{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:18:02Z","timestamp":1779887882164,"version":"3.53.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-025-06550-4","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T02:27:10Z","timestamp":1756261630000},"page":"5809-5818","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pegaspargase administration and tolerability in patients aged 55\u00a0years or older with acute lymphoblastic leukemia treated with the LAL1913 program. A subanalysis of the Campus ALL group"],"prefix":"10.1007","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7568-9656","authenticated-orcid":false,"given":"Davide","family":"Lazzarotto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Testi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Fanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Mosna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Chiaretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Papayannidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Curti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Piccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Fracchiolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Fumagalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Zappasodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Imbergamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Minetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Guolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Lussana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cerrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Forghieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Leoncin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Olivi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Lunghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Trappolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Mazzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Defina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Aprile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crescenza","family":"Pasciolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ciccone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endri","family":"Mauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Mul\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Camb\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Delia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cignetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Fanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Bonifacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelina","family":"Dargenio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicetto","family":"Ferrara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pizzolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Fo\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Candoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"issue":"16","key":"6550_CR1","doi-asserted-by":"publisher","first-page":"4448","DOI":"10.1182\/bloodadvances.2022009596","volume":"7","author":"R Bassan","year":"2023","unstructured":"Bassan R, Chiaretti S, Della Starza I et al (2023) Pegaspargase modified risk-oriented program for adult acute lymphoblastic leukemia: results of the GIMEMA LAL1913 trial. Blood Adv 7(16):4448\u20134461","journal-title":"Blood Adv"},{"issue":"11","key":"6550_CR2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41408-020-00383-2","volume":"10","author":"R Bassan","year":"2020","unstructured":"Bassan R, Pavoni C, Intermesoli T et al (2020) Updated risk-oriented strategy for acute lymphoblastic leukemia in adult patients 18\u201365 years: NILG ALL 10\/07. Blood Cancer J 10(11):119","journal-title":"Blood Cancer J"},{"issue":"6","key":"6550_CR3","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1200\/JCO.2008.18.6916","volume":"27","author":"F Huguet","year":"2009","unstructured":"Huguet F, Leguay T, Raffoux E et al (2009) Pediatric-inspired therapy in adults with Philadelphia chromosome negative acute lymphoblastic leukemia: the GRAALL-2003 study. J Clin Oncol 27(6):911\u2013918","journal-title":"J Clin Oncol"},{"issue":"24","key":"6550_CR4","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1200\/JCO.2017.76.8192","volume":"36","author":"F Huguet","year":"2018","unstructured":"Huguet F, Chevret S, Leguay T et al (2018) Intensified therapy of acute lymphoblastic leukemia in adults: report of the randomized GRAALL-2005 clinical trial. J Clin Oncol 36(24):2514\u20132523","journal-title":"J Clin Oncol"},{"issue":"2","key":"6550_CR5","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/j.1600-0609.2006.00778.x","volume":"78","author":"JM Sancho","year":"2007","unstructured":"Sancho JM, Ribera JM, Xicoy B et al (2007) Results of the PETHEMA ALL-96 trial in elderly patients with Philadelphia chromosome-negative acute lymphoblastic leukemia. Eur J Haematol 78(2):102\u2013110","journal-title":"Eur J Haematol"},{"issue":"3","key":"6550_CR6","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/leu.2014.229","volume":"29","author":"DJ DeAngelo","year":"2015","unstructured":"DeAngelo DJ, Stevenson KE, Dahlberg SE et al (2015) Long-term outcome of a pediatric-inspired regimen used for adults aged 18\u201350 years with newly diagnosed acute lymphoblastic leukemia. Leukemia 29(3):526\u2013534","journal-title":"Leukemia"},{"issue":"3","key":"6550_CR7","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/ajh.26066","volume":"96","author":"AM Testi","year":"2021","unstructured":"Testi AM, Canichella M, Vitale A et al (2021) Adolescent and young adult acute lymphoblastic leukemia. Final results of the phase <scp>II<\/scp>pediatric\u2010like <scp>GIMEMA LAL<\/scp>\u20101308 trial. Am J Hematol 96(3):292\u2013301","journal-title":"Am J Hematol"},{"issue":"9","key":"6550_CR8","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1200\/JCO.2013.50.2708","volume":"32","author":"D Douer","year":"2014","unstructured":"Douer D, Aldoss I, Lunning MA et al (2014) Pharmacokinetics-based integration of multiple doses of intravenous pegaspargase in a pediatric regimen for adults with newly diagnosed acute lymphoblastic leukemia. J Clin Oncol 32(9):905\u2013911","journal-title":"J Clin Oncol"},{"issue":"8","key":"6550_CR9","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1182\/blood-2012-07-379016","volume":"122","author":"N G\u00f6kbuget","year":"2013","unstructured":"G\u00f6kbuget N (2013) How i treat older patients with ALL. Blood 122(8):1366\u20131375","journal-title":"Blood"},{"issue":"4","key":"6550_CR10","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/ejh.12600","volume":"96","author":"I Aldoss","year":"2016","unstructured":"Aldoss I, Douer D, Behrendt CE et al (2016) Toxicity profile of repeated doses of PEG-asparaginase incorporated into a pediatric-type regimen for adult acute lymphoblastic leukemia. Eur J Haematol 96(4):375\u2013380","journal-title":"Eur J Haematol"},{"issue":"7","key":"6550_CR11","first-page":"2423","volume":"32","author":"VI Avramis","year":"2012","unstructured":"Avramis VI (2012) Asparaginases: biochemical pharmacology and modes of drug resistance. Anticancer Res 32(7):2423\u20132437","journal-title":"Anticancer Res"},{"issue":"12","key":"6550_CR12","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.3109\/10428194.2011.596963","volume":"52","author":"W Stock","year":"2011","unstructured":"Stock W, Douer D, DeAngelo DJ et al (2011) Prevention and management of asparaginase\/pegasparaginase-associated toxicities in adults and older adolescents: recommendations of an expert panel. Leuk Lymphoma 52(12):2237\u20132253","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"6550_CR13","first-page":"55","volume":"110","author":"D Lazzarotto","year":"2025","unstructured":"Lazzarotto D, Cerrano M, Papayannidis C et al (2025) Outcome of 421 adult patients with Philadelphia-negative acute lymphoblastic leukemia treated under an intensive program inspired by the GIMEMA LAL1913 clinical trial: a campus ALL study. Haematologica 110(1):55\u201367","journal-title":"Haematologica"},{"issue":"11","key":"6550_CR14","doi-asserted-by":"publisher","first-page":"3962","DOI":"10.1182\/blood.V112.11.3962.3962","volume":"112","author":"S Kao","year":"2008","unstructured":"Kao S, Xu W, Gupta V et al (2008) Outcome of patients age 60 and over with acute lymphoblastic leukemia (ALL) treated with a modified pediatric protocol. Blood 112(11):3962","journal-title":"Blood"},{"issue":"1","key":"6550_CR15","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1080\/10428194.2020.1824068","volume":"62","author":"RJ Daley","year":"2021","unstructured":"Daley RJ, Rajeeve S, Kabel CC et al (2021) Tolerability and toxicity of pegaspargase in adults 40 years and older with acute lymphoblastic leukemia. Leuk Lymphoma 62(1):176\u2013184","journal-title":"Leuk Lymphoma"},{"issue":"10","key":"6550_CR16","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1080\/10428194.2021.1919666","volume":"62","author":"MJ Rees","year":"2021","unstructured":"Rees MJ, Wu S, Mokoonlall M et al (2021) The real-world tolerability and efficacy of asparaginase in adults aged 40 years and older with Philadelphia-negative acute lymphoblastic leukemia. Leuk Lymphoma 62(10):2531\u20132534","journal-title":"Leuk Lymphoma"},{"issue":"3","key":"6550_CR17","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/jha2.224","volume":"2","author":"AA Patel","year":"2021","unstructured":"Patel AA, Heng J, Dworkin E et al (2021) Efficacy and tolerability of a modified pediatric-inspired intensive regimen for acute lymphoblastic leukemia in older adults. EJHaem 2(3):413\u2013420","journal-title":"EJHaem"},{"issue":"4","key":"6550_CR18","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/s41375-024-02201-1","volume":"38","author":"MA Perusini","year":"2024","unstructured":"Perusini MA, Andrews C, Eshetu AG et al (2024) Asparaginase completion among adults including older patients with acute lymphoblastic leukemia treated with a modified DFCI protocol. Leukemia 38(4):912\u2013913","journal-title":"Leukemia"},{"issue":"1","key":"6550_CR19","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1186\/s12885-020-07461-5","volume":"20","author":"F Lussana","year":"2020","unstructured":"Lussana F, Minetto P, Ferrara F, Chiaretti S, Specchia G, Bassan R (2020) National Italian Delphi panel consensus: which measures are indicated to minimize pegylated-asparaginase associated toxicity during treatment of adult acute lymphoblastic leukemia? BMC Cancer 20(1):956","journal-title":"BMC Cancer"},{"issue":"21","key":"6550_CR20","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1182\/blood.2024027500","volume":"145","author":"R Bassan","year":"2025","unstructured":"Bassan R, Chiaretti S, Della Starza I et al (2025) Up-front blinatumomab improves MRD clearance and outcome in adult Ph- B-lineage ALL: the GIMEMA LAL2317 phase 2 study. Blood 145(21):2447\u20132459","journal-title":"Blood"},{"issue":"13","key":"6550_CR21","first-page":"987","volume":"135","author":"I Aldoss","year":"2020","unstructured":"Aldoss I, Douer D (2020) How i treat the toxicities of pegasparaginase in adults with acute lymphoblastic leukemia. Blood 135(13):987\u2013995","journal-title":"Blood"},{"issue":"3","key":"6550_CR22","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1080\/10428194.2019.1680839","volume":"61","author":"BA Derman","year":"2020","unstructured":"Derman BA, Streck M, Wynne J et al (2020) Efficacy and toxicity of reduced vs. standard dose pegylated asparaginase in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia. Leuk Lymphoma 61(3):614\u2013622","journal-title":"Leuk Lymphoma"},{"key":"6550_CR23","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2024.286744","author":"E Curran","year":"2025","unstructured":"Curran E, Luskin MR, Alachkar H et al (2025) Recognition, prevention, and management of adverse events associated with asparaginase \/ pegaspargase treatment of acute lymphoblastic leukemia in adults: consensus of an expert panel. Haematologica. https:\/\/doi.org\/10.3324\/haematol.2024.286744","journal-title":"Haematologica"},{"issue":"4","key":"6550_CR24","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1056\/NEJMoa2312948","volume":"391","author":"MR Litzow","year":"2024","unstructured":"Litzow MR, Sun Z, Mattison RJ et al (2024) Blinatumomab for MRD-negative acute lymphoblastic leukemia in adults. N Engl J Med 391(4):320\u2013333","journal-title":"N Engl J Med"},{"issue":"6","key":"6550_CR25","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1080\/10428194.2025.2449582","volume":"66","author":"J Senapati","year":"2025","unstructured":"Senapati J, Kantarjian H, Habib D et al (2025) Frontline immunotherapeutic combination strategies in adult B-cell acute lymphoblastic leukemia: reducing chemotherapy intensity and toxicity and harnessing efficacy. Leuk Lymphoma 66(6):989\u20131000","journal-title":"Leuk Lymphoma"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06550-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-025-06550-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06550-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T02:31:23Z","timestamp":1764729083000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-025-06550-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":25,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["6550"],"URL":"https:\/\/doi.org\/10.1007\/s00277-025-06550-4","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]},"assertion":[{"value":"30 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}