{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:28:03Z","timestamp":1788449283858,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-024-06041-y","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T06:02:02Z","timestamp":1729058522000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of chromosomal aberrations detected by chromosome banding analysis in symptomatic Waldenstr\u00f6m\u2019s macroglobulinemia"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5882-7631","authenticated-orcid":false,"given":"Kenichi","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9860-8257","authenticated-orcid":false,"given":"Naohiro","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"issue":"7","key":"6041_CR1","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","volume":"36","author":"R Alaggio","year":"2022","unstructured":"Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E et al (2022) The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours. Lymphoid Neoplasms Leuk 36(7):1720\u20131748. https:\/\/doi.org\/10.1038\/s41375-022-01620-2","journal-title":"Lymphoid Neoplasms Leuk"},{"issue":"9","key":"6041_CR2","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1056\/NEJMoa1200710","volume":"367","author":"SP Treon","year":"2012","unstructured":"Treon SP, Xu L, Yang G, Zhou Y, Liu X, Cao Y et al (2012) MYD88 L265P somatic mutation in Waldenstr\u00f6m\u2019s macroglobulinemia. N Engl J Med 367(9):826\u2013833. https:\/\/doi.org\/10.1056\/NEJMoa1200710","journal-title":"N Engl J Med"},{"issue":"6","key":"6041_CR3","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1158\/1078-0432.Ccr-15-0646","volume":"22","author":"S Poulain","year":"2016","unstructured":"Poulain S, Roumier C, Venet-Caillault A, Figeac M, Herbaux C, Marot G et al (2016) Genomic Landscape of CXCR4 mutations in Waldenstr\u00f6m Macroglobulinemia. Clin Cancer Res 22(6):1480\u20131488. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-15-0646","journal-title":"Clin Cancer Res"},{"issue":"11","key":"6041_CR4","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1182\/blood-2013-09-525808","volume":"123","author":"ZR Hunter","year":"2014","unstructured":"Hunter ZR, Xu L, Yang G, Zhou Y, Liu X, Cao Y et al (2014) The genomic landscape of Waldenstrom macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis. Blood 123(11):1637\u20131646. https:\/\/doi.org\/10.1182\/blood-2013-09-525808","journal-title":"Blood"},{"issue":"11","key":"6041_CR5","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1182\/blood-2012-09-454355","volume":"121","author":"L Xu","year":"2013","unstructured":"Xu L, Hunter ZR, Yang G, Zhou Y, Cao Y, Liu X et al (2013) MYD88 L265P in Waldenstr\u00f6m macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction. Blood 121(11):2051\u20132058. https:\/\/doi.org\/10.1182\/blood-2012-09-454355","journal-title":"Blood"},{"issue":"22","key":"6041_CR6","doi-asserted-by":"publisher","first-page":"8604","DOI":"10.1021\/ac202028g","volume":"83","author":"BJ Hindson","year":"2011","unstructured":"Hindson BJ, Ness KD, Masquelier DA, Belgrader P, Heredia NJ, Makarewicz AJ et al (2011) High-throughput droplet digital PCR system for absolute quantitation of DNA copy number. Anal Chem 83(22):8604\u20138610. https:\/\/doi.org\/10.1021\/ac202028g","journal-title":"Anal Chem"},{"issue":"7","key":"6041_CR7","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.jmoldx.2023.03.010","volume":"25","author":"AN Markou","year":"2023","unstructured":"Markou AN, Bagratuni T, Tsakiri C, Tserpeli V, Skourti S, Koutsoukou M, N., et al (2023) Highly sensitive detection method of CXCR4 tumor hotspot mutations by Drop-Off Droplet Digital PCR in patients with IgM Monoclonal gammopathies. J Mol Diagn 25(7):502\u2013512. https:\/\/doi.org\/10.1016\/j.jmoldx.2023.03.010","journal-title":"J Mol Diagn"},{"issue":"2","key":"6041_CR8","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/bjh.18502","volume":"200","author":"DF Moreno","year":"2023","unstructured":"Moreno DF, L\u00f3pez-Guerra M, Paz S, Oliver-Cald\u00e9s A, Mena MP, Correa JG et al (2023) Prognostic impact of MYD88 and CXCR4 mutations assessed by droplet digital polymerase chain reaction in IgM monoclonal gammopathy of undetermined significance and smouldering Waldenstr\u00f6m macroglobulinaemia. Br J Haematol 200(2):187\u2013196. https:\/\/doi.org\/10.1111\/bjh.18502","journal-title":"Br J Haematol"},{"issue":"18","key":"6041_CR9","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1182\/blood-2014-01-550905","volume":"123","author":"SP Treon","year":"2014","unstructured":"Treon SP, Cao Y, Xu L, Yang G, Liu X, Hunter ZR (2014) Somatic mutations in MYD88 and CXCR4 are determinants of clinical presentation and overall survival in Waldenstrom macroglobulinemia. Blood 123(18):2791\u20132796. https:\/\/doi.org\/10.1182\/blood-2014-01-550905","journal-title":"Blood"},{"issue":"15","key":"6041_CR10","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1056\/NEJMoa1501548","volume":"372","author":"SP Treon","year":"2015","unstructured":"Treon SP, Tripsas CK, Meid K, Warren D, Varma G, Green R et al (2015) Ibrutinib in previously treated Waldenstr\u00f6m\u2019s macroglobulinemia. N Engl J Med 372(15):1430\u20131440. https:\/\/doi.org\/10.1056\/NEJMoa1501548","journal-title":"N Engl J Med"},{"issue":"27","key":"6041_CR11","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1200\/jco.2018.78.6426","volume":"36","author":"SP Treon","year":"2018","unstructured":"Treon SP, Gustine J, Meid K, Yang G, Xu L, Liu X et al (2018) Ibrutinib Monotherapy in Symptomatic, Treatment-Na\u00efve patients with Waldenstr\u00f6m Macroglobulinemia. J Clin Oncol 36(27):2755\u20132761. https:\/\/doi.org\/10.1200\/jco.2018.78.6426","journal-title":"J Clin Oncol"},{"issue":"3","key":"6041_CR12","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1111\/bjh.16088","volume":"187","author":"JJ Castillo","year":"2019","unstructured":"Castillo JJ, Xu L, Gustine JN, Keezer A, Meid K, Dubeau TE et al (2019) CXCR4 mutation subtypes impact response and survival outcomes in patients with Waldenstr\u00f6m macroglobulinaemia treated with ibrutinib. Br J Haematol 187(3):356\u2013363. https:\/\/doi.org\/10.1111\/bjh.16088","journal-title":"Br J Haematol"},{"issue":"4","key":"6041_CR13","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3324\/haematol.2012.070458","volume":"98","author":"F Nguyen-Khac","year":"2013","unstructured":"Nguyen-Khac F, Lambert J, Chapiro E, Grelier A, Mould S, Barin C et al (2013) Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenstr\u00f6m\u2019s macroglobulinemia. Haematologica 98(4):649\u2013654. https:\/\/doi.org\/10.3324\/haematol.2012.070458","journal-title":"Haematologica"},{"issue":"2","key":"6041_CR14","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.cancergencyto.2006.04.009","volume":"169","author":"RF Schop","year":"2006","unstructured":"Schop RF, Van Wier SA, Xu R, Ghobrial I, Ahmann GJ, Greipp PR et al (2006) 6q deletion discriminates Waldenstr\u00f6m macroglobulinemia from IgM monoclonal gammopathy of undetermined significance. Cancer Genet Cytogenet 169(2):150\u2013153. https:\/\/doi.org\/10.1016\/j.cancergencyto.2006.04.009","journal-title":"Cancer Genet Cytogenet"},{"issue":"1","key":"6041_CR15","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3816\/CLM.2009.n.008","volume":"9","author":"H Chang","year":"2009","unstructured":"Chang H, Qi C, Trieu Y, Jiang A, Young KH, Chesney A et al (2009) Prognostic relevance of 6q deletion in Waldenstr\u00f6m\u2019s macroglobulinemia: a multicenter study. Clin Lymphoma Myeloma 9(1):36\u201338. https:\/\/doi.org\/10.3816\/CLM.2009.n.008","journal-title":"Clin Lymphoma Myeloma"},{"issue":"5","key":"6041_CR16","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/bjh.17028","volume":"192","author":"R Garcia-Sanz","year":"2021","unstructured":"Garcia-Sanz R, Dogliotti I, Zaccaria GM, Ocio EM, Rubio A, Murillo I et al (2021) 6q deletion in Waldenstr\u00f6m macroglobulinaemia negatively affects time to transformation and survival. Br J Haematol 192(5):843\u2013852. https:\/\/doi.org\/10.1111\/bjh.17028","journal-title":"Br J Haematol"},{"key":"6041_CR17","doi-asserted-by":"publisher","unstructured":"Sekiguchi N, Nomoto J, Nagata A, Kiyota M, Fukuda I, Yamada K, Takezako N, Kobayashi Y (2018) Gene Expression Profile Signature of Aggressive Waldenstr\u00f6m Macroglobulinemia with Chromosome 6q Deletion. Biomed Res Int, 2018, 6728128. https:\/\/doi.org\/10.1155\/2018\/6728128","DOI":"10.1155\/2018\/6728128"},{"issue":"20","key":"6041_CR18","doi-asserted-by":"publisher","first-page":"6325","DOI":"10.1158\/1078-0432.Ccr-17-0007","volume":"23","author":"S Poulain","year":"2017","unstructured":"Poulain S, Roumier C, Bertrand E, Renneville A, Caillault-Venet A, Doye E et al (2017) TP53 mutation and its prognostic significance in Waldenstrom\u2019s Macroglobulinemia. Clin Cancer Res 23(20):6325\u20136335. https:\/\/doi.org\/10.1158\/1078-0432.Ccr-17-0007","journal-title":"Clin Cancer Res"},{"issue":"2","key":"6041_CR19","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/s41375-022-01762-3","volume":"37","author":"I Dogliotti","year":"2023","unstructured":"Dogliotti I, Jim\u00e9nez C, Varettoni M, Talaulikar D, Bagratuni T, Ferrante M et al (2023) Diagnostics in Waldenstr\u00f6m\u2019s macroglobulinemia: a consensus statement of the European Consortium for Waldenstr\u00f6m\u2019s Macroglobulinemia. Leukemia 37(2):388\u2013395. https:\/\/doi.org\/10.1038\/s41375-022-01762-3","journal-title":"Leukemia"},{"issue":"2","key":"6041_CR20","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1053\/j.seminhematol.2023.03.007","volume":"60","author":"R Garcia-Sanz","year":"2023","unstructured":"Garcia-Sanz R, Varettoni M, Jim\u00e9nez C, Ferrero S, Poulain S, San-Miguel JF et al (2023) Report of Consensus Panel 3 from the 11th International workshop on Waldenstr\u00f6m\u2019s Macroglobulinemia: recommendations for molecular diagnosis in Waldenstr\u00f6m\u2019s Macroglobulinemia. Semin Hematol 60(2):90\u201396. https:\/\/doi.org\/10.1053\/j.seminhematol.2023.03.007","journal-title":"Semin Hematol"},{"issue":"12","key":"6041_CR21","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1002\/ajh.26339","volume":"96","author":"D Krzisch","year":"2021","unstructured":"Krzisch D, Guedes N, Boccon-Gibod C, Baron M, Bravetti C, Davi F et al (2021) Cytogenetic and molecular abnormalities in Waldenstr\u00f6m\u2019s macroglobulinemia patients: correlations and prognostic impact. Am J Hematol 96(12):1569\u20131579. https:\/\/doi.org\/10.1002\/ajh.26339","journal-title":"Am J Hematol"},{"key":"6041_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-024-05770-4","author":"N Danesin","year":"2024","unstructured":"Danesin N, Bonaldi L, Martines A, Nalio S, Bertorelle R, Compagno S et al (2024) Impact of the presence and number of chromosomal abnormalities on the clinical outcome in Waldenstr\u00f6m Macroglobulinemia: a monocentric experience. Ann Hematol. https:\/\/doi.org\/10.1007\/s00277-024-05770-4","journal-title":"Ann Hematol"},{"issue":"6","key":"6041_CR23","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","volume":"5","author":"MM Oken","year":"1982","unstructured":"Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, Carbone PP (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5(6):649\u2013655","journal-title":"Am J Clin Oncol"},{"issue":"18","key":"6041_CR24","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.1182\/blood-2008-08-174961","volume":"113","author":"P Morel","year":"2009","unstructured":"Morel P, Duhamel A, Gobbi P, Dimopoulos MA, Dhodapkar MV, McCoy J et al (2009) International prognostic scoring system for Waldenstrom macroglobulinemia. Blood 113(18):4163\u20134170. https:\/\/doi.org\/10.1182\/blood-2008-08-174961","journal-title":"Blood"},{"issue":"11","key":"6041_CR25","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1038\/s41375-019-0431-y","volume":"33","author":"E Kastritis","year":"2019","unstructured":"Kastritis E, Morel P, Duhamel A, Gavriatopoulou M, Kyrtsonis MC, Durot E et al (2019) A revised international prognostic score system for Waldenstr\u00f6m\u2019s macroglobulinemia. Leukemia 33(11):2654\u20132661. https:\/\/doi.org\/10.1038\/s41375-019-0431-y","journal-title":"Leukemia"},{"issue":"2","key":"6041_CR26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cancergen.2010.12.006","volume":"204","author":"N Muthusamy","year":"2011","unstructured":"Muthusamy N, Breidenbach H, Andritsos L et al (2011) Enhanced Detection of Chromosomal Abnormalities in chronic lymphocytic leukemia by Conventional cytogenetics using CpG oligonucleotide in combination with Pokeweed Mitogen and phorbol myristate acetate. Cancer Genet 204(2):77\u201383","journal-title":"Cancer Genet"},{"issue":"5","key":"6041_CR27","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1002\/gcc.22527","volume":"57","author":"KA Dun","year":"2018","unstructured":"Dun KA, Riley LA, Diano G et al (2018) DSP30 and interleukin-2 as a mitotic stimulant in B-cell disorders including those with a low disease burden. Genes Chromosomes Cancer 57(5):260\u2013267","journal-title":"Genes Chromosomes Cancer"},{"key":"6041_CR28","unstructured":"McGowan-Jordan J, Hastings RJ, Moore S, International Standing Committee on Human Cytogenomic Nomenclature (2020) ISCN 2020: an Internatonal System. for Human Cytogenomic Nomenclature. Karger"},{"issue":"9","key":"6041_CR29","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1182\/blood-2014-03-565135","volume":"124","author":"MA Dimopoulos","year":"2014","unstructured":"Dimopoulos MA, Kastritis E, Owen RG, Kyle RA, Landgren O, Morra E et al (2014) Treatment recommendations for patients with Waldenstr\u00f6m macroglobulinemia (WM) and related disorders: IWWM-7 consensus. Blood 124(9):1404\u20131411. https:\/\/doi.org\/10.1182\/blood-2014-03-565135","journal-title":"Blood"},{"issue":"5","key":"6041_CR30","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1007\/s12185-019-02730-x","volume":"110","author":"Y Kobayashi","year":"2019","unstructured":"Kobayashi Y (2019) JSH practical guidelines for hematological malignancies, 2018: II. Lymphoma-3. Lymphoplasmacytic lymphoma\/Waldenstr\u00f6m\u2019s macroglobulinemia (LPL\/WM). Int J Hematol 110(5):524\u2013528. https:\/\/doi.org\/10.1007\/s12185-019-02730-x","journal-title":"Int J Hematol"},{"key":"6041_CR31","doi-asserted-by":"publisher","unstructured":"Castillo JJ, Advani RH, Branagan AR, Buske C, Dimopoulos MA, D\u2019Sa S et al (2020) Consensus treatment recommendations from the tenth International Workshop for Waldenstr\u00f6m Macroglobulinaemia. Lancet Haematol, 7(11), e827-e837. https:\/\/doi.org\/10.1016\/s2352-3026(20)30224-6","DOI":"10.1016\/s2352-3026(20)30224-6"},{"key":"6041_CR32","doi-asserted-by":"publisher","unstructured":"Owen RG, Kyle RA, Stone MJ, Rawstron AC, Leblond V, Merlini G et al (2013) Response assessment in Waldenstr\u00f6m macroglobulinaemia: update from the VIth International Workshop. Br J Haematol, 160(2), 171\u2013176. https:\/\/doi.org\/10.1111\/bjh.12102","DOI":"10.1111\/bjh.12102"},{"issue":"7","key":"6041_CR33","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1182\/blood-2012-12-475111","volume":"122","author":"G Yang","year":"2013","unstructured":"Yang G, Zhou Y, Liu X, Xu L, Cao Y, Manning RJ et al (2013) A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenstr\u00f6m macroglobulinemia. Blood 122(7):1222\u20131232. https:\/\/doi.org\/10.1182\/blood-2012-12-475111","journal-title":"Blood"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-06041-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-024-06041-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-06041-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T17:02:09Z","timestamp":1729098129000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-024-06041-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,16]]},"references-count":33,"alternative-id":["6041"],"URL":"https:\/\/doi.org\/10.1007\/s00277-024-06041-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4736953\/v1","asserted-by":"object"}]},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,16]]},"assertion":[{"value":"14 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. This study was approved by the institutional review board at our hospital (Disaster Medical Center IRB-2022-33).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from the patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Patients signed informed consent regarding publishing their data and photographs.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Naohiro Sekiguchi receives honoraria from Janssen, Ono, and research funding from Incyte Biosciences Japan, Janssen, Mitsubishi Tanabe Pharma Corporation, MSD, Ono.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}