{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T02:35:48Z","timestamp":1764729348493,"version":"3.46.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority","award":["XTZD20180204","XTZD20180204","XTZD20180204"],"award-info":[{"award-number":["XTZD20180204","XTZD20180204","XTZD20180204"]}]},{"name":"Science and Technology Development Program of Jinan Municipal Health Commission","award":["2024304013"],"award-info":[{"award-number":["2024304013"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-025-06672-9","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:30:19Z","timestamp":1762158619000},"page":"5685-5694","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of the clinical characteristics and prognostic factors of multicenter childhood Burkitt leukemia"],"prefix":"10.1007","volume":"104","author":[{"given":"Wenting","family":"Pei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanlong","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunpeng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mincui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kailan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lirong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xige","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunju","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zifen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"6672_CR1","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1056\/NEJMoa055351","volume":"354","author":"M Hummel","year":"2006","unstructured":"Hummel M, Bentink S, Berger H et al (2006) A biologic definition of burkitt\u2019s lymphoma from transcriptional and genomic profiling. N Engl J Med 354:2419\u20132430. https:\/\/doi.org\/10.1056\/NEJMoa055351","journal-title":"N Engl J Med"},{"key":"6672_CR2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41572-022-00404-3","volume":"8","author":"C L\u00f3pez","year":"2022","unstructured":"L\u00f3pez C, Burkhardt B, Chan JKC et al (2022) Burkitt lymphoma. Nat Rev Dis Primers 8:78. https:\/\/doi.org\/10.1038\/s41572-022-00404-3","journal-title":"Nat Rev Dis Primers"},{"key":"6672_CR3","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/ped4.12260","volume":"5","author":"J Zhu","year":"2021","unstructured":"Zhu J, Zhen Z, Wang J et al (2021) Outcomes of Burkitt lymphoma with bone marrow involvement or Burkitt leukemia in Chinese children. Pediatr Investig 5:112\u2013117. https:\/\/doi.org\/10.1002\/ped4.12260","journal-title":"Pediatr Investig"},{"key":"6672_CR4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3969\/j.issn.1006-7795.2016.02.007","volume":"37","author":"D Yanlong","year":"2016","unstructured":"Yanlong D, Ling J, Jing Y et al (2016) Clinical characteristics of 26 children with burkitt\u2019s leukemia and outcome of treatment with revised LMB 89 protocol. J Cap Med Univ 37:141\u2013147. https:\/\/doi.org\/10.3969\/j.issn.1006-7795.2016.02.007","journal-title":"J Cap Med Univ"},{"key":"6672_CR5","first-page":"332","volume":"7","author":"SB Murphy","year":"1980","unstructured":"Murphy SB (1980) Classification, staging and end results of treatment of childhood non-Hodgkin\u2019s lymphomas: dissimilarities from lymphomas in adults. Semin Oncol 7:332\u2013339 PMID: 7414342","journal-title":"Semin Oncol"},{"key":"6672_CR6","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.3760\/cma.j.cn112140-20220429-00390","volume":"60","author":"Z Meng","year":"2022","unstructured":"Meng Z, Pan W, Yanlong D et al (2022) Midterm efficacy of China net childhood Lymphoma- mature B-cell lymphoma 2017 regimen in the treatment of pediatric Burkitt lymphoma. Chin J Pediatr 60:1011\u20131018. https:\/\/doi.org\/10.3760\/cma.j.cn112140-20220429-00390","journal-title":"Chin J Pediatr"},{"key":"6672_CR7","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1007\/s00432-019-03010-1","volume":"145","author":"I Demina","year":"2019","unstructured":"Demina I, Zerkalenkova E, Illarionova O et al (2019) Heterogeneity of childhood acute leukemia with mature B-cell immunophenotype. J Cancer Res Clin Oncol 145:2803\u20132811. https:\/\/doi.org\/10.1007\/s00432-019-03010-1","journal-title":"J Cancer Res Clin Oncol"},{"key":"6672_CR8","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3760\/cma.j.cn112140-20240210-00106","volume":"62","author":"S Li","year":"2024","unstructured":"Li S, Ling J, Yonghong Z et al (2024) A multicenter study on effect of delayed chemotherapy on prognosis of Burkitt lymphoma in children. Chin J Pediatr 62:941\u2013948. https:\/\/doi.org\/10.3760\/cma.j.cn112140-20240210-00106","journal-title":"Chin J Pediatr"},{"key":"6672_CR9","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/pbc.22047","volume":"53","author":"SM Mbulaiteye","year":"2009","unstructured":"Mbulaiteye SM, Biggar RJ, Bhatia K, Linet MS, Devesa SS (2009) Sporadic childhood Burkitt lymphoma incidence in the united States during 1992\u20132005. Pediatr Blood Cancer 53:366\u2013370. https:\/\/doi.org\/10.1002\/pbc.22047","journal-title":"Pediatr Blood Cancer"},{"key":"6672_CR10","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1182\/blood.2020009446","volume":"137","author":"K Raastad","year":"2021","unstructured":"Raastad K, Huang Q (2021) Burkitt leukemia with immature B-cell phenotype mimicking acute lymphoblastic leukemia. Blood 137:718. https:\/\/doi.org\/10.1182\/blood.2020009446","journal-title":"Blood"},{"key":"6672_CR11","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1097\/MPH.0000000000001354","volume":"42","author":"IO Al","year":"2020","unstructured":"Al IO, Bayram C, Koc B et al (2020) Burkitt leukemia with precursor B-cell immunophenotype and dual translocation of t (14;18) and t (8;14) in a child: case report and review of the literature. J Pediatr Hematol Oncol 42:e61\u2013e63. https:\/\/doi.org\/10.1097\/MPH.0000000000001354","journal-title":"J Pediatr Hematol Oncol"},{"key":"6672_CR12","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/sj.leu.2401244","volume":"13","author":"F Navid","year":"1999","unstructured":"Navid F, Mosijczuk AD, Head DR et al (1999) Acute lymphoblastic leukemia with the (8;14) (q24; q32) translocation and FAB L3 morphology associated with a B-precursor immunophenotype: the pediatric oncology group experience. Leukemia 13:135\u2013141. https:\/\/doi.org\/10.1038\/sj.leu.2401244","journal-title":"Leukemia"},{"key":"6672_CR13","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1054\/bjoc.1999.1083","volume":"82","author":"A Atra","year":"2000","unstructured":"Atra A, Imeson JD, Hobson R et al (2000) Improved outcome in children with advanced stage B-cell non-Hodgkin\u2019s lymphoma (B-NHL): results of the united Kingdom children cancer study group (UKCCSG) 9002 protocol. Br J Cancer 82:1396\u20131402. https:\/\/doi.org\/10.1054\/bjoc.1999.1083","journal-title":"Br J Cancer"},{"key":"6672_CR14","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1182\/blood-2006-07-036665","volume":"109","author":"MS Cairo","year":"2007","unstructured":"Cairo MS, Gerrard M, Sposto R (2007) Results of a randomized international study of high risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents. Blood 109:2736\u20132743. https:\/\/doi.org\/10.1182\/blood-2006-07-036665","journal-title":"Blood"},{"key":"6672_CR15","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1182\/blood.v97.11.3370","volume":"97","author":"C Patte","year":"2001","unstructured":"Patte C, Auperin A, Michon J et al (2001) The Societe Franqaise d\u2019oncologie pediatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B cell lymphomas and L3 leukemia. Blood 97:3370\u20133379. https:\/\/doi.org\/10.1182\/blood.v97.11.3370","journal-title":"Blood"},{"key":"6672_CR16","doi-asserted-by":"publisher","first-page":"359","DOI":"10.4143\/crt.2019.219","volume":"52","author":"JK Suh","year":"2020","unstructured":"Suh JK, Gao Y-J, Tang JY et al (2020) Clinical characteristics and treatment outcomes of pediatric patients with non-Hodgkin lymphoma in East Asia. Cancer Res Treat 52:359\u2013368. https:\/\/doi.org\/10.4143\/crt.2019.219","journal-title":"Cancer Res Treat"},{"key":"6672_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/10428194.2015.1085529","volume":"57","author":"JY Song","year":"2016","unstructured":"Song JY, Venkataraman G, Fedoriw Y et al (2016) Burkitt leukemia limited to the bone marrow has a better prognosis than Burkitt lymphoma with bone marrow involvement in adults. Leuk Lymphoma 57:1\u20136. https:\/\/doi.org\/10.3109\/10428194.2015.1085529","journal-title":"Leuk Lymphoma"},{"key":"6672_CR18","doi-asserted-by":"publisher","first-page":"358","DOI":"10.4143\/crt.2013.047","volume":"46","author":"H Kim","year":"2014","unstructured":"Kim H, Park ES, Lee SH et al (2014) Clinical outcome of relapsed or refractory Burkitt lymphoma and mature B-cell lymphoblastic leukemia in children and adolescents. Cancer Res Treat 46:358\u2013365. https:\/\/doi.org\/10.4143\/crt.2013.047","journal-title":"Cancer Res Treat"},{"key":"6672_CR19","doi-asserted-by":"publisher","first-page":"748","DOI":"10.3760\/cma.j.issn","volume":"55","author":"H Shuang","year":"2017","unstructured":"Shuang H, Ling J, Jing Y et al (2017) Clinical pathologic characteristics and treatment outcomes of 19 relapsed pediatric B-cell lymphoma. Chin J Pediatr 55:748\u2013753. https:\/\/doi.org\/10.3760\/cma.j.issn","journal-title":"Chin J Pediatr"},{"key":"6672_CR20","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1182\/blood.2019003591","volume":"135","author":"W Woessmann","year":"2020","unstructured":"Woessmann W, Zimmermann M, Meinhardt A et al (2020) Progressive or relapsed Burkitt lymphoma or leukemia in children and adolescents after BFM-type first-line therapy. Blood 135:1124\u20131132. https:\/\/doi.org\/10.1182\/blood.2019003591","journal-title":"Blood"},{"key":"6672_CR21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.21037\/tcr.2017.01.08","volume":"6","author":"A Pishko","year":"2017","unstructured":"Pishko A, Nasta SD (2017) The role of novel immunotherapies in non-Hodgkin lymphoma. Transl Cancer Res 6:93\u2013103. https:\/\/doi.org\/10.21037\/tcr.2017.01.08","journal-title":"Transl Cancer Res"},{"key":"6672_CR22","doi-asserted-by":"publisher","first-page":"281","DOI":"10.4274\/tjh.2015.0088","volume":"33","author":"\u00dcY Malkan","year":"2016","unstructured":"Malkan \u00dcY, Gune\u015f G, G\u00f6ker H et al (2016) The prognosis of adult burkitt\u2019s cell leukemia in real-life clinical practice. Turkish Journal of Hematology 33:281\u2013285. https:\/\/doi.org\/10.4274\/tjh.2015.0088","journal-title":"Turkish Journal of Hematology"},{"key":"6672_CR23","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1056\/NEJMoa1915315","volume":"382","author":"V Minard-Colin","year":"2020","unstructured":"Minard-Colin V, Aup\u00e9rin A, Pillon M et al (2020) Rituximab for high-risk, mature B-cell non-Hodgkin\u2019s lymphoma in children. N Engl J Med 382:2207\u20132219. https:\/\/doi.org\/10.1056\/NEJMoa1915315","journal-title":"N Engl J Med"},{"key":"6672_CR24","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/bjh.13040","volume":"167","author":"S Goldman","year":"2014","unstructured":"Goldman S, Smith L, Galardy P et al (2014) Rituximab with chemotherapy in children and adolescents with central nervous system and\/or bone marrow-positive Burkitt lymphoma\/leukaemia: a children\u2019s oncology group report. Br J Haematol 167:394\u2013401. https:\/\/doi.org\/10.1111\/bjh.13040","journal-title":"Br J Haematol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06672-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-025-06672-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06672-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T02:31:37Z","timestamp":1764729097000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-025-06672-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":24,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["6672"],"URL":"https:\/\/doi.org\/10.1007\/s00277-025-06672-9","relation":{},"ISSN":["1432-0584"],"issn-type":[{"type":"electronic","value":"1432-0584"}],"subject":[],"published":{"date-parts":[[2025,11,3]]},"assertion":[{"value":"20 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Ethics Committee of Beijing Children\u2019s Hospital discussed and approved the study protocol (IEC-C-008-A08-V.05.1).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants"}},{"value":"Guardians and children (aged\u2009\u2265\u20098 years old) signed an informed consent form.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}