{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T04:20:07Z","timestamp":1794284407672,"version":"4.9.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100010580","name":"Department of Science and Technology, Hubei Provincial People's Government","doi-asserted-by":"publisher","award":["XGFY2020000027"],"award-info":[{"award-number":["XGFY2020000027"]}],"id":[{"id":"10.13039\/501100010580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010580","name":"Department of Science and Technology, Hubei Provincial People's Government","doi-asserted-by":"publisher","award":["YFYB2020001694"],"award-info":[{"award-number":["YFYB2020001694"]}],"id":[{"id":"10.13039\/501100010580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010580","name":"Department of Science and Technology, Hubei Provincial People's Government","doi-asserted-by":"publisher","award":["2020FCA014"],"award-info":[{"award-number":["2020FCA014"]}],"id":[{"id":"10.13039\/501100010580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010580","name":"Department of Science and Technology, Hubei Provincial People's Government","doi-asserted-by":"publisher","award":["2020BHB017"],"award-info":[{"award-number":["2020BHB017"]}],"id":[{"id":"10.13039\/501100010580","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s00277-023-05186-6","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T07:04:41Z","timestamp":1681196681000},"page":"1589-1598","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gut microbiome alterations in patients with COVID-19-related coagulopathy"],"prefix":"10.1007","volume":"102","author":[{"given":"Youli","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erchuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binlian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Rasche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Einsele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"5186_CR1","doi-asserted-by":"publisher","first-page":"e438","DOI":"10.1016\/S2352-3026(20)30145-9","volume":"7","author":"M Levi","year":"2020","unstructured":"Levi M, Thachil J, Iba T, Levy JH (2020) Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol 7:e438\u2013ee40","journal-title":"Lancet Haematol"},{"key":"5186_CR2","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1016\/j.mayocp.2020.08.030","volume":"95","author":"RD McBane 2nd","year":"2020","unstructured":"McBane RD 2nd, Torres Roldan VD, Niven AS, Pruthi RK, Franco PM, Linderbaum JA et al (2020) Anticoagulation in COVID-19: A systematic review, meta-analysis, and rapid guidance from Mayo Clinic. Mayo Clin Proc 95:2467\u20132486","journal-title":"Mayo Clin Proc"},{"key":"5186_CR3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12959-021-00343-1","volume":"19","author":"S Zhang","year":"2021","unstructured":"Zhang S, Li Y, Liu G, Su B (2021) Intermediate-to-therapeutic versus prophylactic anticoagulation for coagulopathy in hospitalized COVID-19 patients: a systemic review and meta-analysis. Thromb J 19:91","journal-title":"Thromb J"},{"key":"5186_CR4","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","volume":"19","author":"Y Fan","year":"2021","unstructured":"Fan Y, Pedersen O (2021) Gut microbiota in human metabolic health and disease. Nat Rev Microbiol 19:55\u201371","journal-title":"Nat Rev Microbiol"},{"key":"5186_CR5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","volume":"165","author":"W Zhu","year":"2016","unstructured":"Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z et al (2016) Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell 165:111\u2013124","journal-title":"Cell"},{"key":"5186_CR6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12865-016-0187-3","volume":"18","author":"L Lin","year":"2017","unstructured":"Lin L, Zhang J (2017) Role of intestinal microbiota and metabolites on gut homeostasis and human diseases. BMC Immunol 18:2","journal-title":"BMC Immunol"},{"key":"5186_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2021.101492","volume":"35","author":"VL Jansen","year":"2021","unstructured":"Jansen VL, Gerdes VE, Middeldorp S, van Mens TE (2021) Gut microbiota and their metabolites in cardiovascular disease. Best Pract Res Clin Endocrinol Metab 35:101492","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"5186_CR8","first-page":"814","volume":"38","author":"XS Li","year":"2017","unstructured":"Li XS, Obeid S, Klingenberg R, Gencer B, Mach F, R\u00e4ber L et al (2017) Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors. Eur Heart J 38:814\u2013824","journal-title":"Eur Heart J"},{"key":"5186_CR9","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.cell.2020.02.016","volume":"180","author":"I Nemet","year":"2020","unstructured":"Nemet I, Saha PP, Gupta N, Zhu W, Romano KA, Skye SM et al (2020) A cardiovascular disease-linked gut microbial metabolite acts via adrenergic receptors. Cell 180:862\u201377.e22","journal-title":"Cell"},{"key":"5186_CR10","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.70240","volume":"11","author":"X Zhang","year":"2022","unstructured":"Zhang X, Zhang X, Tong F, Cai Y, Zhang Y, Song H et al (2022) Gut microbiota induces high platelet response in patients with ST segment elevation myocardial infarction after ticagrelor treatment. eLife 11:e70240","journal-title":"eLife"},{"key":"5186_CR11","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1182\/blood-2016-11-754416","volume":"130","author":"S J\u00e4ckel","year":"2017","unstructured":"J\u00e4ckel S, Kiouptsi K, Lillich M, Hendrikx T, Khandagale A, Kollar B et al (2017) Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. Blood 130:542\u2013553","journal-title":"Blood"},{"key":"5186_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110087","volume":"37","author":"BA Daisley","year":"2021","unstructured":"Daisley BA, Koenig D, Engelbrecht K, Doney L, Hards K, Al KF et al (2021) Emerging connections between gut microbiome bioenergetics and chronic metabolic diseases. Cell Reports 37:110087","journal-title":"Cell Reports"},{"key":"5186_CR13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.thromres.2020.03.003","volume":"189","author":"RA Hasan","year":"2020","unstructured":"Hasan RA, Koh AY, Zia A (2020) The gut microbiome and thromboembolism. Thromb Res 189:77\u201387","journal-title":"Thromb Res"},{"key":"5186_CR14","doi-asserted-by":"crossref","unstructured":"Synowiec A, Szczepa\u0144ski A, Barreto-Duran E, Lie LK, Pyrc K (2021) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection. Clin Microbiol Rev 34","DOI":"10.1128\/CMR.00133-20"},{"key":"5186_CR15","doi-asserted-by":"crossref","unstructured":"Zhang F, Wan Y, Zuo T, Yeoh YK, Liu Q, Zhang L et al (2021) Prolonged impairment of short-chain fatty acid and Lisoleucine biosynthesis in gut microbiome in patients with COVID-19. Gastroenterology","DOI":"10.1053\/j.gastro.2021.10.013"},{"key":"5186_CR16","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1053\/j.gastro.2020.06.048","volume":"159","author":"T Zuo","year":"2020","unstructured":"Zuo T, Zhan H, Zhang F, Liu Q, Tso EYK, Lui GCY et al (2020) Alterations in fecal fungal microbiome of patients with covid-19 during time of hospitalization until discharge. Gastroenterology 159:1302\u201310.e5","journal-title":"Gastroenterology"},{"key":"5186_CR17","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1053\/j.gastro.2020.05.048","volume":"159","author":"T Zuo","year":"2020","unstructured":"Zuo T, Zhang F, Lui GCY, Yeoh YK, Li AYL, Zhan H et al (2020) Alterations in gut microbiota of patients with COVID-19 during time of hospitalization. Gastroenterology 159:944\u201355.e8","journal-title":"Gastroenterology"},{"key":"5186_CR18","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41569-020-00469-1","volume":"18","author":"SX Gu","year":"2021","unstructured":"Gu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM et al (2021) Thrombocytopathy and endotheliopathy: Crucial contributors to COVID-19 thromboinflammation. Nat Rev Cardiol 18:194\u2013209","journal-title":"Nat Rev Cardiol"},{"key":"5186_CR19","unstructured":"National Health Commission of the People\u2019s Republic of China, National Administration of Traditional Chinese Medicine. Guideline for Diagnosis and Treatment of COVID-19 (7th version). 2020."},{"key":"5186_CR20","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1097\/JTO.0b013e3181ec173d","volume":"5","author":"JN Mandrekar","year":"2010","unstructured":"Mandrekar JN (2010) Receiver operating characteristic curve in diagnostic test assessment. J Thorac Oncol 5:1315\u20131316","journal-title":"J Thorac Oncol"},{"key":"5186_CR21","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3389\/fcimb.2019.00454","volume":"9","author":"G Wie\u00ebrs","year":"2019","unstructured":"Wie\u00ebrs G, Belkhir L, Enaud R, Leclercq S, Philippart de Foy JM, Dequenne I et al (2019) How probiotics affect the microbiota. Front Cell Infect Microbiol 9:454","journal-title":"Front Cell Infect Microbiol"},{"key":"5186_CR22","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.molmed.2016.04.003","volume":"22","author":"S Becattini","year":"2016","unstructured":"Becattini S, Taur Y, Pamer EG (2016) Antibiotic-induced changes in the intestinal microbiota and disease. Trends Mol Med 22:458\u2013478","journal-title":"Trends Mol Med"},{"key":"5186_CR23","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3945\/ajcn.2008.26219","volume":"89","author":"K Whelan","year":"2009","unstructured":"Whelan K, Judd PA, Tuohy KM, Gibson GR, Preedy VR, Taylor MA (2009) Fecal microbiota in patients receiving enteral feeding are highly variable and may be altered in those who develop diarrhea. Am J Clin Nutr 89:240\u2013247","journal-title":"Am J Clin Nutr"},{"key":"5186_CR24","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3389\/fcimb.2019.00434","volume":"9","author":"S Katagiri","year":"2019","unstructured":"Katagiri S, Shiba T, Tohara H, Yamaguchi K, Hara K, Nakagawa K et al (2019) Re-initiation of oral food intake following enteral nutrition alters oral and gut microbiota communities. Front Cell Infect Microbiol 9:434","journal-title":"Front Cell Infect Microbiol"},{"key":"5186_CR25","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.molmed.2021.09.009","volume":"27","author":"A Sarkar","year":"2021","unstructured":"Sarkar A, Harty S, Moeller AH, Klein SL, Erdman SE, Friston KJ et al (2021) The gut microbiome as a biomarker of differential susceptibility to SARS-CoV-2. Trends Mol Med 27:1115\u20131134","journal-title":"Trends Mol Med"},{"key":"5186_CR26","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1023\/A:1010920819831","volume":"45","author":"DJ Hand","year":"2001","unstructured":"Hand DJ, Till RJ (2001) A simple generalisation of the area under the roc curve for multiple class classification problems. Mach Learn 45:171\u2013186","journal-title":"Mach Learn"},{"key":"5186_CR27","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.gpb.2021.09.004","volume":"19","author":"T Zuo","year":"2021","unstructured":"Zuo T, Wu X, Wen W, Lan P (2021) Gut microbiome alterations in COVID-19. Genom Proteom Bioinform 19:679\u2013688","journal-title":"Genom Proteom Bioinform"},{"key":"5186_CR28","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1038\/s41598-021-82726-y","volume":"11","author":"F Durazzi","year":"2021","unstructured":"Durazzi F, Sala C, Castellani G, Manfreda G, Remondini D, De Cesare A (2021) Comparison between 16S rRNA and shotgun sequencing data for the taxonomic characterization of the gut microbiota. Sci Rep 11:3030","journal-title":"Sci Rep"},{"key":"5186_CR29","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1136\/gutjnl-2020-323020","volume":"70","author":"YK Yeoh","year":"2021","unstructured":"Yeoh YK, Zuo T, Lui GC, Zhang F, Liu Q, Li AY et al (2021) Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut 70:698\u2013706","journal-title":"Gut"},{"key":"5186_CR30","doi-asserted-by":"crossref","unstructured":"Stojanov S, Berlec A, \u0160trukelj B (2020) The influence of probiotics on the firmicutes\/bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease. Microorganisms:8","DOI":"10.3390\/microorganisms8111715"},{"key":"5186_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.705020","volume":"12","author":"A Moreira-Ros\u00e1rio","year":"2021","unstructured":"Moreira-Ros\u00e1rio A, Marques C, Pinheiro H, Ara\u00fajo JR, Ribeiro P, Rocha R et al (2021) Gut microbiota diversity and c-reactive protein are predictors of disease severity in COVID-19 patients. Front Microbiol 12:705020","journal-title":"Front Microbiol"},{"key":"5186_CR32","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.thromres.2020.03.012","volume":"190","author":"C Liu","year":"2020","unstructured":"Liu C, Cheng L, Ji L, Li F, Zhan Y, Wu B et al (2020) Intestinal microbiota dysbiosis play a role in pathogenesis of patients with primary immune thrombocytopenia. Thromb Res 190:11\u201319","journal-title":"Thromb Res"},{"key":"5186_CR33","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1111\/jth.14820","volume":"18","author":"DRJ Arachchillage","year":"2020","unstructured":"Arachchillage DRJ, Laffan M (2020) Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 18:1233\u20131234","journal-title":"J Thromb Haemost"},{"key":"5186_CR34","doi-asserted-by":"crossref","unstructured":"Martinovi\u0107 A, Cocuzzi R, Arioli S, Mora D (2020) streptococcus thermophilus: to survive, or not to survive the gastrointestinal tract, that is the question! Nutrients 12","DOI":"10.3390\/nu12082175"},{"key":"5186_CR35","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1161\/CIRCRESAHA.118.314642","volume":"124","author":"A Kurilshikov","year":"2019","unstructured":"Kurilshikov A, ICLvd M, Chen L, Bonder MJ, Schraa K, JHW R et al (2019) Gut microbial associations to plasma metabolites linked to cardiovascular phenotypes and risk. Circulation Research 124:1808\u20131820","journal-title":"Circulation Research"},{"key":"5186_CR36","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.2174\/092986710791959783","volume":"17","author":"N Dionisio","year":"2010","unstructured":"Dionisio N, Jard\u00edn I, Salido GM, Rosado JA (2010) Homocysteine, intracellular signaling and thrombotic disorders. Curr Med Chem 17:3109\u20133119","journal-title":"Curr Med Chem"},{"key":"5186_CR37","doi-asserted-by":"publisher","first-page":"107602961878034","DOI":"10.1177\/1076029618780344","volume":"25","author":"E Lupi-Herrera","year":"2019","unstructured":"Lupi-Herrera E, Soto-L\u00f3pez ME, Lugo-Dimas AJ, N\u00fa\u00f1ez-Mart\u00ednez ME, Gamboa R, Huesca-G\u00f3mez C et al (2019) Polymorphisms C677T and A1298C of MTHFR gene: homocysteine levels and prothrombotic biomarkers in coronary and pulmonary thromboembolic disease. Clin Appl Thromb Hemost 25:1076029618780344","journal-title":"Clin Appl Thromb Hemost"},{"key":"5186_CR38","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.numecd.2019.09.018","volume":"30","author":"M Verdoia","year":"2020","unstructured":"Verdoia M, Rolla R, Negro F, Tonon F, Pergolini P, Nardin M et al (2020) Homocysteine levels and platelet reactivity in coronary artery disease patients treated with ticagrelor. Nutr Metab Cardiovasc Dis 30:292\u2013299","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"5186_CR39","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1080\/10408363.2020.1770685","volume":"57","author":"G Ponti","year":"2020","unstructured":"Ponti G, Maccaferri M, Ruini C, Tomasi A, Ozben T (2020) Biomarkers associated with COVID-19 disease progression. Crit Rev Clin Lab Sci 57:389\u2013399","journal-title":"Crit Rev Clin Lab Sci"},{"key":"5186_CR40","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1111\/jth.15122","volume":"18","author":"O Ibrahimagi\u0107","year":"2020","unstructured":"Ibrahimagi\u0107 O, Smajlovi\u0107 D, Dostovi\u0107 Z, Kuni\u0107 S, \u0160ehanovi\u0107 A, Koji\u0107 B (2020) Comment on an article: \"Coagulopathy in COVID-19\". J Thromb Haemost 18:3381\u20133382","journal-title":"J Thromb Haemost"},{"key":"5186_CR41","doi-asserted-by":"crossref","unstructured":"Krawczyk B, Wityk P, Ga\u0142\u0119cka M, Michalik M (2021) The many faces of enterococcus spp.-commensal, probiotic and opportunistic pathogen. Microorganisms:9","DOI":"10.3390\/microorganisms9091900"},{"key":"5186_CR42","doi-asserted-by":"publisher","first-page":"18255","DOI":"10.1038\/srep18255","volume":"5","author":"AM Guzm\u00e1n Prieto","year":"2015","unstructured":"Guzm\u00e1n Prieto AM, Urbanus RT, Zhang X, Bierschenk D, Koekman CA, van Luit-Asbroek M et al (2015) The N-terminal domain of the thermo-regulated surface protein PrpA of Enterococcus faecium binds to fibrinogen, fibronectin and platelets. Sci Rep 5:18255","journal-title":"Sci Rep"},{"key":"5186_CR43","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/s41564-019-0407-8","volume":"4","author":"EM Velazquez","year":"2019","unstructured":"Velazquez EM, Nguyen H, Heasley KT, Saechao CH, Gil LM, Rogers AWL et al (2019) Endogenous Enterobacteriaceae underlie variation in susceptibility to Salmonella infection. Nature Microbiology 4:1057\u20131064","journal-title":"Nature Microbiology"},{"key":"5186_CR44","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1136\/gutjnl-2021-324090","volume":"71","author":"Y Chen","year":"2022","unstructured":"Chen Y, Gu S, Chen Y, Lu H, Shi D, Guo J et al (2022) Six-month follow-up of gut microbiota richness in patients with COVID-19. Gut 71:222\u2013225","journal-title":"Gut"},{"key":"5186_CR45","doi-asserted-by":"publisher","first-page":"2802","DOI":"10.1097\/MIB.0000000000000972","volume":"22","author":"K Takeshita","year":"2016","unstructured":"Takeshita K, Mizuno S, Mikami Y, Sujino T, Saigusa K, Matsuoka K et al (2016) A single species of clostridium subcluster xiva decreased in ulcerative colitis patients. Inflamm Bowel Dis 22:2802\u20132810","journal-title":"Inflamm Bowel Dis"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-023-05186-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-023-05186-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-023-05186-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T10:17:41Z","timestamp":1683886661000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-023-05186-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,11]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["5186"],"URL":"https:\/\/doi.org\/10.1007\/s00277-023-05186-6","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,11]]},"assertion":[{"value":"25 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from all patients for being included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}