{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:39:00Z","timestamp":1787582340905,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s00277-025-06266-5","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T13:16:46Z","timestamp":1741180606000},"page":"2537-2543","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sideroblastic anemia in children: challenges in diagnosis and management in three cases"],"prefix":"10.1007","volume":"104","author":[{"given":"Samia","family":"Rekaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhem","family":"Ben Fraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rym","family":"Hamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aicha","family":"Ben Taieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani","family":"Merdassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamida","family":"Jouini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajer","family":"Zarrouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"Zaiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ridha","family":"Kouki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Bejaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fethi","family":"Mellouli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Ben Khaled","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Ouederni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"6266_CR1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.2147\/JBM.S232644","volume":"11","author":"G Abu-Zeinah","year":"2020","unstructured":"Abu-Zeinah G, DeSancho MT (2020) Understanding Sideroblastic Anemia: An overview of genetics, epidemiology, pathophysiology and current therapeutic options. J Blood Med 11:305\u2013318. https:\/\/doi.org\/10.2147\/JBM.S232644","journal-title":"J Blood Med"},{"key":"6266_CR2","unstructured":"Ashorobi D, Chhabra A (2024) Sideroblastic anemia. StatPearls Publishing, StatPearls, Treasure Island (FL)"},{"key":"6266_CR3","doi-asserted-by":"publisher","unstructured":"Bottomley SS, Fleming MD (2014) Sideroblastic anemia: diagnosis and management. Hematol Oncol Clin North Am 28:653\u201370), v. https:\/\/doi.org\/10.1016\/j.hoc.2014.04.008","DOI":"10.1016\/j.hoc.2014.04.008"},{"key":"6266_CR4","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","volume":"127","author":"DA Arber","year":"2016","unstructured":"Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM et al (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127:2391\u20132405. https:\/\/doi.org\/10.1182\/blood-2016-03-643544","journal-title":"Blood"},{"key":"6266_CR5","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1182\/blood.2023020078","volume":"142","author":"RP Hasserjian","year":"2023","unstructured":"Hasserjian RP, Germing U, Malcovati L (2023) Diagnosis and classification of myelodysplastic syndromes. Blood 142:2247\u20132257. https:\/\/doi.org\/10.1182\/blood.2023020078","journal-title":"Blood"},{"key":"6266_CR6","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1182\/blood-2002-11-3444","volume":"102","author":"G Kardos","year":"2003","unstructured":"Kardos G, Baumann I, Passmore SJ, Locatelli F, Hasle H, Schultz KR et al (2003) Refractory anemia in childhood: a retrospective analysis of 67 patients with particular reference to monosomy 7. Blood 102:1997\u20132003. https:\/\/doi.org\/10.1182\/blood-2002-11-3444","journal-title":"Blood"},{"key":"6266_CR7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1182\/blood-2018-08-815951","volume":"133","author":"S Ducamp","year":"2019","unstructured":"Ducamp S, Fleming MD (2019) The molecular genetics of sideroblastic anemia. Blood 133:59\u201369. https:\/\/doi.org\/10.1182\/blood-2018-08-815951","journal-title":"Blood"},{"key":"6266_CR8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00428-022-03447-9","volume":"482","author":"M Rudelius","year":"2023","unstructured":"Rudelius M, Weinberg OK, Niemeyer CM, Shimamura A, Calvo KR (2023) The international consensus classification (ICC) of hematologic neoplasms with germline predisposition, pediatric myelodysplastic syndrome, and juvenile myelomonocytic leukemia. Virchows Arch Int J Pathol 482:113\u2013130. https:\/\/doi.org\/10.1007\/s00428-022-03447-9","journal-title":"Virchows Arch Int J Pathol"},{"key":"6266_CR9","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1007\/s12098-013-1130-8","volume":"80","author":"T Chatterjee","year":"2013","unstructured":"Chatterjee T, Choudhry VP (2013) Childhood myelodysplastic syndrome. Indian J Pediatr 80:764\u2013771. https:\/\/doi.org\/10.1007\/s12098-013-1130-8","journal-title":"Indian J Pediatr"},{"key":"6266_CR10","first-page":"69","volume":"49","author":"B Boles","year":"2023","unstructured":"Boles B, Shiel M, Gardner J-A, Conant JL (2023) Pediatric myelodysplastic syndrome with SF3B1 mutation. J Assoc Genet Technol 49:69\u201372","journal-title":"J Assoc Genet Technol"},{"key":"6266_CR11","doi-asserted-by":"publisher","unstructured":"Farrukh F, Abdelmagid M, Mangaonkar A, Patnaik M, Al-Kali A, Elliott MA et al (2020) Prognostic impact of SF3B1 mutation and multilineage dysplasia in myelodysplastic syndromes with ring sideroblasts: a Mayo Clinic study of 170 informative cases. Haematologica 2525\u201332.  https:\/\/doi.org\/10.3324\/haematol.2023.284719","DOI":"10.3324\/haematol.2023.284719"},{"key":"6266_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.102832","volume":"145","author":"PA Jafari","year":"2020","unstructured":"Jafari PA, Sadeghian MH, Miri HH, Sadeghi R, Bagheri R, Lavasani S et al (2020) Prognostic significance of SF3B1 mutations in patients with myelodysplastic syndromes: a meta-analysis. Crit Rev Oncol Hematol 145. https:\/\/doi.org\/10.1016\/j.critrevonc.2019.102832","journal-title":"Crit Rev Oncol Hematol"},{"key":"6266_CR13","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1182\/hematology.2020000158","volume":"2020","author":"MD Cappellini","year":"2020","unstructured":"Cappellini MD, Russo R, Andolfo I, Iolascon A (2020) Inherited microcytic anemias. Hematol Am Soc Hematol Educ Program 2020:465\u2013470. https:\/\/doi.org\/10.1182\/hematology.2020000158","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"6266_CR14","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2018.08.008","volume":"133","author":"T Fujiwara","year":"2019","unstructured":"Fujiwara T, Harigae H (2019) Molecular pathophysiology and genetic mutations in congenital sideroblastic anemia. Free Radic Biol Med 133:179\u2013185. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.08.008","journal-title":"Free Radic Biol Med"},{"key":"6266_CR15","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1111\/bjh.16100","volume":"187","author":"C Fouquet","year":"2019","unstructured":"Fouquet C, Le Rouzic M-A, Leblanc T, Fouyssac F, Leverger G, Hessissen L et al (2019) Genotype\/phenotype correlations of childhood-onset congenital sideroblastic anaemia in a European cohort. Br J Haematol 187:530\u2013542. https:\/\/doi.org\/10.1111\/bjh.16100","journal-title":"Br J Haematol"},{"key":"6266_CR16","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/pbc.22244","volume":"54","author":"AK Bergmann","year":"2010","unstructured":"Bergmann AK, Campagna DR, McLoughlin EM, Agarwal S, Fleming MD, Bottomley SS et al (2010) Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. Pediatr Blood Cancer 54:273\u2013278. https:\/\/doi.org\/10.1002\/pbc.22244","journal-title":"Pediatr Blood Cancer"},{"key":"6266_CR17","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.gene.2018.05.074","volume":"668","author":"Z Long","year":"2018","unstructured":"Long Z, Li H, Du Y, Han B (2018) Congenital sideroblastic anemia: advances in gene mutations and pathophysiology. Gene 668:182\u2013189. https:\/\/doi.org\/10.1016\/j.gene.2018.05.074","journal-title":"Gene"},{"key":"6266_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12090819","volume":"12","author":"A Ricci","year":"2022","unstructured":"Ricci A, Di Betto G, Bergamini E, Buzzetti E, Corradini E, Ventura P (2022) Iron metabolism in the disorders of heme biosynthesis. Metabolites 12. https:\/\/doi.org\/10.3390\/metabo12090819","journal-title":"Metabolites"},{"key":"6266_CR19","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1002\/humu.24267","volume":"42","author":"MM Heeney","year":"2021","unstructured":"Heeney MM, Berhe S, Campagna DR, Oved JH, Kurre P, Shaw PJ et al (2021) Mutation update SLC25A38. Hum Mutat 42:1367\u20131383. https:\/\/doi.org\/10.1002\/humu.24267","journal-title":"Hum Mutat"},{"key":"6266_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bcmd.2017.07.003","volume":"66","author":"M-A Le Rouzic","year":"2017","unstructured":"Le Rouzic M-A, Fouquet C, Leblanc T, Touati M, Fouyssac F, Vermylen C et al (2017) Non syndromic childhood onset congenital sideroblastic anemia: A report of 13 patients identified with an ALAS2 or SLC25A38 mutation. Blood Cells Mol Dis 66:11\u201318. https:\/\/doi.org\/10.1016\/j.bcmd.2017.07.003","journal-title":"Blood Cells Mol Dis"},{"key":"6266_CR21","doi-asserted-by":"publisher","unstructured":"G A-Z, Mt D (2020) Understanding sideroblastic anemia: an overview of genetics, epidemiology, pathophysiology and current therapeutic options. J Blood Med 11. https:\/\/doi.org\/10.2147\/JBM.S232644","DOI":"10.2147\/JBM.S232644"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06266-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-025-06266-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06266-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T03:13:52Z","timestamp":1746414832000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-025-06266-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,5]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["6266"],"URL":"https:\/\/doi.org\/10.1007\/s00277-025-06266-5","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,5]]},"assertion":[{"value":"15 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from the patients for the publication of any potentially identifiable data included in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}