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We conducted a simulation for scheduled CVC removal within the multicenter CRBSI registry (SECRECY). Non-tunneled jugular and subclavian CVC in patients with hematological disease or with germ cell tumors (including patients receiving autologous stem cell transplantation [SCT]) were included. Cases were randomized in a 1:1:1:1 ratio to either a simulated, scheduled CVC removal after 7, 14, and 21\u00a0days, or to non-simulated, unscheduled CVC removal (control group). The primary endpoint was definitive CRBSI incidence for a scheduled CVC removal after 14\u00a0days (dCRBSI-D14<jats:sub>rmv<\/jats:sub>). Among other, secondary endpoints were definite CRBSI incidence for a scheduled removal after 7\u00a0days (dCRBSI-D7<jats:sub>rmv<\/jats:sub>) and 21\u00a0days \ufeff(dCRBSI-D21<jats:sub>rmv<\/jats:sub>). Data on 2984 CVC were included. Patients\u2019 median age was 59 (range 16\u201395) years, 58.8% being male. The vast majority (98.4%) were patients with hematological malignancies. Jugular veins were the main insertion site (93.2%). dCRBSI-D14<jats:sub>rmv<\/jats:sub> was 3.10\/1000 CVC days as compared to 4.15\/1000 CVC days in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.23). There was a significant difference between dCRBSI-D7<jats:sub>rmv<\/jats:sub> (0.86\/1000 CVC days) and controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but not between dCRBSI-D21<jats:sub>rmv<\/jats:sub> (4.10\/1000 CVC days) and controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.96). Our data suggest that in patients with hematological diseases or autologous SCT recipients scheduled CVC removal after 14\u00a0days does not result in a lower CRBSI incidence compared to unscheduled removal.<\/jats:p><jats:p><jats:bold>Trial registration:<\/jats:bold> DRKS00006551, 2014\/09\/29, retrospectively registered.<\/jats:p>","DOI":"10.1007\/s00277-022-04958-w","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T21:02:26Z","timestamp":1660770146000},"page":"2317-2324","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Scheduled removal of central venous catheters (CVC) to prevent CVC-related bloodstream infections in patients with hematological disease or autologous stem cell transplantation: a registry-based randomized simulation-study"],"prefix":"10.1007","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6316-3112","authenticated-orcid":false,"given":"Jens","family":"Panse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"T\u00f6lle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1639-5751","authenticated-orcid":false,"given":"Eva","family":"Fiegle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-7938","authenticated-orcid":false,"given":"Jan-Hendrik","family":"Naendrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3071-6945","authenticated-orcid":false,"given":"Martin","family":"Schmidt-Hieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-0981","authenticated-orcid":false,"given":"Boris","family":"B\u00f6ll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5622-348X","authenticated-orcid":false,"given":"Marcus","family":"Hentrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7351-8060","authenticated-orcid":false,"given":"Daniel","family":"Teschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1892-5098","authenticated-orcid":false,"given":"Enrico","family":"Schalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"4958_CR1","doi-asserted-by":"publisher","first-page":"e162","DOI":"10.1093\/cid\/cir25","volume":"52","author":"NP O'Grady","year":"2011","unstructured":"O\u2019Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, Raad II, Randolph AG, Rupp ME, Saint S, Healthcare Infection Control Practices Advisory Committee (HICPAC) (2011) Guidelines for the prevention of intravascular catheter-related infections. 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The SECRECY registry was approved by the central ethics committee (Magdeburg University Hospital, approval no. 84\/14) as well as by respective local ethics committees.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Given the nature of routine clinical data and the anonymization of patients\u2019 data, written informed consent was not required within the study. However, written informed consent was mandatory for procedures during the clinical routine.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"SECRECY (Study to Evaluate Central Venous Catheter-related Infections in Hematology and Oncology) was registered in the German Clinical Trial Register (DRKS; no. DRKS00006551).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial registration"}}]}}