{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:45:25Z","timestamp":1788777925873,"version":"build-2803163510"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s00277-022-04985-7","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T17:04:01Z","timestamp":1664471041000},"page":"2781-2784","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and efficacy of splenectomy for the treatment of chronic immune thrombocytopenia"],"prefix":"10.1007","volume":"101","author":[{"given":"Artur","family":"Saldanha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7908-9073","authenticated-orcid":false,"given":"Fernanda A.","family":"Orsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Rothschild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Prestes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Stefanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderson","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Villaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"4985_CR1","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1182\/blood-2008-07-162503","volume":"113","author":"F Rodeghiero","year":"2009","unstructured":"Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, Bussel JB, Cines DB, Chong BH, Cooper N et al (2009) Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood 113:2386\u20132393. https:\/\/doi.org\/10.1182\/blood-2008-07-162503","journal-title":"Blood"},{"key":"4985_CR2","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1056\/NEJMcp1810479","volume":"381","author":"N Cooper","year":"2019","unstructured":"Cooper N, Ghanima W (2019) Immune thrombocytopenia. N Engl J Med 381:945\u2013955. https:\/\/doi.org\/10.1056\/NEJMcp1810479","journal-title":"N Engl J Med"},{"issue":"21","key":"4985_CR3","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1182\/blood-2017-03-754119","volume":"129","author":"MP Lambert","year":"2017","unstructured":"Lambert MP, Gernsheimer TB (2017) Clinical updates in adult immune thrombocytopenia. Blood 129(21):2829\u20132835. https:\/\/doi.org\/10.1182\/blood-2017-03-754119","journal-title":"Blood"},{"issue":"2","key":"4985_CR4","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/cei.12935","volume":"188","author":"S Audia","year":"2017","unstructured":"Audia S, Santegoets K, Laarhoven AG, Vidarsson G, Facy O, Deballon O, Samson M, Janikashvili N, Saas P, Bonotte B et al (2017) Fc\u03b3 receptor expression on splenic macrophages in adult immune thrombocytopenia. Clin Exp Immunol 188(2):275\u2013282. https:\/\/doi.org\/10.1111\/cei.12935","journal-title":"Clin Exp Immunol"},{"issue":"11","key":"4985_CR5","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1182\/blood-2017-09-742353","volume":"131","author":"S Chaturvedi","year":"2018","unstructured":"Chaturvedi S, Arnold DM, McCrae KR (2018) Splenectomy for immune thrombocytopenia: down but not out. Blood 131(11):1172\u20131182. https:\/\/doi.org\/10.1182\/blood-2017-09-742353","journal-title":"Blood"},{"issue":"2","key":"4985_CR6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/bjh.15090","volume":"181","author":"F Rodeghiero","year":"2018","unstructured":"Rodeghiero F (2018) A critical appraisal of the evidence for the role of splenectomy in adults and children with ITP. British Journal of Hematology 181(2):183\u2013195. https:\/\/doi.org\/10.1111\/bjh.15090","journal-title":"British Journal of Hematology"},{"issue":"2","key":"4985_CR7","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1182\/blood-2009-06-225565","volume":"115","author":"D Provan","year":"2010","unstructured":"Provan D, Stasi R, Newland AC, Blanchett VS, Bolton-Maggs P, Bussel JB, Chong BH, Cines DB, Gernsheimer TB, Godeau B et al (2010) International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 115(2):168\u2013186. https:\/\/doi.org\/10.1182\/blood-2009-06-225565","journal-title":"Blood"},{"key":"4985_CR8","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1182\/blood-2015-07-659656","volume":"127","author":"Y Wei","year":"2016","unstructured":"Wei Y, Ji XB, Wang YW, Wang JX, Yang EQ, Wang ZC, Sang YQ, Bi ZM, Ren CA, Zhou F et al (2016) High-dose dexamethasone vs prednisone for treatment of adult immune thrombocytopenia: a prospective multicenter randomized trial. Blood 127:296\u2013302. https:\/\/doi.org\/10.1182\/blood-2015-07-659656","journal-title":"Blood"},{"key":"4985_CR9","doi-asserted-by":"publisher","first-page":"3829","DOI":"10.1182\/bloodadvances.2019000966","volume":"3","author":"C Neunert","year":"2019","unstructured":"Neunert C, Terrell DR, Arnold DM, Buchanan G, Cines DB, Cooper N, Cuker A, Despotovic JM, George JN, Grace RF et al (2019) American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Adv 3:3829\u20133866. https:\/\/doi.org\/10.1182\/bloodadvances.2019000966","journal-title":"Blood Adv"},{"issue":"1","key":"4985_CR10","first-page":"72","volume":"90","author":"N Vianelli","year":"2005","unstructured":"Vianelli N, Galli M, de Vivo A, Intermesoli T, Giannini B, Mazzucconi MG, Barbui T, Tura S, Baccarani M (2005) Gruppo Italiano per lo Studio delle Malattie Ematologiche dell\u2019Adulto. Efficacy and safety of splenectomy in immune thrombocytopenic purpura: long-term results of 402 cases. Haematologica 90(1):72\u201377","journal-title":"Haematologica"},{"key":"4985_CR11","doi-asserted-by":"publisher","first-page":"4782","DOI":"10.1182\/blood-2012-12-467068","volume":"121","author":"S Boyle","year":"2013","unstructured":"Boyle S, White RH, Brunson A, Wun T (2013) Splenectomy and the incidence of venous thromboembolism and sepsis in patients with immune thrombocytopenia. Blood 121:4782\u20134790. https:\/\/doi.org\/10.1182\/blood-2012-12-467068","journal-title":"Blood"},{"issue":"48","key":"4985_CR12","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005098","volume":"95","author":"LH Thai","year":"2016","unstructured":"Thai LH, Mahevas M, Roudot-Thoraval F, Limal N, Languille L, Dumas G, Khellaf M, Bierling P, Michel M, Godeau B (2016) Long-term complications of splenectomy in adult immune thrombocytopenia. Medicine (Baltimore) 95(48):e5098. https:\/\/doi.org\/10.1097\/MD.0000000000005098","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"4985_CR13","doi-asserted-by":"publisher","first-page":"875","DOI":"10.3324\/haematol.2012.075648","volume":"98","author":"N Vianelli","year":"2013","unstructured":"Vianelli N, Palandri F, Polverelli N, Stasi R, Joelsson J, Johansson E, Ruggeri M, Francesco Zaja, Cantoni S, Catucci AE et al (2013) Splenectomy as a curative treatment for immune thrombocytopenia: a retrospective analysis of 233 patients with a minimum follow up of 10 years. Haematologica 98(6):875\u2013880","journal-title":"Haematologica"},{"issue":"6","key":"4985_CR14","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1111\/j.1538-7836.2010.03849.x","volume":"8","author":"RW Thomsen","year":"2010","unstructured":"Thomsen RW, Schoonen WM, Farkas DK, Riis A, Fryzek JP, S\u00f8rensen HT (2010) Risk of venous thromboembolism in splenectomized patients compared with the general population and appendectomized patients: a 10-year nationwide cohort study. J Thromb Haemost 8(6):1413\u20131416. https:\/\/doi.org\/10.1111\/j.1538-7836.2010.03849.x","journal-title":"J Thromb Haemost"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-022-04985-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-022-04985-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-022-04985-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T08:08:55Z","timestamp":1667981335000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-022-04985-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["4985"],"URL":"https:\/\/doi.org\/10.1007\/s00277-022-04985-7","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,29]]},"assertion":[{"value":"1 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in compliance with the Helsinki Declaration and approved by the ethics committees of the institution (Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP). An informed written consent was obtained from patients during follow-up.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}