{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:20:49Z","timestamp":1793740849567,"version":"4.6.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Beijing Natural Science Foundation","award":["7192168"],"award-info":[{"award-number":["7192168"]}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2016-I2M-3-004"],"award-info":[{"award-number":["2016-I2M-3-004"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the National Key Research and Development Program of China","award":["2016YFC0901500"],"award-info":[{"award-number":["2016YFC0901500"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s00277-020-04105-3","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T16:03:52Z","timestamp":1591113832000},"page":"1485-1491","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Immunosuppression therapy is effective for both acquired tumor-associated and primary pure red cell aplasia: a match pair case-control study"],"prefix":"10.1007","volume":"99","author":[{"given":"Zesong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"4105_CR1","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1182\/blood-2016-05-717140","volume":"128","author":"RT Means","year":"2016","unstructured":"Means RT (2016) Pure red cell aplasia. Blood 128:2504\u20132509. https:\/\/doi.org\/10.1182\/blood-2016-05-717140","journal-title":"Blood"},{"key":"4105_CR2","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/j.1365-2141.2008.07216.x","volume":"142","author":"K Sawada","year":"2008","unstructured":"Sawada K, Fujishima N, Hirokawa M (2008) Acquired pure red cell aplasia: updated review of treatment. Br J Haematol 142:505\u2013514. https:\/\/doi.org\/10.1111\/j.1365-2141.2008.07216.x","journal-title":"Br J Haematol"},{"key":"4105_CR3","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3324\/haematol.11192","volume":"92","author":"K Sawada","year":"2007","unstructured":"Sawada K, Hirokawa M, Fujishima N et al (2007) Long-term outcome of patients with acquired primary idiopathic pure red cell aplasia receiving cyclosporine A. A nationwide cohort study in Japan for the PRCA Collaborative Study Group. Haematologica 92:1021\u20131028","journal-title":"Haematologica"},{"key":"4105_CR4","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.11406\/rinketsu.56.1922","volume":"56","author":"M Hirokawa","year":"2015","unstructured":"Hirokawa M (2015) Diagnosis and management of pure red cell aplasia. Rinsho Ketsueki 56:1922\u20131931. https:\/\/doi.org\/10.11406\/rinketsu.56.1922","journal-title":"Rinsho Ketsueki"},{"key":"4105_CR5","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3760\/cma.j.issn.0253-2727.2015.05.002","volume":"36","author":"Red Blood Cell Disease (Anemia) Group, Chinese Society of Hematology, Chinese Medical Association","year":"2015","unstructured":"Red Blood Cell Disease (Anemia) Group, Chinese Society of Hematology, Chinese Medical Association (2015) Chinese expert consensus on the treatment and diagnosis of acquired pure red cell aplasia (2015). Zhonghua Xue Ye Xue Za Zhi 36:363\u2013366. https:\/\/doi.org\/10.3760\/cma.j.issn.0253-2727.2015.05.002","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"4105_CR6","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1093\/cid\/cis1046","volume":"56","author":"Y Crabol","year":"2013","unstructured":"Crabol Y, Terrier B, Rozenberg F, Pestre V, Legendre C, Hermine O, Montagnier-Petrissans C, Guillevin L, Mouthon L, for the Groupe d'experts de l'Assistance Publique-Hopitaux de Paris, Loic G, Annette B, Alain F, Bertrand F, Bertrand G, Amelie L, Isabelle L, Catherine MP, Luc M, Eric O, Nathalie P, Helene S, Tarek S, Hopital Ambroise P, Jean-Marie LP, Bruno F, Bernard C, Thomas P, Francois D, Loic G, Zora M, Olivier H, Christophe L, Philippe L, Olivier L, Jean-Charles P, Norbert-Claude G, Jean-Paul F, Eric O, Guy L, Hopital B, Hopital N, Amina B (2013) Intravenous immunoglobulin therapy for pure red cell aplasia related to human parvovirus b19 infection: a retrospective study of 10 patients and review of the literature. Clin Infect Dis 56:968\u2013977. https:\/\/doi.org\/10.1093\/cid\/cis1046","journal-title":"Clin Infect Dis"},{"key":"4105_CR7","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00277-014-2192-z","volume":"94","author":"C Cerchione","year":"2015","unstructured":"Cerchione C, Catalano L, Cerciello G, Avilia S, Picardi M, Risitano AM, Pisano I, Alfinito F, Pane F (2015) Role of lenalidomide in the management of myelodysplastic syndromes with del(5q) associated with pure red cell aplasia (PRCA). Ann Hematol 94:531\u2013534. https:\/\/doi.org\/10.1007\/s00277-014-2192-z","journal-title":"Ann Hematol"},{"key":"4105_CR8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3324\/haematol.11655","volume":"93","author":"M Hirokawa","year":"2008","unstructured":"Hirokawa M, Sawada K, Fujishima N, Nakao S, Urabe A, Dan K, Fujisawa S, Yonemura Y, Kawano F, Omine M, Ozawa K, for the PRCA Collaborative Study Group (2008) Long-term response and outcome following immunosuppressive therapy in thymoma-associated pure red cell aplasia: a nationwide cohort study in Japan by the PRCA collaborative study group. Haematologica 93:27\u201333. https:\/\/doi.org\/10.3324\/haematol.11655","journal-title":"Haematologica"},{"key":"4105_CR9","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.3324\/haematol.12871","volume":"93","author":"N Fujishima","year":"2008","unstructured":"Fujishima N, Sawada K, Hirokawa M, Oshimi K, Sugimoto K, Matsuda A, Teramura M, Karasawa M, Arai A, Yonemura Y, Nakao S, Urabe A, Omine M, Ozawa K (2008) Long-term responses and outcomes following immunosuppressive therapy in large granular lymphocyte leukemia-associated pure red cell aplasia: a nationwide cohort study in Japan for the PRCA collaborative study group. Haematologica 93:1555\u20131559. https:\/\/doi.org\/10.3324\/haematol.12871","journal-title":"Haematologica"},{"key":"4105_CR10","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/ajh.21354","volume":"84","author":"M Hirokawa","year":"2009","unstructured":"Hirokawa M, Sawada K, Fujishima N, Kawano F, Kimura A, Watanabe T, Arai A, Matsui T, Nakao S, Urabe A, Omine M, Ozawa K (2009) Acquired pure red cell aplasia associated with malignant lymphomas: a nationwide cohort study in Japan for the PRCA collaborative study group. Am J Hematol 84:144\u2013148. https:\/\/doi.org\/10.1002\/ajh.21354","journal-title":"Am J Hematol"},{"key":"4105_CR11","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1007\/s00277-018-3431-5","volume":"97","author":"Z Long","year":"2018","unstructured":"Long Z, Yu F, Du Y et al (2018) Successful treatment of refractory\/relapsed acquired pure red cell aplasia with sirolimus. Ann Hematol 97:2047\u20132054. https:\/\/doi.org\/10.1007\/s00277-018-3431-5","journal-title":"Ann Hematol"},{"key":"4105_CR12","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S0270-9295(03)00090-1","volume":"23","author":"EA Burdmann","year":"2003","unstructured":"Burdmann EA, Andoh TF, Yu L, Bennett WM (2003) Cyclosporine nephrotoxicity. Semin Nephrol 23:465\u2013476","journal-title":"Semin Nephrol"},{"key":"4105_CR13","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/01.mnh.0000040045.55337.97","volume":"11","author":"RWG Johnson","year":"2002","unstructured":"Johnson RWG (2002) Sirolimus (Rapamune) in renal transplantation. Curr Opin Nephrol Hypertens 11:603\u2013607. https:\/\/doi.org\/10.1097\/01.mnh.0000040045.55337.97","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"4105_CR14","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1097\/00007890-200109150-00007","volume":"72","author":"RW Johnson","year":"2001","unstructured":"Johnson RW, Kreis H, Oberbauer R et al (2001) Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure. Transplantation 72:777\u2013786","journal-title":"Transplantation"},{"key":"4105_CR15","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1097\/01.TP.0000038525.79886.B5","volume":"74","author":"TA Gonwa","year":"2002","unstructured":"Gonwa TA, Hricik DE, Brinker K, Grinyo JM, Schena FP, Sirolimus Renal Function Study Group (2002) Improved renal function in sirolimus-treated renal transplant patients after early cyclosporine elimination. Transplantation 74:1560\u20131567. https:\/\/doi.org\/10.1097\/01.TP.0000038525.79886.B5","journal-title":"Transplantation"},{"key":"4105_CR16","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1111\/bjh.13376","volume":"169","author":"M Hirokawa","year":"2015","unstructured":"Hirokawa M, Sawada K, Fujishima N, Teramura M, Bessho M, Dan K, Tsurumi H, Nakao S, Urabe A, Fujisawa S, Yonemura Y, Kawano F, Oshimi K, Sugimoto K, Matsuda A, Karasawa M, Arai A, Komatsu N, Harigae H, Omine M, Ozawa K, Kurokawa M, the PRCA Collaborative Study Group (2015) Long-term outcome of patients with acquired chronic pure red cell aplasia (PRCA) following immunosuppressive therapy: a final report of the nationwide cohort study in 2004\/2006 by the Japan PRCA collaborative study group. Br J Haematol 169:879\u2013886. https:\/\/doi.org\/10.1111\/bjh.13376","journal-title":"Br J Haematol"},{"key":"4105_CR17","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1080\/10245332.2015.1101977","volume":"21","author":"G Peng","year":"2016","unstructured":"Peng G, Yang W, Zhang L et al (2016) Moderate-dose cyclophosphamide in the treatment of relapsed\/refractory T-cell large granular lymphocytic leukemia-associated pure red cell aplasia. Hematology 21:128\u2013143. https:\/\/doi.org\/10.1080\/10245332.2015.1101977","journal-title":"Hematology"},{"key":"4105_CR18","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1080\/10428194.2017.1339880","volume":"59","author":"SR Sanikommu","year":"2018","unstructured":"Sanikommu SR, Clemente MJ, Chomczynski P, Afable MG II, Jerez A, Thota S, Patel B, Hirsch C, Nazha A, Desamito J, Lichtin A, Pohlman B, Sekeres MA, Radivoyevitch T, Maciejewski JP (2018) Clinical features and treatment outcomes in large granular lymphocytic leukemia (LGLL). Leuk Lymphoma 59:416\u2013422. https:\/\/doi.org\/10.1080\/10428194.2017.1339880","journal-title":"Leuk Lymphoma"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-020-04105-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-020-04105-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-020-04105-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T05:17:25Z","timestamp":1622524645000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-020-04105-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["4105"],"URL":"https:\/\/doi.org\/10.1007\/s00277-020-04105-3","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,1]]},"assertion":[{"value":"7 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}