{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:35:54Z","timestamp":1780403754296,"version":"3.54.1"},"reference-count":4,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Acute leukemia with <jats:italic>TCF3::ZNF384<\/jats:italic> is a distinct type of acute leukemia that present most commonly as B-acute lymphoblastic leukemia or mixed-phenotype acute leukemia (B\/myeloid). We report the first case of <jats:italic>TCF3::ZNF384<\/jats:italic> mixed-phenotype leukemia presenting as isolated extramedullary disease in the mediastinum. Diagnosis using RNA-sequencing and whole genome sequencing on the primary issue is illustrated. <\/jats:p>","DOI":"10.1007\/s00277-024-06042-x","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T07:28:38Z","timestamp":1731396518000},"page":"2023-2025","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mixed-phenotype leukemia with TCF3::ZNF384 fusion presenting as an isolated mediastinal mass"],"prefix":"10.1007","volume":"104","author":[{"given":"Wing-Yan","family":"Au","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chit","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka-Fai","family":"To","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond S.K.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene C.L.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai-Lun","family":"Yip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.H.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harinder","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"6042_CR1","doi-asserted-by":"publisher","first-page":"709036","DOI":"10.3389\/fonc.2021.709036","volume":"11","author":"N Lin","year":"2021","unstructured":"Lin N, Yan X, Cai D, Wang L (2021) Leukemia with TCF3-ZNF384 rearrangement as a distinct subtype of disease with distinct treatments: perspectives from a case report and literature review. Front Oncol 11:709036","journal-title":"Front Oncol"},{"issue":"4","key":"6042_CR2","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/ijlh.14072","volume":"45","author":"E Zerkalenkova","year":"2023","unstructured":"Zerkalenkova E, Menchits Y, Borkovskaia A, Sokolova S, Soldatkina O, Mikhailova E, Popov A, Komkov A, Rumiantseva Y, Karachunskii A (2023) TCF3 gene rearrangements in pediatric B-cell acute lymphoblastic leukemia\u2014A single center experience. Int J Lab Hematol 45(4):533\u2013540","journal-title":"Int J Lab Hematol"},{"issue":"1","key":"6042_CR3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3324\/haematol.2016.151035","volume":"102","author":"S Hirabayashi","year":"2017","unstructured":"Hirabayashi S, Ohki K, Nakabayashi K, Ichikawa H, Momozawa Y, Okamura K, Yaguchi A, Terada K, Saito Y, Yoshimi A (2017) ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype. Haematologica 102(1):118","journal-title":"Haematologica"},{"issue":"9","key":"6042_CR4","doi-asserted-by":"publisher","first-page":"e27265","DOI":"10.1002\/pbc.27265","volume":"65","author":"MJ Oberley","year":"2018","unstructured":"Oberley MJ, Gaynon PS, Bhojwani D, Pulsipher MA, Gardner RA, Hiemenz MC, Ji J, Han J, O\u2019Gorman MR, Wayne AS (2018) Myeloid lineage switch following chimeric antigen receptor T-cell therapy in a patient with TCF3\u2010ZNF384 fusion\u2010positive B\u2010lymphoblastic leukemia. Pediatr Blood Cancer 65(9):e27265","journal-title":"Pediatr Blood Cancer"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-06042-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-024-06042-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-06042-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:10:04Z","timestamp":1745575804000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-024-06042-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":4,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["6042"],"URL":"https:\/\/doi.org\/10.1007\/s00277-024-06042-x","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"12 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}