{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:26:20Z","timestamp":1783664780792,"version":"3.55.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Advancements in allogeneic haematopoietic stem cell transplant (alloHSCT) procedures have improved patient outcomes over the last two decades, though invasive fungal infections (IFIs) remain a significant risk. The incidence of IFIs in alloHSCT recipients is estimated at 6%, with a mortality rate of 13%, and Aspergillus species are the most common pathogens involved. Posaconazole is effective in preventing IFIs post-transplant and is standard care during neutropenia or when managing graft-versus-host disease (GvHD) with high-dose steroids. However, azole prophylaxis may cause resistant Aspergillus species like A. calidoustus, which are difficult to treat. We report a case from our institution where a patient developed a dual infection with Aspergillus calidoustus and Talaromyces columbinus after alloHSCT and posaconazole prophylaxis. While A. calidoustus is known to cause IFIs in HSCT recipients, T. columbinus represents a previously unreported occurrence in medical literature. This case underscores the importance of a multifaceted diagnostic strategy, integrating BAL diagnosis, mycological cultures, direct microscopy, fungal speciation, susceptibility testing, and biomarkers. These comprehensive approaches are indispensable for accurate pathogen identification and effective management of IFIs with appropriate antifungal agents.<\/jats:p>","DOI":"10.1007\/s00277-024-05980-w","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T03:35:12Z","timestamp":1725420912000},"page":"4797-4800","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Aspergillus calidoustus and Talaromyces columbinus infections in chronic graft-versus-host disease"],"prefix":"10.1007","volume":"103","author":[{"given":"Emanuele","family":"Pacini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Schelenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Abdolrasouli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Mehra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Mansour","family":"Ceesay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pagliuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Avenoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"5980_CR1","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1086\/651263","volume":"50","author":"DP Kontoyiannis","year":"2010","unstructured":"Kontoyiannis DP, Marr KA, Park BJ et al (2010) Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001\u20132006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) database. Clin Infect Dis 50:1091\u20131100. https:\/\/doi.org\/10.1086\/651263","journal-title":"Clin Infect Dis"},{"key":"5980_CR2","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1056\/NEJMoa061094","volume":"356","author":"A Cornely Oliver","year":"2007","unstructured":"Cornely Oliver A, Johan M, Winston Drew J et al (2007) Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in patients with Neutropenia. N Engl J Med 356:348\u2013359. https:\/\/doi.org\/10.1056\/NEJMoa061094","journal-title":"N Engl J Med"},{"key":"5980_CR3","doi-asserted-by":"publisher","unstructured":"Maertens JA, Girmenia C, Br\u00fcggemann RJ et al (2018) European guidelines for primary antifungal prophylaxis in adult haematology patients: summary of the updated recommendations from the European Conference on Infections in Leukaemia. J Antimicrob Chemother 73:3221\u20133230. https:\/\/doi.org\/10.1093\/jac\/dky286","DOI":"10.1093\/jac\/dky286"},{"key":"5980_CR4","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.1128\/JCM.01070-09","volume":"47","author":"SA Balajee","year":"2009","unstructured":"Balajee SA, Kano R, Baddley JW et al (2009) Molecular identification of aspergillus species collected for the Transplant-Associated Infection Surveillance Network. J Clin Microbiol 47:3138\u20133141. https:\/\/doi.org\/10.1128\/JCM.01070-09","journal-title":"J Clin Microbiol"},{"key":"5980_CR5","doi-asserted-by":"publisher","first-page":"e2024002","DOI":"10.4084\/MJHID.2024.002","volume":"16","author":"D Avenoso","year":"2024","unstructured":"Avenoso D, Serpenti F, Slonim LB et al (2024) Haploidentical transplant with post-transplant cyclophosphamide for Acute myeloid leukaemia and myelodysplastic syndromes patients: the role of previous lines of Therapy. Mediterr J Hematol Infect Dis 16:e2024002. https:\/\/doi.org\/10.4084\/MJHID.2024.002","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"5980_CR6","doi-asserted-by":"publisher","first-page":"e02206","DOI":"10.1128\/aac.02206-21","volume":"66","author":"JF Camargo","year":"2022","unstructured":"Camargo JF, Jabr R, Anderson AD et al (2022) Successful treatment of disseminated Disease due to highly resistant aspergillus calidoustus with a Novel Antifungal Therapy. Antimicrob Agents Chemother 66:e02206\u2013e02221. https:\/\/doi.org\/10.1128\/aac.02206-21","journal-title":"Antimicrob Agents Chemother"},{"key":"5980_CR7","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s11046-019-00423-x","volume":"185","author":"MA Mendoza","year":"2020","unstructured":"Mendoza MA, Anderson A, Morris MI et al (2020) Successful treatment of invasive fungal infection due to highly resistant aspergillus calidoustus in an allogeneic hematopoietic cell transplant recipient. Mycopathologia 185:399\u2013403. https:\/\/doi.org\/10.1007\/s11046-019-00423-x","journal-title":"Mycopathologia"},{"key":"5980_CR8","doi-asserted-by":"publisher","unstructured":"Seroy J, Antiporta P, Grim SA et al (2017) Aspergillus Calidoustus case series and review of the literature. Transpl Infect Dis 19. https:\/\/doi.org\/10.1111\/tid.12755","DOI":"10.1111\/tid.12755"},{"key":"5980_CR9","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1080\/13693780600967089","volume":"44","author":"PE Santos","year":"2006","unstructured":"Santos PE, Piontelli E, Shea YR et al (2006) Penicillium piceum infection: diagnosis and successful treatment in chronic granulomatous disease. Med Mycol 44:749\u2013753. https:\/\/doi.org\/10.1080\/13693780600967089","journal-title":"Med Mycol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-05980-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-024-05980-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-05980-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T09:29:20Z","timestamp":1730712560000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-024-05980-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["5980"],"URL":"https:\/\/doi.org\/10.1007\/s00277-024-05980-w","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]},"assertion":[{"value":"16 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Patient provided written consent collect data for publication. The manuscript was approved by the internal board of the institution.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"No conflict of interest to be reported.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial disclosure"}}]}}