{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:47:17Z","timestamp":1768679237513,"version":"3.49.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s00277-021-04412-3","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T11:03:17Z","timestamp":1610622197000},"page":"2269-2277","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Low absolute neutrophil count during induction therapy is an adverse prognostic factor in childhood acute lymphoblastic leukaemia"],"prefix":"10.1007","volume":"100","author":[{"given":"Xiaoyan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenQi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lipeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihui","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixian","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingchi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2572-6495","authenticated-orcid":false,"given":"Xiaofan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"issue":"26","key":"4412_CR1","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.1182\/blood-2015-02-580043","volume":"125","author":"SP Hunger","year":"2015","unstructured":"Hunger SP, Mullighan CG (2015) Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine. Blood 125(26):3977\u20133987. https:\/\/doi.org\/10.1182\/blood-2015-02-580043","journal-title":"Blood"},{"issue":"27","key":"4412_CR2","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1200\/JCO.2014.59.1636","volume":"33","author":"C Pui","year":"2015","unstructured":"Pui C, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A et al (2015) Childhood acute lymphoblastic leukemia: progress through collaboration. J Clin Oncol 33(27):2924\u20132938. https:\/\/doi.org\/10.1200\/JCO.2014.59.1636","journal-title":"J Clin Oncol"},{"issue":"10230","key":"4412_CR3","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/S0140-6736(19)33018-1","volume":"395","author":"M Florent","year":"2020","unstructured":"Florent M, Mohamad M (2020) Acute lymphoblastic leukaemia. Lancet 395(10230):1146\u20131162. https:\/\/doi.org\/10.1016\/S0140-6736(19)33018-1","journal-title":"Lancet"},{"issue":"e1705807","key":"4412_CR4","doi-asserted-by":"publisher","first-page":"e170580","DOI":"10.1001\/jamaoncol.2017.0580","volume":"3","author":"DA Berry","year":"2017","unstructured":"Berry DA, Zhou S, Higley H, Mukundan L, Fu S, Reaman GH, Wood BL, Kelloff GJ, Jessup JM, Radich JP (2017) Association of minimal residual disease with clinical outcome in pediatric and adult acute lymphoblastic leukemia a meta-analysis. Jama Oncol 3(e1705807):e170580. https:\/\/doi.org\/10.1001\/jamaoncol.2017.0580","journal-title":"Jama Oncol"},{"issue":"4","key":"4412_CR5","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S1470-2045(15)70082-3","volume":"16","author":"C Pui","year":"2015","unstructured":"Pui C, Pei D, Coustan-Smith E, Jeha S, Cheng C, Bowman WP et al (2015) Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study. Lancet Oncol 16(4):465\u2013474. https:\/\/doi.org\/10.1016\/S1470-2045(15)70082-3","journal-title":"Lancet Oncol"},{"issue":"1","key":"4412_CR6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.pcl.2014.09.004","volume":"62","author":"D Bhojwani","year":"2015","unstructured":"Bhojwani D, Yang JJ, Pui C (2015) Biology of childhood acute lymphoblastic leukemia. Pediatr Clin N Am 62(1):47\u201360. https:\/\/doi.org\/10.1016\/j.pcl.2014.09.004","journal-title":"Pediatr Clin N Am"},{"issue":"3","key":"4412_CR7","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1001\/jamaoncol.2019.5868","volume":"6","author":"S Shen","year":"2020","unstructured":"Shen S, Chen X, Cai J, Yu J, Gao J, Hu S, Zhai X, Liang C, Ju X, Jiang H, Jin R, Wu X, Wang N, Tian X, Pan K, Jiang H, Sun L, Fang Y, Li CK, Hu Q, Yang M, Zhu Y, Zhang H, Li C, Pei D, Jeha S, Yang JJ, Cheng C, Tang J, Zhu X, Pui CH (2020) Effect of dasatinib vs imatinib in the treatment of pediatric philadelphia chromosome-positive acute lymphoblastic leukemia a randomized clinical trial. Jama Oncol 6(3):358\u2013366. https:\/\/doi.org\/10.1001\/jamaoncol.2019.5868","journal-title":"Jama Oncol"},{"issue":"10","key":"4412_CR8","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1200\/JCO.2005.04.012","volume":"23","author":"SJ Laughton","year":"2005","unstructured":"Laughton SJ, Ashton LJ, Kwan E, Norris MD, Haber M, Marshall GM (2005) Early responses to chemotherapy of normal and malignant hematologic cells are prognostic in children with acute lymphoblastic leukemia. J Clin Oncol 23(10):2264\u20132271. https:\/\/doi.org\/10.1200\/JCO.2005.04.012","journal-title":"J Clin Oncol"},{"issue":"3","key":"4412_CR9","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3324\/haematol.2011.045229","volume":"97","author":"L Zeidler","year":"2012","unstructured":"Zeidler L, Zimmermann M, Moericke A, Meissner B, Bartels D, Tschan C et al (2012) Low platelet counts after induction therapy for childhood acute lymphoblastic leukemia are strongly associated with poor early response to treatment as measured by minimal residual disease and are prognostic for treatment outcome. Haematologica 97(3):402\u2013409. https:\/\/doi.org\/10.3324\/haematol.2011.045229","journal-title":"Haematologica"},{"issue":"11","key":"4412_CR10","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1038\/leu.2013.135","volume":"27","author":"C Meyer","year":"2013","unstructured":"Meyer C, Hofmann J, Burmeister T, Groeger D, Park TS, Emerenciano M et al (2013) The MLL recombinome of acute leukemias in 2013. Leukemia 27(11):2165\u20132176. https:\/\/doi.org\/10.1038\/leu.2013.135","journal-title":"Leukemia"},{"issue":"2","key":"4412_CR11","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11899-020-00582-5","volume":"15","author":"F El Chaer","year":"2020","unstructured":"El Chaer F, Keng M, Ballen KK (2020) MLL-rearranged acute lymphoblastic leukemia. Curr Hematol Malig Rep 15(2):83\u201389. https:\/\/doi.org\/10.1007\/s11899-020-00582-5","journal-title":"Curr Hematol Malig Rep"},{"issue":"7","key":"4412_CR12","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1038\/leu.2014.30","volume":"28","author":"KR Schultz","year":"2014","unstructured":"Schultz KR, Carroll A, Heerema NA, Bowman WP, Aledo A, Slayton WB et al (2014) Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children\u2019s Oncology Group Study AALL0031. Leukemia 28(7):1467\u20131471. https:\/\/doi.org\/10.1038\/leu.2014.30","journal-title":"Leukemia"},{"issue":"3","key":"4412_CR13","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s12307-012-0114-y","volume":"5","author":"M Huang","year":"2012","unstructured":"Huang M, Zhu J (2012) The regulation of normal and leukemic hematopoietic stem cells by niches. Cancer Microenviron 5(3):295\u2013305. https:\/\/doi.org\/10.1007\/s12307-012-0114-y","journal-title":"Cancer Microenviron"},{"key":"4412_CR14","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s12967-015-0543-8","volume":"13","author":"C Jiang","year":"2015","unstructured":"Jiang C, Hu X, Wang L, Cheng H, Lin Y, Pang Y, Yuan W, Cheng T, Wang J (2015) Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model. J Transl Med 13:234. https:\/\/doi.org\/10.1186\/s12967-015-0543-8","journal-title":"J Transl Med"},{"issue":"2","key":"4412_CR15","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/cncr.23168","volume":"112","author":"G De Angulo","year":"2008","unstructured":"De Angulo G, Yuen C, Palla SL, Anderson PM, Zweidler-McKay PA (2008) Absolute lymphocyte count is a novel prognostic indicator in ALL and AML-implications for risk stratification and future studies. Cancer 112(2):407\u2013415. https:\/\/doi.org\/10.1002\/cncr.23168","journal-title":"Cancer"},{"issue":"11","key":"4412_CR16","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1002\/cncr.28026","volume":"119","author":"JE Rubnitz","year":"2013","unstructured":"Rubnitz JE, Campbell P, Zhou Y, Sandlund JT, Jeha S, Ribeiro RC, Inaba H, Bhojwani D, Relling MV, Howard SC, Campana D, Pui CH (2013) Prognostic impact of absolute lymphocyte counts at the end of remission induction in childhood acute lymphoblastic leukemia. Cancer 119(11):2061\u20132066. https:\/\/doi.org\/10.1002\/cncr.28026","journal-title":"Cancer"},{"issue":"1","key":"4412_CR17","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1080\/16078454.2019.1621019","volume":"24","author":"JD Grunnan","year":"2019","unstructured":"Grunnan JD, Rosthoj S (2019) Time course of peripheral blood count recovery during induction chemotherapy for childhood acute lymphoblastic leukemia. Hematology 24(1):467\u2013472. https:\/\/doi.org\/10.1080\/16078454.2019.1621019","journal-title":"Hematology"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-021-04412-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-021-04412-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-021-04412-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T05:05:32Z","timestamp":1628658332000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-021-04412-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,14]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["4412"],"URL":"https:\/\/doi.org\/10.1007\/s00277-021-04412-3","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,14]]},"assertion":[{"value":"22 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was obtained from the Ethics Committee and Institutional Review Board of Chinese Academy of Medical Sciences and Peking Union Medical College (approval number: IIT2015010-EC-1).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from legal guardians.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Legal guardians signed informed consent regarding publishing their data.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}