{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:28:16Z","timestamp":1791923296569,"version":"4.3.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Major Program of Changsha Municipal Natural Science Foundation, China","award":["KH2103010"],"award-info":[{"award-number":["KH2103010"]}]},{"name":"Major Program of Changsha Municipal Natural Science Foundation, China","award":["KH2103010"],"award-info":[{"award-number":["KH2103010"]}]},{"name":"Major Program of Changsha Municipal Natural Science Foundation, China","award":["KH2103010"],"award-info":[{"award-number":["KH2103010"]}]},{"name":"Major Program of Changsha Municipal Natural Science Foundation, China","award":["KH2103010"],"award-info":[{"award-number":["KH2103010"]}]},{"name":"Major Program of Changsha Municipal Natural Science Foundation, China","award":["KH2103010"],"award-info":[{"award-number":["KH2103010"]}]},{"name":"Major Program of Changsha Municipal Natural Science Foundation, China","award":["KH2103010"],"award-info":[{"award-number":["KH2103010"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s00277-024-05718-8","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T09:03:37Z","timestamp":1719479017000},"page":"3219-3227","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["APTT critical value establishment in four different reagent\/instrument systems based on single factor deficiencies"],"prefix":"10.1007","volume":"103","author":[{"given":"Hualan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianji","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"issue":"1","key":"5718_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1093\/ajcp\/71.1.22","volume":"71","author":"WE Hathaway","year":"1979","unstructured":"Hathaway WE, Assmus SL, Montgomery RR, Dubansky AS (1979) Activated partial thromboplastin time and minor coagulopathies. Am J Clin Pathol 71(1):22\u201325. https:\/\/doi.org\/10.1093\/ajcp\/71.1.22","journal-title":"Am J Clin Pathol"},{"issue":"2","key":"5718_CR2","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1055\/s-0033-1364186","volume":"40","author":"RA Marlar","year":"2014","unstructured":"Marlar RA, Gausman JN, Engel JW (2014) Validation of hemostasis and coagulation assays: recommendations and guidelines. Semin Thromb Hemost 40(2):186\u2013194. https:\/\/doi.org\/10.1055\/s-0033-1364186","journal-title":"Semin Thromb Hemost"},{"key":"5718_CR3","doi-asserted-by":"publisher","unstructured":"Gosselin RC, Adcock D, Dorgalaleh A, Favaloro EJ, Lippi G, Pego (2020) JM International council for standardization in haematology recommendations for hemostasis critical values, tests, and reporting. Semin Thromb Hemost 46(4): 398\u2013409. https:\/\/doi.org\/10.1055\/s-0039-1697677","DOI":"10.1055\/s-0039-1697677"},{"issue":"1","key":"5718_CR4","first-page":"11","volume":"14","author":"L Thomas","year":"2003","unstructured":"Thomas L (2003) Critical limits of laboratory results for urgent clinician notification. Ejifcc 14(1):11\u201318","journal-title":"Ejifcc"},{"key":"5718_CR5","doi-asserted-by":"publisher","unstructured":"Campbell CA, Georgiou A, Westbrook JI, Horvath AR (2016) What alert thresholds should be used to identify critical risk results: a systematic review of the evidence. Clin Chem62(11): 1445-57. https:\/\/doi.org\/10.1373\/clinchem. 2016.260638","DOI":"10.1373\/clinchem"},{"issue":"2","key":"5718_CR6","doi-asserted-by":"publisher","first-page":"193","DOI":"10.11613\/BM.2015.019","volume":"25","author":"LM Kopcinovic","year":"2015","unstructured":"Kopcinovic LM, Trifunovic J, Pavosevic T, Nikolac N (2015) Croatian survey on critical results reporting. Biochem Med 25(2):193\u2013202. https:\/\/doi.org\/10.11613\/BM.2015.019","journal-title":"Biochem Med"},{"issue":"3","key":"5718_CR7","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1093\/ajcp\/108.3.247","volume":"108","author":"K Emancipator","year":"1997","unstructured":"Emancipator K (1997) Critical values: ascp practice parameter. American society of clinical pathologists. Am J Clin Pathol 108(3):247\u2013253. https:\/\/doi.org\/10.1093\/ajcp\/108.3.247","journal-title":"Am J Clin Pathol"},{"issue":"12","key":"5718_CR8","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.5858\/2007-131-1769-CVCACO","volume":"131","author":"EA Wagar","year":"2007","unstructured":"Wagar EA, Friedberg RC, Souers R, Stankovic AK (2007) Critical values comparison: a college of American pathologists q-probes survey of 163 clinical laboratories. Arch Pathol Lab Med 131(12):1769\u20131775. https:\/\/doi.org\/10.5858\/2007-131-1769-CVCACO","journal-title":"Arch Pathol Lab Med"},{"issue":"6","key":"5718_CR9","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1309\/AJCP8O8GIPPPNUSH","volume":"136","author":"M Pai","year":"2011","unstructured":"Pai M, Moffat KA, Plumhoff E, Hayward CP (2011) Critical values in the coagulation laboratory: results of a survey of the north American specialized coagulation laboratory association. Am J Clin Pathol 136(6):836\u2013841. https:\/\/doi.org\/10.1309\/AJCP8O8GIPPPNUSH","journal-title":"Am J Clin Pathol"},{"issue":"07","key":"5718_CR10","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3969\/j.issn.1673-4130.2016.07.003","volume":"37","author":"Z Fei Yang","year":"2016","unstructured":"Fei Yang Z, Rong W, Wei Z, Kun H, Falin, Wang Zhiguo (2016) Investigation andanalysis of critical values of hematological test items among 561 clinical laboratories in Chinese. Int J Lab Med 37(07):871\u2013874. https:\/\/doi.org\/10.3969\/j.issn.1673-4130.2016.07.003","journal-title":"Int J Lab Med"},{"key":"5718_CR11","doi-asserted-by":"publisher","unstructured":"Ye YY, Zhao HJ, Fei Y, Wang W, Wang ZG (2017) Critical values in hematology of 862 institutions in China. Int J Lab Hematol 39(5). https:\/\/doi.org\/10.1111\/ijlh.12681","DOI":"10.1111\/ijlh.12681"},{"issue":"3","key":"5718_CR12","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/PTS.0000000000000217","volume":"15","author":"R Mosallam","year":"2019","unstructured":"Mosallam R, Ibrahim SZ (2019) Critical value reporting at Egyptian laboratories. J Patient Saf 15(3):205\u2013211. https:\/\/doi.org\/10.1097\/PTS.0000000000000217","journal-title":"J Patient Saf"},{"issue":"1","key":"5718_CR13","doi-asserted-by":"publisher","first-page":"65","DOI":"10.7196\/samj.7057","volume":"104","author":"E Schapkaitz","year":"2013","unstructured":"Schapkaitz E, Mafika Z (2013) Critical value reporting: a survey of 36 clinical laboratories in South Africa. Samj S Afr Med J 104(1):65\u201367. https:\/\/doi.org\/10.7196\/samj.7057","journal-title":"Samj S Afr Med J"},{"issue":"4","key":"5718_CR14","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1515\/CCLM.2010.096","volume":"48","author":"E Piva","year":"2010","unstructured":"Piva E, Sciacovelli L, Laposata M, Plebani M (2010) Assessment of critical values policies in Italian institutions: comparison with the us situation. Clin Chem Lab Med 48(4):461\u2013468. https:\/\/doi.org\/10.1515\/CCLM.2010.096","journal-title":"Clin Chem Lab Med"},{"issue":"3","key":"5718_CR15","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/j.1600-0609.2008.01191.x","volume":"82","author":"JJ van Veen","year":"2009","unstructured":"van Veen JJ, Laidlaw S, Swanevelder J, Harvey N, Watson C, Kitchen Set al et al (2009) Contact factor deficiencies and cardiopulmonary bypass surgery: detection of the defect and monitoring of heparin. Eur J Haematol 82(3):208\u2013212. https:\/\/doi.org\/10.1111\/j.1600-0609.2008.01191.x","journal-title":"Eur J Haematol"},{"key":"5718_CR16","doi-asserted-by":"publisher","unstructured":"Xiao-Jun Huang (2022) Guidelines for the diagnosis and treatment of hemophilia a (2022 edition). Clinical Education of General Practice 20(07): 579\u2009\u2013\u200983. https:\/\/doi.org\/10.13558\/j.cnki.issn1672-3686.2022.007.002","DOI":"10.13558\/j.cnki.issn1672-3686.2022.007.002"},{"issue":"5","key":"5718_CR17","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1309\/R53X-VC2U-5CH6-TNG8","volume":"125","author":"AS Dighe","year":"2006","unstructured":"Dighe AS, Rao A, Coakley AB, Lewandrowski KB (2006) Analysis of laboratory critical value reporting at a large academic medical center. Am J Clin Pathol 125(5):758\u2013764. https:\/\/doi.org\/10.1309\/R53X-VC2U-5CH6-TNG8","journal-title":"Am J Clin Pathol"},{"key":"5718_CR18","doi-asserted-by":"crossref","unstructured":"Guzman DA, Solari SS, Lagos LM, Poggi MH, Sanchez PT Madrid QA(2009) Laboratory alert value reporting by the clinical laboratory at an academic medical network. Rev Med Chile 137(9): 1137\u20131144","DOI":"10.4067\/S0034-98872009000900001"},{"key":"5718_CR19","doi-asserted-by":"publisher","unstructured":"Toulon P, Eloit Y, Smahi M, Sigaud C, Jambou D Fischer F(2016) in vitro sensitivity of different activated partial thromboplastin time reagents to mild clotting factor deficiencies. Int J Lab Hematol 38(4): 389\u2013396. https:\/\/doi.org\/10.1111\/ijlh.12499","DOI":"10.1111\/ijlh.12499"},{"issue":"7\u20138","key":"5718_CR20","doi-asserted-by":"publisher","first-page":"921","DOI":"10.7754\/clin.lab.2012.120909","volume":"59","author":"L Rozen","year":"2013","unstructured":"Rozen L, Copette F, Noubouossie DF, Demulder A (2013) Evaluation of three aptt reagents in a routine laboratory: toward a compromise. Clin Lab 59(7\u20138):921\u2013924. https:\/\/doi.org\/10.7754\/clin.lab.2012.120909","journal-title":"Clin Lab"},{"issue":"2","key":"5718_CR21","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1751-553X.2010.01261.x","volume":"33","author":"A Bowyer","year":"2011","unstructured":"Bowyer A, Kitchen S, Makris M (2011) The responsiveness of different aptt reagents to mild factor viii, ix and xi deficiencies. Int J Lab Hematol 33(2):154\u2013158. https:\/\/doi.org\/10.1111\/j.1751-553X.2010.01261.x","journal-title":"Int J Lab Hematol"},{"issue":"5","key":"5718_CR22","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1093\/clinchem\/12.5.269","volume":"12","author":"JG Lenahan","year":"1966","unstructured":"Lenahan JG, Phillips GE (1966) Some variables which influence the activated partial thromboplastin time assay. Clin Chem 12(5):269\u2013273. https:\/\/doi.org\/10.1093\/clinchem\/12.5.269","journal-title":"Clin Chem"},{"issue":"7","key":"5718_CR23","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1056\/NEJM197208172870703","volume":"287","author":"D Basu","year":"1972","unstructured":"Basu D, Gallus A, Hirsh J, Cade J (1972) A prospective study of the value of monitoring heparin treatment with the activated partial thromboplastin time. New Engl J Med 287(7):324\u2013327. https:\/\/doi.org\/10.1056\/NEJM197208172870703","journal-title":"New Engl J Med"},{"key":"5718_CR24","doi-asserted-by":"publisher","unstructured":"Lansberg MG, O\u2019Donnell MJ, Khatri P, Lang ES, Nguyen-Huynh MN, Schwartz (2012) NE Antithrombotic and thrombolytic therapy for ischemic stroke: antithrombotic therapy and prevention of thrombosis, 9th ed: american college of chest physicians evidence-based clinical practice guidelines. Chest 141(2 Suppl): e601S-e636S. https:\/\/doi.org\/10.1378\/chest.11-2302","DOI":"10.1378\/chest.11-2302"},{"issue":"6","key":"5718_CR25","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/ijlh.12424","volume":"37","author":"M Martinuzzo","year":"2015","unstructured":"Martinuzzo M, Barrera L, Rodriguez M, D\u2019Adamo MA, Lopez MS, Otaso JC (2015) Do pt and aptt sensitivities to factors\u2019 deficiencies calculated by the h47-a2 2008 clsi guideline reflect the deficiencies found in plasmas from patients? Int J Lab Hematol 37(6):853\u2013860. https:\/\/doi.org\/10.1111\/ijlh.12424","journal-title":"Int J Lab Hematol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-05718-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-024-05718-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-05718-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T06:10:34Z","timestamp":1722060634000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-024-05718-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["5718"],"URL":"https:\/\/doi.org\/10.1007\/s00277-024-05718-8","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,27]]},"assertion":[{"value":"26 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in accordance with the principles of the Declaration of Helsinki. The Institutional Ethics Committee of each participating center approved the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}