{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:17:09Z","timestamp":1782962229701,"version":"3.54.5"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The MIOT project received \u201cno-profit support\u201d from Chiesi Farmaceutici S.p.A."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s00277-022-05057-6","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T10:27:11Z","timestamp":1669976831000},"page":"261-270","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic value of multiparametric cardiac magnetic resonance in sickle cell patients"],"prefix":"10.1007","volume":"102","author":[{"given":"Antonella","family":"Meloni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pistoia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Quota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Messina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Ricchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Bagnato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calogera","family":"Gerardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Cuccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Renne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Vallone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Righi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Positano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Pepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0579-3279","authenticated-orcid":false,"given":"Filippo","family":"Cademartiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"issue":"9","key":"5057_CR1","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1093\/oxfordjournals.aje.a010288","volume":"151","author":"A Ashley-Koch","year":"2000","unstructured":"Ashley-Koch A, Yang Q, Olney RS (2000) Sickle hemoglobin (HbS) allele and sickle cell disease: a HuGE review. Am J Epidemiol 151(9):839\u2013845. https:\/\/doi.org\/10.1093\/oxfordjournals.aje.a010288","journal-title":"Am J Epidemiol"},{"key":"5057_CR2","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1100\/tsw.2008.157","volume":"8","author":"MH Steinberg","year":"2008","unstructured":"Steinberg MH (2008) Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches. ScientificWorldJournal 8:1295\u20131324. https:\/\/doi.org\/10.1100\/tsw.2008.157","journal-title":"ScientificWorldJournal"},{"issue":"2","key":"5057_CR3","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1177\/003335491312800206","volume":"128","author":"S Lanzkron","year":"2013","unstructured":"Lanzkron S, Carroll CP, Haywood C Jr (2013) Mortality rates and age at death from sickle cell disease: U.S., 1979\u20132005. Public Health Rep 128(2):110\u2013116. https:\/\/doi.org\/10.1177\/003335491312800206","journal-title":"Public Health Rep"},{"issue":"6","key":"5057_CR4","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1111\/j.1365-2141.2012.09143.x","volume":"157","author":"E Voskaridou","year":"2012","unstructured":"Voskaridou E, Christoulas D, Terpos E (2012) Sickle-cell disease and the heart: review of the current literature. Br J Haematol 157(6):664\u2013673. https:\/\/doi.org\/10.1111\/j.1365-2141.2012.09143.x","journal-title":"Br J Haematol"},{"issue":"3","key":"5057_CR5","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.tcm.2020.02.002","volume":"31","author":"V Sachdev","year":"2021","unstructured":"Sachdev V, Rosing DR, Thein SL (2021) Cardiovascular complications of sickle cell disease. Trends Cardiovasc Med 31(3):187\u2013193. https:\/\/doi.org\/10.1016\/j.tcm.2020.02.002","journal-title":"Trends Cardiovasc Med"},{"issue":"13","key":"5057_CR6","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.jacc.2011.10.900","volume":"59","author":"MT Gladwin","year":"2012","unstructured":"Gladwin MT, Sachdev V (2012) Cardiovascular abnormalities in sickle cell disease. J Am Coll Cardiol 59(13):1123\u20131133. https:\/\/doi.org\/10.1016\/j.jacc.2011.10.900","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"5057_CR7","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1002\/ajh.21475","volume":"84","author":"GJ Kato","year":"2009","unstructured":"Kato GJ, Hebbel RP, Steinberg MH, Gladwin MT (2009) Vasculopathy in sickle cell disease: biology, pathophysiology, genetics, translational medicine, and new research directions. Am J Hematol 84(9):618\u2013625. https:\/\/doi.org\/10.1002\/ajh.21475","journal-title":"Am J Hematol"},{"issue":"3","key":"5057_CR8","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1172\/JCI133639","volume":"130","author":"RP Hebbel","year":"2020","unstructured":"Hebbel RP, Belcher JD, Vercellotti GM (2020) The multifaceted role of ischemia\/reperfusion in sickle cell anemia. J Clin Invest 130(3):1062\u20131072. https:\/\/doi.org\/10.1172\/JCI133639","journal-title":"J Clin Invest"},{"issue":"3","key":"5057_CR9","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/0002-8703(72)90445-0","volume":"83","author":"MA Varat","year":"1972","unstructured":"Varat MA, Adolph RJ, Fowler NO (1972) Cardiovascular effects of anemia. Am Heart J 83(3):415\u2013426","journal-title":"Am Heart J"},{"issue":"4","key":"5057_CR10","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1001\/archinte.1974.00320160137012","volume":"133","author":"J Lindsay Jr","year":"1974","unstructured":"Lindsay J Jr, Meshel JC, Patterson RH (1974) The cardiovascular manifestations of sickle cell disease. Arch Intern Med 133(4):643\u2013651","journal-title":"Arch Intern Med"},{"issue":"3","key":"5057_CR11","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1161\/01.CIR.88.3.1127","volume":"88","author":"DT Kremastinos","year":"1993","unstructured":"Kremastinos DT, Tsiapras DP, Tsetsos GA, Rentoukas EI, Vretou HP, Toutouzas PK (1993) Left ventricular diastolic Doppler characteristics in beta-thalassemia major. Circulation 88(3):1127\u20131135","journal-title":"Circulation"},{"issue":"1","key":"5057_CR12","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1172\/JCI108079","volume":"56","author":"W Grossman","year":"1975","unstructured":"Grossman W, Jones D, McLaurin LP (1975) Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest 56(1):56\u201364. https:\/\/doi.org\/10.1172\/JCI108079","journal-title":"J Clin Invest"},{"issue":"9","key":"5057_CR13","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.jcmg.2016.04.004","volume":"9","author":"YNV Reddy","year":"2016","unstructured":"Reddy YNV, Borlaug BA (2016) High-output heart failure in sickle cell anemia. JACC Cardiovasc Imaging 9(9):1122\u20131123. https:\/\/doi.org\/10.1016\/j.jcmg.2016.04.004","journal-title":"JACC Cardiovasc Imaging"},{"issue":"8","key":"5057_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135472","volume":"10","author":"S Mushemi-Blake","year":"2015","unstructured":"Mushemi-Blake S, Melikian N, Drasar E, Bhan A, Lunt A, Desai SR, Greenough A, Monaghan MJ, Thein SL, Shah AM (2015) Pulmonary haemodynamics in sickle cell disease are driven predominantly by a high-output state rather than elevated pulmonary vascular resistance: a prospective 3-dimensional echocardiography\/Doppler study. PLoS ONE 10(8):e0135472. https:\/\/doi.org\/10.1371\/journal.pone.0135472","journal-title":"PLoS ONE"},{"issue":"9","key":"5057_CR15","first-page":"686","volume":"5","author":"R Ware","year":"2007","unstructured":"Ware R (2007) Principles and indications of chronic transfusion therapy for children with sickle cell disease. Clin Adv Hematol Oncol 5(9):686\u2013688","journal-title":"Clin Adv Hematol Oncol"},{"key":"5057_CR16","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1146\/annurev.nu.07.070187.002413","volume":"7","author":"VR Gordeuk","year":"1987","unstructured":"Gordeuk VR, Bacon BR, Brittenham GM (1987) Iron overload: causes and consequences. Annu Rev Nutr 7:485\u2013508","journal-title":"Annu Rev Nutr"},{"issue":"2","key":"5057_CR17","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3324\/haematol.11958","volume":"93","author":"W Li","year":"2008","unstructured":"Li W, Coates T, Wood JC (2008) Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major. Haematologica 93(2):311\u2013312","journal-title":"Haematologica"},{"issue":"5","key":"5057_CR18","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1111\/j.1365-2141.2008.07092.x","volume":"141","author":"YF Cheung","year":"2008","unstructured":"Cheung YF, Chan GC, Ha SY (2008) Effect of deferasirox (ICL670) on arterial function in patients with beta-thalassaemia major. Br J Haematol 141(5):728\u2013733","journal-title":"Br J Haematol"},{"key":"5057_CR19","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1196\/annals.1345.047","volume":"1054","author":"JC Wood","year":"2005","unstructured":"Wood JC, Enriquez C, Ghugre N, Otto-Duessel M, Aguilar M, Nelson MD, Moats R, Coates TD (2005) Physiology and pathophysiology of iron cardiomyopathy in thalassemia. Ann N Y Acad Sci 1054:386\u2013395","journal-title":"Ann N Y Acad Sci"},{"issue":"23","key":"5057_CR20","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1053\/euhj.2001.2822","volume":"22","author":"LJ Anderson","year":"2001","unstructured":"Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, Firmin DN, Wonke B, Porter J, Walker JM, Pennell DJ (2001) Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 22(23):2171\u20132179","journal-title":"Eur Heart J"},{"issue":"5","key":"5057_CR21","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1182\/blood-2003-06-1919","volume":"103","author":"JC Wood","year":"2004","unstructured":"Wood JC, Tyszka JM, Carson S, Nelson MD, Coates TD (2004) Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. Blood 103(5):1934\u20131936","journal-title":"Blood"},{"issue":"7","key":"5057_CR22","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/ajh.23721","volume":"89","author":"A Meloni","year":"2014","unstructured":"Meloni A, Puliyel M, Pepe A, Berdoukas V, Coates TD, Wood JC (2014) Cardiac iron overload in sickle-cell disease. Am J Hematol 89(7):678\u2013683. https:\/\/doi.org\/10.1002\/ajh.23721","journal-title":"Am J Hematol"},{"issue":"3","key":"5057_CR23","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.tmrv.2019.04.001","volume":"33","author":"AHJ Tavares","year":"2019","unstructured":"Tavares AHJ, Benites BD, Fertrin KY (2019) Myocardial iron overload in sickle cell disease: a rare but potentially fatal complication of transfusion. Transfus Med Rev 33(3):170\u2013175. https:\/\/doi.org\/10.1016\/j.tmrv.2019.04.001","journal-title":"Transfus Med Rev"},{"key":"5057_CR24","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1182\/asheducation-2011.1.443","volume":"2011","author":"JC Wood","year":"2011","unstructured":"Wood JC (2011) Impact of iron assessment by MRI. Hematology Am Soc Hematol Educ Program 2011:443\u2013450","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"14","key":"5057_CR25","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1161\/CIRCULATIONAHA.110.007641","volume":"123","author":"JP Carpenter","year":"2011","unstructured":"Carpenter JP, He T, Kirk P, Roughton M, Anderson LJ, de Noronha SV, Sheppard MN, Porter JB, Walker JM, Wood JC, Galanello R, Forni G, Catani G, Matta G, Fucharoen S, Fleming A, House MJ, Black G, Firmin DN, St Pierre TG, Pennell DJ (2011) On T2* magnetic resonance and cardiac iron. Circulation 123(14):1519\u20131528","journal-title":"Circulation"},{"issue":"5","key":"5057_CR26","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1007\/s00330-018-5783-6","volume":"29","author":"A Meloni","year":"2020","unstructured":"Meloni A, Maggio A, Positano V, Leto F, Angelini A, Putti MC, Maresi E, Pucci A, Basso C, Perazzolo Marra M, Pistoia L, De Marchi D, Pepe A (2020) CMR for myocardial iron overload quantification: calibration curve from the MIOT network. Eur Radiol 29(5):2246\u20132252","journal-title":"Eur Radiol"},{"issue":"2","key":"5057_CR27","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.ahj.2003.10.005","volume":"147","author":"F Grothues","year":"2004","unstructured":"Grothues F, Moon JC, Bellenger NG, Smith GS, Klein HU, Pennell DJ (2004) Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance. Am Heart J 147(2):218\u2013223. https:\/\/doi.org\/10.1016\/j.ahj.2003.10.005","journal-title":"Am Heart J"},{"issue":"9249","key":"5057_CR28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0140-6736(00)03567-4","volume":"357","author":"E Wu","year":"2001","unstructured":"Wu E, Judd RM, Vargas JD, Klocke FJ, Bonow RO, Kim RJ (2001) Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction. Lancet 357(9249):21\u201328","journal-title":"Lancet"},{"issue":"35","key":"5057_CR29","doi-asserted-by":"publisher","first-page":"9670","DOI":"10.1073\/pnas.1611899113","volume":"113","author":"JC Wood","year":"2016","unstructured":"Wood JC (2016) The heart in sickle cell disease, a model for heart failure with preserved ejection fraction. Proc Natl Acad Sci U S A 113(35):9670\u20139672. https:\/\/doi.org\/10.1073\/pnas.1611899113","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"5057_CR30","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1002\/jmri.20566","volume":"23","author":"A Pepe","year":"2006","unstructured":"Pepe A, Positano V, Santarelli F, Sorrentino F, Cracolici E, De Marchi D, Maggio A, Midiri M, Landini L, Lombardi M (2006) Multislice multiecho T2* cardiovascular magnetic resonance for detection of the heterogeneous distribution of myocardial iron overload. J Magn Reson Imaging 23(5):662\u2013668","journal-title":"J Magn Reson Imaging"},{"issue":"1","key":"5057_CR31","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/jmri.21781","volume":"30","author":"A Ramazzotti","year":"2009","unstructured":"Ramazzotti A, Pepe A, Positano V, Rossi G, De Marchi D, Brizi MG, Luciani A, Midiri M, Sallustio G, Valeri G, Caruso V, Centra M, Cianciulli P, De Sanctis V, Maggio A, Lombardi M (2009) Multicenter validation of the magnetic resonance t2* technique for segmental and global quantification of myocardial iron. J Magn Reson Imaging 30(1):62\u201368","journal-title":"J Magn Reson Imaging"},{"issue":"8","key":"5057_CR32","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.ijmedinf.2009.02.011","volume":"78","author":"A Meloni","year":"2009","unstructured":"Meloni A, Ramazzotti A, Positano V, Salvatori C, Mangione M, Marcheschi P, Favilli B, De Marchi D, Prato S, Pepe A, Sallustio G, Centra M, Santarelli MF, Lombardi M, Landini L (2009) Evaluation of a web-based network for reproducible T2* MRI assessment of iron overload in thalassemia. Int J Med Inform 78(8):503\u2013512","journal-title":"Int J Med Inform"},{"issue":"2","key":"5057_CR33","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.mri.2008.06.004","volume":"27","author":"V Positano","year":"2009","unstructured":"Positano V, Salani B, Pepe A, Santarelli MF, De Marchi D, Ramazzotti A, Favilli B, Cracolici E, Midiri M, Cianciulli P, Lombardi M, Landini L (2009) Improved T2* assessment in liver iron overload by magnetic resonance imaging. Magn Reson Imaging 27(2):188\u2013197","journal-title":"Magn Reson Imaging"},{"issue":"1","key":"5057_CR34","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/mrm.22410","volume":"64","author":"A Meloni","year":"2010","unstructured":"Meloni A, Positano V, Pepe A, Rossi G, Dell\u2019Amico M, Salvatori C, Keilberg P, Filosa A, Sallustio G, Midiri M, D\u2019Ascola D, Santarelli MF, Lombardi M (2010) Preferential patterns of myocardial iron overload by multislice multiecho T*2 CMR in thalassemia major patients. Magn Reson Med 64(1):211\u2013219","journal-title":"Magn Reson Med"},{"issue":"6","key":"5057_CR35","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1002\/nbm.1121","volume":"20","author":"V Positano","year":"2007","unstructured":"Positano V, Pepe A, Santarelli MF, Scattini B, De Marchi D, Ramazzotti A, Forni G, Borgna-Pignatti C, Lai ME, Midiri M, Maggio A, Lombardi M, Landini L (2007) Standardized T2* map of normal human heart in vivo to correct T2* segmental artefacts. NMR Biomed 20(6):578\u2013590","journal-title":"NMR Biomed"},{"issue":"2","key":"5057_CR36","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1002\/jmri.22417","volume":"33","author":"A Meloni","year":"2011","unstructured":"Meloni A, Luciani A, Positano V, De Marchi D, Valeri G, Restaino G, Cracolici E, Caruso V, Dell\u2019amico MC, Favilli B, Lombardi M, Pepe A (2011) Single region of interest versus multislice T2* MRI approach for the quantification of hepatic iron overload. J Magn Reson Imaging 33(2):348\u2013355","journal-title":"J Magn Reson Imaging"},{"issue":"4","key":"5057_CR37","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1182\/blood-2004-10-3982","volume":"106","author":"JC Wood","year":"2005","unstructured":"Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, Nelson MD, Coates TD (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 106(4):1460\u20131465","journal-title":"Blood"},{"issue":"6","key":"5057_CR38","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1111\/bjh.12296","volume":"161","author":"A Meloni","year":"2013","unstructured":"Meloni A, Rienhoff HY Jr, Jones A, Pepe A, Lombardi M, Wood JC (2013) The use of appropriate calibration curves corrects for systematic differences in liver R2* values measured using different software packages. Br J Haematol 161(6):888\u2013891","journal-title":"Br J Haematol"},{"issue":"4","key":"5057_CR39","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1161\/hc0402.102975","volume":"105","author":"MD Cerqueira","year":"2002","unstructured":"Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 105(4):539\u2013542","journal-title":"Circulation"},{"issue":"1","key":"5057_CR40","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/jmri.27169","volume":"53","author":"A Meloni","year":"2021","unstructured":"Meloni A, Righi R, Missere M, Renne S, Schicchi N, Gamberini MR, Cuccia L, Lisi R, Spasiano A, Roberti MG, Zuccarelli A, Ait-Ali L, Festa P, Aquaro GD, Mangione M, Barra V, Positano V, Pepe A (2021) Biventricular reference values by body surface area, age, and gender in a large cohort of well-treated thalassemia major patients without heart damage using a multiparametric CMR approach. J Magn Reson Imaging 53(1):61\u201370","journal-title":"J Magn Reson Imaging"},{"key":"5057_CR41","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1136\/hrt.2008.156497","volume":"95","author":"A Pepe","year":"2009","unstructured":"Pepe A, Positano V, Capra M, Maggio A, Lo Pinto C, Spasiano A, Forni G, Derchi G, Favilli B, Rossi G, Cracolici E, Midiri M, Lombardi M (2009) Myocardial scarring by delayed enhancement cardiovascular magnetic resonance in thalassaemia major. Heart 95:1688\u20131693","journal-title":"Heart"},{"issue":"11","key":"5057_CR42","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.3324\/haematol.2009.010181","volume":"94","author":"A Meloni","year":"2009","unstructured":"Meloni A, Favilli B, Positano V, Cianciulli P, Filosa A, Quarta A, D\u2019Ascola D, Restaino G, Lombardi M, Pepe A (2009) Safety of cardiovascular magnetic resonance gadolinium chelates contrast agents in patients with hemoglobinopaties. Haematologica 94(11):1625\u20131627","journal-title":"Haematologica"},{"issue":"5","key":"5057_CR43","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1056\/NEJM200008033430503","volume":"343","author":"E Angelucci","year":"2000","unstructured":"Angelucci E, Brittenham GM, McLaren CE, Ripalti M, Baronciani D, Giardini C, Galimberti M, Polchi P, Lucarelli G (2000) Hepatic iron concentration and total body iron stores in thalassemia major. N Engl J Med 343(5):327\u2013331","journal-title":"N Engl J Med"},{"issue":"36","key":"5057_CR44","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","volume":"42","author":"TA McDonagh","year":"2021","unstructured":"McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bohm M, Burri H, Butler J, Celutkiene J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A, Group ESCSD (2021) 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 42(36):3599\u20133726. https:\/\/doi.org\/10.1093\/eurheartj\/ehab368","journal-title":"Eur Heart J"},{"issue":"23","key":"5057_CR45","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1161\/CIRCULATIONAHA.106.180199","volume":"114","author":"AE Buxton","year":"2006","unstructured":"Buxton AE, Calkins H, Callans DJ, DiMarco JP, Fisher JD, Greene HL, Haines DE, Hayes DL, Heidenreich PA, Miller JM, Poppas A, Prystowsky EN, Schoenfeld MH, Zimetbaum PJ, Goff DC, Grover FL, Malenka DJ, Peterson ED, Radford MJ, Redberg RF (2006) ACC\/AHA\/HRS 2006 key data elements and definitions for electrophysiological studies and procedures: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Data Standards (ACC\/AHA\/HRS Writing Committee to Develop Data Standards on Electrophysiology). Circulation 114(23):2534\u20132570","journal-title":"Circulation"},{"issue":"5","key":"5057_CR46","doi-asserted-by":"publisher","first-page":"515","DOI":"10.2459\/JCM.0b013e3282f20847","volume":"9","author":"T Cogliandro","year":"2008","unstructured":"Cogliandro T, Derchi G, Mancuso L, Mayer MC, Pannone B, Pepe A, Pili M, Bina P, Cianciulli P, De Sanctis V, Maggio A (2008) Guideline recommendations for heart complications in thalassemia major. J Cardiovasc Med (Hagerstown) 9(5):515\u2013525","journal-title":"J Cardiovasc Med (Hagerstown)"},{"issue":"2","key":"5057_CR47","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1055\/s-0032-1311792","volume":"33","author":"IC Mos","year":"2012","unstructured":"Mos IC, Klok FA, Kroft LJ, de Roos A, Huisman MV (2012) Imaging tests in the diagnosis of pulmonary embolism. Semin Respir Crit Care Med 33(2):138\u2013143. https:\/\/doi.org\/10.1055\/s-0032-1311792","journal-title":"Semin Respir Crit Care Med"},{"key":"5057_CR48","doi-asserted-by":"publisher","unstructured":"Coutts SB (2017) Diagnosis and management of transient ischemic attack. Continuum (Minneap Minn) 23 (1, Cerebrovascular Disease):82\u201392. https:\/\/doi.org\/10.1212\/CON.0000000000000424","DOI":"10.1212\/CON.0000000000000424"},{"issue":"4","key":"5057_CR49","first-page":"341","volume":"74","author":"L Perseu","year":"1989","unstructured":"Perseu L, Ristaldi MS, Dibenedetto SP, Testa R, Schiliro G, Pirastu M, Cao A (1989) The effect of the beta thalassemia mutation on the clinical severity of the sickle beta thalassemia syndrome. Haematologica 74(4):341\u2013345","journal-title":"Haematologica"},{"issue":"1","key":"5057_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/03630269.2010.546306","volume":"35","author":"GR Serjeant","year":"2011","unstructured":"Serjeant GR, Serjeant BE, Fraser RA, Hambleton IR, Higgs DR, Kulozik AE, Donaldson A (2011) Hb S-beta-thalassemia: molecular, hematological and clinical comparisons. Hemoglobin 35(1):1\u201312. https:\/\/doi.org\/10.3109\/03630269.2010.546306","journal-title":"Hemoglobin"},{"issue":"2","key":"5057_CR51","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.htct.2018.09.003","volume":"41","author":"BD Benites","year":"2019","unstructured":"Benites BD, Cisneiros IS, Bastos SO, Lino A, Costa FF, Gilli SCO, Saad STO (2019) Echocardiografic abnormalities in patients with sickle cell\/beta-thalassemia do not depend on the beta-thalassemia phenotype. Hematol Transfus Cell Ther 41(2):158\u2013163. https:\/\/doi.org\/10.1016\/j.htct.2018.09.003","journal-title":"Hematol Transfus Cell Ther"},{"issue":"5","key":"5057_CR52","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.cardfail.2013.03.009","volume":"19","author":"S Poludasu","year":"2013","unstructured":"Poludasu S, Ramkissoon K, Salciccioli L, Kamran H, Lazar JM (2013) Left ventricular systolic function in sickle cell anemia: a meta-analysis. J Card Fail 19(5):333\u2013341. https:\/\/doi.org\/10.1016\/j.cardfail.2013.03.009","journal-title":"J Card Fail"},{"issue":"10037","key":"5057_CR53","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1016\/S0140-6736(16)00647-4","volume":"387","author":"MT Gladwin","year":"2016","unstructured":"Gladwin MT (2016) Cardiovascular complications and risk of death in sickle-cell disease. Lancet 387(10037):2565\u20132574. https:\/\/doi.org\/10.1016\/S0140-6736(16)00647-4","journal-title":"Lancet"},{"issue":"6","key":"5057_CR54","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1540-8175.2008.00666.x","volume":"25","author":"AG Almeida","year":"2008","unstructured":"Almeida AG, Araujo F, Rego F, David C, Lopes MG, Ducla-Soares J (2008) Abnormal myocardial flow reserve in sickle cell disease: a myocardial contrast echocardiography study. Echocardiography 25(6):591\u2013599. https:\/\/doi.org\/10.1111\/j.1540-8175.2008.00666.x","journal-title":"Echocardiography"},{"issue":"5","key":"5057_CR55","first-page":"507","volume":"96","author":"P Acar","year":"2003","unstructured":"Acar P, Maunoury C, de Montalembert M, Dulac Y (2003) Abnormalities of myocardial perfusion in sickle cell disease in childhood: a study of myocardial scintigraphy. Arch Mal Coeur Vaiss 96(5):507\u2013510","journal-title":"Arch Mal Coeur Vaiss"},{"issue":"4","key":"5057_CR56","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1136\/adc.2003.027326","volume":"89","author":"M de Montalembert","year":"2004","unstructured":"de Montalembert M, Maunoury C, Acar P, Brousse V, Sidi D, Lenoir G (2004) Myocardial ischaemia in children with sickle cell disease. Arch Dis Child 89(4):359\u2013362. https:\/\/doi.org\/10.1136\/adc.2003.027326","journal-title":"Arch Dis Child"},{"issue":"4","key":"5057_CR57","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1159\/000338705","volume":"121","author":"S Apostolakis","year":"2012","unstructured":"Apostolakis S, Konstantinides S (2012) The right ventricle in health and disease: insights into physiology, pathophysiology and diagnostic management. Cardiology 121(4):263\u2013273. https:\/\/doi.org\/10.1159\/000338705","journal-title":"Cardiology"},{"key":"5057_CR58","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/1532-429X-15-83","volume":"15","author":"FP Junqueira","year":"2013","unstructured":"Junqueira FP, Fernandes JL, Cunha GM, Kubo TTA, Lima CMAO, Lima DBP, Uellendhal M, Sales SR, Cunha CAS, de Pessoa VLR, Lobo CLC, Marchiori E (2013) Right and left ventricular function and myocardial scarring in adult patients with sickle cell disease: a comprehensive magnetic resonance assessment of hepatic and myocardial iron overload. J Cardiovasc Magn Reson 15:83. https:\/\/doi.org\/10.1186\/1532-429X-15-83","journal-title":"J Cardiovasc Magn Reson"},{"issue":"12","key":"5057_CR59","doi-asserted-by":"publisher","first-page":"703","DOI":"10.4330\/wjc.v8.i12.703","volume":"8","author":"R Mathew","year":"2016","unstructured":"Mathew R, Huang J, Wu JM, Fallon JT, Gewitz MH (2016) Hematological disorders and pulmonary hypertension. World J Cardiol 8(12):703\u2013718. https:\/\/doi.org\/10.4330\/wjc.v8.i12.703","journal-title":"World J Cardiol"},{"key":"5057_CR60","doi-asserted-by":"publisher","unstructured":"Mushemi-Blake S, Melikian N, Drasar E, Bhan A, Lunt A, Desai SR, Greenough A, Monaghan MJ, Thein SL, Shah AM (2015) Pulmonary haemodynamics in sickle cell disease are driven predominantly by a high-output state rather than elevated pulmonary vascular resistance. A prospective 3-dimensional echocardiography\/Doppler study 10 (8). https:\/\/doi.org\/10.1371\/journal.pone.0135472","DOI":"10.1371\/journal.pone.0135472"},{"key":"5057_CR61","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1182\/asheducation-2014.1.425","volume":"1","author":"KI Ataga","year":"2014","unstructured":"Ataga KI (2014) Klings ES (2014) Pulmonary hypertension in sickle cell disease: diagnosis and management. Hematology Am Soc Hematol Educ Program 1:425\u2013431. https:\/\/doi.org\/10.1182\/asheducation-2014.1.425","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"1","key":"5057_CR62","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1056\/NEJMoa1005565","volume":"365","author":"F Parent","year":"2011","unstructured":"Parent F, Bachir D, Inamo J, Lionnet F, Driss F, Loko G, Habibi A, Bennani S, Savale L, Adnot S, Maitre B, Yaici A, Hajji L, O\u2019Callaghan DS, Clerson P, Girot R, Galacteros F, Simonneau G (2011) A hemodynamic study of pulmonary hypertension in sickle cell disease. N Engl J Med 365(1):44\u201353. https:\/\/doi.org\/10.1056\/NEJMoa1005565","journal-title":"N Engl J Med"},{"issue":"20","key":"5057_CR63","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1161\/CIRCULATIONAHA.109.874487","volume":"120","author":"P Kirk","year":"2009","unstructured":"Kirk P, Roughton M, Porter JB, Walker JM, Tanner MA, Patel J, Wu D, Taylor J, Westwood MA, Anderson LJ, Pennell DJ (2009) Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation 120(20):1961\u20131968","journal-title":"Circulation"},{"issue":"3","key":"5057_CR64","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1093\/ehjci\/jex012","volume":"19","author":"A Pepe","year":"2018","unstructured":"Pepe A, Meloni A, Rossi G, Midiri M, Missere M, Valeri G, Sorrentino F, D\u2019Ascola DG, Spasiano A, Filosa A, Cuccia L, Dello Iacono N, Forni G, Caruso V, Maggio A, Pitrolo L, Peluso A, De Marchi D, Positano V, Wood JC (2018) Prediction of cardiac complications for thalassemia major in the widespread cardiac magnetic resonance era: a prospective multicentre study by a multi-parametric approach. Eur Heart J Cardiovasc Imaging 19(3):299\u2013309","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"3","key":"5057_CR65","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.ijcard.2014.09.139","volume":"177","author":"A Meloni","year":"2014","unstructured":"Meloni A, Restaino G, Borsellino Z, Caruso V, Spasiano A, Zuccarelli A, Valeri G, Toia P, Salvatori C, Positano V, Midiri M, Pepe A (2014) Different patterns of myocardial iron distribution by whole-heart T2* magnetic resonance as risk markers for heart complications in thalassemia major. Int J Cardiol 177(3):1012\u20131019","journal-title":"Int J Cardiol"},{"issue":"2","key":"5057_CR66","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.bcmd.2014.11.003","volume":"54","author":"A Meloni","year":"2015","unstructured":"Meloni A, Detterich J, Pepe A, Harmatz P, Coates TD, Wood JC (2015) Pulmonary hypertension in well-transfused thalassemia major patients. Blood Cells Mol Dis 54(2):189\u2013194","journal-title":"Blood Cells Mol Dis"},{"issue":"3","key":"5057_CR67","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1161\/CIR.0b013e31829b2be6","volume":"128","author":"DJ Pennell","year":"2013","unstructured":"Pennell DJ, Udelson JE, Arai AE, Bozkurt B, Cohen AR, Galanello R, Hoffman TM, Kiernan MS, Lerakis S, Piga A, Porter JB, Walker JM, Wood J (2013) Cardiovascular function and treatment in beta-thalassemia major: a consensus statement from the American Heart Association. Circulation 128(3):281\u2013308","journal-title":"Circulation"},{"issue":"Suppl 2","key":"5057_CR68","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1016\/S0268-960X(08)70004-3","volume":"22","author":"JC Wood","year":"2008","unstructured":"Wood JC (2008) Cardiac iron across different transfusion-dependent diseases. Blood Rev 22(Suppl 2):S14-21","journal-title":"Blood Rev"},{"issue":"5","key":"5057_CR69","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.jcmg.2019.06.030","volume":"13","author":"TD Karamitsos","year":"2020","unstructured":"Karamitsos TD, Arvanitaki A, Karvounis H, Neubauer S, Ferreira VM (2020) Myocardial tissue characterization and fibrosis by imaging. JACC Cardiovasc Imaging 13(5):1221\u20131234. https:\/\/doi.org\/10.1016\/j.jcmg.2019.06.030","journal-title":"JACC Cardiovasc Imaging"},{"issue":"35","key":"5057_CR70","doi-asserted-by":"publisher","first-page":"E5182","DOI":"10.1073\/pnas.1600311113","volume":"113","author":"N Bakeer","year":"2016","unstructured":"Bakeer N, James J, Roy S, Wansapura J, Shanmukhappa SK, Lorenz JN, Osinska H, Backer K, Huby AC, Shrestha A, Niss O, Fleck R, Quinn CT, Taylor MD, Purevjav E, Aronow BJ, Towbin JA, Malik P (2016) Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology. Proc Natl Acad Sci U S A 113(35):E5182-5191. https:\/\/doi.org\/10.1073\/pnas.1600311113","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"5057_CR71","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1182\/blood-2017-02-767624","volume":"130","author":"O Niss","year":"2017","unstructured":"Niss O, Fleck R, Makue F, Alsaied T, Desai P, Towbin JA, Malik P, Taylor MD, Quinn CT (2017) Association between diffuse myocardial fibrosis and diastolic dysfunction in sickle cell anemia. Blood 130(2):205\u2013213. https:\/\/doi.org\/10.1182\/blood-2017-02-767624","journal-title":"Blood"},{"key":"5057_CR72","doi-asserted-by":"publisher","first-page":"615312","DOI":"10.1155\/2014\/615312","volume":"2014","author":"J Wu","year":"2014","unstructured":"Wu J, Xia S, Kalionis B, Wan W, Sun T (2014) The role of oxidative stress and inflammation in cardiovascular aging. Biomed Res Int 2014:615312. https:\/\/doi.org\/10.1155\/2014\/615312","journal-title":"Biomed Res Int"},{"issue":"2","key":"5057_CR73","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.rec.2016.01.002","volume":"69","author":"N Galie","year":"2016","unstructured":"Galie N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M (2016) 2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Rev Esp Cardiol (Engl Ed) 69(2):177. https:\/\/doi.org\/10.1016\/j.rec.2016.01.002","journal-title":"Rev Esp Cardiol (Engl Ed)"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-022-05057-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-022-05057-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-022-05057-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T09:06:48Z","timestamp":1675156008000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-022-05057-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,2]]},"references-count":73,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["5057"],"URL":"https:\/\/doi.org\/10.1007\/s00277-022-05057-6","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,2]]},"assertion":[{"value":"20 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}