{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:06:08Z","timestamp":1788887168152,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s00277-023-05098-5","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T04:28:45Z","timestamp":1673324925000},"page":"359-367","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic significance of absolute monocyte count and lymphocyte to monocyte ratio in mucosa-associated lymphoid tissue (MALT) lymphoma"],"prefix":"10.1007","volume":"102","author":[{"given":"Chun-Yu","family":"Shang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Zhu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Min","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-7477","authenticated-orcid":false,"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"issue":"2","key":"5098_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3322\/caac.21330","volume":"66","author":"M Raderer","year":"2016","unstructured":"Raderer M, Kiesewetter B, Ferreri AJ (2016) Clinicopathologic characteristics and treatment of marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). CA Cancer J Clin 66(2):153\u2013171. https:\/\/doi.org\/10.3322\/caac.21330","journal-title":"CA Cancer J Clin"},{"issue":"12","key":"5098_CR2","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1182\/blood-2017-03-771915","volume":"130","author":"C Thieblemont","year":"2017","unstructured":"Thieblemont C, Cascione L, Conconi A et al (2017) A MALT lymphoma prognostic index. Blood 130(12):1409\u20131417. https:\/\/doi.org\/10.1182\/blood-2017-03-771915","journal-title":"Blood"},{"key":"5098_CR3","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1056\/NEJM199811193392104","volume":"339","author":"D Hasenclever","year":"1998","unstructured":"Hasenclever D, Diehl V (1998) A prognostic score for advanced Hodgkin\u2019s disease. International Prognostic Factors Project on Advanced Hodgkin\u2019s Disease. N Engl J Med 339:1506\u20131514. https:\/\/doi.org\/10.1056\/NEJM199811193392104","journal-title":"N Engl J Med"},{"key":"5098_CR4","doi-asserted-by":"publisher","unstructured":"Pathria P, Louis TL, Varner JA (2019) Targeting tumor-associated macrophages in cancer. Trends Immunol 40:310\u2013327. https:\/\/doi.org\/10.1016\/j.it.2019.02.003","DOI":"10.1016\/j.it.2019.02.003"},{"issue":"1","key":"5098_CR5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cmet.2019.06.001","volume":"30","author":"I Vitale","year":"2019","unstructured":"Vitale I, Manic G, Coussens LM, Kroemer G, Galluzzi L (2019) Macrophages and metabolism in the tumor microenvironment. Cell Metab 30(1):36\u201350. https:\/\/doi.org\/10.1016\/j.cmet.2019.06.001","journal-title":"Cell Metab"},{"key":"5098_CR6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1146\/annurev-pathmechdis-012418-013058","volume":"16","author":"S Ugel","year":"2021","unstructured":"Ugel S, Cane S, De Sanctis F, Bronte V (2021) Monocytes in the tumor microenvironment. Annu Rev Pathol 16:93\u2013122. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-012418-013058","journal-title":"Annu Rev Pathol"},{"issue":"6","key":"5098_CR7","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1111\/bjh.16263","volume":"188","author":"L Bento","year":"2020","unstructured":"Bento L, D\u00edaz-L\u00f3pez A, Barranco G et al (2020) New prognosis score including absolute lymphocyte\/monocyte ratio, red blood cell distribution width and beta-2 microglobulin in patients with diffuse large B-cell lymphoma treated with R-CHOP: Spanish Lymphoma Group Experience (GELTAMO). Br J Haematol 188(6):888\u2013897. https:\/\/doi.org\/10.1111\/bjh.16263","journal-title":"Br J Haematol"},{"issue":"9","key":"5098_CR8","doi-asserted-by":"publisher","first-page":"e606","DOI":"10.1016\/j.clml.2020.03.007","volume":"20","author":"A Mohsen","year":"2020","unstructured":"Mohsen A, Taalab M, Abousamra N, Mabed M (2020) Prognostic significance of absolute lymphocyte count, absolute monocyte count, and absolute lymphocyte count to absolute monocyte count ratio in follicular non-Hodgkin lymphoma. Clin Lymphoma Myeloma Leuk 20(9):e606\u2013e615. https:\/\/doi.org\/10.1016\/j.clml.2020.03.007","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"5098_CR9","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","volume":"127","author":"SH Swerdlow","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA et al (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127:2375\u20132390. https:\/\/doi.org\/10.1182\/blood-2016-01-643569","journal-title":"Blood"},{"key":"5098_CR10","doi-asserted-by":"publisher","unstructured":"Ravindranathan D, Master VA, Bilen MA (2021) Inflammatory markers in cancer immunotherapy. Biology (Basel) 10(4):325. https:\/\/doi.org\/10.3390\/biology10040325","DOI":"10.3390\/biology10040325"},{"issue":"31","key":"5098_CR11","doi-asserted-by":"publisher","first-page":"4639","DOI":"10.3748\/wjg.v26.i31.4639","volume":"26","author":"K Jakubowska","year":"2020","unstructured":"Jakubowska K, Koda M, Grudzinska M, Kanczuga-Koda L, Famulski W (2020) Monocyte-to-lymphocyte ratio as a prognostic factor in peripheral whole blood samples of colorectal cancer patients. World J Gastroenterol 26(31):4639\u20134655. https:\/\/doi.org\/10.3748\/wjg.v26.i31.4639","journal-title":"World J Gastroenterol"},{"key":"5098_CR12","doi-asserted-by":"publisher","unstructured":"Biernat MM, Wrobel T (2021) Bacterial infection and non-Hodgkin B-cell lymphoma: interactions between pathogen, host and the tumor environment. Int J Mol Sci 22(14):7372. https:\/\/doi.org\/10.3390\/ijms22147372","DOI":"10.3390\/ijms22147372"},{"key":"5098_CR13","doi-asserted-by":"publisher","unstructured":"Della BC, Soluri MF, Puccio S, et al (2021) The helicobacter pylori CagY protein drives gastric th1 and th17 inflammation and b cell proliferation in gastric MALT lymphoma. Int J Mol Sci 22(17):9459. https:\/\/doi.org\/10.3390\/ijms22179459","DOI":"10.3390\/ijms22179459"},{"key":"5098_CR14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.semcancer.2013.11.005","volume":"24","author":"C Thieblemont","year":"2014","unstructured":"Thieblemont C, Bertoni F, Copie-Bergman C, Ferreri AJ, Ponzoni M (2014) Chronic inflammation and extra-nodal marginal-zone lymphomas of MALT-type. Semin Cancer Biol 24:33\u201342. https:\/\/doi.org\/10.1016\/j.semcancer.2013.11.005","journal-title":"Semin Cancer Biol"},{"issue":"4","key":"5098_CR15","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.ccell.2019.02.009","volume":"35","author":"L Cassetta","year":"2019","unstructured":"Cassetta L, Fragkogianni S, Sims AH et al (2019) Human tumor-associated macrophage and monocyte transcriptional landscapes reveal cancer-specific reprogramming, biomarkers, and therapeutic targets. Cancer Cell 35(4):588\u2013602. https:\/\/doi.org\/10.1016\/j.ccell.2019.02.009","journal-title":"Cancer Cell"},{"issue":"16","key":"5098_CR16","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1182\/blood-2017-07-796342","volume":"131","author":"F Vari","year":"2018","unstructured":"Vari F, Arpon D, Keane C et al (2018) Immune evasion via PD-1\/PD-L1 on NK cells and monocyte\/macrophages is more prominent in Hodgkin lymphoma than DLBCL. Blood 131(16):1809\u20131819. https:\/\/doi.org\/10.1182\/blood-2017-07-796342","journal-title":"Blood"},{"key":"5098_CR17","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.addr.2017.04.010","volume":"114","author":"C Ngambenjawong","year":"2017","unstructured":"Ngambenjawong C, Gustafson HH, Pun SH (2017) Progress in tumor-associated macrophage (TAM)-targeted therapeutics. Adv Drug Deliv Rev 114:206\u2013221. https:\/\/doi.org\/10.1016\/j.addr.2017.04.010","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"5098_CR18","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00005-017-0480-8","volume":"66","author":"K Sawa-Wejksza","year":"2018","unstructured":"Sawa-Wejksza K, Kandefer-Szerszen M (2018) Tumor-associated macrophages as target for antitumor therapy. Arch Immunol Ther Exp (Warsz) 66(2):97\u2013111. https:\/\/doi.org\/10.1007\/s00005-017-0480-8","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"issue":"15","key":"5098_CR19","doi-asserted-by":"publisher","first-page":"7002","DOI":"10.7150\/thno.46176","volume":"10","author":"D Zeng","year":"2020","unstructured":"Zeng D, Ye Z, Wu J et al (2020) Macrophage correlates with immunophenotype and predicts anti-PD-L1 response of urothelial cancer. Theranostics 10(15):7002\u20137014. https:\/\/doi.org\/10.7150\/thno.46176","journal-title":"Theranostics"},{"issue":"9","key":"5098_CR20","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1158\/0008-5472.CAN-17-2867","volume":"78","author":"YL Zhang","year":"2018","unstructured":"Zhang YL, Li Q, Yang XM et al (2018) SPON2 promotes m1-like macrophage recruitment and inhibits hepatocellular carcinoma metastasis by distinct Integrin-Rho GTPase-Hippo pathways. Cancer Res 78(9):2305\u20132317. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-2867","journal-title":"Cancer Res"},{"key":"5098_CR21","doi-asserted-by":"publisher","unstructured":"Weng YS, Tseng HY, Chen YA et al (2019) MCT-1\/miR-34a\/IL-6\/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer. Mol Cancer 18(1):42. https:\/\/doi.org\/10.1186\/s12943-019-0988-0","DOI":"10.1186\/s12943-019-0988-0"},{"issue":"25","key":"5098_CR22","doi-asserted-by":"publisher","first-page":"11535","DOI":"10.7150\/thno.45261","volume":"10","author":"Y Wang","year":"2020","unstructured":"Wang Y, Lyu Z, Qin Y et al (2020) FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma. Theranostics 10(25):11535\u201311548. https:\/\/doi.org\/10.7150\/thno.45261","journal-title":"Theranostics"},{"issue":"1","key":"5098_CR23","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s12964-020-00589-8","volume":"18","author":"Q Hao","year":"2020","unstructured":"Hao Q, Vadgama JV, Wang P (2020) CCL2\/CCR2 signaling in cancer pathogenesis. Cell Commun Signal 18(1):82. https:\/\/doi.org\/10.1186\/s12964-020-00589-8","journal-title":"Cell Commun Signal"},{"issue":"1","key":"5098_CR24","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13048-019-0527-z","volume":"12","author":"J Gong","year":"2019","unstructured":"Gong J, Jiang H, Shu C et al (2019) Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: a meta-analysis. J Ovarian Res 12(1):51. https:\/\/doi.org\/10.1186\/s13048-019-0527-z","journal-title":"J Ovarian Res"},{"issue":"1","key":"5098_CR25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12885-017-3931-z","volume":"18","author":"F Sun","year":"2018","unstructured":"Sun F, Zhu J, Lu S et al (2018) An inflammation-based cumulative prognostic score system in patients with diffuse large B cell lymphoma in rituximab era. BMC Cancer 18(1):5. https:\/\/doi.org\/10.1186\/s12885-017-3931-z","journal-title":"BMC Cancer"},{"key":"5098_CR26","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s00277-018-3516-1","volume":"98","author":"J Hong","year":"2019","unstructured":"Hong J, Cho J, Ko YH, Kim SJ, Kim WS (2019) Validation of the Marginal Zone Lymphoma International Prognostic Index. Ann Hematol 98:457\u2013464. https:\/\/doi.org\/10.1007\/s00277-018-3516-1","journal-title":"Ann Hematol"},{"key":"5098_CR27","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/ajh.25446","volume":"94","author":"JP Alderuccio","year":"2019","unstructured":"Alderuccio JP, Zhao W, Desai A et al (2019) Short survival and frequent transformation in extranodal marginal zone lymphoma with multiple mucosal sites presentation. Am J Hematol 94:585\u2013596. https:\/\/doi.org\/10.1002\/ajh.25446","journal-title":"Am J Hematol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-023-05098-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-023-05098-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-023-05098-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T09:10:42Z","timestamp":1675156242000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-023-05098-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,10]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["5098"],"URL":"https:\/\/doi.org\/10.1007\/s00277-023-05098-5","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,10]]},"assertion":[{"value":"12 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}