{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:33:14Z","timestamp":1787067194220,"version":"build-2736575974"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-025-06477-w","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T09:06:47Z","timestamp":1757408807000},"page":"5819-5828","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Age interaction in associations between geriatric nutritional risk index and prognosis in diffuse large B-cell lymphoma"],"prefix":"10.1007","volume":"104","author":[{"given":"Kei","family":"Fujita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Tsukasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiju","family":"Negoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Oiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Tsurumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"6477_CR1","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","volume":"127","author":"SH Swerdlow","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA et al (2016) The 2016 revision of the world health organization classification of lymphoid neoplasms. Blood 127:2375\u20132390","journal-title":"Blood"},{"key":"6477_CR2","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/j.1365-2559.2008.03076.x","volume":"53","author":"SO Yoon","year":"2008","unstructured":"Yoon SO, Jeon YK, Paik JH et al (2008) MYC translocation and an increased copy number predict poor prognosis in adult diffuse large B-cell lymphoma (DLBCL), especially in germinal centre-like B cell (GCB) type. Histopathology 53:205\u2013217","journal-title":"Histopathology"},{"key":"6477_CR3","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.humpath.2008.06.032","volume":"40","author":"MG Tibiletti","year":"2009","unstructured":"Tibiletti MG, Martin V, Bernasconi B et al (2009) BCL2, BCL6, MYC, MALT 1, and BCL10 rearrangements in nodal diffuse large B-cell lymphomas: a multicenter evaluation of a new set of fluorescent in situ hybridization probes and correlation with clinical outcome. Hum Pathol 40:645\u2013652","journal-title":"Hum Pathol"},{"key":"6477_CR4","doi-asserted-by":"publisher","first-page":"4022","DOI":"10.1200\/JCO.2010.28.4257","volume":"28","author":"SS McAllister","year":"2010","unstructured":"McAllister SS, Weinberg RA (2010) Tumor-host interactions: a far-reaching relationship. J Clin Oncol 28:4022\u20134028","journal-title":"J Clin Oncol"},{"key":"6477_CR5","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1007\/s00277-018-3273-1","volume":"97","author":"Y Kanemasa","year":"2018","unstructured":"Kanemasa Y, Shimoyama T, Sasaki Y, Hishima T, Omuro Y (2018) Geriatric nutritional risk index as a prognostic factor in patients with diffuse large B cell lymphoma. Ann Hematol 97:999\u20131007","journal-title":"Ann Hematol"},{"key":"6477_CR6","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1111\/bjh.16743","volume":"192","author":"S Lee","year":"2021","unstructured":"Lee S, Fujita K, Morishita T et al (2021) Prognostic utility of a geriatric nutritional risk index in combination with a comorbidity index in elderly patients with diffuse large B cell lymphoma. Br J Haematol 192:100\u2013109","journal-title":"Br J Haematol"},{"key":"6477_CR7","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1080\/10428194.2023.2295787","volume":"65","author":"Y Kaneda","year":"2024","unstructured":"Kaneda Y, Kanemura N, Nakamura N et al (2024) The pretreatment controlling nutritional status score is an independent prognostic factor in elderly patients with diffuse large B-cell lymphoma. Leuk Lymphoma 65:339\u2013345","journal-title":"Leuk Lymphoma"},{"key":"6477_CR8","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1007\/s00277-014-2031-2","volume":"93","author":"S Dalia","year":"2014","unstructured":"Dalia S, Chavez J, Little B et al (2014) Serum albumin retains independent prognostic significance in diffuse large B-cell lymphoma in the post-rituximab era. Ann Hematol 93:1305\u20131312","journal-title":"Ann Hematol"},{"key":"6477_CR9","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1634\/theoncologist.2016-0260","volume":"22","author":"K Miura","year":"2017","unstructured":"Miura K, Konishi J, Miyake T et al (2017) A Host-Dependent prognostic model for elderly patients with diffuse large B-Cell lymphoma. Oncologist 22:554\u2013560","journal-title":"Oncologist"},{"key":"6477_CR10","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/ajcn\/82.4.777","volume":"82","author":"O Bouillanne","year":"2005","unstructured":"Bouillanne O, Morineau G, Dupont C et al (2005) Geriatric nutritional risk index: a new index for evaluating at-risk elderly medical patients. Am J Clin Nutr 82:777\u2013783","journal-title":"Am J Clin Nutr"},{"key":"6477_CR11","first-page":"295","volume":"4","author":"X H\u00e9buterne","year":"2001","unstructured":"H\u00e9buterne X, Bermon S, Schneider SM (2001) Ageing and muscle: the effects of malnutrition, re-nutrition, and physical exercise. Curr Opin Clin Nutr Metab Care 4:295\u2013300","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"6477_CR12","volume-title":"WHO Classification of tumours of haematopoietic and lymphoid tissues","author":"SH Swerdlow","year":"2008","unstructured":"Swerdlow SH, Campo E, Harris NL et al (2008) WHO Classification of tumours of haematopoietic and lymphoid tissues, 4th edn. IARC Press","edition":"4"},{"key":"6477_CR13","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00277-011-1363-4","volume":"91","author":"N Goto","year":"2012","unstructured":"Goto N, Tsurumi H, Goto H et al (2012) Serum soluble interleukin-2 receptor (sIL-2R) level is associated with the outcome of patients with diffuse large B cell lymphoma treated with R-CHOP regimens. Ann Hematol 91:705\u2013714","journal-title":"Ann Hematol"},{"key":"6477_CR14","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373\u2013383","journal-title":"J Chronic Dis"},{"key":"6477_CR15","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1002\/ajh.24819","volume":"92","author":"C Saygin","year":"2017","unstructured":"Saygin C, Jia X, Hill B et al (2017) Impact of comorbidities on outcomes of elderly patients with diffuse large B-cell lymphoma. Am J Hematol 92:989\u2013996","journal-title":"Am J Hematol"},{"key":"6477_CR16","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJM199309303291402","volume":"329","author":"International Non-Hodgkin's Lymphoma Prognostic Factors Project","year":"1993","unstructured":"International Non-Hodgkin\u2019s Lymphoma Prognostic Factors Project (1993) A predictive model for aggressive non-Hodgkin\u2019s lymphoma. N Engl J Med 329:987\u2013994. https:\/\/doi.org\/10.1056\/NEJM199309303291402","journal-title":"N Engl J Med"},{"key":"6477_CR17","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y (2013) Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transpl 48:452\u2013458","journal-title":"Bone Marrow Transpl"},{"key":"6477_CR18","volume-title":"R: A Language and environment for statistical computing","author":"RFS Computing","year":"2016","unstructured":"Team RC, Computing RFS (2016) R: A Language and environment for statistical computing. Austria, Vienna"},{"key":"6477_CR19","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1007\/s00277-020-04089-0","volume":"99","author":"S Kaito","year":"2020","unstructured":"Kaito S, Wada A, Adachi H et al (2020) Geriatric nutritional risk index as a useful prognostic factor in second allogeneic hematopoietic stem cell transplantation. Ann Hematol 99:1655\u20131665","journal-title":"Ann Hematol"},{"key":"6477_CR20","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.ijbiomac.2021.06.140","volume":"184","author":"A Sheinenzon","year":"2021","unstructured":"Sheinenzon A, Shehadeh M, Michelis R, Shaoul E, Ronen O (2021) Serum albumin levels and inflammation. Int J Biol Macromol 184:857\u2013862","journal-title":"Int J Biol Macromol"},{"key":"6477_CR21","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454:436\u2013444","journal-title":"Nature"},{"key":"6477_CR22","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12885-017-3931-z","volume":"18","author":"F Sun","year":"2018","unstructured":"Sun F, Zhu J, Lu S et al (2018) An inflammation-based cumulative prognostic score system in patients with diffuse large B cell lymphoma in rituximab era. BMC Cancer 18:5","journal-title":"BMC Cancer"},{"key":"6477_CR23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/bjc.2014.277","volume":"111","author":"KT Troppan","year":"2014","unstructured":"Troppan KT, Schlick K, Deutsch A et al (2014) C-reactive protein level is a prognostic indicator for survival and improves the predictive ability of the R-IPI score in diffuse large B-cell lymphoma patients. Br J Cancer 111:55\u201360","journal-title":"Br J Cancer"},{"key":"6477_CR24","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/S1470-2045(11)70069-9","volume":"12","author":"F Peyrade","year":"2011","unstructured":"Peyrade F, Jardin F, Thieblemont C et al (2011) Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-arm, phase 2 trial. Lancet Oncol 12:460\u2013468","journal-title":"Lancet Oncol"},{"key":"6477_CR25","doi-asserted-by":"publisher","first-page":"e415","DOI":"10.3324\/haematol.2019.234435","volume":"105","author":"S Lee","year":"2020","unstructured":"Lee S, Fujita K, Negoro E et al (2020) Impact of relative dose intensity of standard regimens on survival in elderly patients aged 80 years and older with diffuse large B-cell lymphoma. Haematologica 105:e415\u2013e418","journal-title":"Haematologica"},{"key":"6477_CR26","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S0002-9343(97)00279-9","volume":"104","author":"MM Wilson","year":"1998","unstructured":"Wilson MM, Vaswani S, Liu D, Morley JE, Miller DK (1998) Prevalence and causes of undernutrition in medical outpatients. Am J Med 104:56\u201363","journal-title":"Am J Med"},{"key":"6477_CR27","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.nut.2004.06.023","volume":"21","author":"M Pirlich","year":"2005","unstructured":"Pirlich M, Sch\u00fctz T, Kemps M et al (2005) Social risk factors for hospital malnutrition. Nutrition 21:295\u2013300","journal-title":"Nutrition"},{"key":"6477_CR28","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1002\/hon.3002","volume":"40","author":"S Mancuso","year":"2022","unstructured":"Mancuso S, Mattana M, Santoro M, Carlisi M, Buscemi S, Siragusa S (2022) Host-related factors and cancer: malnutrition and non-Hodgkin lymphoma. Hematol Oncol 40:320\u2013331","journal-title":"Hematol Oncol"},{"key":"6477_CR29","doi-asserted-by":"publisher","first-page":"e108687","DOI":"10.1371\/journal.pone.0108687","volume":"9","author":"I Bourdel-Marchasson","year":"2014","unstructured":"Bourdel-Marchasson I, Blanc-Bisson C, Doussau A et al (2014) Nutritional advice in older patients at risk of malnutrition during treatment for chemotherapy: a two-year randomized controlled trial. PLoS ONE 9:e108687","journal-title":"PLoS ONE"},{"key":"6477_CR30","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1016\/j.clnu.2021.02.005","volume":"40","author":"M Muscaritoli","year":"2021","unstructured":"Muscaritoli M, Arends J, Bachmann P et al (2021) ESPEN practical guideline: clinical nutrition in cancer. Clin Nutr 40:2898\u20132913","journal-title":"Clin Nutr"},{"key":"6477_CR31","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.clnesp.2021.10.015","volume":"46","author":"B Cucchiaro","year":"2021","unstructured":"Cucchiaro B, Weekes CE (2021) Systematic review of nutrition support interventions in adult haematology and oncology patients receiving CAR T cell therapy. Clin Nutr ESPEN 46:60\u201365","journal-title":"Clin Nutr ESPEN"},{"key":"6477_CR32","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/ageing\/afq034","volume":"39","author":"AJ Cruz-Jentoft","year":"2010","unstructured":"Cruz-Jentoft AJ, Baeyens JP, Bauer JM et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people. Age Ageing 39:412\u2013423","journal-title":"Age Ageing"},{"key":"6477_CR33","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.clnu.2009.12.004","volume":"29","author":"M Muscaritoli","year":"2010","unstructured":"Muscaritoli M, Anker SD, Argil\u00e9s J et al (2010) Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by special interest groups (SIG) cachexia-anorexia in chronic wasting diseases and nutrition in geriatrics. Clin Nutr 29:154\u2013159","journal-title":"Clin Nutr"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06477-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-025-06477-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06477-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T21:01:46Z","timestamp":1768942906000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-025-06477-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":33,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["6477"],"URL":"https:\/\/doi.org\/10.1007\/s00277-025-06477-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6492181\/v1","asserted-by":"object"}]},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"21 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was reviewed and approved by the Institutional Review Board of University of Fukui Hospital (IRB number: 20180081) before the initiation of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declared no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}