{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:55:26Z","timestamp":1768280126316,"version":"3.49.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Key Research and Development Program of China","award":["No. 2017YFA0105500"],"award-info":[{"award-number":["No. 2017YFA0105500"]}]},{"name":"National Key Research and Development Program of China","award":["No. 2017YFA0105503"],"award-info":[{"award-number":["No. 2017YFA0105503"]}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["No. Z171100001017084"],"award-info":[{"award-number":["No. Z171100001017084"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81670116"],"award-info":[{"award-number":["No. 81670116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Program of National Natural Science Foundation of China","award":["No. 81730004"],"award-info":[{"award-number":["No. 81730004"]}]},{"name":"Beijing Natural Science Foundation","award":["No. 7171013, No. H2018206423"],"award-info":[{"award-number":["No. 7171013, No. H2018206423"]}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81621001"],"award-info":[{"award-number":["81621001"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s00277-020-04201-4","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T22:06:25Z","timestamp":1596146785000},"page":"2659-2670","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Comparison of different cytomegalovirus diseases following haploidentical hematopoietic stem cell transplantation"],"prefix":"10.1007","volume":"99","author":[{"given":"Xing-Ye","family":"Meng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Xia","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Lu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Zhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Hua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Dong","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding-Bao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Jun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan-Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-6792","authenticated-orcid":false,"given":"Xiao-Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"issue":"Suppl 1","key":"4201_CR1","doi-asserted-by":"publisher","first-page":"S70","DOI":"10.1038\/bmt.2008.120","volume":"42","author":"P Ljungman","year":"2008","unstructured":"Ljungman P (2008) CMV infections after hematopoietic stem cell transplantation. Bone Marrow Transplant 42(Suppl 1):S70\u2013s72. https:\/\/doi.org\/10.1038\/bmt.2008.120","journal-title":"Bone Marrow Transplant"},{"issue":"12","key":"4201_CR2","doi-asserted-by":"publisher","first-page":"1121.e1129","DOI":"10.1016\/j.cmi.2015.06.009","volume":"21","author":"J Liu","year":"2015","unstructured":"Liu J, Kong J, Chang YJ, Chen H, Chen YH, Han W, Wang Y, Yan CH, Wang JZ, Wang FR, Chen Y, Zhang XH, Xu LP, Liu KY, Huang XJ (2015) Patients with refractory cytomegalovirus (CMV) infection following allogeneic haematopoietic stem cell transplantation are at high risk for CMV disease and non-relapse mortality. Clin Microbiol Infect 21(12):1121.e1129\u20131121.e1115. https:\/\/doi.org\/10.1016\/j.cmi.2015.06.009","journal-title":"Clin Microbiol Infect"},{"issue":"3","key":"4201_CR3","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1016\/s2352-3026(15)00289-6","volume":"3","author":"ML Green","year":"2016","unstructured":"Green ML, Leisenring W, Xie H, Mast TC, Cui Y, Sandmaier BM, Sorror ML, Goyal S, Ozkok S, Yi J, Sahoo F, Kimball LE, Jerome KR, Marks MA, Boeckh M (2016) Cytomegalovirus viral load and mortality after haemopoietic stem cell transplantation in the era of pre-emptive therapy: a retrospective cohort study. Lancet Haematol 3(3):e119\u2013e127. https:\/\/doi.org\/10.1016\/s2352-3026(15)00289-6","journal-title":"Lancet Haematol"},{"issue":"1","key":"4201_CR4","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/cid\/ciw668","volume":"64","author":"P Ljungman","year":"2017","unstructured":"Ljungman P, Boeckh M, Hirsch HH, Josephson F, Lundgren J, Nichols G, Pikis A, Razonable RR, Miller V, Griffiths PD (2017) Definitions of cytomegalovirus infection and disease in transplant patients for use in clinical trials. Clin Infect Dis 64(1):87\u201391. https:\/\/doi.org\/10.1093\/cid\/ciw668","journal-title":"Clin Infect Dis"},{"issue":"8","key":"4201_CR5","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1086\/339329","volume":"34","author":"P Ljungman","year":"2002","unstructured":"Ljungman P, Griffiths P, Paya C (2002) Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 34(8):1094\u20131097. https:\/\/doi.org\/10.1086\/339329","journal-title":"Clin Infect Dis"},{"issue":"3","key":"4201_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2034","volume":"29","author":"M Zuhair","year":"2019","unstructured":"Zuhair M, Smit GSA, Wallis G, Jabbar F, Smith C, Devleesschauwer B, Griffiths P (2019) Estimation of the worldwide seroprevalence of cytomegalovirus: a systematic review and meta-analysis. Rev Med Virol 29(3):e2034. https:\/\/doi.org\/10.1002\/rmv.2034","journal-title":"Rev Med Virol"},{"issue":"2","key":"4201_CR7","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1182\/blood-2002-03-0993","volume":"101","author":"M Boeckh","year":"2003","unstructured":"Boeckh M, Leisenring W, Riddell SR, Bowden RA, Huang ML, Myerson D, Stevens-Ayers T, Flowers ME, Cunningham T, Corey L (2003) Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity. Blood 101(2):407\u2013414. https:\/\/doi.org\/10.1182\/blood-2002-03-0993","journal-title":"Blood"},{"issue":"1","key":"4201_CR8","first-page":"78","volume":"91","author":"P Ljungman","year":"2006","unstructured":"Ljungman P, Perez-Bercoff L, Jonsson J, Avetisyan G, Sparrelid E, Aschan J, Barkholt L, Larsson K, Winiarski J, Yun Z, Ringden O (2006) Risk factors for the development of cytomegalovirus disease after allogeneic stem cell transplantation. Haematologica 91(1):78\u201383","journal-title":"Haematologica"},{"issue":"5","key":"4201_CR9","doi-asserted-by":"publisher","first-page":"ofy080","DOI":"10.1093\/ofid\/ofy080","volume":"5","author":"IP Lodding","year":"2018","unstructured":"Lodding IP, da Cunha BC, Sorensen SS, Gustafsson F, Iversen M, Kirkby N, Perch M, Rasmussen A, Sengelov H, Mocroft A, Lundgren JD (2018) Cytomegalovirus (CMV) disease despite weekly pre-emptive CMV strategy for recipients of solid organ and hematopoietic stem cell transplantation. Open Forum Infect Dis 5(5):ofy080. https:\/\/doi.org\/10.1093\/ofid\/ofy080","journal-title":"Open Forum Infect Dis"},{"issue":"12","key":"4201_CR10","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1093\/cid\/ciu201","volume":"58","author":"P Hiwarkar","year":"2014","unstructured":"Hiwarkar P, Gajdosova E, Qasim W, Worth A, Breuer J, Chiesa R, Ridout D, Edelsten C, Moore A, Amrolia P, Veys P, Rao K (2014) Frequent occurrence of cytomegalovirus retinitis during immune reconstitution warrants regular ophthalmic screening in high-risk pediatric allogeneic hematopoietic stem cell transplant recipients. Clin Infect Dis 58(12):1700\u20131706. https:\/\/doi.org\/10.1093\/cid\/ciu201","journal-title":"Clin Infect Dis"},{"issue":"2","key":"4201_CR11","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1086\/318447","volume":"32","author":"F Crippa","year":"2001","unstructured":"Crippa F, Corey L, Chuang EL, Sale G, Boeckh M (2001) Virological, clinical, and ophthalmologic features of cytomegalovirus retinitis after hematopoietic stem cell transplantation. Clin Infect Dis 32(2):214\u2013219. https:\/\/doi.org\/10.1086\/318447","journal-title":"Clin Infect Dis"},{"issue":"4","key":"4201_CR12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/sj.bmt.1705445","volume":"38","author":"XJ Huang","year":"2006","unstructured":"Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W, Chen YH, Wang JZ, Gao ZY, Zhang YC, Jiang Q, Shi HX, Lu DP (2006) Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies. Bone Marrow Transplant 38(4):291\u2013297. https:\/\/doi.org\/10.1038\/sj.bmt.1705445","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"4201_CR13","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/bjh.14225","volume":"175","author":"LP Xu","year":"2016","unstructured":"Xu LP, Wang SQ, Wu DP, Wang JM, Gao SJ, Jiang M, Wang CB, Zhang X, Liu QF, Xia LH, Wang X, Huang XJ (2016) Haplo-identical transplantation for acquired severe aplastic anaemia in a multicentre prospective study. Br J Haematol 175(2):265\u2013274. https:\/\/doi.org\/10.1111\/bjh.14225","journal-title":"Br J Haematol"},{"issue":"4","key":"4201_CR14","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1177\/0885066613476454","volume":"29","author":"G Travi","year":"2014","unstructured":"Travi G, Pergam SA (2014) Cytomegalovirus pneumonia in hematopoietic stem cell recipients. J Intensive Care Med 29(4):200\u2013212. https:\/\/doi.org\/10.1177\/0885066613476454","journal-title":"J Intensive Care Med"},{"issue":"2","key":"4201_CR15","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.ccm.2016.12.008","volume":"38","author":"B Harris","year":"2017","unstructured":"Harris B, Geyer AI (2017) Diagnostic evaluation of pulmonary abnormalities in patients with hematologic malignancies and hematopoietic cell transplantation. Clin Chest Med 38(2):317\u2013331. https:\/\/doi.org\/10.1016\/j.ccm.2016.12.008","journal-title":"Clin Chest Med"},{"issue":"12","key":"4201_CR16","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1007\/s00330-014-3326-3","volume":"24","author":"AK Omeri","year":"2014","unstructured":"Omeri AK, Okada F, Takata S, Ono A, Nakayama T, Ando Y, Sato H, Hiramatsu K, Mori H (2014) Comparison of high-resolution computed tomography findings between Pseudomonas aeruginosa pneumonia and Cytomegalovirus pneumonia. Eur Radiol 24(12):3251\u20133259. https:\/\/doi.org\/10.1007\/s00330-014-3326-3","journal-title":"Eur Radiol"},{"issue":"10","key":"4201_CR17","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1093\/infdis\/jix048","volume":"215","author":"M Boeckh","year":"2017","unstructured":"Boeckh M, Stevens-Ayers T, Travi G, Huang ML, Cheng GS, Xie H, Leisenring W, Erard V, Seo S, Kimball L, Corey L, Pergam SA, Jerome KR (2017) Cytomegalovirus (CMV) DNA quantitation in bronchoalveolar lavage fluid from hematopoietic stem cell transplant recipients with CMV pneumonia. J Infect Dis 215(10):1514\u20131522. https:\/\/doi.org\/10.1093\/infdis\/jix048","journal-title":"J Infect Dis"},{"issue":"1","key":"4201_CR18","doi-asserted-by":"publisher","first-page":"ofv212","DOI":"10.1093\/ofid\/ofv212","volume":"3","author":"SK Tan","year":"2016","unstructured":"Tan SK, Burgener EB, Waggoner JJ, Gajurel K, Gonzalez S, Chen SF, Pinsky BA (2016) Molecular and culture-based bronchoalveolar lavage fluid testing for the diagnosis of cytomegalovirus pneumonitis. Open Forum Infect Dis 3(1):ofv212. https:\/\/doi.org\/10.1093\/ofid\/ofv212","journal-title":"Open Forum Infect Dis"},{"issue":"6","key":"4201_CR19","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/bmt.2017.11","volume":"52","author":"L Iglesias","year":"2017","unstructured":"Iglesias L, Perera MM, Torres-Minana L, Pena-Lopez MJ (2017) CMV viral load in bronchoalveolar lavage for diagnosis of pneumonia in allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 52(6):895\u2013897. https:\/\/doi.org\/10.1038\/bmt.2017.11","journal-title":"Bone Marrow Transplant"},{"issue":"24","key":"4201_CR20","doi-asserted-by":"publisher","first-page":"39736","DOI":"10.18632\/oncotarget.14504","volume":"8","author":"HY Lee","year":"2017","unstructured":"Lee HY, Rhee CK, Choi JY, Lee HY, Lee JW, Lee DG (2017) Diagnosis of cytomegalovirus pneumonia by quantitative polymerase chain reaction using bronchial washing fluid from patients with hematologic malignancies. Oncotarget 8(24):39736\u201339745. https:\/\/doi.org\/10.18632\/oncotarget.14504","journal-title":"Oncotarget"},{"key":"4201_CR21","doi-asserted-by":"publisher","unstructured":"Beam E, Germer JJ, Lahr B, Yao JDC, Limper AH, Binnicker MJ, Razonable RR (2018) Cytomegalovirus (CMV) DNA quantification in bronchoalveolar lavage fluid of immunocompromised patients with CMV pneumonia. Clin Transpl 32(1). https:\/\/doi.org\/10.1111\/ctr.13149","DOI":"10.1111\/ctr.13149"},{"issue":"1","key":"4201_CR22","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1513\/AnnalsATS.201212-114FR","volume":"10","author":"B Harris","year":"2013","unstructured":"Harris B, Lowy FD, Stover DE, Arcasoy SM (2013) Diagnostic bronchoscopy in solid-organ and hematopoietic stem cell transplantation. Ann Am Thorac Soc 10(1):39\u201349. https:\/\/doi.org\/10.1513\/AnnalsATS.201212-114FR","journal-title":"Ann Am Thorac Soc"},{"issue":"5","key":"4201_CR23","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1111\/ejh.12855","volume":"98","author":"XH Zhang","year":"2017","unstructured":"Zhang XH, Zhang JM, Han W, Chen H, Chen YH, Wang FR, Wang JZ, Zhang YY, Mo XD, Chen Y, Wang Y, Chang YJ, Xu LP, Liu KY, Huang XJ (2017) Viral encephalitis after haplo-identical hematopoietic stem cell transplantation: causative viral spectrum, characteristics, and risk factors. Eur J Haematol 98(5):450\u2013458. https:\/\/doi.org\/10.1111\/ejh.12855","journal-title":"Eur J Haematol"},{"key":"4201_CR24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jns.2018.02.029","volume":"388","author":"A Baghban","year":"2018","unstructured":"Baghban A, Malinis M (2018) Ganciclovir and foscarnet dual-therapy for cytomegalovirus encephalitis: a case report and review of the literature. J Neurol Sci 388:28\u201336. https:\/\/doi.org\/10.1016\/j.jns.2018.02.029","journal-title":"J Neurol Sci"},{"issue":"8","key":"4201_CR25","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1093\/infdis\/jiz298","volume":"220","author":"J Piret","year":"2019","unstructured":"Piret J, Schibler M, Pham VD, Hantz S, Giannotti F, Masouridi-Levrat S, Kaiser L, Goyette N, Alain S, Shi R, Boivin G (2019) Compartmentalization of a multidrug-resistant cytomegalovirus UL54 mutant in a stem cell transplant recipient with encephalitis. J Infect Dis 220(8):1302\u20131306. https:\/\/doi.org\/10.1093\/infdis\/jiz298","journal-title":"J Infect Dis"},{"issue":"1","key":"4201_CR26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1080\/16078454.2019.1710945","volume":"25","author":"P Ke","year":"2020","unstructured":"Ke P, Bao X, Zhou J, Li X, Zhuang J, He X, Wu D, Zhang X, Ma X (2020) Donor CMV-specific cytotoxic T lymphocytes successfully treated drug-resistant cytomegalovirus encephalitis after allogeneic hematopoietic stem cell transplantation. Hematology (Amsterdam, Netherlands) 25(1):43\u201347. https:\/\/doi.org\/10.1080\/16078454.2019.1710945","journal-title":"Hematology (Amsterdam, Netherlands)"},{"key":"4201_CR27","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1093\/cid\/ciy696","volume":"68","author":"RF Chemaly","year":"2018","unstructured":"Chemaly RF, Chou S, Einsele H, Griffiths P, Avery R, Razonable RR, Mullane KM, Kotton C, Lundgren J, Komatsu TE, Lischka P, Josephson F, Douglas CM, Umeh O, Miller V, Ljungman P (2018) Definitions of resistant and refractory cytomegalovirus infection and disease in transplant recipients for use in clinical trials. Clin Infect Dis 68:1420\u20131426. https:\/\/doi.org\/10.1093\/cid\/ciy696","journal-title":"Clin Infect Dis"},{"issue":"10","key":"4201_CR28","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1007\/s00277-015-2440-x","volume":"94","author":"YQ Sun","year":"2015","unstructured":"Sun YQ, He GL, Chang YJ, Xu LP, Zhang XH, Han W, Chen H, Chen YH, Wang Y, Wang FR, Wang JZ, Liu KY, Huang XJ (2015) The incidence, risk factors, and outcomes of primary poor graft function after unmanipulated haploidentical stem cell transplantation. Ann Hematol 94(10):1699\u20131705. https:\/\/doi.org\/10.1007\/s00277-015-2440-x","journal-title":"Ann Hematol"},{"issue":"12","key":"4201_CR29","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1086\/588660","volume":"46","author":"B De Pauw","year":"2008","unstructured":"De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T, Pappas PG, Maertens J, Lortholary O, Kauffman CA, Denning DW, Patterson TF, Maschmeyer G, Bille J, Dismukes WE, Herbrecht R, Hope WW, Kibbler CC, Kullberg BJ, Marr KA, Munoz P, Odds FC, Perfect JR, Restrepo A, Ruhnke M, Segal BH, Sobel JD, Sorrell TC, Viscoli C, Wingard JR, Zaoutis T, Bennett JE (2008) Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group. Clin Infect Dis 46(12):1813\u20131821. https:\/\/doi.org\/10.1086\/588660","journal-title":"Clin Infect Dis"},{"issue":"7","key":"4201_CR30","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3324\/haematol.2016.144428","volume":"101","author":"J Styczynski","year":"2016","unstructured":"Styczynski J, van der Velden W, Fox CP, Engelhard D, de la Camara R, Cordonnier C, Ljungman P (2016) Management of Epstein-Barr Virus infections and post-transplant lymphoproliferative disorders in patients after allogeneic hematopoietic stem cell transplantation: Sixth European Conference on Infections in Leukemia (ECIL-6) guidelines. Haematologica 101(7):803\u2013811. https:\/\/doi.org\/10.3324\/haematol.2016.144428","journal-title":"Haematologica"},{"issue":"4","key":"4201_CR31","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.biologicals.2016.04.005","volume":"44","author":"JF Fryer","year":"2016","unstructured":"Fryer JF, Heath AB, Minor PD (2016) A collaborative study to establish the 1st WHO International Standard for human cytomegalovirus for nucleic acid amplification technology. Biologicals 44(4):242\u2013251. https:\/\/doi.org\/10.1016\/j.biologicals.2016.04.005","journal-title":"Biologicals"},{"issue":"20","key":"4201_CR32","doi-asserted-by":"publisher","first-page":"4360","DOI":"10.1182\/blood-2010-01-262089","volume":"116","author":"T Feuchtinger","year":"2010","unstructured":"Feuchtinger T, Opherk K, Bethge WA, Topp MS, Schuster FR, Weissinger EM, Mohty M, Or R, Maschan M, Schumm M, Hamprecht K, Handgretinger R, Lang P, Einsele H (2010) Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation. Blood 116(20):4360\u20134367. https:\/\/doi.org\/10.1182\/blood-2010-01-262089","journal-title":"Blood"},{"issue":"4","key":"4201_CR33","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/sj.bmt.1702526","volume":"26","author":"CM Machado","year":"2000","unstructured":"Machado CM, Dulley FL, Boas LS, Castelli JB, Macedo MC, Silva RL, Pallota R, Saboya RS, Pannuti CS (2000) CMV pneumonia in allogeneic BMT recipients undergoing early treatment of pre-emptive ganciclovir therapy. Bone Marrow Transplant 26(4):413\u2013417. https:\/\/doi.org\/10.1038\/sj.bmt.1702526","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"4201_CR34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1093\/cid\/civ215","volume":"61","author":"V Erard","year":"2015","unstructured":"Erard V, Guthrie KA, Seo S, Smith J, Huang M, Chien J, Flowers ME, Corey L, Boeckh M (2015) Reduced mortality of cytomegalovirus pneumonia after hematopoietic cell transplantation due to antiviral therapy and changes in transplantation practices. Clin Infect Dis 61(1):31\u201339. https:\/\/doi.org\/10.1093\/cid\/civ215","journal-title":"Clin Infect Dis"},{"issue":"9","key":"4201_CR35","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1016\/j.ophtha.2012.03.032","volume":"119","author":"S Jeon","year":"2012","unstructured":"Jeon S, Lee WK, Lee Y, Lee DG, Lee JW (2012) Risk factors for cytomegalovirus retinitis in patients with cytomegalovirus viremia after hematopoietic stem cell transplantation. Ophthalmology 119(9):1892\u20131898. https:\/\/doi.org\/10.1016\/j.ophtha.2012.03.032","journal-title":"Ophthalmology"},{"issue":"6","key":"4201_CR36","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1038\/s41409-020-0790-z","volume":"55","author":"CH Yan","year":"2020","unstructured":"Yan CH, Wang Y, Mo XD, Sun YQ, Wang FR, Fu HX, Chen Y, Han TT, Kong J, Cheng YF, Zhang XH, Xu LP, Liu KY, Huang XJ (2020) Incidence, risk factors, and outcomes of cytomegalovirus retinitis after haploidentical hematopoietic stem cell transplantation. Bone Marrow Transplant 55(6):1147\u20131160. https:\/\/doi.org\/10.1038\/s41409-020-0790-z","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"4201_CR37","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bbmt.2014.10.004","volume":"21","author":"D Bhutani","year":"2015","unstructured":"Bhutani D, Dyson G, Manasa R, Deol A, Ratanatharathorn V, Ayash L, Abidi M, Lum LG, Al-Kadhimi Z, Uberti JP (2015) Incidence, risk factors, and outcome of cytomegalovirus viremia and gastroenteritis in patients with gastrointestinal graft-versus-host disease. Biol Blood Marrow Transplant 21(1):159\u2013164. https:\/\/doi.org\/10.1016\/j.bbmt.2014.10.004","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"4201_CR38","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s00277-012-1632-x","volume":"92","author":"BS Cho","year":"2013","unstructured":"Cho BS, Yahng SA, Kim JH, Yoon JH, Shin SH, Lee SE, Choi SM, Lee DG, Eom KS, Park G, Kim YJ, Kim HJ, Lee S, Min CK, Cho SG, Kim DW, Lee JW, Min WS, Park CW (2013) Impact of cytomegalovirus gastrointestinal disease on the clinical outcomes in patients with gastrointestinal graft-versus-host disease in the era of preemptive therapy. Ann Hematol 92(4):497\u2013504. https:\/\/doi.org\/10.1007\/s00277-012-1632-x","journal-title":"Ann Hematol"},{"issue":"8","key":"4201_CR39","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1111\/apt.12468","volume":"38","author":"A Liu","year":"2013","unstructured":"Liu A, Meyer E, Johnston L, Brown J, Gerson LB (2013) Prevalence of graft versus host disease and cytomegalovirus infection in patients post-haematopoietic cell transplantation presenting with gastrointestinal symptoms. Aliment Pharmacol Ther 38(8):955\u2013966. https:\/\/doi.org\/10.1111\/apt.12468","journal-title":"Aliment Pharmacol Ther"},{"issue":"6","key":"4201_CR40","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/bmt.2010.35","volume":"45","author":"SM Reddy","year":"2010","unstructured":"Reddy SM, Winston DJ, Territo MC, Schiller GJ (2010) CMV central nervous system disease in stem-cell transplant recipients: an increasing complication of drug-resistant CMV infection and protracted immunodeficiency. Bone Marrow Transplant 45(6):979\u2013984. https:\/\/doi.org\/10.1038\/bmt.2010.35","journal-title":"Bone Marrow Transplant"},{"key":"4201_CR41","doi-asserted-by":"publisher","first-page":"e260","DOI":"10.1016\/s1473-3099(19)30107-0","volume":"19","author":"P Ljungman","year":"2019","unstructured":"Ljungman P, de la Camara R, Robin C, Crocchiolo R, Einsele H, Hill JA, Hubacek P, Navarro D, Cordonnier C, Ward KN (2019) Guidelines for the management of cytomegalovirus infection in patients with haematological malignancies and after stem cell transplantation from the 2017 European Conference on Infections in Leukaemia (ECIL 7). Lancet Infect Dis 19:e260\u2013e272. https:\/\/doi.org\/10.1016\/s1473-3099(19)30107-0","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"4201_CR42","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1093\/cid\/cix793","volume":"66","author":"Y Natori","year":"2018","unstructured":"Natori Y, Alghamdi A, Tazari M, Miller V, Husain S, Komatsu T, Griffiths P, Ljungman P, Orchanian-Cheff A, Kumar D, Humar A (2018) Use of viral load as a surrogate marker in clinical studies of cytomegalovirus in solid organ transplantation: a systematic review and meta-analysis. Clin Infect Dis 66(4):617\u2013631. https:\/\/doi.org\/10.1093\/cid\/cix793","journal-title":"Clin Infect Dis"},{"issue":"25","key":"4201_CR43","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1056\/NEJMoa1706640","volume":"377","author":"FM Marty","year":"2017","unstructured":"Marty FM, Ljungman P, Chemaly RF, Maertens J, Dadwal SS, Duarte RF, Haider S, Ullmann AJ, Katayama Y, Brown J, Mullane KM, Boeckh M, Blumberg EA, Einsele H, Snydman DR, Kanda Y, DiNubile MJ, Teal VL, Wan H, Murata Y, Kartsonis NA, Leavitt RY, Badshah C (2017) Letermovir prophylaxis for cytomegalovirus in hematopoietic-cell transplantation. N Engl J Med 377(25):2433\u20132444. https:\/\/doi.org\/10.1056\/NEJMoa1706640","journal-title":"N Engl J Med"},{"key":"4201_CR44","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1093\/cid\/ciz490","volume":"70","author":"P Ljungman","year":"2019","unstructured":"Ljungman P, Schmitt M, Marty FM, Maertens J, Chemaly RF, Kartsonis NA, Butterton JR, Wan H, Teal VL, Sarratt K, Murata Y, Leavitt RY, Badshah C (2019) A mortality analysis of letermovir prophylaxis for cytomegalovirus (CMV) in CMV-seropositive recipients of allogeneic hematopoietic-cell transplantation. Clin Infect Dis 70:1525\u20131533. https:\/\/doi.org\/10.1093\/cid\/ciz490","journal-title":"Clin Infect Dis"},{"issue":"3","key":"4201_CR45","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/rmv.1873","volume":"26","author":"AB Campos","year":"2016","unstructured":"Campos AB, Ribeiro J, Boutolleau D, Sousa H (2016) Human cytomegalovirus antiviral drug resistance in hematopoietic stem cell transplantation: current state of the art. Rev Med Virol 26(3):161\u2013182. https:\/\/doi.org\/10.1002\/rmv.1873","journal-title":"Rev Med Virol"},{"issue":"3","key":"4201_CR46","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1093\/jac\/dkn521","volume":"63","author":"T Allice","year":"2009","unstructured":"Allice T, Busca A, Locatelli F, Falda M, Pittaluga F, Ghisetti V (2009) Valganciclovir as pre-emptive therapy for cytomegalovirus infection post-allogenic stem cell transplantation: implications for the emergence of drug-resistant cytomegalovirus. J Antimicrob Chemother 63(3):600\u2013608. https:\/\/doi.org\/10.1093\/jac\/dkn521","journal-title":"J Antimicrob Chemother"},{"issue":"12","key":"4201_CR47","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1093\/jac\/dkq368","volume":"65","author":"S Hantz","year":"2010","unstructured":"Hantz S, Garnier-Geoffroy F, Mazeron MC, Garrigue I, Merville P, Mengelle C, Rostaing L, Saint Marcoux F, Essig M, Rerolle JP, Cotin S, Germi R, Pillet S, Lebranchu Y, Turlure P, Alain S (2010) Drug-resistant cytomegalovirus in transplant recipients: a French cohort study. J Antimicrob Chemother 65(12):2628\u20132640. https:\/\/doi.org\/10.1093\/jac\/dkq368","journal-title":"J Antimicrob Chemother"},{"issue":"12","key":"4201_CR48","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.1128\/aac.45.12.3669-3671.2001","volume":"45","author":"C Gilbert","year":"2001","unstructured":"Gilbert C, Roy J, Belanger R, Delage R, Beliveau C, Demers C, Boivin G (2001) Lack of emergence of cytomegalovirus UL97 mutations conferring ganciclovir (GCV) resistance following preemptive GCV therapy in allogeneic stem cell transplant recipients. Antimicrob Agents Chemother 45(12):3669\u20133671. https:\/\/doi.org\/10.1128\/aac.45.12.3669-3671.2001","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"4201_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7326\/m13-2729","volume":"162","author":"M Boeckh","year":"2015","unstructured":"Boeckh M, Nichols WG, Chemaly RF, Papanicolaou GA, Wingard JR, Xie H, Syrjala KL, Flowers ME, Stevens-Ayers T, Jerome KR, Leisenring W (2015) Valganciclovir for the prevention of complications of late cytomegalovirus infection after allogeneic hematopoietic cell transplantation: a randomized trial. Ann Intern Med 162(1):1\u201310. https:\/\/doi.org\/10.7326\/m13-2729","journal-title":"Ann Intern Med"},{"issue":"4","key":"4201_CR50","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1093\/infdis\/jit475","volume":"209","author":"E Shmueli","year":"2014","unstructured":"Shmueli E, Or R, Shapira MY, Resnick IB, Caplan O, Bdolah-Abram T, Wolf DG (2014) High rate of cytomegalovirus drug resistance among patients receiving preemptive antiviral treatment after haploidentical stem cell transplantation. J Infect Dis 209(4):557\u2013561. https:\/\/doi.org\/10.1093\/infdis\/jit475","journal-title":"J Infect Dis"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-020-04201-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-020-04201-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-020-04201-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T23:20:32Z","timestamp":1627600832000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-020-04201-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,30]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["4201"],"URL":"https:\/\/doi.org\/10.1007\/s00277-020-04201-4","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,30]]},"assertion":[{"value":"6 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendment or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}