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Little is known about the effects of <jats:italic>WT1<\/jats:italic> on the leukemic cells and their targets. This work used data obtained from gene expression arrays performed on AML samples with high and low <jats:italic>WT1<\/jats:italic> mRNA levels to pinpoint genes that WT1 can regulate. We singled out <jats:italic>SGK1<\/jats:italic>, which showed an inverse correlation between its mRNA levels and <jats:italic>WT1<\/jats:italic> in leukemic cell lines and AML samples. In cellular models, forced expression of <jats:italic>WT1<\/jats:italic> reduced mRNA and protein levels of <jats:italic>SGK1<\/jats:italic>. Furthermore, <jats:italic>WT1<\/jats:italic> repressed the SGK1 promoter activity, and accordingly, WT1 knockdown showed an increased expression of <jats:italic>SGK1<\/jats:italic>. We also detected an inverse correlation between <jats:italic>WT1<\/jats:italic> and <jats:italic>SGK1<\/jats:italic> during leukemic cell-line differentiation. <jats:italic>WT1<\/jats:italic> genetic knockdown displayed decreased cell viability under nutrient deprivation. By contrast, <jats:italic>SGK1<\/jats:italic> knockdown or pharmacologic inhibition increased resistance to apoptosis in response to serum starvation, acting on cell cycle progression. The effects of <jats:italic>SGK1<\/jats:italic> targeting in hematologic conditions merit further investigation.<\/jats:p>","DOI":"10.1007\/s00277-025-06458-z","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T03:42:58Z","timestamp":1751600578000},"page":"3655-3667","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SGK1 repression by WT1 may confer a survival advantage to leukemic cells under stress conditions"],"prefix":"10.1007","volume":"104","author":[{"given":"Miguel A.","family":"Rubio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Cisa-Wieczorek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Mozos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Castellet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Bussaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maite","family":"Carricondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Hern\u00e1ndez-Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep F.","family":"Nomded\u00e9u","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"6458_CR1","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","volume":"374","author":"E Papaemmanuil","year":"2016","unstructured":"Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND et al (2016) Genomic classification and prognosis in acute myeloid leukemia. 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