{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:12:01Z","timestamp":1788999121480,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s00277-025-06426-7","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:52:22Z","timestamp":1753404742000},"page":"4071-4080","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Semen quality in acute leukemia patients: a retrospective study"],"prefix":"10.1007","volume":"104","author":[{"given":"Alessandra","family":"Buonacquisto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-0669","authenticated-orcid":false,"given":"Maria Ilaria","family":"Del Principe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pallotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Bianchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Buzzatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Caponecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Chiaretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Cicolani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Chiara","family":"Conflitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Di Chiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Fucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Kasmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Minotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovangiacinto","family":"Paterno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Tiravanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Venditti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Lombardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Paoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"6426_CR1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.bpobgyn.2018.12.004","volume":"55","author":"S Barak","year":"2019","unstructured":"Barak S (2019) Fertility preservation in male patients with cancer. Best practice & research. Clin Obstet Gynecol 55:59\u201366. https:\/\/doi.org\/10.1016\/j.bpobgyn.2018.12.004","journal-title":"Clin Obstet Gynecol"},{"issue":"3","key":"6426_CR2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.5489\/cuaj.1077","volume":"3","author":"P.T. Chan","year":"2009","unstructured":"Chan P T(2009) Fertility after cancer in men. Can Urol Association J 3(3):223\u2013224. https:\/\/doi.org\/10.5489\/cuaj.1077","journal-title":"Can Urol Association J = J De l\u2019Association Des Urologues Du Can"},{"issue":"9","key":"6426_CR3","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1002\/(SICI)1097-0142(19990501)85:9<1973::AID-CNCR14>3.0.CO;2-0","volume":"85","author":"J Hallak","year":"1999","unstructured":"Hallak J, Kolettis PN, Sekhon VS, Thomas AJ Jr, Agarwal A (1999) Cryopreservation of sperm from patients with leukemia: is it worth the effort? Cancer 85(9):1973\u20131978","journal-title":"Cancer"},{"issue":"4","key":"6426_CR4","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1093\/humrep\/deg163","volume":"18","author":"L Gandini","year":"2003","unstructured":"Gandini L, Lombardo F, Salacone P, Paoli D, Anselmo AP, Culasso F, Dondero F, Lenzi A. (2003) Hum Reprod. Oxford England, 18(4), 796\u2013801. https:\/\/doi.org\/10.1093\/humrep\/deg163","journal-title":"England)"},{"issue":"3","key":"6426_CR5","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/and.12451","volume":"48","author":"L Caponecchia","year":"2016","unstructured":"Caponecchia L, Cimino G, Sacchetto R, Fiori C, Sebastianelli A, Salacone P, Marcucci I, Tomassini S, Rago R (2016) Do malignant diseases affect semen quality? Sperm parameters of men with cancers. Andrologia 48(3):333\u2013340. https:\/\/doi.org\/10.1111\/and.12451","journal-title":"Andrologia"},{"issue":"2","key":"6426_CR6","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/humrep\/dev310","volume":"31","author":"D Paoli","year":"2016","unstructured":"Paoli D, Rizzo F, Fiore G, Pallotti F, Pulsoni A, Annechini G, Lombardo F, Lenzi A, Gandini L (2016) Spermatogenesis in Hodgkin\u2019s lymphoma patients: a retrospective study of semen quality before and after different chemotherapy regimens. Hum Reprod (Oxford England) 31(2):263\u2013272. https:\/\/doi.org\/10.1093\/humrep\/dev310","journal-title":"Hum Reprod (Oxford England)"},{"issue":"1","key":"6426_CR7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/humrep\/deaa266","volume":"36","author":"F Pallotti","year":"2021","unstructured":"Pallotti F, Pelloni M, Faja F, Di Chiano S, Di Rocco A, Lenzi A, Lombardo F, Paoli D (2021) Semen quality in non-Hodgkin lymphoma survivors: a monocentric retrospective study. Hum Reprod (Oxford England) 36(1):16\u201325. https:\/\/doi.org\/10.1093\/humrep\/deaa266","journal-title":"Hum Reprod (Oxford England)"},{"key":"6426_CR8","doi-asserted-by":"publisher","unstructured":"Auger J, Sermondade N, Eustache F (2016) Semen quality of 4480 young cancer and systemic disease patients: baseline data and clinical considerations. 26:3. Basic and clinical andrologyhttps:\/\/doi.org\/10.1186\/s12610-016-0031-x","DOI":"10.1186\/s12610-016-0031-x"},{"issue":"5","key":"6426_CR9","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1080\/10428194.2018.1533126","volume":"60","author":"Y Michailov","year":"2019","unstructured":"Michailov Y, Lunenfeld E, Kapelushnik J, Huleihel M (2019) Leukemia and male infertility: past, present, and future. Leuk Lymphoma 60(5):1126\u20131135. https:\/\/doi.org\/10.1080\/10428194.2018.1533126","journal-title":"Leuk Lymphoma"},{"issue":"6","key":"6426_CR10","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1038\/s41375-018-0314-7","volume":"33","author":"AMJ Reedijk","year":"2019","unstructured":"Reedijk AMJ, Klein K, Coebergh JWW, Kremer LC, Dinmohamed AG, de Haas V, Versluijs AB, Ossenkoppele GJ, Beverloo HB, Pieters R, Zwaan CM, Kaspers GJL, Karim-Kos HE (2019) Improved survival for children and young adolescents with acute myeloid leukemia: a Dutch study on incidence, survival and mortality. Leukemia 33(6):1349\u20131359. https:\/\/doi.org\/10.1038\/s41375-018-0314-7","journal-title":"Leukemia"},{"issue":"14","key":"6426_CR11","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1182\/blood-2018-10-881961","volume":"133","author":"W Stock","year":"2019","unstructured":"Stock W, Luger SM, Advani AS, Yin J, Harvey RC, Mullighan CG, Willman CL, Fulton N, Laumann KM, Malnassy G, Paietta E, Parker E, Geyer S, Mr\u00f3zek K, Bloomfield CD, Sanford B, Marcucci G, Liedtke M, Claxton DF, Foster MC, Larson RA (2019) A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403. Blood 133(14):1548\u20131559. https:\/\/doi.org\/10.1182\/blood-2018-10-881961","journal-title":"Blood"},{"issue":"5","key":"6426_CR12","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1200\/JCO.2010.30.1382","volume":"29","author":"R Bassan","year":"2011","unstructured":"Bassan R, Hoelzer D (2011) Modern therapy of acute lymphoblastic leukemia. J Clin Oncology; Official J Am Soc Clin Oncol 29(5):532\u2013543. https:\/\/doi.org\/10.1200\/JCO.2010.30.1382","journal-title":"J Clin Oncology; Official J Am Soc Clin Oncol"},{"key":"6426_CR13","volume-title":"Laboratory manual for the examination of human semen and semen-Cervical mucus interaction","author":"World Health Organization WHO","year":"1992","unstructured":"World Health Organization WHO (1992) Laboratory manual for the examination of human semen and semen-Cervical mucus interaction, 3rd edn. Cambridge University Press, Cambridge","edition":"3"},{"key":"6426_CR14","volume-title":"Laboratory manual for the examination of human semen and semen-Cervical mucus interaction","author":"World Health Organization WHO","year":"1999","unstructured":"World Health Organization WHO (1999) Laboratory manual for the examination of human semen and semen-Cervical mucus interaction, 4th edn. Cambridge University Press, Cambridge","edition":"4"},{"key":"6426_CR15","volume-title":"Laboratory manual for the examination and processing of human semen","author":"World Health OrganisationWHO","year":"2010","unstructured":"World Health OrganisationWHO (2010) Laboratory manual for the examination and processing of human semen, 5th edn. WHO, Geneva, Switzerland","edition":"5"},{"key":"6426_CR16","unstructured":"World Health Organization (2021) WHO laboratory manual for the examination and processing of human semen, 6th edn. World Health Organization: Geneva, Switzerland,"},{"issue":"2","key":"6426_CR17","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.fertnstert.2012.09.031","volume":"99","author":"JM Hotaling","year":"2013","unstructured":"Hotaling JM, Lopushnyan NA, Davenport M, Christensen H, Pagel ER, Muller CH, Walsh TJ (2013) Raw and test-thaw semen parameters after cryopreservation among men with newly diagnosed cancer. Fertil Steril 99(2):464\u2013469. https:\/\/doi.org\/10.1016\/j.fertnstert.2012.09.031","journal-title":"Fertil Steril"},{"issue":"1","key":"6426_CR18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ejogrb.2013.06.021","volume":"170","author":"MD Johnson","year":"2013","unstructured":"Johnson MD, Cooper AR, Jungheim ES, Lanzendorf SE, Odem RR, Ratts VS (2013) Sperm banking for fertility preservation: a 20-year experience. Eur J Obstet Gynecol Reprod Biol 170(1):177\u2013182. https:\/\/doi.org\/10.1016\/j.ejogrb.2013.06.021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"2","key":"6426_CR19","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1590\/s1677-55382009000200009","volume":"35","author":"TC Bonetti","year":"2009","unstructured":"Bonetti TC, Pasqualotto FF, Queiroz P, Iaconelli A Jr, Borges E Jr (2009) Sperm banking for male cancer patients: social and semen profiles. Int Braz J Urol 35(2):190\u2013198. https:\/\/doi.org\/10.1590\/s1677-55382009000200009","journal-title":"Int Braz J Urol"},{"issue":"1","key":"6426_CR20","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/pbc.21780","volume":"52","author":"NJ van Casteren","year":"2009","unstructured":"van Casteren NJ, van der Linden GH, Hakvoort-Cammel FG, H\u00e4hlen K, Dohle GR, van den Heuvel-Eibrink MM (2009) Effect of childhood cancer treatment on fertility markers in adult male long-term survivors. Pediatr Blood Cancer 52(1):108\u2013112. https:\/\/doi.org\/10.1002\/pbc.21780","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"6426_CR21","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1002\/pbc.22475","volume":"55","author":"A Marquis","year":"2010","unstructured":"Marquis A, Kuehni CE, Strippoli MP, K\u00fchne T, Brazzola P, Swiss Pediatric Oncology Group (2010) Sperm analysis of patients after successful treatment of childhood acute lymphoblastic leukemia with chemotherapy. Pediatr Blood Cancer 55(1):208\u2013210. https:\/\/doi.org\/10.1002\/pbc.22475","journal-title":"Pediatr Blood Cancer"},{"issue":"4","key":"6426_CR22","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.fertnstert.2011.07.1147","volume":"96","author":"K Jahnukainen","year":"2011","unstructured":"Jahnukainen K, Heikkinen R, Henriksson M, Cooper TG, Puukko-Viertomies LR, M\u00e4kitie O (2011) Semen quality and fertility in adult long-term survivors of childhood acute lymphoblastic leukemia. Fertil Steril 96(4):837\u2013842. https:\/\/doi.org\/10.1016\/j.fertnstert.2011.07.1147","journal-title":"Fertil Steril"},{"issue":"14","key":"6426_CR23","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1002\/cncr.29989","volume":"122","author":"A Haavisto","year":"2016","unstructured":"Haavisto A, Henriksson M, Heikkinen R, Puukko-Viertomies LR, Jahnukainen K (2016) Sexual function in male long-term survivors of childhood acute lymphoblastic leukemia. Cancer 122(14):2268\u20132276. https:\/\/doi.org\/10.1002\/cncr.29989","journal-title":"Cancer"},{"issue":"5","key":"6426_CR24","first-page":"398","volume":"52","author":"P Lemez","year":"2005","unstructured":"Lemez P, Urb\u00e1nek V (2005) Chemotherapy for acute myeloid leukemias with cytosine arabinoside, Daunorubicin, Etoposide, and Mitoxantrone May cause permanent oligoasthenozoospermia or amenorrhea in middle-aged patients. Neoplasma 52(5):398\u2013401","journal-title":"Neoplasma"},{"issue":"6","key":"6426_CR25","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1111\/bjh.15740","volume":"184","author":"J Noetzli","year":"2019","unstructured":"Noetzli J, Voruz S, Wunder D, Primi MP, Spertini O, Blum S (2019) Ten-year single-centre experience in fertility preservation of 459 patients suffering from acute leukaemia. Br J Haematol 184(6):969\u2013973. https:\/\/doi.org\/10.1111\/bjh.15740","journal-title":"Br J Haematol"},{"issue":"7","key":"6426_CR26","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1182\/blood.2019004583","volume":"136","author":"C R\u00f6llig","year":"2020","unstructured":"R\u00f6llig C, Kramer M, Schliemann C, Mikesch JH, Steffen B, Kr\u00e4mer A, Noppeney R, Sch\u00e4fer-Eckart K, Krause SW, H\u00e4nel M, Herbst R, Kunzmann V, Einsele H et al (2020) Does time from diagnosis to treatment affect the prognosis of patients with newly diagnosed acute myeloid leukemia? Blood 136(7):823\u2013830. https:\/\/doi.org\/10.1182\/blood.2019004583","journal-title":"Blood"},{"issue":"4","key":"6426_CR27","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1182\/blood-2016-08-733196","volume":"129","author":"H D\u00f6hner","year":"2017","unstructured":"D\u00f6hner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, B\u00fcchner T, Dombret H, Ebert BL, Fenaux P, Larson RA, Levine RL, Lo-Coco F, Naoe T, Niederwieser D, Ossenkoppele GJ, Sanz M, Sierra J, Tallman MS, Tien HF, Wei AH, Bloomfield CD (2017) Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood 129(4):424\u2013447. https:\/\/doi.org\/10.1182\/blood-2016-08-733196","journal-title":"Blood"},{"issue":"35","key":"6426_CR28","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.1200\/JCO.20.01392","volume":"38","author":"R Palmieri","year":"2020","unstructured":"Palmieri R, Othus M, Halpern AB, Percival MM, Godwin CD, Becker PS, Walter RB (2020) Accuracy of SIE\/SIES\/GITMO consensus criteria for unfitness to predict early mortality after intensive chemotherapy in adults with AML or other High-Grade myeloid neoplasm. J Clin Oncology: Official J Am Soc Clin Oncol 38(35):4163\u20134174. https:\/\/doi.org\/10.1200\/JCO.20.01392","journal-title":"J Clin Oncology: Official J Am Soc Clin Oncol"},{"key":"6426_CR29","doi-asserted-by":"publisher","unstructured":"Hoelzer D, Bassan R, Boissel N, Roddie C, Ribera JM, Jerkeman M & ESMO guidelines committee. Electronic address: clinicalguidelines@esmo.org (2024). ESMO clinical practice guideline interim update on the use of targeted therapy in acute lymphoblastic leukaemia. Annals Oncology: Official J Eur Soc Med Oncol, 35(1), 15\u201328. https:\/\/doi.org\/10.1016\/j.annonc.2023.09.3112","DOI":"10.1016\/j.annonc.2023.09.3112"},{"issue":"3","key":"6426_CR30","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1053\/j.seminhematol.2020.08.001","volume":"57","author":"CU Rank","year":"2020","unstructured":"Rank CU, Schmiegelow K (2020) Optimal approach to the treatment of young adults with acute lymphoblastic leukemia in 2020. Semin Hematol 57(3):102\u2013114. https:\/\/doi.org\/10.1053\/j.seminhematol.2020.08.001","journal-title":"Semin Hematol"},{"key":"6426_CR31","doi-asserted-by":"publisher","unstructured":"Bassan R, Chiaretti S, Della Starza I, Spinelli O, Santoro A, Paoloni F, Messina M, Elia L, De Propris MS, Scattolin AM, Audisio E, Marbello L, Borlenghi E, Zappasodi P, Mauro E, Martinelli G et al Pegaspargase-modified risk-oriented program for adult acute lymphoblastic leukemia: results of the GIMEMA LAL1913 trial. Blood Adv, 7(16), 4448\u20134461. https:\/\/doi.org\/10.1182\/bloodadvances.2022009596","DOI":"10.1182\/bloodadvances.2022009596"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06426-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-025-06426-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06426-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T07:48:59Z","timestamp":1757663339000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-025-06426-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["6426"],"URL":"https:\/\/doi.org\/10.1007\/s00277-025-06426-7","relation":{},"ISSN":["0939-5555","1432-0584"],"issn-type":[{"value":"0939-5555","type":"print"},{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]},"assertion":[{"value":"7 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by Policlinico Umberto I Ethics Committee (Prot. 0671\/2024).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}