{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:00:29Z","timestamp":1783119629722,"version":"3.54.6"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1007\/s00277-024-05900-y","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T10:02:15Z","timestamp":1722333735000},"page":"3649-3656","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lymphoma-associated hemophagocytic syndrome: a retrospective, single-center study of 86 patients"],"prefix":"10.1007","volume":"103","author":[{"given":"Shijia","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"issue":"5","key":"5900_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.2147\/jbm.S46255","volume":"12","author":"MR George","year":"2014","unstructured":"George MR (2014) Hemophagocytic lymphohistiocytosis: review of etiologies and management. J Blood Med 12(5):69\u201386. https:\/\/doi.org\/10.2147\/jbm.S46255","journal-title":"J Blood Med"},{"issue":"4","key":"5900_CR2","doi-asserted-by":"publisher","first-page":"101515","DOI":"10.1016\/j.berh.2020.101515","volume":"34","author":"G Griffin","year":"2020","unstructured":"Griffin G, Shenoi S, Hughes GC (2020) Hemophagocytic lymphohistiocytosis: an update on pathogenesis, diagnosis, and therapy.Best Pract. Res Clin Rheumatol 34(4):101515. https:\/\/doi.org\/10.1016\/j.berh.2020.101515","journal-title":"Res Clin Rheumatol"},{"key":"5900_CR3","doi-asserted-by":"publisher","unstructured":"Ramos-Casals M, Brito-Zer\u00f3n P, L\u00f3pez-Guillermo A, Khamashta MA, Bosch X (2014) Adult haemophagocytic syndrome.Lancet. 383(9927):1503\u20131516. https:\/\/doi.org\/10.1016\/s0140-6736(13)61048-x","DOI":"10.1016\/s0140-6736(13)61048-x"},{"issue":"7","key":"5900_CR4","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1097\/00000478-200107000-00004","volume":"25","author":"Y Allory","year":"2001","unstructured":"Allory Y, Challine D, Haioun C, Copie-Bergman C, Delfau-Larue MH, Boucher E, Charlotte F, Fabre M, Michel M, Gaulard P (2001) Bone marrow involvement in lymphomas with hemophagocytic syndrome at presentation: a clinicopathologic study of 11 patients in a western institution. Am J Surg Pathol 25(7):865\u2013874. https:\/\/doi.org\/10.1097\/00000478-200107000-00004","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"5900_CR5","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1007\/s12032-014-0902-y","volume":"31","author":"F Li","year":"2014","unstructured":"Li F, Li P, Zhang R, Yang G, Ji D, Huang X, Xu Q, Wei Y, Rao J, Huang R, Chen G (2014) Identification of clinical features of lymphoma-associated hemophagocytic syndrome (LAHS): an analysis of 69 patients with hemophagocytic syndrome from a single-center in central region of China. Med Oncol 31(4):902. https:\/\/doi.org\/10.1007\/s12032-014-0902-y","journal-title":"Med Oncol"},{"issue":"4","key":"5900_CR6","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1080\/15384047.2017.1295176","volume":"18","author":"N Li","year":"2017","unstructured":"Li N, Zhang L, Liu J, Zhang J, Weng HW, Zhuo HY, Zou LQ (2017) A clinical study of 21 patients with hemophagocytic syndrome in 295 cases diagnosed with nasal type, extranodal nature killer\/T cell lymphoma. Cancer Biol Ther 18(4):252\u2013256. https:\/\/doi.org\/10.1080\/15384047.2017.1295176","journal-title":"Cancer Biol Ther"},{"issue":"1","key":"5900_CR7","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/bjh.15506","volume":"183","author":"C Bigenwald","year":"2018","unstructured":"Bigenwald C, Fardet L, Coppo P, Meignin V, Lazure T, Fabiani B, Kohn M, Oksenhendler E, Boutboul D, Uzzan M, Lambotte O, Galicier L (2018) A comprehensive analysis of lymphoma-associated haemophagocytic syndrome in a large French multicentre cohort detects some clues to improve prognosis. Br J Haematol 183(1):68\u201375. https:\/\/doi.org\/10.1111\/bjh.15506","journal-title":"Br J Haematol"},{"issue":"2","key":"5900_CR8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/pbc.21039","volume":"48","author":"JI Henter","year":"2007","unstructured":"Henter JI, Horne A, Aric\u00f3 M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka G (2007) HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 48(2):124\u2013131. https:\/\/doi.org\/10.1002\/pbc.21039","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"5900_CR9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/pbc.24188","volume":"60","author":"RA Marsh","year":"2013","unstructured":"Marsh RA, Allen CE, McClain KL, Weinstein JL, Kanter J, Skiles J, Lee ND, Khan SP, Lawrence J, Mo JQ, Bleesing JJ, Filipovich AH, Jordan MB (2013) Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab. Pediatr Blood Cancer 60(1):101\u2013109. https:\/\/doi.org\/10.1002\/pbc.24188","journal-title":"Pediatr Blood Cancer"},{"issue":"3","key":"5900_CR10","doi-asserted-by":"publisher","first-page":"e217","DOI":"10.1016\/s2352-3026(21)00366-5","volume":"9","author":"A Setiadi","year":"2022","unstructured":"Setiadi A, Zoref-Lorenz A, Lee CY, Jordan MB, Chen LYC (2022) Malignancy-associated haemophagocytic lymphohistiocytosis. Lancet Haematol 9(3):e217\u2013e227. https:\/\/doi.org\/10.1016\/s2352-3026(21)00366-5","journal-title":"Lancet Haematol"},{"key":"5900_CR11","doi-asserted-by":"publisher","unstructured":"Zoref-Lorenz A, Murakami J, Hofstetter L, Iyer S, Alotaibi AS, Mohamed SF, Miller PG, Guber E, Weinstein S, Yacobovich J, Nikiforow S, Ebert BL, Lane A, Pasvolsky O, Raanani P, Nagler A, Berliner N, Daver N, Ellis M, Jordan MB (2022) An improved index for diagnosis and mortality prediction in malignancy-associated hemophagocytic lymphohistiocytosis.Blood 139(7):1098\u20131110.https:\/\/doi.org\/10.1182\/blood.2021012764","DOI":"10.1182\/blood.2021012764"},{"issue":"3","key":"5900_CR12","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 Countries.CA. Cancer J Clin 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"Cancer J Clin"},{"issue":"3","key":"5900_CR13","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1182\/blood.2023020715","volume":"143","author":"A L\u00f6fstedt","year":"2024","unstructured":"L\u00f6fstedt A, J\u00e4dersten M, Meeths M, Henter JI (2024) Malignancy-associated hemophagocytic lymphohistiocytosis in Sweden: incidence, clinical characteristics. Survival Blood 143(3):233\u2013242. https:\/\/doi.org\/10.1182\/blood.2023020715","journal-title":"Survival Blood"},{"issue":"7","key":"5900_CR14","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00277-007-0278-6","volume":"86","author":"AR Han","year":"2007","unstructured":"Han AR, Lee HR, Park BB, Hwang IG, Park S, Lee SC, Kim K, Lim HY, Ko YH, Kim SH, Kim WS (2007) Lymphoma-associated hemophagocytic syndrome: clinical features and treatment outcome. Ann Hematol 86(7):493\u2013498. https:\/\/doi.org\/10.1007\/s00277-007-0278-6","journal-title":"Ann Hematol"},{"issue":"1","key":"5900_CR15","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1080\/16078454.2022.2113600","volume":"27","author":"N Li","year":"2022","unstructured":"Li N, Jiang M, Wu WC, Zhou HJ, Zou LQ (2022) Lymphoma-associated hemophagocytic syndrome: a retrospective study from a. Single Cent Hematol 27(1):909\u2013916. https:\/\/doi.org\/10.1080\/16078454.2022.2113600","journal-title":"Single Cent Hematol"},{"issue":"5","key":"5900_CR16","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1002\/ajh.21811","volume":"86","author":"K Liapis","year":"2011","unstructured":"Liapis K, Apostolidis J, Delimpasis S (2011) EBV-associated hemophagocytic syndrome. Am J Hematol 86(5):422. https:\/\/doi.org\/10.1002\/ajh.21811","journal-title":"Am J Hematol"},{"issue":"11","key":"5900_CR17","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s00277-013-1784-3","volume":"92","author":"JT Yu","year":"2013","unstructured":"Yu JT, Wang CY, Yang Y, Wang RC, Chang KH, Hwang WL, Teng CL (2013) Lymphoma-associated hemophagocytic lymphohistiocytosis: experience in adults from a single institution. Ann Hematol 92(11):1529\u20131536. https:\/\/doi.org\/10.1007\/s00277-013-1784-3","journal-title":"Ann Hematol"},{"key":"5900_CR18","doi-asserted-by":"publisher","unstructured":"Bhatt NS, Oshrine B, An Talano J (2019) Hemophagocytic lymphohistiocytosis in adults.Leuk lymphoma. 60(1):19\u201328. https:\/\/doi.org\/10.1080\/10428194.2018.1482543","DOI":"10.1080\/10428194.2018.1482543"},{"key":"5900_CR19","doi-asserted-by":"publisher","unstructured":"Jordan MB, Allen CE, Weitzman S, Filipovich AH, McClain KL (2011) How I treat hemophagocytic lymphohistiocytosis.Blood 118(15):4041\u20134052.https:\/\/doi.org\/10.1182\/blood-2011-03-278127","DOI":"10.1182\/blood-2011-03-278127"},{"issue":"1","key":"5900_CR20","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.3324\/haematol.2019.220301","volume":"105","author":"JH Liang","year":"2020","unstructured":"Liang JH, Wang L, Zhu HY, Qian J, Liao H, Wu JZ, Xia Y, Wu W, Cao L, Fan L, Li JY, Xu W (2020) Dose-adjusted EPOCH regimen as first-line treatment for non-hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis: a single-arm, open-label. Phase II Trial Haematol 105(1):e29\u2013e32. https:\/\/doi.org\/10.3324\/haematol.2019.220301","journal-title":"Phase II Trial Haematol"},{"issue":"7","key":"5900_CR21","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1007\/s00277-015-2350-y","volume":"94","author":"BI Dalal","year":"2015","unstructured":"Dalal BI, Vakil AP, Khare NS, Wang SY, Richards MJ, Chen LY (2015) Abnormalities of the lymphocyte subsets and their immunophenotype, and their prognostic significance in adult patients with hemophagocytic lymphohistiocytosis. Ann Hematol 94(7):1111\u20131117. https:\/\/doi.org\/10.1007\/s00277-015-2350-y","journal-title":"Ann Hematol"},{"issue":"6","key":"5900_CR22","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3109\/00365548.2015.1007475","volume":"47","author":"M Boisseau","year":"2015","unstructured":"Boisseau M, Lambotte O, Galicier L, Lerolle N, Marzac C, Aumont C, Coppo P, Fardet L (2015) Epstein-Barr virus viral load in human immunodeficiency virus-positive patients with reactive hemophagocytic syndrome. Infect Dis (Lond) 47(6):423\u2013427. https:\/\/doi.org\/10.3109\/00365548.2015.1007475","journal-title":"Infect Dis (Lond)"},{"issue":"11","key":"5900_CR23","doi-asserted-by":"publisher","first-page":"997","DOI":"10.2147\/ott.S153942","volume":"26","author":"Q Fei","year":"2018","unstructured":"Fei Q, Tian XK, Wu J, Zhu HM, Wang Y, Peng FY, Zhang WJ, Yin L, He X (2018) Prognostic significance of Epstein-Barr virus DNA in NK\/T-cell lymphoma: a meta-analysis. Onco Targets Ther 26(11):997\u20131004. https:\/\/doi.org\/10.2147\/ott.S153942","journal-title":"Onco Targets Ther"},{"issue":"7","key":"5900_CR24","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1002\/ajh.25112","volume":"93","author":"JJ Castillo","year":"2018","unstructured":"Castillo JJ, Beltran BE, Miranda RN, Young KH, Chavez JC, Sotomayor EM (2018) EBV-positive diffuse large B-cell lymphoma, not otherwise specified: 2018 update on diagnosis, risk-stratification and management. Am J Hematol 93(7):953\u2013962. https:\/\/doi.org\/10.1002\/ajh.25112","journal-title":"Am J Hematol"},{"issue":"1","key":"5900_CR25","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1532\/ijh97.07012","volume":"86","author":"E Ishii","year":"2007","unstructured":"Ishii E, Ohga S, Imashuku S, Yasukawa M, Tsuda H, Miura I, Yamamoto K, Horiuchi H, Takada K, Ohshima K, Nakamura S, Kinukawa N, Oshimi K, Kawa K (2007) Nationwide survey of hemophagocytic lymphohistiocytosis in Japan. Int J Hematol 86(1):58\u201365. https:\/\/doi.org\/10.1532\/ijh97.07012","journal-title":"Int J Hematol"},{"issue":"2","key":"5900_CR26","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nri.2017.112","volume":"18","author":"MN Wykes","year":"2018","unstructured":"Wykes MN, Lewin SR (2018) Immune checkpoint blockade in infectious diseases. Nat Rev Immunol 18(2):91\u2013104. https:\/\/doi.org\/10.1038\/nri.2017.112","journal-title":"Nat Rev Immunol"},{"key":"5900_CR27","doi-asserted-by":"publisher","unstructured":"Liu P, Pan X, Chen C, Niu T, Shuai X, Wang J, Chen X, Liu J, Guo Y, Xie L, Wu Y, Liu Y, Liu T (2020) Nivolumab treatment of relapsed\/refractory Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults.Blood. 135(11):826\u2013833. https:\/\/doi.org\/10.1182\/blood.2019003886","DOI":"10.1182\/blood.2019003886"},{"issue":"7","key":"5900_CR28","doi-asserted-by":"publisher","first-page":"e452","DOI":"10.1038\/bcj.2016.63","volume":"6","author":"M Wilhelm","year":"2016","unstructured":"Wilhelm M, Smetak M, Reimer P, Geissinger E, Ruediger T, Metzner B, Schmitz N, Engert A, Schaefer-Eckart K, Birkmann J (2016) First-line therapy of peripheral T-cell lymphoma: extension and long-term follow-up of a study investigating the role of autologous stem cell transplantation. Blood Cancer J 6(7):e452. https:\/\/doi.org\/10.1038\/bcj.2016.63","journal-title":"Blood Cancer J"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-05900-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-024-05900-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-05900-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T09:18:58Z","timestamp":1724836738000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-024-05900-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["5900"],"URL":"https:\/\/doi.org\/10.1007\/s00277-024-05900-y","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,30]]},"assertion":[{"value":"4 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}