{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:57:39Z","timestamp":1762869459705,"version":"3.32.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:00:00Z","timestamp":1729987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:00:00Z","timestamp":1729987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82102285"],"award-info":[{"award-number":["82102285"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2022JJ40203","2023JJ40351"],"award-info":[{"award-number":["2022JJ40203","2023JJ40351"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research Project of Hunan Provincial Health Commission","award":["202217012704","B202217018341"],"award-info":[{"award-number":["202217012704","B202217018341"]}]},{"name":"Hunan Provincial Science and Technology Department Project","award":["2021SK50524"],"award-info":[{"award-number":["2021SK50524"]}]},{"name":"Hunan Provincial Health High-Level Talent Scientific Research Project","award":["R2023156"],"award-info":[{"award-number":["R2023156"]}]},{"name":"Hunan Provincial Key Laboratory of Emergency Medicine for Children","award":["2018TP1028"],"award-info":[{"award-number":["2018TP1028"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s00277-024-06073-4","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T08:41:13Z","timestamp":1730104873000},"page":"5145-5155","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pre-diagnostic trajectory of pediatric hemophagocytic lymphohistiocytosis: observations from hematological and hepatic parameters"],"prefix":"10.1007","volume":"103","author":[{"given":"Xun","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haipeng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zili","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longlong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaotian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiulan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghui","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,27]]},"reference":[{"issue":"5","key":"6073_CR1","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1097\/ccm.0000000000005361","volume":"50","author":"MR Hines","year":"2021","unstructured":"Hines MR, von Bahr Greenwood T, Beutel G, Beutel K, Hays JA, Horne A et al (2021) Consensus-based guidelines for the Recognition, diagnosis, and management of Hemophagocytic Lymphohistiocytosis in critically ill children and adults. Crit Care Med 50(5):860\u2013872. https:\/\/doi.org\/10.1097\/ccm.0000000000005361","journal-title":"Crit Care Med"},{"issue":"15","key":"6073_CR2","doi-asserted-by":"publisher","first-page":"4041","DOI":"10.1182\/blood-2011-03-278127","volume":"118","author":"MB Jordan","year":"2011","unstructured":"Jordan MB, Allen CE, Weitzman S, Filipovich AH, McClain KL (2011) How I treat hemophagocytic lymphohistiocytosis. Blood 118(15):4041\u20134052. https:\/\/doi.org\/10.1182\/blood-2011-03-278127","journal-title":"Blood"},{"issue":"1","key":"6073_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08880018.2019.1572253","volume":"36","author":"MM Oguz","year":"2019","unstructured":"Oguz MM, Sahin G, Altinel Acoglu E, Polat E, Yucel H, Oztek Celebi FZ et al (2019) Secondary hemophagocytic lymphohistiocytosis in pediatric patients: a single center experience and factors that influenced patient prognosis. Pediatr Hematol Oncol 36(1):1\u201316. https:\/\/doi.org\/10.1080\/08880018.2019.1572253","journal-title":"Pediatr Hematol Oncol"},{"issue":"3","key":"6073_CR4","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1651-2227.2011.02501.x","volume":"101","author":"H Trottestam","year":"2012","unstructured":"Trottestam H, Berglof E, Horne A, Onelov E, Beutel K, Lehmberg K et al (2012) Risk factors for early death in children with haemophagocytic lymphohistiocytosis. Acta Paediatr 101(3):313\u2013318. https:\/\/doi.org\/10.1111\/j.1651-2227.2011.02501.x","journal-title":"Acta Paediatr"},{"issue":"3","key":"6073_CR5","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/ajh.23911","volume":"90","author":"ZK Otrock","year":"2015","unstructured":"Otrock ZK, Eby CS (2015) Clinical characteristics, prognostic factors, and outcomes of adult patients with hemophagocytic lymphohistiocytosis. Am J Hematol 90(3):220\u2013224. https:\/\/doi.org\/10.1002\/ajh.23911","journal-title":"Am J Hematol"},{"issue":"9","key":"6073_CR6","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1007\/s00277-016-2727-6","volume":"95","author":"Q Bin","year":"2016","unstructured":"Bin Q, Gao JH, Luo JM (2016) Prognostic factors of early outcome in pediatric hemophagocytic lymphohistiocytosis: an analysis of 116 cases. Ann Hematol 95(9):1411\u20131418. https:\/\/doi.org\/10.1007\/s00277-016-2727-6","journal-title":"Ann Hematol"},{"issue":"1","key":"6073_CR7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s13023-020-01515-4","volume":"15","author":"X Li","year":"2020","unstructured":"Li X, Yan H, Zhang X, Huang J, Xiang S-T, Yao Z et al (2020) Clinical profiles and risk factors of 7-day and 30-day mortality among 160 pediatric patients with hemophagocytic lymphohistiocytosis. Orphanet J Rare Dis 15(1):229. https:\/\/doi.org\/10.1186\/s13023-020-01515-4","journal-title":"Orphanet J Rare Dis"},{"issue":"2","key":"6073_CR8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/pbc.21039","volume":"48","author":"JI Henter","year":"2007","unstructured":"Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S et al (2007) HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 48(2):124\u2013131. https:\/\/doi.org\/10.1002\/pbc.21039","journal-title":"Pediatr Blood Cancer"},{"key":"6073_CR9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.2147\/JBM.S46255","volume":"5","author":"MR George","year":"2014","unstructured":"George MR (2014) Hemophagocytic lymphohistiocytosis: review of etiologies and management. J Blood Med 5:69\u201386. https:\/\/doi.org\/10.2147\/JBM.S46255","journal-title":"J Blood Med"},{"issue":"9","key":"6073_CR10","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1002\/art.38690","volume":"66","author":"L Fardet","year":"2014","unstructured":"Fardet L, Galicier L, Lambotte O, Marzac C, Aumont C, Chahwan D et al (2014) Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol 66(9):2613\u20132620. https:\/\/doi.org\/10.1002\/art.38690","journal-title":"Arthritis Rheumatol"},{"key":"6073_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-023-01458-y","author":"X Li","year":"2023","unstructured":"Li X, Yan H, Xiao Z, Luo T, Xie L, Yang Y et al (2023) A three-step Screening Procedure for early identification of children at high risk of Hemophagocytic Lymphohistiocytosis. J Clin Immunol. https:\/\/doi.org\/10.1007\/s10875-023-01458-y","journal-title":"J Clin Immunol"},{"key":"6073_CR12","doi-asserted-by":"publisher","first-page":"5719751","DOI":"10.1155\/2020\/5719751","volume":"2020","author":"G Yin","year":"2020","unstructured":"Yin G, Man C, Liao S, Qiu H (2020) The Prognosis Role of AST\/ALT (De Ritis) ratio in patients with adult secondary Hemophagocytic Lymphohistiocytosis. Mediat Inflamm 2020:5719751. https:\/\/doi.org\/10.1155\/2020\/5719751","journal-title":"Mediat Inflamm"},{"issue":"2","key":"6073_CR13","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1080\/10428194.2021.1992623","volume":"63","author":"G Yin","year":"2022","unstructured":"Yin G, Man C, Cheng W, Gao X, Wang J, Tian T et al (2022) The prevalence and prognosis of hyponatraemia in non-hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis. Leuk Lymphoma 63(2):362\u2013369. https:\/\/doi.org\/10.1080\/10428194.2021.1992623","journal-title":"Leuk Lymphoma"},{"issue":"5","key":"6073_CR14","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1002\/(SICI)1096-911X(199705)28:5<342::AID-MPO3>3.0.CO;2-H","volume":"28","author":"JI Henter","year":"1997","unstructured":"Henter JI, Arico M, Egeler RM, Elinder G, Favara BE, Filipovich AH et al (1997) HLH-94: a treatment protocol for hemophagocytic lymphohistiocytosis. HLH study Group of the Histiocyte Society. Med Pediatr Oncol 28(5):342\u2013347","journal-title":"Med Pediatr Oncol"},{"issue":"2","key":"6073_CR15","doi-asserted-by":"publisher","first-page":"458","DOI":"10.3324\/haematol.2023.283478","volume":"109","author":"J Ge","year":"2024","unstructured":"Ge J, Zhang Q, Ma H, Wang D, Zhao Y, Zhu T et al (2024) Ruxolitinib-based regimen in children with primary hemophagocytic lymphohistiocytosis. Haematologica 109(2):458\u2013465. https:\/\/doi.org\/10.3324\/haematol.2023.283478","journal-title":"Haematologica"},{"issue":"3","key":"6073_CR16","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.hemonc.2017.07.002","volume":"12","author":"JH Sin","year":"2019","unstructured":"Sin JH, Zangardi ML (2019) Ruxolitinib for secondary hemophagocytic lymphohistiocytosis: first case report. Hematol Oncol Stem Cell Ther 12(3):166\u2013170. https:\/\/doi.org\/10.1016\/j.hemonc.2017.07.002","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"6073_CR17","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012217","author":"S Chandrakasan","year":"2024","unstructured":"Chandrakasan S, Jordan MB, Baker A, Behrens EM, Bhatla D, Chien M et al (2024) Real-world treatment patterns and outcomes in patients with primary hemophagocytic lymphohistiocytosis treated with emapalumab. Blood Adv. https:\/\/doi.org\/10.1182\/bloodadvances.2023012217","journal-title":"Blood Adv"},{"key":"6073_CR18","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.3389\/fimmu.2017.01102","volume":"8","author":"E Brisse","year":"2017","unstructured":"Brisse E, Wouters CH, Andrei G, Matthys P (2017) How viruses Contribute to the pathogenesis of Hemophagocytic Lymphohistiocytosis. Front Immunol 8:1102. https:\/\/doi.org\/10.3389\/fimmu.2017.01102","journal-title":"Front Immunol"},{"key":"6073_CR19","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1182\/asheducation-2015.1.177","volume":"2015","author":"CE Allen","year":"2015","unstructured":"Allen CE, McClain KL (2015) Pathophysiology and epidemiology of hemophagocytic lymphohistiocytosis. Hematol Am Soc Hematol Educ Program 2015:177\u2013182. https:\/\/doi.org\/10.1182\/asheducation-2015.1.177","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"6073_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-023-01573-w","author":"X Li","year":"2023","unstructured":"Li X, Luo T, Yan H, Xie L, Yang Y, Gong L et al (2023) Proteomic Analysis of Pediatric Hemophagocytic Lymphohistiocytosis: a comparative study with Healthy Controls, Sepsis, critical Ill, and active Epstein-Barr virus infection to identify altered pathways and candidate biomarkers. J Clin Immunol. https:\/\/doi.org\/10.1007\/s10875-023-01573-w","journal-title":"J Clin Immunol"},{"issue":"3","key":"6073_CR21","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1007\/s10875-020-00950-z","volume":"41","author":"F Debaugnies","year":"2021","unstructured":"Debaugnies F, Mahadeb B, Nagant C, Meuleman N, De Bels D, Wolff F et al (2021) Biomarkers for early diagnosis of Hemophagocytic Lymphohistiocytosis in critically ill patients. J Clin Immunol 41(3):658\u2013665. https:\/\/doi.org\/10.1007\/s10875-020-00950-z","journal-title":"J Clin Immunol"},{"issue":"10","key":"6073_CR22","doi-asserted-by":"publisher","first-page":"e27909","DOI":"10.1002\/pbc.27909","volume":"66","author":"Y Cui","year":"2019","unstructured":"Cui Y, Xiong X, Ren Y, Wang F, Wang C, Zhang Y (2019) CD163 as a valuable diagnostic and prognostic biomarker of sepsis-associated hemophagocytic lymphohistiocytosis in critically ill children. Pediatr Blood Cancer 66(10):e27909. https:\/\/doi.org\/10.1002\/pbc.27909","journal-title":"Pediatr Blood Cancer"},{"issue":"3","key":"6073_CR23","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.jaip.2018.11.050","volume":"7","author":"KA Risma","year":"2019","unstructured":"Risma KA, Marsh RA (2019) Hemophagocytic Lymphohistiocytosis: clinical presentations and diagnosis. J Allergy Clin Immunol Pract 7(3):824\u2013832. https:\/\/doi.org\/10.1016\/j.jaip.2018.11.050","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"6073_CR24","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1097\/SHK.0000000000001048","volume":"50","author":"G Lachmann","year":"2018","unstructured":"Lachmann G, Spies C, Schenk T, Brunkhorst FM, Balzer F, La Rosee P (2018) Hemophagocytic Lymphohistiocytosis: potentially underdiagnosed in Intensive Care Units. Shock 50(2):149\u2013155. https:\/\/doi.org\/10.1097\/SHK.0000000000001048","journal-title":"Shock"},{"issue":"6","key":"6073_CR25","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1007\/s10875-021-01005-7","volume":"41","author":"BM Smits","year":"2021","unstructured":"Smits BM, van Montfrans J, Merrill SA, van de Corput L, van Gijn M, de Vries A et al (2021) A minimal parameter set facilitating early decision-making in the diagnosis of Hemophagocytic Lymphohistiocytosis. J Clin Immunol 41(6):1219\u20131228. https:\/\/doi.org\/10.1007\/s10875-021-01005-7","journal-title":"J Clin Immunol"},{"issue":"6","key":"6073_CR26","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/j.jpeds.2012.11.081","volume":"162","author":"K Lehmberg","year":"2013","unstructured":"Lehmberg K, Pink I, Eulenburg C, Beutel K, Maul-Pavicic A, Janka G (2013) Differentiating macrophage activation syndrome in systemic juvenile idiopathic arthritis from other forms of hemophagocytic lymphohistiocytosis. J Pediatr 162(6):1245\u20131251. https:\/\/doi.org\/10.1016\/j.jpeds.2012.11.081","journal-title":"J Pediatr"},{"key":"6073_CR27","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1146\/annurev.clinpsy.121208.131413","volume":"6","author":"DS Nagin","year":"2010","unstructured":"Nagin DS, Odgers CL (2010) Group-based trajectory modeling in clinical research. Annu Rev Clin Psychol 6:109\u2013138. https:\/\/doi.org\/10.1146\/annurev.clinpsy.121208.131413","journal-title":"Annu Rev Clin Psychol"},{"issue":"1","key":"6073_CR28","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s13054-022-04071-4","volume":"26","author":"Z Xu","year":"2022","unstructured":"Xu Z, Mao C, Su C, Zhang H, Siempos I, Torres LK et al (2022) Sepsis subphenotyping based on organ dysfunction trajectory. Crit Care 26(1):197. https:\/\/doi.org\/10.1186\/s13054-022-04071-4","journal-title":"Crit Care"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-06073-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-024-06073-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-024-06073-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T01:12:00Z","timestamp":1735866720000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-024-06073-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,27]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["6073"],"URL":"https:\/\/doi.org\/10.1007\/s00277-024-06073-4","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"type":"print","value":"0939-5555"},{"type":"electronic","value":"1432-0584"}],"subject":[],"published":{"date-parts":[[2024,10,27]]},"assertion":[{"value":"22 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was reviewed and approved by the Medical Ethics Committee of the Hunan Children\u2019s Hospital (HCHLL-2023-97).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}