{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:37:27Z","timestamp":1780411047182,"version":"3.54.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s00277-022-05024-1","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T07:03:58Z","timestamp":1668236638000},"page":"563-570","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of anemia at diagnosis of pediatric chronic myeloid leukemia and prognostic impact on the disease course"],"prefix":"10.1007","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2431-398X","authenticated-orcid":false,"given":"Fanny","family":"Delehaye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Rouger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Brossier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinolf","family":"Suttorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalet Meral","family":"G\u00fcne\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Sedlacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Versluys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Kong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Kalwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Lausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Culic","family":"Srdjana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dworzak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Hraskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"De Moerloose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Roula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Briant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Parienti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Millot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"issue":"5405","key":"5024_CR1","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/243290a0","volume":"243","author":"JD Rowley","year":"1973","unstructured":"Rowley JD (1973) A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 243(5405):290\u2013293","journal-title":"Nature"},{"issue":"14","key":"5024_CR2","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1056\/NEJM200104053441409","volume":"344","author":"JM Goldman","year":"2001","unstructured":"Goldman JM, Melo JV (2001) Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemiA. N Engl J Med 344(14):1084\u20131086","journal-title":"N Engl J Med"},{"issue":"5","key":"5024_CR3","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1002\/mpo.1342","volume":"38","author":"Z Jakab","year":"2002","unstructured":"Jakab Z, Balogh E, Kiss C, Ol\u00e1h \u00c9 (2002) Epidemiologic studies in a population-based childhood cancer registry in Northeast Hungary: childhood cancer incidence in NE Hungary. Med Pediatr Oncol 38(5):338\u2013344","journal-title":"Med Pediatr Oncol"},{"issue":"8","key":"5024_CR4","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/sj.leu.2402194","volume":"15","author":"K Horibe","year":"2001","unstructured":"Horibe K, Tsukimoto I, Ohno R (2001) Clinicopathologic characteristics of leukemia in Japanese children and young adults. Leukemia 15(8):1256\u20131261","journal-title":"Leukemia"},{"key":"5024_CR5","unstructured":"Ries LAG (1999) Cancer incidence and survival among children and adolescents: United States SEER Program 1975\u20131995. National Cancer Institute, SEER Program NIH Pub. No.99\u20134649"},{"issue":"4","key":"5024_CR6","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1182\/blood-2015-06-648667","volume":"127","author":"N Hijiya","year":"2016","unstructured":"Hijiya N, Schultz KR, Metzler M, Millot F, Suttorp M (2016) Pediatric chronic myeloid leukemia is a unique disease that requires a different approach. Blood 127(4):392\u2013399","journal-title":"Blood"},{"issue":"1","key":"5024_CR7","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1542\/peds.2004-2473","volume":"116","author":"F Millot","year":"2005","unstructured":"Millot F (2005) Clinical and biological features at diagnosis in 40 children with chronic myeloid leukemia. Pediatrics 116(1):140\u2013143","journal-title":"Pediatrics"},{"issue":"9","key":"5024_CR8","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1182\/blood-2011-08-358135","volume":"119","author":"H Kantarjian","year":"2012","unstructured":"Kantarjian H, O\u2019Brien S, Jabbour E, Garcia-Manero G, Quintas-Cardama A, Shan J et al (2012) Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: a single-institution historical experience. Blood 119(9):1981\u20131987","journal-title":"Blood"},{"issue":"1","key":"5024_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/bjh.12977","volume":"167","author":"J de la Fuente","year":"2014","unstructured":"de la Fuente J, Baruchel A, Biondi A, de Bont E, Dresse M-F, Suttorp M et al (2014) Managing children with chronic myeloid leukaemia (CML): recommendations for the management of CML in children and young people up to the age of 18 years. Br J Haematol 167(1):33\u201347","journal-title":"Br J Haematol"},{"issue":"1","key":"5024_CR10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.pcl.2014.09.008","volume":"62","author":"N Hijiya","year":"2015","unstructured":"Hijiya N, Millot F, Suttorp M (2015) Chronic myeloid leukemia in children. Pediatr Clin North Am 62(1):107\u2013119","journal-title":"Pediatr Clin North Am"},{"issue":"22","key":"5024_CR11","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1182\/blood.2018882233","volume":"133","author":"N Hijiya","year":"2019","unstructured":"Hijiya N, Suttorp M (2019) How I treat chronic myeloid leukemia in children and adolescents. Blood 133(22):2374\u20132384","journal-title":"Blood"},{"issue":"8","key":"5024_CR12","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1182\/blood-2011-10-380774","volume":"119","author":"JR Andolina","year":"2012","unstructured":"Andolina JR, Neudorf SM, Corey SJ (2012) How I treat childhood CML. Blood 119(8):1821\u20131830","journal-title":"Blood"},{"key":"5024_CR13","doi-asserted-by":"publisher","unstructured":"Athale U, Hijiya N, Patterson BC, Bergsagel J, Andolina JR, Bittencourt H et al. (2019) Management of chronic myeloid leukemia in children and adolescents: recommendations from the Children\u2019s Oncology Group CML Working Group. Pediatr Blood Cancer 66(9). https:\/\/doi.org\/10.1002\/pbc.27827","DOI":"10.1002\/pbc.27827"},{"issue":"10","key":"5024_CR14","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.3324\/haematol.2017.170035","volume":"102","author":"F Millot","year":"2017","unstructured":"Millot F, Guilhot J, Suttorp M, G\u00fcne\u015f AM, Sedlacek P, De Bont E et al (2017) Prognostic discrimination based on the EUTOS long-term survival score within the International Registry for Chronic Myeloid Leukemia in children and adolescents. Haematologica 102(10):1704\u20131708","journal-title":"Haematologica"},{"issue":"10","key":"5024_CR15","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1080\/03007995.2017.1356708","volume":"33","author":"P-S Ko","year":"2017","unstructured":"Ko P-S, Yu Y-B, Liu Y-C, Wu Y-T, Hung M-H, Gau J-P et al (2017) Moderate anemia at diagnosis is an independent prognostic marker of the EUTOS, Sokal, and Hasford scores for survival and treatment response in chronic-phase, chronic myeloid leukemia patients with frontline imatinib. Curr Med Res Opin 33(10):1737\u20131744","journal-title":"Curr Med Res Opin"},{"issue":"1","key":"5024_CR16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1046\/j.1365-2141.1997.d01-1982.x","volume":"96","author":"DG Savage","year":"1997","unstructured":"Savage DG, Szydlo RM, Goldman JM (1997) Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period. Br J Haematol 96(1):111\u2013116","journal-title":"Br J Haematol"},{"issue":"1","key":"5024_CR17","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/annonc\/mdu490","volume":"26","author":"F Castagnetti","year":"2015","unstructured":"Castagnetti F, Gugliotta G, Baccarani M, Breccia M, Specchia G, Levato L et al (2015) Differences among young adults, adults and elderly chronic myeloid leukemia patients. Ann Oncol 26(1):185\u2013192","journal-title":"Ann Oncol"},{"issue":"7","key":"5024_CR18","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1002\/1097-0142(19871001)60:7<1651::AID-CNCR2820600738>3.0.CO;2-J","volume":"60","author":"SB Lansky","year":"1987","unstructured":"Lansky SB, List MA, Lansky LL, Ritter-Sterr C, Miller DR (1987) The measurement of performance in childhood cancer patients. Cancer 60(7):1651\u20131656","journal-title":"Cancer"},{"issue":"11","key":"5024_CR19","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1080\/17474086.2017.1354696","volume":"10","author":"S Allali","year":"2017","unstructured":"Allali S, Brousse V, Sacri A-S, Chalumeau M, de Montalembert M (2017) Anemia in children: prevalence, causes, diagnostic work-up, and long-term consequences. Expert Rev Hematol 10(11):1023\u20131028","journal-title":"Expert Rev Hematol"},{"key":"5024_CR20","unstructured":"WHO (2021) Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System [Internet]. Available on:\u00a0http:\/\/www.who.int\/vmnis\/indicators\/haemoglobin.pdf"},{"key":"5024_CR21","unstructured":"Brugnara C (2015) Diagnosis approach to the anemic patient. In: Nathan and Oski\u2019s Hematology and Oncology of Infancy and Childhood. 8th edition. Philadelphia; p.293"},{"key":"5024_CR22","unstructured":"Cembrowski G (2004) NHANES 1999\u20132000 data used to create comprehensive health-associated race-, sex- and age-stratified pediatric reference intervals for the Coulter MAXM 10:245"},{"issue":"5","key":"5024_CR23","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1542\/peds.2010-2576","volume":"126","author":"RD Baker","year":"2010","unstructured":"Baker RD, Greer FR (2010) The Committee on Nutrition Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0\u20133 years of age). Pediatrics 126(5):1040\u201350","journal-title":"Pediatrics"},{"issue":"6","key":"5024_CR24","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1002\/1097-0142(19860915)58:6<1357::AID-CNCR2820580629>3.0.CO;2-M","volume":"58","author":"M Prabhu","year":"1986","unstructured":"Prabhu M, Kochupillai V, Sharma S, Ramachandran P, Sundaram KR, Bijlani L et al (1986) Prognostic assessment of various parameters in chronic myeloid leukemia. Cancer 58(6):1357\u20131360","journal-title":"Cancer"},{"key":"5024_CR25","unstructured":"Faber E (2015) Significance of anemia in patients with cml at diagnosis and during the treatment with imatinib outside the clinical trials: Camelia Registry Experience"},{"issue":"21","key":"5024_CR26","doi-asserted-by":"publisher","first-page":"5174","DOI":"10.1182\/blood.V122.21.5174.5174","volume":"122","author":"KI Korubo","year":"2013","unstructured":"Korubo KI, Omunakwe HE, Nwauche CA (2013) Chronic myeloid leukemia: clinical and laboratory features at presentation to a referral hospital in Southern Nigeria. Blood 122(21):5174\u20135174","journal-title":"Blood"},{"issue":"Supplement 1","key":"5024_CR27","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1182\/blood-2018-99-112905","volume":"132","author":"AM Gunes","year":"2018","unstructured":"Gunes AM, Millot F, Kalwak K, Lausen B, Sedlacek P, Versluijs B et al (2018) Features and outcome of chronic myeloid leukemia (CML) at very young age: data from the International Pediatric CML Registry (I-CML-Ped Study). Blood 132(Supplement 1):1748\u20131748","journal-title":"Blood"},{"issue":"4","key":"5024_CR28","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1182\/blood.V47.4.629.629","volume":"47","author":"CE Hess","year":"1976","unstructured":"Hess CE, Ayers CR, Sandusky WR, Carpenter MA, Wetzel RA, Mohler DN (1976) Mechanism of dilutional anemia in massive splenomegaly. Blood 47(4):629\u2013644","journal-title":"Blood"},{"issue":"2","key":"5024_CR29","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s11899-012-0113-6","volume":"7","author":"M Suttorp","year":"2012","unstructured":"Suttorp M, Eckardt L, Tauer JT, Millot F (2012) Management of chronic myeloid leukemia in childhood. Curr Hematol Malig Rep 7(2):116\u2013124","journal-title":"Curr Hematol Malig Rep"},{"issue":"6","key":"5024_CR30","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1182\/blood.V66.6.1352.1352","volume":"66","author":"JE Sokal","year":"1985","unstructured":"Sokal JE, Baccarani M, Tura S, Fiacchini M, Cervantes F, Rozman C et al (1985) Prognostic discrimination among younger patients with chronic granulocytic leukemia: relevance to bone marrow transplantation. Blood 66(6):1352\u20131357","journal-title":"Blood"},{"issue":"18","key":"5024_CR31","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.1002\/cncr.30767","volume":"123","author":"F Millot","year":"2017","unstructured":"Millot F, Dupraz C, Guilhot J, Suttorp M, Brizard F, Leblanc T et al (2017) Additional cytogenetic abnormalities and variant t(9;22) at the diagnosis of childhood chronic myeloid leukemia: the experience of the International Registry for Chronic Myeloid Leukemia in Children and Adolescents: Cytogenetics of Childhood CML. Cancer 123(18):3609\u20133616","journal-title":"Cancer"},{"issue":"18","key":"5024_CR32","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.1016\/j.ejca.2014.10.007","volume":"50","author":"F Millot","year":"2014","unstructured":"Millot F, Guilhot J, Baruchel A, Petit A, Leblanc T, Bertrand Y et al (2014) Growth deceleration in children treated with imatinib for chronic myeloid leukaemia. Eur J Cancer 50(18):3206\u20133211","journal-title":"Eur J Cancer"},{"issue":"10021","key":"5024_CR33","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/S0140-6736(15)60865-0","volume":"387","author":"A Lopez","year":"2016","unstructured":"Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L (2016) Iron deficiency anaemia. The Lancet 387(10021):907\u2013916","journal-title":"The Lancet"},{"issue":"12","key":"5024_CR34","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1159\/000502801","volume":"42","author":"L Cesini","year":"2019","unstructured":"Cesini L, Carmosino I, Breccia M, De Benedittis D, Mohamed S, De Luca ML et al (2019) Incidence of clinically significanT (\u226410 g\/dL) late anemia in elderly patients with newly diagnosed chronic myeloid leukemia treated with imatinib. Oncol Res Treat 42(12):660\u2013664","journal-title":"Oncol Res Treat"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-022-05024-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-022-05024-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-022-05024-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T06:05:52Z","timestamp":1677650752000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-022-05024-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,12]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["5024"],"URL":"https:\/\/doi.org\/10.1007\/s00277-022-05024-1","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,12]]},"assertion":[{"value":"6 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}