{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:21:31Z","timestamp":1772119291309,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-025-06396-w","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:34:51Z","timestamp":1758267291000},"page":"5513-5519","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary effusion lymphoma with biphenotypic and bigenotypic features of T-cell receptor and IGH genes in an HIV-negative patient with kidney transplant"],"prefix":"10.1007","volume":"104","author":[{"given":"Taesung","family":"Jeon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Hyeh","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Na","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunsung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka-Won","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Min","family":"Sim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeseul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"6396_CR1","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1056\/NEJM199505043321802","volume":"332","author":"E Cesarman","year":"1995","unstructured":"Cesarman E, Chang Y, Moore PS et al (1995) Kaposi\u2019s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 332:1186\u20131191","journal-title":"N Engl J Med"},{"key":"6396_CR2","unstructured":"Arber DA (2025) The international consensus classification of myeloid and lymphoid neoplasms, 1th edn. LWW"},{"key":"6396_CR3","unstructured":"WHO Classification of Tumours Editorial Board (2024) Haematolymphoid tumours: WHO classification of tumours, 5th edn. World Health Organization"},{"key":"6396_CR4","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1186\/s12885-021-08215-7","volume":"21","author":"M Zanelli","year":"2021","unstructured":"Zanelli M, Sanguedolce F, Zizzo M et al (2021) Primary effusion lymphoma occurring in the setting of transplanted patients: a systematic review of a rare, life-threatening post-transplantation occurrence. BMC Cancer 21:468","journal-title":"BMC Cancer"},{"key":"6396_CR5","doi-asserted-by":"publisher","first-page":"e919032","DOI":"10.12659\/AJCR.919032","volume":"21","author":"J Kropf","year":"2020","unstructured":"Kropf J, Gerges M, Perez Perez A et al (2020) T cell primary effusion lymphoma in an HIV-negative man with liver cirrhosis. Am J Case Rep 21:e919032","journal-title":"Am J Case Rep"},{"key":"6396_CR6","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1097\/PAS.0b013e318185d231","volume":"33","author":"J Wang","year":"2009","unstructured":"Wang J, Chen C, Lau S et al (2009) CD3-positive large B-cell lymphoma. Am J Surg Pathol 33:505\u2013512","journal-title":"Am J Surg Pathol"},{"key":"6396_CR7","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1002\/path.1192","volume":"198","author":"B Vergier","year":"2002","unstructured":"Vergier B, Dubus P, Kutschmar A et al (2002) Combined analysis of T cell receptor gamma and Immunoglobulin heavy chain gene rearrangements at the single-cell level in lymphomas with dual genotype. J Pathol 198:171\u2013180","journal-title":"J Pathol"},{"key":"6396_CR8","doi-asserted-by":"publisher","first-page":"257","DOI":"10.5858\/1999-123-0257-HIIPEL","volume":"123","author":"JW Said","year":"1999","unstructured":"Said JW, Shintaku IP, Asou H et al (1999) Herpesvirus 8 inclusions in primary effusion lymphoma: report of a unique case with T-cell phenotype. Arch Pathol Lab Med 123:257\u2013260","journal-title":"Arch Pathol Lab Med"},{"key":"6396_CR9","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1182\/blood-2015-06-648923","volume":"126","author":"HY Wang","year":"2015","unstructured":"Wang HY, Thorson JA (2015) T-cell primary effusion lymphoma with pseudo-monoclonal rearrangements for Immunoglobulin heavy chain. Blood 126:1856","journal-title":"Blood"},{"key":"6396_CR10","doi-asserted-by":"publisher","first-page":"4115","DOI":"10.1182\/blood-2002-10-3090","volume":"101","author":"U Klein","year":"2003","unstructured":"Klein U, Gloghini A, Gaidano G et al (2003) Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts. Blood 101:4115\u20134121","journal-title":"Blood"},{"key":"6396_CR11","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1097\/01.pas.0000138177.10829.5c","volume":"28","author":"A Chadburn","year":"2004","unstructured":"Chadburn A, Hyjek E, Mathew S et al (2004) KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma. Am J Surg Pathol 28:1401\u20131416","journal-title":"Am J Surg Pathol"},{"key":"6396_CR12","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/ajh.24251","volume":"91","author":"S Guillet","year":"2016","unstructured":"Guillet S, Gerard L, Meignin V et al (2016) Classic and extracavitary primary effusion lymphoma in 51 HIV-infected patients from a single institution. Am J Hematol 91:233\u2013237","journal-title":"Am J Hematol"},{"key":"6396_CR13","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/ajh.20163","volume":"77","author":"LG Lau","year":"2004","unstructured":"Lau LG, Tan LK, Koay ES et al (2004) Acute lymphoblastic leukemia with the phenotype of a putative B-cell\/T-cell bipotential precursor. Am J Hematol 77:156\u2013160","journal-title":"Am J Hematol"},{"key":"6396_CR14","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1182\/blood-2012-06-439455","volume":"121","author":"G Venkataraman","year":"2013","unstructured":"Venkataraman G, Song JY, Tzankov A et al (2013) Aberrant T-cell antigen expression in classical hodgkin lymphoma is associated with decreased event-free survival and overall survival. Blood 121:1795\u20131804","journal-title":"Blood"},{"key":"6396_CR15","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1097\/PAS.0b013e31825e63a9","volume":"36","author":"JL Oliveira","year":"2012","unstructured":"Oliveira JL, Grogg KL, Macon WR et al (2012) Clinicopathologic features of B-Cell lineage neoplasms with aberrant expression of CD3: a study of 21 cases. Am J Surg Pathol 36:1364\u20131370","journal-title":"Am J Surg Pathol"},{"key":"6396_CR16","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1097\/00000478-200206000-00005","volume":"26","author":"B Petitjean","year":"2002","unstructured":"Petitjean B, Jardin F, Joly B et al (2002) Pyothorax-associated lymphoma: a peculiar clinicopathologic entity derived from B cells at late stage of differentiation and with occasional aberrant dual B- and T-cell phenotype. Am J Surg Pathol 26:724\u2013732","journal-title":"Am J Surg Pathol"},{"key":"6396_CR17","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1600-0609.2007.00882.x","volume":"79","author":"M Hansson","year":"2007","unstructured":"Hansson M, Jerkeman M, Dictor M (2007) Biphenotypic bigenotypic lymphoma with simultaneous expression of PAX5\/BSAP and B- and T-cell markers. Eur J Haematol 79:159\u2013165","journal-title":"Eur J Haematol"},{"key":"6396_CR18","first-page":"705","volume":"53","author":"H Arai","year":"2012","unstructured":"Arai H, Maki K, Tadokoro J et al (2012) [CD20-positive peripheral T-cell lymphoma, not otherwise specified]. Rinsho Ketsueki 53:705\u2013709","journal-title":"Rinsho Ketsueki"},{"key":"6396_CR19","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1016\/j.leukres.2008.09.034","volume":"33","author":"Y Hirata","year":"2009","unstructured":"Hirata Y, Yokote T, Kobayashi K et al (2009) Rituximab for the treatment of CD20-positive peripheral T-cell lymphoma, unspecified. Leuk Res 33:e13\u201316","journal-title":"Leuk Res"},{"key":"6396_CR20","doi-asserted-by":"crossref","unstructured":"Matnani RG, Stewart RL, Pulliam J et al (2013) Peripheral T-cell lymphoma with aberrant expression of CD19, CD20, and CD79a: case report and literature review. Case Rep Hematol 2013:183134","DOI":"10.1155\/2013\/183134"},{"key":"6396_CR21","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1038\/leu.2013.41","volume":"27","author":"SY Tan","year":"2013","unstructured":"Tan SY, Chuang SS, Tang T et al (2013) Type II EATL (epitheliotropic intestinal T-cell lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8alphaalpha phenotype. Leukemia 27:1688\u20131696","journal-title":"Leukemia"},{"key":"6396_CR22","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s00428-020-02776-x","volume":"477","author":"Y Huang","year":"2020","unstructured":"Huang Y, Chen S, Wei R et al (2020) CD20-positive extranodal NK\/T cell lymphoma: clinicopathologic and prognostic features. Virchows Arch 477:873\u2013883","journal-title":"Virchows Arch"},{"key":"6396_CR23","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1097\/PAS.0000000000001210","volume":"43","author":"Y Huang","year":"2019","unstructured":"Huang Y, Shi X, Zhong P et al (2019) De Novo testicular extranodal NK\/T-Cell lymphoma: A clinicopathologic study of 21 cases with review of additional 18 cases in the literature. Am J Surg Pathol 43:549\u2013558","journal-title":"Am J Surg Pathol"},{"key":"6396_CR24","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1007\/s00277-016-2749-0","volume":"95","author":"B Wu","year":"2016","unstructured":"Wu B, Vallangeon B, Galeotti J et al (2016) Epstein-Barr virus-negative diffuse large B cell lymphoma with aberrant expression of CD3 and other T cell-associated antigens: report of three cases with a review of the literature. Ann Hematol 95:1671\u20131683","journal-title":"Ann Hematol"},{"key":"6396_CR25","doi-asserted-by":"publisher","first-page":"156","DOI":"10.5045\/br.2013.48.2.156","volume":"48","author":"M Lee","year":"2013","unstructured":"Lee M, Cha HJ, Yoon DH et al (2013) EBV-positive diffuse large B-cell lymphoma of the elderly with aberrant expression of CD3 and TIA-1. Blood Res 48:156\u2013160","journal-title":"Blood Res"},{"key":"6396_CR26","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1016\/S0002-9440(10)65443-0","volume":"154","author":"F Fend","year":"1999","unstructured":"Fend F, Quintanilla-Martinez L, Kumar S et al (1999) Composite low grade B-cell lymphomas with two immunophenotypically distinct cell populations are true biclonal lymphomas. A molecular analysis using laser capture microdissection. Am J Pathol 154:1857\u20131866","journal-title":"Am J Pathol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06396-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-025-06396-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06396-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T08:19:22Z","timestamp":1763194762000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-025-06396-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":26,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["6396"],"URL":"https:\/\/doi.org\/10.1007\/s00277-025-06396-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6062454\/v1","asserted-by":"object"}]},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,19]]},"assertion":[{"value":"19 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the patient\u2019s family to publish this case report. No personal details that can identify the patient were included in the submission.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"Written informed consent was obtained from the patient\u2019s family to publish this case report. No personal details that could identify the patient were included in the submission.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent statement"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study reports a rare case of simultaneous T-cell antigen expression and monoclonal TCR gene rearrangement in PEL, a phenomenon rarely discussed in the existing literature. It provides a concise overview of other instances of lineage infidelity, with a particular focus on EBV and other potential underlying causes. This report provides valuable insights for both diagnostic and clinical research. Presenting a case of lymphoma with mixed immunophenotypic and genetic features highlights the challenges in diagnosing hematologic malignancies and expands the understanding of the relationship between EBV and gene regulation mechanisms. These findings are likely to attract significant interest from hematologists, oncologists, and molecular pathologists studying hematologic malignancies involving lineage infidelity.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of significance"}}]}}