{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T21:16:42Z","timestamp":1763414202363,"version":"3.45.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immune thrombocytopenia (ITP) is the most common acquired bleeding disorder in children and a frequent source of clinical concern. This study aimed to evaluate the clinical outcomes and treatment responses to different therapeutic lines. This observational study included 90 children with newly diagnosed ITP who were registered and followed at Cairo University Children\u2019s Hospital between June 2022 and December 2023. The study cohort consisted of 40 males (44.4%) and 50 females (55.6%), with a mean age of 5.3 years. The mean platelet count at presentation was 9.9\u2009\u00b1\u200911.9\u2009\u00d7\u200910\u2079\/L, increasing to 384.6\u2009\u00b1\u2009141.0\u2009\u00d7\u200910\u2079\/L at six months post-treatment. Six patients (5.8%) experienced spontaneous recovery without treatment, while 84 patients (94.2%) received therapeutic interventions including corticosteroids or intravenous immunoglobulin (IVIG). By three months, 61 patients (68.9%) had responded to treatment, while 29 patients (32.2%) required second-line therapy with thrombopoietin receptor agonists (TPO-RAs). Corticosteroids remain the cornerstone of first-line therapy in newly diagnosed pediatric ITP. Patients who do not respond to initial treatment or experience relapse demonstrate favorable outcomes with TPO-RA therapy.<\/jats:p>","DOI":"10.1007\/s00277-025-06626-1","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:34:28Z","timestamp":1758872068000},"page":"5003-5010","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcome and response to different management regimens in pediatric patients with immune thrombocytopenia (ITP)"],"prefix":"10.1007","volume":"104","author":[{"given":"Rasha AbdelRaouf","family":"AbdelAziz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia","family":"El-Sayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma El Zahraa","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Al","family":"Komy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"6626_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.870064","volume":"10","author":"VE Ro\u015fu","year":"2022","unstructured":"Ro\u015fu VE, Spoial\u0103 EL, Ro\u015fu TS, Ivanov AV, Mocanu A, Munteanu A, Gavrilovici C (2022) The use of clinical scores in the management of immune thrombocytopenic purpura in children. Front Pediatr 10:870064","journal-title":"Front Pediatr"},{"issue":"1","key":"6626_CR2","doi-asserted-by":"publisher","first-page":"4247","DOI":"10.21608\/ejhm.2022.256576","volume":"89","author":"MA Mohammed","year":"2022","unstructured":"-Mohammed MA, Abdelhamid SS, Zidan NI, Karim AE, N. E.A (2022) Predictive and prognostic value of mean platelets volume in immune thrombocytopenia in children. Egypt J Hosp Med 89(1):4247\u20134250","journal-title":"Egypt J Hosp Med"},{"issue":"1","key":"6626_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.phoj.2016.04.002","volume":"1","author":"AH Sabhan","year":"2016","unstructured":"-Sabhan AH, Al-Jadiry MF, Ghali HH, Abed WM, Al-Hadad SA (2016) Chronic immune thrombocytopenic purpura in children overview of 60 patients. Pediatr Hematol Oncol J 1(1):9\u201312","journal-title":"Pediatr Hematol Oncol J"},{"issue":"3","key":"6626_CR4","first-page":"253","volume":"22","author":"G Russo","year":"2024","unstructured":"Russo G, Parodi E, Farruggia P, Notarangelo LD, Perrotta S, Casale M et al (2024) Recommendations for the management of acute immune thrombocytopenia in children. A Consensus Conference from the Italian Association of Pediatric Hematology and Oncology. Blood Transfus. 22(3):253","journal-title":"Blood Transfus."},{"issue":"2","key":"6626_CR5","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00431-013-2254-6","volume":"173","author":"V Labarque","year":"2014","unstructured":"-Labarque V, Van Geet C (2014) Clinical practice: immune thrombocytopenia in pediatrics. Eur J Pediatrics 173(2):163\u2013172","journal-title":"Eur J Pediatrics"},{"issue":"4","key":"6626_CR6","doi-asserted-by":"publisher","DOI":"10.5045\/br.2017.52.4.254","volume":"52","author":"JH Jang","year":"2017","unstructured":"Jang JH, Kim JY, Mun YC, Bang SM, Lim YJ, Shin DY, Kook H (2017) Management of immune thrombocytopenia: Korean experts\u2019 recommendation in 2017. Blood Res 52(4):254","journal-title":"Blood Res"},{"issue":"23","key":"6626_CR7","doi-asserted-by":"publisher","first-page":"3829","DOI":"10.1182\/bloodadvances.2019000966","volume":"3","author":"C Neunert","year":"2019","unstructured":"Neunert C, Terrell DR, Arnold DM, Buchanan G, Cines DB, Cooper N, Vesely SK (2019) American society of hematology 2019 guidelines for immune thrombocy-topenia. Blood Adv 3(23):3829\u20133866","journal-title":"Blood Adv"},{"key":"6626_CR8","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1111\/jth.14683","volume":"18","author":"P Gresele","year":"2020","unstructured":"Gresele P, Orsini S et al (2020) Validation of the ISTH\/SSC bleeding assessment tool for inherited platelet disorders: a communication from the platelet physiology SSC. J Thromb Haemost 18:732\u2013739","journal-title":"J Thromb Haemost"},{"issue":"2","key":"6626_CR9","first-page":"39","volume":"66","author":"MES Haroun","year":"2018","unstructured":"Haroun MES, Afifi RAERAEA, Habib NM (2018) Outcome of different treatment regimens used in newly diagnosed ITP pediatric patients. Egypt Pediatr Assoc Gaz 66(2):39\u201342","journal-title":"Egypt Pediatr Assoc Gaz"},{"issue":"1","key":"6626_CR10","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2174\/1573396315666191023122542","volume":"16","author":"DO Acero-Garc\u00e9s","year":"2020","unstructured":"Acero-Garc\u00e9s DO, Garc\u00eda-Perdomo HA (2020) First line treatments for newly diagnosed primary immune thrombocytopenia in children: a systematic review and network meta-analysis. Curr Pediatr Rev 16(1):61\u201370","journal-title":"Curr Pediatr Rev"},{"issue":"4","key":"6626_CR11","volume":"11","author":"G Mokhtar","year":"2024","unstructured":"Mokhtar G, Abdelbaky A, Adly A, Ezzat D, Abdel Hakeem G, Hassab H, Florez I (2024) Egyptian pediatric guidelines for the management of children with isolated thrombocytopenia using the adapted ADAPTE methodology\u2014a limited-resource country perspective. Children (Basel) 11(4):452","journal-title":"Children (Basel)"},{"issue":"17","key":"6626_CR12","first-page":"100295","volume":"1","author":"A Abbasi","year":"2022","unstructured":"-Abbasi A, Shaikh M, Ali N, Khan M, Soomar S (2022) Response of Eltrombopag in immune thrombocytopenia and acquired idiopathic aplastic anemia: A single-center experience. Leuk. Res. Reports 1(17):100295","journal-title":"Leuk. Res. Reports"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06626-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-025-06626-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06626-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T20:02:43Z","timestamp":1763409763000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-025-06626-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":12,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["6626"],"URL":"https:\/\/doi.org\/10.1007\/s00277-025-06626-1","relation":{},"ISSN":["1432-0584"],"issn-type":[{"type":"electronic","value":"1432-0584"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"29 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the declaration of Helsinki for studies including human participants and was approved by the institutional research ethics committees at Faculty of Medicine, Cairo University (REC code: MS28-2024). Written informed consent was obtained from the parents. Participant data has been anonymized.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}