YJ, Kim HJ, Lee S, Min CK, Cho SG, Lee JW (2019) Treatment outcomes and prognostic factors in adult patients with secondary hemophagocytic lymphohistiocytosis not associated with malignancy. Haematologica 104:269\u2013276","journal-title":"Haematologica"},{"key":"4083_CR15","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/ajh.23911","volume":"90","author":"ZK Otrock","year":"2015","unstructured":"Otrock ZK, Eby CS (2015) Clinical characteristics, prognostic factors, and outcomes of adult patients with hemophagocytic lymphohistiocytosis. Am J Hematol 90:220\u2013224","journal-title":"Am J Hematol"},{"key":"4083_CR16","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1080\/10428194.2018.1480772","volume":"60","author":"SW Lim","year":"2019","unstructured":"Lim SW, Ryu KJ, Lee H, Ko YH, Kim WS, Kim SJ (2019) Serum IL18 is associated with hemophagocytosis and poor survival in extranodal natural killer\/T-cell lymphoma. Leuk Lymphoma 60:317\u2013325","journal-title":"Leuk Lymphoma"},{"key":"4083_CR17","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s00277-013-1784-3","volume":"92","author":"JT Yu","year":"2013","unstructured":"Yu JT, Wang CY, Yang Y, Wang RC, Chang KH, Hwang WL, Teng CLJ (2013) Lymphoma-associated hemophagocytic lymphohistiocytosis: experience in adults from a single institution. Ann Hematol 92:1529\u20131536","journal-title":"Ann Hematol"},{"key":"4083_CR18","doi-asserted-by":"publisher","first-page":"5991","DOI":"10.1182\/blood.V128.22.5991.5991","volume":"128","author":"ZL Jin","year":"2016","unstructured":"Jin ZL, Wang YN (2016) Adult lymphoma-associated hemophagocytic syndrome is a life-threatening disease: retrospective 10-year review of 89 cases at a single center. Blood 128:5991\u20135991","journal-title":"Blood"},{"key":"4083_CR19","first-page":"5205","volume":"130","author":"EI Apodaca","year":"2017","unstructured":"Apodaca EI, Demichelis R, Aguayo A et al (2017) Clinical characteristics and outcomes of hemophagocytic lymphohistiocytosis-associated lymphoma: a case-control study. Blood 130:5205\u20135205","journal-title":"Blood"},{"key":"4083_CR20","first-page":"997","volume":"100","author":"K Lehmberg","year":"2015","unstructured":"Lehmberg K, Nichols KE, Henter JI, Girschikofsky M, Greenwood T, Jordan M, Kumar A, Minkov M, la Ros\u00e9e P, Weitzman S, Study Group on Hemophagocytic Lymphohistiocytosis Subtypes of the Histiocyte Society (2015) Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies. Haematologica 100:997\u20131004","journal-title":"Haematologica"},{"key":"4083_CR21","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4103\/0971-5851.133726","volume":"35","author":"A Kumar","year":"2014","unstructured":"Kumar A, Raina V (2014) Non-Hodgkins lymphoma with lactic acidosis at presentation: a case report of a rare oncologic emergency. Indian J Med Paediatr Oncol 35:83\u201385","journal-title":"Indian J Med Paediatr Oncol"},{"key":"4083_CR22","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/2110-5820-3-12","volume":"3","author":"J Bakker","year":"2013","unstructured":"Bakker J, Nijsten MW, Jansen TC (2013) Clinical use of lactate monitoring in critically ill patients. Ann Intensive Care 3:12","journal-title":"Ann Intensive Care"},{"key":"4083_CR23","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1186\/s13054-014-0503-3","volume":"18","author":"M Garcia-Alvarez","year":"2014","unstructured":"Garcia-Alvarez M, Marik P, Bellomo R (2014) Sepsis-associated hyperlactatemia. Crit Care 18:503","journal-title":"Crit Care"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-020-04083-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-020-04083-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-020-04083-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T23:16:56Z","timestamp":1621552616000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-020-04083-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,21]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["4083"],"URL":"https:\/\/doi.org\/10.1007\/s00277-020-04083-6","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,21]]},"assertion":[{"value":"23 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.Ethical approvalAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from all participants included in the study.Financial disclosureThe authors have no relevant financial interests that relate to this study to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}