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We herein report a 58-year-old woman presenting with massive pleural effusion approximately 1\u00a0year after allogeneic HSCT, who was successfully treated with corticosteroid. She had discontinued tacrolimus approximately 1\u00a0month before she presented with pleural effusion, which was attributed to cGVHD after a thorough exclusion process. This case illustrates a unique manifestation of atypical cGVHD and highlights the need for prompt therapy initiation.<\/jats:p>","DOI":"10.1007\/s00277-024-05643-w","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T11:02:31Z","timestamp":1706526151000},"page":"1403-1407","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Isolated massive pleural effusion as a manifestation of chronic graft versus host disease successfully treated with corticosteroid"],"prefix":"10.1007","volume":"103","author":[{"given":"Yasutaka","family":"Masuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Masamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineo","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"issue":"4","key":"5643_CR1","first-page":"443","volume":"150","author":"PW Noble","year":"1989","unstructured":"Noble PW (1989) The pulmonary complications of bone marrow transplantation in adults. 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Written consent was obtained from the case.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}