{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:39:22Z","timestamp":1777426762930,"version":"3.51.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s00277-022-04944-2","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T02:02:29Z","timestamp":1660874549000},"page":"2281-2287","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hemophagocytic lymphohistiocytosis in HIV-associated lymphoproliferative disorders"],"prefix":"10.1007","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5659-9345","authenticated-orcid":false,"given":"Pascal","family":"Migaud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keikawus","family":"Arast\u00e9h","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Hentrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Stocker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"issue":"22","key":"4944_CR1","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1182\/blood-2016-01-690636","volume":"127","author":"JF Emile","year":"2016","unstructured":"Emile JF et al (2016) Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood 127(22):2672\u20132681","journal-title":"Blood"},{"issue":"9927","key":"4944_CR2","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/S0140-6736(13)61048-X","volume":"383","author":"M Ramos-Casals","year":"2014","unstructured":"Ramos-Casals M et al (2014) Adult haemophagocytic syndrome. Lancet 383(9927):1503\u20131516","journal-title":"Lancet"},{"issue":"4","key":"4944_CR3","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1007\/s00432-020-03139-4","volume":"146","author":"S Birndt","year":"2020","unstructured":"Birndt S et al (2020) Hemophagocytic lymphohistiocytosis in adults: collaborative analysis of 137 cases of a nationwide German registry. J Cancer Res Clin Oncol 146(4):1065\u20131077","journal-title":"J Cancer Res Clin Oncol"},{"issue":"23","key":"4944_CR4","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1182\/blood.2018894618","volume":"133","author":"P La Rosee","year":"2019","unstructured":"La Rosee P et al (2019) Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood 133(23):2465\u20132477","journal-title":"Blood"},{"issue":"2","key":"4944_CR5","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1086\/375224","volume":"37","author":"L Fardet","year":"2003","unstructured":"Fardet L et al (2003) Human herpesvirus 8-associated hemophagocytic lymphohistiocytosis in human immunodeficiency virus-infected patients. Clin Infect Dis 37(2):285\u2013291","journal-title":"Clin Infect Dis"},{"issue":"9","key":"4944_CR6","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1097\/QAD.0b013e328339e55b","volume":"24","author":"L Fardet","year":"2010","unstructured":"Fardet L et al (2010) Reactive haemophagocytic syndrome in 58 HIV-1-infected patients: clinical features, underlying diseases and prognosis. AIDS 24(9):1299\u20131306","journal-title":"AIDS"},{"issue":"15","key":"4944_CR7","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1097\/QAD.0000000000000428","volume":"28","author":"TM Gibson","year":"2014","unstructured":"Gibson TM et al (2014) Risk of non-Hodgkin lymphoma subtypes in HIV-infected people during the HAART era: a population-based study. AIDS (London, England) 28(15):2313\u20132318","journal-title":"AIDS (London, England)"},{"issue":"8","key":"4944_CR8","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1097\/QAD.0000000000000222","volume":"28","author":"P Morlat","year":"2014","unstructured":"Morlat P et al (2014) Causes of death among HIV-infected patients in France in 2010 (national survey): trends since 2000. AIDS 28(8):1181\u20131191","journal-title":"AIDS"},{"issue":"3","key":"4944_CR9","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1111\/bjh.17515","volume":"194","author":"M Hentrich","year":"2021","unstructured":"Hentrich M et al (2021) Characteristics and outcome of human immunodeficiency virus (HIV)-associated primary effusion lymphoma as observed in the German HIV-related lymphoma cohort study. Br J Haematol 194(3):642\u2013646","journal-title":"Br J Haematol"},{"issue":"5","key":"4944_CR10","doi-asserted-by":"publisher","first-page":"857","DOI":"10.3324\/haematol.2017.180893","volume":"103","author":"P Schommers","year":"2018","unstructured":"Schommers P et al (2018) Incidence and risk factors for relapses in HIV-associated non-Hodgkin lymphoma as observed in the German HIV-related lymphoma cohort study. Haematologica 103(5):857\u2013864","journal-title":"Haematologica"},{"issue":"2","key":"4944_CR11","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/pbc.21039","volume":"48","author":"JI Henter","year":"2007","unstructured":"Henter JI et al (2007) HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 48(2):124\u2013131","journal-title":"Pediatr Blood Cancer"},{"issue":"9","key":"4944_CR12","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1002\/art.38690","volume":"66","author":"L Fardet","year":"2014","unstructured":"Fardet L et al (2014) Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol 66(9):2613\u20132620","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"4944_CR13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1093\/biomet\/67.1.145","volume":"67","author":"D Schoenfeld","year":"1980","unstructured":"Schoenfeld D (1980) Chi-squared goodness-of-fit tests for the proportional hazards regression model. Biometrika 67(1):145\u2013153","journal-title":"Biometrika"},{"issue":"9","key":"4944_CR14","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1093\/oxfordjournals.aje.a009532","volume":"147","author":"DA Savitz","year":"1998","unstructured":"Savitz DA, Olshan AF (1998) Describing data requires no adjustment for multiple comparisons: a reply from Savitz and Olshan. Am J Epidemiol 147(9):813\u20134 (discussion 815)","journal-title":"Am J Epidemiol"},{"issue":"9","key":"4944_CR15","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1093\/oxfordjournals.aje.a009530","volume":"147","author":"JR Thompson","year":"1998","unstructured":"Thompson JR (1998) Invited commentary: re: \u201cMultiple comparisons and related issues in the interpretation of epidemiologic data.\u201d Am J Epidemiol 147(9):801\u2013806","journal-title":"Am J Epidemiol"},{"issue":"6","key":"4944_CR16","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s00277-014-2058-4","volume":"93","author":"M Hentrich","year":"2014","unstructured":"Hentrich M et al (2014) Therapy of HIV-associated lymphoma-recommendations of the oncology working group of the German Study Group of Physicians in Private Practice Treating HIV-Infected Patients (DAGNA), in cooperation with the German AIDS Society (DAIG). Ann Hematol 93(6):913\u2013921","journal-title":"Ann Hematol"},{"issue":"11","key":"4944_CR17","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.amjmed.2014.04.034","volume":"127","author":"S Riviere","year":"2014","unstructured":"Riviere S et al (2014) Reactive hemophagocytic syndrome in adults: a retrospective analysis of 162 patients. Am J Med 127(11):1118\u20131125","journal-title":"Am J Med"},{"issue":"4","key":"4944_CR18","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3109\/10428194.2010.551153","volume":"52","author":"M Machaczka","year":"2011","unstructured":"Machaczka M et al (2011) Malignancy-associated hemophagocytic lymphohistiocytosis in adults: a retrospective population-based analysis from a single center. Leuk Lymphoma 52(4):613\u2013619","journal-title":"Leuk Lymphoma"},{"issue":"6","key":"4944_CR19","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1111\/bjh.12823","volume":"165","author":"H Sano","year":"2014","unstructured":"Sano H et al (2014) Risk factor analysis of non-Hodgkin lymphoma-associated haemophagocytic syndromes: a multicentre study. Br J Haematol 165(6):786\u2013792","journal-title":"Br J Haematol"},{"issue":"1","key":"4944_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/QCO.0b013e32832180b0","volume":"22","author":"T Doyle","year":"2009","unstructured":"Doyle T, Bhagani S, Cwynarski K (2009) Haemophagocytic syndrome and HIV. Curr Opin Infect Dis 22(1):1\u20136","journal-title":"Curr Opin Infect Dis"},{"issue":"27","key":"4944_CR21","doi-asserted-by":"publisher","first-page":"e459","DOI":"10.1200\/JCO.2010.28.3077","volume":"28","author":"BK Shah","year":"2010","unstructured":"Shah BK et al (2010) HIV-associated primary bone marrow Hodgkin\u2019s lymphoma: a distinct entity? J Clin Oncol 28(27):e459\u2013e460","journal-title":"J Clin Oncol"},{"issue":"4","key":"4944_CR22","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1002\/hon.2314","volume":"35","author":"C Cattaneo","year":"2017","unstructured":"Cattaneo C et al (2017) Adult onset hemophagocytic lymphohistiocytosis prognosis is affected by underlying disease and coexisting viral infection: analysis of a single institution series of 35 patients. Hematol Oncol 35(4):828\u2013834","journal-title":"Hematol Oncol"},{"issue":"1","key":"4944_CR23","doi-asserted-by":"publisher","first-page":"84","DOI":"10.4049\/jimmunol.1302282","volume":"192","author":"TS Johnson","year":"2014","unstructured":"Johnson TS et al (2014) Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis. J Immunol 192(1):84\u201391","journal-title":"J Immunol"},{"issue":"4","key":"4944_CR24","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1080\/10428194.2020.1849671","volume":"62","author":"G Meng","year":"2021","unstructured":"Meng G et al (2021) The DEP regimen is superior to the HLH-1994 regimen as first-line therapy for lymphoma-associated haemophagocytic lymphohistiocytosis. Leuk Lymphoma 62(4):854\u2013860","journal-title":"Leuk Lymphoma"},{"issue":"12","key":"4944_CR25","doi-asserted-by":"publisher","first-page":"e630","DOI":"10.1016\/S2352-3026(19)30156-5","volume":"6","author":"A Ahmed","year":"2019","unstructured":"Ahmed A et al (2019) Ruxolitinib in adult patients with secondary haemophagocytic lymphohistiocytosis: an open-label, single-centre, pilot trial. Lancet Haematol 6(12):e630\u2013e637","journal-title":"Lancet Haematol"},{"issue":"21","key":"4944_CR26","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1182\/blood.2019002289","volume":"134","author":"M Vallurupalli","year":"2019","unstructured":"Vallurupalli M, Berliner N (2019) Emapalumab for the treatment of relapsed\/refractory hemophagocytic lymphohistiocytosis. Blood 134(21):1783\u20131786","journal-title":"Blood"}],"updated-by":[{"DOI":"10.1007\/s00277-023-05137-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000}}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-022-04944-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-022-04944-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-022-04944-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T07:08:06Z","timestamp":1676531286000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-022-04944-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,19]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["4944"],"URL":"https:\/\/doi.org\/10.1007\/s00277-022-04944-2","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00277-023-05137-1","asserted-by":"object"}]},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,19]]},"assertion":[{"value":"2 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2023","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00277-023-05137-1","URL":"https:\/\/doi.org\/10.1007\/s00277-023-05137-1","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval was obtained from the ethics committees of the University of Cologne (IRC Cologne: 05\u2013174), Germany.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was given by each participating patient.Permission to reproduce material from other sources.No material from third parties was used.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}