{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:02:24Z","timestamp":1740106944693,"version":"3.37.3"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005296","name":"Universit\u00e4tsklinikum Regensburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005296","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allogeneic hematopoietic stem cell transplantation (alloSCT) is the cornerstone treatment for various hematopoietic disorders, but its utility is often compromised by chronic graft-versus-host disease (cGvHD), affecting skin integrity and leading to ulcer formations. Traditional treatments, including systemic and topical therapies, frequently fail in severe cases. This study retrospectively examines three patients with therapy-resistant ulcers due to cGvHD post-alloSCT treated at the University Hospital of Regensburg in 2023. We evaluated the therapeutic impact of human amniotic membrane (hAM) transplantation\u2014a novel approach utilizing hAM\u2019s anti-inflammatory, anti-microbial, and anti-fibrotic properties for wound healing. Surgical debridement was followed by hAM application and routine follow-up. HAM transplantation led to complete wound closure in two out of three patients and a significant reduction in local pain and infection rates. The treatment alleviated the need for regular dressing changes within three months in two patients, demonstrating the hAM\u2019s efficacy in fostering rapid and sustained healing. The utilization of hAM represents a promising alternative for the management of refractory skin ulcers in cGvHD patients, particularly when conventional methods are inadequate.<\/jats:p>","DOI":"10.1007\/s00277-024-05990-8","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T03:31:21Z","timestamp":1725593481000},"page":"4783-4787","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Allogeneic amnion transplantation for the management of cutaneous graft-versus-host disease with associated ulcers: A promising therapeutic strategy"],"prefix":"10.1007","volume":"103","author":[{"given":"Andreas","family":"Siegmund","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pagani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ruewe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvan","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Herr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Prantl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Geis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"issue":"17","key":"5990_CR1","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1056\/NEJMra052638","volume":"354","author":"EA Copelan","year":"2006","unstructured":"Copelan EA (2006) Hematopoietic stem-cell transplantation. N Engl J Med 354(17):1813\u20131826. https:\/\/doi.org\/10.1056\/NEJMra052638","journal-title":"N Engl J Med"},{"issue":"15","key":"5990_CR2","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1200\/JCO.2010.30.4121","volume":"29","author":"A Gratwohl","year":"2011","unstructured":"Gratwohl A, Brand R, Niederwieser D et al (2011) Introduction of a Quality Management System and Outcome after hematopoietic stem-cell transplantation. J Clin Oncol 29(15):1980\u20131986. https:\/\/doi.org\/10.1200\/JCO.2010.30.4121","journal-title":"J Clin Oncol"},{"issue":"4","key":"5990_CR3","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1053\/bbmt.2003.50026","volume":"9","author":"SJ Lee","year":"2003","unstructured":"Lee SJ, Vogelsang G, Flowers MED (2003) Chronic graft-versus-host disease. Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl 9(4):215\u2013233. https:\/\/doi.org\/10.1053\/bbmt.2003.50026","journal-title":"Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl"},{"issue":"3","key":"5990_CR4","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","volume":"21","author":"MH Jagasia","year":"2015","unstructured":"Jagasia MH, Greinix HT, Arora M et al (2015) National Institutes of Health Consensus Development Project on Criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 diagnosis and staging Working Group Report. Biol Blood Marrow Transpl 21(3):389\u2013401e1. https:\/\/doi.org\/10.1016\/j.bbmt.2014.12.001","journal-title":"Biol Blood Marrow Transpl"},{"issue":"9674","key":"5990_CR5","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/S0140-6736(09)60237-3","volume":"373","author":"JL Ferrara","year":"2009","unstructured":"Ferrara JL, Levine JE, Reddy P, Holler E (2009) Graft-versus-host disease. Lancet 373(9674):1550\u20131561. https:\/\/doi.org\/10.1016\/S0140-6736(09)60237-3","journal-title":"Lancet"},{"issue":"8","key":"5990_CR6","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1007\/s00277-019-03687-x","volume":"98","author":"P Lamby","year":"2019","unstructured":"Lamby P, Wolff D, Mielke S et al (2019) Allogeneic donor split skin grafts for treatment of refractory ulcers in cutaneous chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation\u2014a retrospective analysis on seven patients. Ann Hematol 98(8):1867\u20131875. https:\/\/doi.org\/10.1007\/s00277-019-03687-x","journal-title":"Ann Hematol"},{"issue":"2","key":"5990_CR7","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s10561-017-9618-5","volume":"18","author":"K Jirsova","year":"2017","unstructured":"Jirsova K, Jones GLA (2017) Amniotic membrane in ophthalmology: properties, preparation, storage and indications for grafting\u2014a review. Cell Tissue Bank 18(2):193\u2013204. https:\/\/doi.org\/10.1007\/s10561-017-9618-5","journal-title":"Cell Tissue Bank"},{"issue":"1","key":"5990_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/bmb\/ldv053","volume":"117","author":"D Ilic","year":"2016","unstructured":"Ilic D, Vicovac L, Nikolic M, Lazic Ilic E (2016) Human amniotic membrane grafts in therapy of chronic non-healing wounds: table 1. Br Med Bull 117(1):59\u201367. https:\/\/doi.org\/10.1093\/bmb\/ldv053","journal-title":"Br Med Bull"},{"issue":"2","key":"5990_CR9","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.bbmt.2016.09.023","volume":"23","author":"KR Cooke","year":"2017","unstructured":"Cooke KR, Luznik L, Sarantopoulos S et al (2017) The Biology of Chronic Graft-versus-host disease: a Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for clinical trials in chronic graft-versus-host disease. 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Published online 2007."}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-05990-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-024-05990-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-05990-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T09:29:20Z","timestamp":1730712560000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-024-05990-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["5990"],"URL":"https:\/\/doi.org\/10.1007\/s00277-024-05990-8","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"type":"print","value":"0939-5555"},{"type":"electronic","value":"1432-0584"}],"subject":[],"published":{"date-parts":[[2024,9,6]]},"assertion":[{"value":"28 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have reviewed the final version of the manuscript and consent to its publication in Annals of hematology.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Informed consent was obtained from all subjects involved in the study. Additionally, all participants gave their written consent for the use of their images for wound documentation in the publication","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}