{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T23:53:18Z","timestamp":1794354798527,"version":"4.9.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical characteristics and prognosis of intracranial hemorrhage (ICH) in patients with hematological diseases remain controversial. This study aimed to describe the clinical characteristics and explore the prognostic factors in such patients. A total of 238 ICH patients with a hematological disease were recruited from the Institute of Hematology and Blood Diseases Hospital, China, from January 2015 to April 2020. The Cox proportional hazards model was used to identify the prognostic factors for 30-day mortality in ICH patients with a hematological disease. There were 123 cases of acute leukemia (AL), 20 of myelodysplasia\/myeloproliferative neoplasm, 35 of aplastic anemia (AA), 29 of immune thrombocytopenia (ITP), 19 of congenital\/acquired coagulation factor deficiency, and 12 of other hematological diseases. Furthermore, 121 patients presented with a multi-site hemorrhage (MSH), 58 with a single-site hemorrhage in the brain parenchyma (PCH), 23 with a subarachnoid hemorrhage, 33 with a subdural hemorrhage (SH), and three with an epidural hemorrhage. The Cox proportional hazards model indicated association of SH (vs PCH, hazard ratio [HR]: 0.230; 95% confidence interval [CI]: 0.053\u20130.996; <jats:italic>P<\/jats:italic>\u2009=\u20090.049), low white blood cells (\u2264\u2009100\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L vs\u2009&gt;\u2009100\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, HR: 0.56; 95% CI: 0.348\u20130.910; <jats:italic>P<\/jats:italic>\u2009=\u20090.019), AA (vs AL, HR: 0.408; 95% CI: 0.203\u20130.821; <jats:italic>P<\/jats:italic>\u2009=\u20090.012), and ITP (vs AL, HR: 0.197; 95% CI: 0.061\u20130.640; <jats:italic>P<\/jats:italic>\u2009=\u20090.007) with improved 30-day mortality. However, increased age (HR: 1.012; 95% CI: 1.001\u20131.022; <jats:italic>P<\/jats:italic>\u2009=\u20090.034), MSH (vs PCH, HR: 1.891; 95% CI: 1.147\u20133.117; <jats:italic>P<\/jats:italic>\u2009=\u20090.012), and a disturbance of consciousness (HR: 1.989; 95% CI: 1.269\u20133.117; <jats:italic>P<\/jats:italic>\u2009=\u20090.003) were associated with increased risk of 30-day mortality. In conclusion, in this study, we revealed the clinical characteristics of Chinese ICH patients with a hematological disease. Moreover, we identified risk factors (age, white blood cells, AA, ITP, SH, MSH, and a disturbance of consciousness) that may influence 30-day mortality.<\/jats:p>","DOI":"10.1007\/s00277-022-04982-w","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T09:11:42Z","timestamp":1664529102000},"page":"2617-2625","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical characteristics and prognostic factors in intracranial hemorrhage patients with hematological diseases"],"prefix":"10.1007","volume":"101","author":[{"given":"Jia-Yuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Shen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Juan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ze","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ke","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Huan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chang","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"4982_CR1","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.02.008","volume":"17","author":"A Gonzalez-Duarte","year":"2008","unstructured":"Gonzalez-Duarte A, Garcia-Ramos GS, Valdes-Ferrer SI et al (2008) Clinical description of intracranial hemorrhage associated with bleeding disorders. 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