{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:49:49Z","timestamp":1777553389838,"version":"3.51.4"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82200922"],"award-info":[{"award-number":["82200922"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-025-06607-4","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T03:16:19Z","timestamp":1758251779000},"page":"5501-5506","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The diagnosis and clinical characterization of -\u03b13.7\/--SEA thalassemia patients: two cases report"],"prefix":"10.1007","volume":"104","author":[{"given":"Xiuling","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"issue":"3","key":"6607_CR1","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.26355\/eurrev_202302_31198","volume":"27","author":"JY Su","year":"2023","unstructured":"Su JY, Chen Y, Chen HF, Tong JR, Wei YN, Huang LL, Deng L (2023) Analysis of the anemia characteristics in early pregnancy and outcomes of pregnant women with hemoglobin H disease. Eur Rev Med Pharmacol Sci 27(3):1027\u20131032. https:\/\/doi.org\/10.26355\/eurrev_202302_31198","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"6607_CR2","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1080\/03630269.2021.2023566","volume":"46","author":"ED Yuson","year":"2022","unstructured":"Yuson ED, Naranjo MLT (2022) Thalassemia in the Philippines. Hemoglobin 46(1):36\u201338. https:\/\/doi.org\/10.1080\/03630269.2021.2023566","journal-title":"Hemoglobin"},{"key":"6607_CR3","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.191613","volume":"192","author":"H Merkeley","year":"2020","unstructured":"Merkeley H, Bolster L (2020) Thalassemia. Can Med Assoc J 192:41E1210. https:\/\/doi.org\/10.1503\/cmaj.191613","journal-title":"Can Med Assoc J"},{"key":"6607_CR4","doi-asserted-by":"publisher","first-page":"e246062","DOI":"10.1590\/1519-6984.246062","volume":"83","author":"F Shafique","year":"2021","unstructured":"Shafique F, Ali S, Almansouri T, Van Eeden F, Shafi N, Khalid M, Khawaja S, Andleeb S, Hassan MU (2021) Thalassemia, a human blood disorder. Brazilian J biology = Revista Brasleira De Biol 83:e246062. https:\/\/doi.org\/10.1590\/1519-6984.246062","journal-title":"Brazilian J biology = Revista Brasleira De Biol"},{"issue":"3","key":"6607_CR5","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1080\/03630269.2025.2495698","volume":"49","author":"C Ruengdit","year":"2025","unstructured":"Ruengdit C, Punyamung M, Maneewong K, Khamphikham P, Tepakhan W, Pornprasert S (2025) Characterization of hbh disease caused by compound heterozygotes \u03b1(+)-thalassemia 3.7 kb deletion and a large novel \u03b1(0)-thalassemia deletion. Hemoglobin 49(3):229\u2013232. https:\/\/doi.org\/10.1080\/03630269.2025.2495698","journal-title":"Hemoglobin"},{"issue":"4","key":"6607_CR6","first-page":"264","volume":"14","author":"YH Lin","year":"2012","unstructured":"Lin YH, Fan L, Zhang Z, Pan ZW, Song CL (2012) [Spectrum of gene deletion in 471 children with \u03b1-thalassemia]. Zhongguo Dang Dai Er Ke Za zhi\u2009=\u2009chinese. J Contemp Pediatr 14(4):264\u2013266","journal-title":"J Contemp Pediatr"},{"issue":"8","key":"6607_CR7","doi-asserted-by":"publisher","first-page":"841","DOI":"10.7499\/j.issn.1008-8830.2104035","volume":"23","author":"DM Li","year":"2021","unstructured":"Li DM, He S (2021) Genotypes of thalassemia in children: an analysis of 30 417 cases. Zhongguo Dang Dai Er Ke Za zhi\u2009=\u2009chinese. J Contemp Pediatr 23(8):841\u2013847. https:\/\/doi.org\/10.7499\/j.issn.1008-8830.2104035","journal-title":"J Contemp Pediatr"},{"issue":"10","key":"6607_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223996","volume":"14","author":"S Pata","year":"2019","unstructured":"Pata S, Laopajon W, Pongpaiboon M, Thongkum W, Polpong N, Munkongdee T, Paiboonsukwong K, Fucharoen S, Tayapiwatana C, Kasinrerk W (2019) Impact of the detection of \u03b6-globin chains and hemoglobin bart\u2019s using immunochromatographic strip tests for \u03b10-thalassemia (-SEA) differential diagnosis. PLoS ONE 14(10):e0223996. https:\/\/doi.org\/10.1371\/journal.pone.0223996","journal-title":"PLoS ONE"},{"issue":"1","key":"6607_CR9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s40246-023-00520-5","volume":"17","author":"T Yang","year":"2023","unstructured":"Yang T, Luo X, Liu Y, Lin M, Zhao Q, Zhang W, Chen Z, Dong M, Wang J, Wang Q, Zhang X, Zhong T (2023) Next-generation sequencing analysis of the molecular spectrum of thalassemia in southern Jiangxi, China. Hum Genomics 17(1):77. https:\/\/doi.org\/10.1186\/s40246-023-00520-5","journal-title":"Hum Genomics"},{"issue":"1","key":"6607_CR10","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1182\/hematology.2021000296","volume":"2021","author":"C Mensah","year":"2021","unstructured":"Mensah C, Sheth S (2021) Optimal strategies for carrier screening and prenatal diagnosis of \u03b1- and \u03b2-thalassemia. Hematology 2021(1):607\u2013613. https:\/\/doi.org\/10.1182\/hematology.2021000296","journal-title":"Hematology"},{"issue":"9","key":"6607_CR11","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1002\/ajh.27006","volume":"98","author":"KM Musallam","year":"2023","unstructured":"Musallam KM, Lombard L, Kistler KD, Arregui M, Gilroy KS, Chamberlain C, Zagadailov E, Ruiz K, Taher AT (2023) Epidemiology of clinically significant forms of alpha- and beta-thalassemia: a global map of evidence and gaps. Am J Hematol 98(9):1436\u20131451. https:\/\/doi.org\/10.1002\/ajh.27006","journal-title":"Am J Hematol"},{"issue":"2","key":"6607_CR12","doi-asserted-by":"publisher","first-page":"195","DOI":"10.5937\/jomb0-37682","volume":"42","author":"AA Almomani","year":"2023","unstructured":"Almomani AA, Shraim AS, Atoom AM, Abdel MBA, Alhmoud JF (2023) Evaluation of the validity of the pre-marriage mean corpuscular volume value as a predictive test for b-thalassemia carrier status. J Med Biochem 42(2):195\u2013205. https:\/\/doi.org\/10.5937\/jomb0-37682","journal-title":"J Med Biochem"},{"issue":"1","key":"6607_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-020-01141-8","volume":"21","author":"RP Shamoon","year":"2020","unstructured":"Shamoon RP, Yassin AK, Polus RK, Ali MD (2020) Genotype-phenotype correlation of hbh disease in Northern Iraq. BMC Med Genet 21(1):203. https:\/\/doi.org\/10.1186\/s12881-020-01141-8","journal-title":"BMC Med Genet"},{"key":"6607_CR14","unstructured":"Harewood J, Azevedo AM (2025)\u00a0Alpha Thalassemia. In: StatPearls [Internet]. StatPearls Publishing Copyright \u00a9 2025, StatPearls Publishing LLC., Treasure Island (FL) ineligible companies. Disclosure: Alexandre Azevedo declares no relevant financial relationships with ineligible companies"},{"issue":"12","key":"6607_CR15","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s13312-022-2660-9","volume":"59","author":"V Gupta","year":"2022","unstructured":"Gupta V, Aggarwal P (2022) Complications in transfusion-dependent thalassemia. Indian Pediatr 59(12):911\u2013912","journal-title":"Indian Pediatr"},{"issue":"1","key":"6607_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-024-03526-1","volume":"24","author":"X Liu","year":"2024","unstructured":"Liu X, Jiang H, Ren L, Cao L (2024) Post-transfusion severe headache in a patient with thalassemia with superficial siderosis of the central nervous system: a case report and literature review. BMC Neurol 24(1):21. https:\/\/doi.org\/10.1186\/s12883-024-03526-1","journal-title":"BMC Neurol"},{"issue":"4","key":"6607_CR17","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.molmed.2023.01.007","volume":"29","author":"L Vitek","year":"2023","unstructured":"Vitek L, Hinds TD Jr., Stec DE, Tiribelli C (2023) The physiology of bilirubin: health and disease equilibrium. Trends Mol Med 29(4):315\u2013328. https:\/\/doi.org\/10.1016\/j.molmed.2023.01.007","journal-title":"Trends Mol Med"},{"issue":"4","key":"6607_CR18","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.jhep.2023.06.004","volume":"79","author":"L V\u00edtek","year":"2023","unstructured":"V\u00edtek L, Tiribelli C (2023) Gilbert\u2019s syndrome revisited. J Hepatol 79(4):1049\u20131055. https:\/\/doi.org\/10.1016\/j.jhep.2023.06.004","journal-title":"J Hepatol"},{"issue":"5","key":"6607_CR19","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s00277-019-03630-0","volume":"98","author":"J Chaloemwong","year":"2019","unstructured":"Chaloemwong J, Tantiworawit A, Rattanathammethee T, Chai-Adisaksopha C, Rattarittamrong E, Norasetthada L, Charoenkwan P, Louthrenoo W (2019) Hyperuricemia, urine uric excretion, and associated complications in thalassemia patients. Ann Hematol 98(5):1101\u20131110. https:\/\/doi.org\/10.1007\/s00277-019-03630-0","journal-title":"Ann Hematol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06607-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-025-06607-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06607-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T08:19:21Z","timestamp":1763194761000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-025-06607-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":19,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["6607"],"URL":"https:\/\/doi.org\/10.1007\/s00277-025-06607-4","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,19]]},"assertion":[{"value":"18 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the ethics committee of The Central Hospital of Wuhan, and the study was conducted in accordance with the local legislation and institutional requirements.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The written inform\u00a0consent\u00a0for publication was obtained from the patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}