{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T09:52:56Z","timestamp":1793267576393,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Paraneoplastic glomerulonephritis (GN) has been reported in non-Hodgkin lymphoma (NHL), Hodgkin Lymphoma (HL), and chronic lymphocytic leukemia (CLL). Despite descriptions in NHL, very few reports have been documented in marginal zone lymphoma (MZL). In this article, we review the literature of currently known cases of MZL-associated GN and we detail two cases of patients with extra-nodal MZL (EMZL) who both presented with renal failure, fluid overload, and proteinuria which were attributed to GN after a renal biopsy. We discuss the pathology of each renal biopsy in depth and how the diagnosis of GN was made, along with potential mechanisms of how EMZL led to GN. We also discuss the treatments each patient received and whether this led to the resolution of their GN. Both cases highlight the importance of maintaining a high index of suspicion for this paraneoplastic syndrome when patients present with signs or symptoms of renal failure, proteinuria or hematuria, or potential renal involvement on imaging. In these cases, a renal biopsy should be pursued to confirm the diagnosis, and treatment should be tailored accordingly.<\/jats:p>","DOI":"10.1007\/s00277-025-06245-w","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:52:44Z","timestamp":1738943564000},"page":"1127-1138","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The rare phenomenon of glomerulonephritis presentation in extra-nodal marginal zone lymphoma: summary of two cases and review of the literature"],"prefix":"10.1007","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4691-7645","authenticated-orcid":false,"given":"Michele D.","family":"Stanchina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-3377","authenticated-orcid":false,"given":"Juan Pablo","family":"Alderuccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7287-0350","authenticated-orcid":false,"given":"Yiqin","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-5013","authenticated-orcid":false,"given":"Daniel","family":"Cassidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9346-9013","authenticated-orcid":false,"given":"Izidore S.","family":"Lossos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"6245_CR1","doi-asserted-by":"publisher","unstructured":"Cerhan JR, Habermann TM (2021) Epidemiology of marginal zone lymphoma. Ann Lymphoma 5. https:\/\/doi.org\/10.21037\/aol-20-28","DOI":"10.21037\/aol-20-28"},{"key":"6245_CR2","doi-asserted-by":"publisher","unstructured":"Di Rocco A, Petrucci L, Assanto GM, Martelli M, Pulsoni A (2022) Extranodal marginal zone lymphoma: pathogenesis, diagnosis and treatment. Cancers (Basel) 14(7). https:\/\/doi.org\/10.3390\/cancers14071742","DOI":"10.3390\/cancers14071742"},{"issue":"3","key":"6245_CR3","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1309\/0T2UKUKV91W3QR6W","volume":"128","author":"M Garcia","year":"2007","unstructured":"Garcia M, Konoplev S, Morosan C, Abruzzo LV, Bueso-Ramos CE, Medeiros LJ (2007) MALT lymphoma involving the kidney: a report of 10 cases and review of the literature. Am J Clin Pathol 128(3):464\u2013473. https:\/\/doi.org\/10.1309\/0T2UKUKV91W3QR6W","journal-title":"Am J Clin Pathol"},{"issue":"2","key":"6245_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3109\/08860220903552132","volume":"32","author":"KN Adamidis","year":"2010","unstructured":"Adamidis KN, Metaxatos G, Hadjiconstantinou V (2010) Splenic marginal lymphoma and glomerulonephritis: case report and review of the literature. Ren Fail 32(2):281\u2013285. https:\/\/doi.org\/10.3109\/08860220903552132","journal-title":"Ren Fail"},{"issue":"2","key":"6245_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nrneph.2010.171","volume":"7","author":"YH Lien","year":"2011","unstructured":"Lien YH, Lai LW (2011) Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis. Nat Rev Nephrol 7(2):85\u201395. https:\/\/doi.org\/10.1038\/nrneph.2010.171","journal-title":"Nat Rev Nephrol"},{"key":"6245_CR6","doi-asserted-by":"publisher","unstructured":"Samarasinghe A, Wong D, Cull G, Chakera A (2019) Marginal zone lymphoma causing accelerated progression of chronic kidney disease. BMJ Case Rep 12(11). https:\/\/doi.org\/10.1136\/bcr-2019-230270","DOI":"10.1136\/bcr-2019-230270"},{"issue":"6","key":"6245_CR7","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1093\/ajcp\/96.6.738","volume":"96","author":"RJ Pelstring","year":"1991","unstructured":"Pelstring RJ, Essell JH, Kurtin PJ, Cohen AR, Banks PM (1991) Diversity of organ site involvement among malignant lymphomas of mucosa-associated tissues. Am J Clin Pathol 96(6):738\u2013745. https:\/\/doi.org\/10.1093\/ajcp\/96.6.738","journal-title":"Am J Clin Pathol"},{"issue":"8","key":"6245_CR8","first-page":"780","volume":"117","author":"T Parveen","year":"1993","unstructured":"Parveen T, Navarro-Roman L, Medeiros LJ, Raffeld M, Jaffe ES (1993) Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue arising in the kidney. Arch Pathol Lab Med 117(8):780\u2013783","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"6245_CR9","doi-asserted-by":"publisher","first-page":"86","DOI":"10.5858\/2006-130-86-lmltli","volume":"130","author":"L Qiu","year":"2006","unstructured":"Qiu L, Unger PD, Dillon RW, Strauchen JA (2006) Low-grade mucosa-associated lymphoid tissue lymphoma involving the kidney: report of 3 cases and review of the literature. Arch Pathol Lab Med 130(1):86\u201389. https:\/\/doi.org\/10.5858\/2006-130-86-lmltli","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"6245_CR10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000050955","volume":"67","author":"B Jindal","year":"2001","unstructured":"Jindal B, Sharma SC, Das A, Banerjee AK (2001) Indolent behaviour of low-grade B cell lymphoma of mucosa-associated lymphoid tissue arising in the kidney. Urol Int 67(1):91\u201393. https:\/\/doi.org\/10.1159\/000050955","journal-title":"Urol Int"},{"issue":"5","key":"6245_CR11","doi-asserted-by":"publisher","first-page":"e15172","DOI":"10.7759\/cureus.15172","volume":"13","author":"A Gromicho","year":"2021","unstructured":"Gromicho A, Ara\u00fajo D, Oliveira V, Ribeiro A, Ferraz L (2021) Mucosa-Associated Lymphoid tissue lymphoma involving the kidney and renal pelvis. Cureus 13(5):e15172. https:\/\/doi.org\/10.7759\/cureus.15172","journal-title":"Cureus"},{"key":"6245_CR12","doi-asserted-by":"publisher","first-page":"7201","DOI":"10.1186\/1757-1626-0002-0000007201","volume":"2","author":"H Alshayeb","year":"2009","unstructured":"Alshayeb H, Wall BM (2009) Non-hodgkin\u2019s lymphoma associated membranoproliferative glomerulonephritis: rare case of long term remission with chemotherapy: a case report. Cases J 2:7201. https:\/\/doi.org\/10.1186\/1757-1626-0002-0000007201","journal-title":"Cases J"},{"issue":"4","key":"6245_CR13","doi-asserted-by":"publisher","first-page":"303","DOI":"10.5414\/cnp57303","volume":"57","author":"MB Stokes","year":"2002","unstructured":"Stokes MB, Wood B, Alpers Ch E (2002) Membranoproliferative glomerulonephritis associated with low-grade B cell lymphoma presenting in the kidney. Clin Nephrol 57(4):303\u2013309. https:\/\/doi.org\/10.5414\/cnp57303","journal-title":"Clin Nephrol"},{"issue":"1","key":"6245_CR14","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/1471-2369-14-158","volume":"14","author":"SC Yeo","year":"2013","unstructured":"Yeo SC, Chuah KL, Lee HY, Liew A (2013) An unusual case of glomerulonephritis in a patient with non-hodgkin mucosal associated lymphoid tissue (MALT) B-cell lymphoma. BMC Nephrol 14(1):158. https:\/\/doi.org\/10.1186\/1471-2369-14-158","journal-title":"BMC Nephrol"},{"issue":"1","key":"6245_CR15","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/s0272-6386(12)80323-4","volume":"20","author":"R Rault","year":"1992","unstructured":"Rault R, Holley JL, Banner BF, el-Shahawy M (1992) Glomerulonephritis and non-hodgkin\u2019s lymphoma: a report of two cases and review of the literature. Am J Kidney Dis 20(1):84\u201389. https:\/\/doi.org\/10.1016\/s0272-6386(12)80323-4","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"6245_CR16","doi-asserted-by":"publisher","first-page":"e95190","DOI":"10.1371\/journal.pone.0095190","volume":"9","author":"SJ Li","year":"2014","unstructured":"Li SJ, Chen HP, Chen YH, Zhang LH, Tu YM, Liu ZH (2014) Renal involvement in non-hodgkin lymphoma: proven by renal biopsy. PLoS ONE 9(4):e95190. https:\/\/doi.org\/10.1371\/journal.pone.0095190","journal-title":"PLoS ONE"},{"issue":"S2","key":"6245_CR17","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/hon.3163_64","volume":"41","author":"JP Alderuccio","year":"2023","unstructured":"Alderuccio JP, Saul EE, Stanchina M, Sassi RH, Zhao W, Moskowitz C, Reis I, Kuker R, Lossos I, Polar M (2023) STAGING FDG-AVIDITY IN EXTRANODAL MARGINAL ZONE LYMPHOMA (EMZL) BY DISEASE LOCATION. Hematol Oncol 41(S2):103\u2013104. https:\/\/doi.org\/10.1002\/hon.3163_64","journal-title":"Hematol Oncol"},{"issue":"Supplement 1","key":"6245_CR18","doi-asserted-by":"publisher","first-page":"5134","DOI":"10.1182\/blood-2023-179478","volume":"142","author":"JP Alderuccio","year":"2023","unstructured":"Alderuccio JP, Stanchina MD, Koff JL, Reis IM, Edelman Saul E, Larson MC, Chihara D, Zhao W, Habermann TM, Martin P, Nastoupil LJ, Chapman-Fredricks JR, Feldman AL, Link BK, Kahl BS, Cohen JB, Polar MK, Henneman Sassi R, Moskowitz CH, Friedberg JW, Cerhan JR, Kuker R, Flowers CR, Lossos IS (2023) PET\/CT enables appropriate staging in extranodal marginal zone lymphoma. Blood 142(Supplement 1):5134\u20135134. https:\/\/doi.org\/10.1182\/blood-2023-179478","journal-title":"Blood"},{"issue":"17","key":"6245_CR19","doi-asserted-by":"publisher","first-page":"4559","DOI":"10.1182\/bloodadvances.2024013434","volume":"8","author":"KN Moalem","year":"2024","unstructured":"Moalem KN, Alderuccio JP, Bommier C, Habermann T, Link BK, Cerhan JR, Florindez J, Lossos IS (2024) Transformation of marginal zone lymphoma to Hodgkin lymphoma. Blood Adv 8(17):4559\u20134562. https:\/\/doi.org\/10.1182\/bloodadvances.2024013434","journal-title":"Blood Adv"},{"key":"6245_CR20","doi-asserted-by":"crossref","unstructured":"Alderuccio JP, Lossos IS (2020) Prognostic factors and risk of transformation in marginal zone lymphoma. Annals Lymphoma 4","DOI":"10.21037\/aol-20-8"},{"issue":"5","key":"6245_CR21","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/ajh.25446","volume":"94","author":"JP Alderuccio","year":"2019","unstructured":"Alderuccio JP, Zhao W, Desai A, Ramdial J, Gallastegui N, Kimble E, de la Fuente MI, Husnain M, Rosenblatt JD, Alencar AJ, Schatz JH, Moskowitz CH, Chapman JR, Vega F, Reis IM, Lossos IS (2019) Short survival and frequent transformation in extranodal marginal zone lymphoma with multiple mucosal sites presentation. Am J Hematol 94(5):585\u2013596. https:\/\/doi.org\/10.1002\/ajh.25446","journal-title":"Am J Hematol"},{"issue":"6","key":"6245_CR22","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1007\/s11255-011-9992-z","volume":"44","author":"R Kasmani","year":"2012","unstructured":"Kasmani R, Marina VP, Abidi S, Johar B, Malhotra D (2012) Minimal change disease associated with MALT lymphoma. Int Urol Nephrol 44(6):1911\u20131913. https:\/\/doi.org\/10.1007\/s11255-011-9992-z","journal-title":"Int Urol Nephrol"},{"issue":"5","key":"6245_CR23","first-page":"713","volume":"53","author":"K Akiyama","year":"2011","unstructured":"Akiyama K, Itabashi M, Shiohira S, Tsuruta Y, Shimizu A, Kamiyama M, Ishihara M, Otsubo S, Takei T, Taneda S, Honda K, Nitta K (2011) Successful rituximab therapy for MALT lymphoma complicating cryoglobulinemic glomerulonephritis. Nihon Jinzo Gakkai Shi 53(5):713\u2013718","journal-title":"Nihon Jinzo Gakkai Shi"},{"issue":"4","key":"6245_CR24","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1053\/ajkd.1998.v31.pm9531192","volume":"31","author":"SK Mak","year":"1998","unstructured":"Mak SK, Wong PN, Lo KY, Wong AK (1998) Successful treatment of IgA nephropathy in association with low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue type. Am J Kidney Dis 31(4):713\u2013718. https:\/\/doi.org\/10.1053\/ajkd.1998.v31.pm9531192","journal-title":"Am J Kidney Dis"},{"key":"6245_CR25","doi-asserted-by":"publisher","first-page":"903315","DOI":"10.3389\/fimmu.2022.903315","volume":"13","author":"G Nie","year":"2022","unstructured":"Nie G, Sun L, Zhang C, Yuan Y, Mao H, Wang Z, Li J, Duan S, Xing C, Zhang B (2022) Clinicopathological features and individualized treatment of kidney involvement in B-cell lymphoproliferative disorder. Front Immunol 13:903315. https:\/\/doi.org\/10.3389\/fimmu.2022.903315","journal-title":"Front Immunol"},{"issue":"3","key":"6245_CR26","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1034\/j.1600-0609.2001.5790493.x","volume":"67","author":"N Da\u2019as","year":"2001","unstructured":"Da\u2019as N, Polliack A, Cohen Y, Amir G, Darmon D, Kleinman Y, Goldfarb AW, Ben-Yehuda D (2001) Kidney involvement and renal manifestations in non-hodgkin\u2019s lymphoma and lymphocytic leukemia: a retrospective study in 700 patients. Eur J Haematol 67(3):158\u2013164. https:\/\/doi.org\/10.1034\/j.1600-0609.2001.5790493.x","journal-title":"Eur J Haematol"},{"issue":"9","key":"6245_CR27","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1177\/0961203306071920","volume":"15","author":"AM Mortlock","year":"2006","unstructured":"Mortlock AM, Lim CS, Morgan H, Wong TW, Joshi A, Kuttikat A, Chakravarty K (2006) Renal MALToma: an unusual lymphoma in a patient with lupus. Lupus 15(9):613\u2013615. https:\/\/doi.org\/10.1177\/0961203306071920","journal-title":"Lupus"},{"issue":"12","key":"6245_CR28","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/s41581-021-00474-8","volume":"17","author":"S Avraham","year":"2021","unstructured":"Avraham S, Korin B, Chung J-J, Oxburgh L, Shaw AS (2021) The mesangial cell \u2014 the glomerular stromal cell. Nat Rev Nephrol 17(12):855\u2013864. https:\/\/doi.org\/10.1038\/s41581-021-00474-8","journal-title":"Nat Rev Nephrol"},{"issue":"2","key":"6245_CR29","first-page":"33","volume":"3","author":"GA Mokhtar","year":"2014","unstructured":"Mokhtar GA, Jalalah S, Sultana S (2014) Pathological patterns of mesangioproliferative glomerulonephritis seen at a tertiary care center. J Nephropharmacol 3(2):33\u201337","journal-title":"J Nephropharmacol"},{"key":"6245_CR30","doi-asserted-by":"publisher","unstructured":"Lionaki S, Marinaki S, Panagiotellis K, Tsoumbou I, Liapis G, Vlahadami I, Tzioufas A, Sfikakis P, Boletis I (2020) Glomerular diseases associated with malignancies: histopathological pattern and association with circulating autoantibodies. Antibodies (Basel) 9(2). https:\/\/doi.org\/10.3390\/antib9020018","DOI":"10.3390\/antib9020018"},{"issue":"4","key":"6245_CR31","doi-asserted-by":"publisher","first-page":"e18391","DOI":"10.5812\/numonthly.18391","volume":"6","author":"E Chelioti","year":"2014","unstructured":"Chelioti E, Efthimiou E, Sotiraki M, Papalexandrou A, Tsilivigkou M (2014) Splenic marginal zone lymphoma and concurrent membranoproliferative glomerulonephritis with IgMKappa deposits in a HCV-seropositive patient. Nephrourol Mon 6(4):e18391. https:\/\/doi.org\/10.5812\/numonthly.18391","journal-title":"Nephrourol Mon"},{"issue":"5","key":"6245_CR32","doi-asserted-by":"publisher","first-page":"A115","DOI":"10.1053\/j.ajkd.2016.03.394","volume":"67","author":"M Yamada","year":"2016","unstructured":"Yamada M, Deitzer D, Herlitz L, Calle JC (2016) Two cases of glomerulonephritis associated with marginal zone lymphoma: case reports. Am J Kidney Dis 67(5):A115. https:\/\/doi.org\/10.1053\/j.ajkd.2016.03.394","journal-title":"Am J Kidney Dis"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06245-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-025-06245-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06245-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T21:19:25Z","timestamp":1743887965000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-025-06245-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["6245"],"URL":"https:\/\/doi.org\/10.1007\/s00277-025-06245-w","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"30 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective review study was approved by the local institutional review board (IRB) in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}