{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T14:23:33Z","timestamp":1775226213383,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008678","name":"Universit\u00e4t Leipzig","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008678","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Patients with hematologic malignancies often require platelet transfusions, but platelet count alone does not sufficiently predict bleeding risk. T-TAS HD-Chip is designed to evaluate the hemostatic function in whole blood samples from thrombocytopenic patients. This study aimed to investigate T-TAS HD-chip in thrombocytopenic patients with myeloid neoplasia. Samples from thrombocytopenic patients with myeloid neoplasia were prospectively collected. The area under the curve (AUC), occlusion start time and occlusion time of T-TAS, platelet count, von Willebrand factor and thrombin generation were measured, and the association of these markers with platelet transfusion, parenteral nutrition and bleeding events was evaluated. A total of 67 samples were collected from 28 patients. No occlusion in T-TAS was detected in samples with platelet counts \u226420\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    per liter but 17 of 35 samples with platelet counts\u2009&gt;\u200920\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    per liter showed occlusion,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001. In samples from patients with platelet counts\u2009&gt;\u200920\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    per liter, 26.3% with parenteral nutrition showed complete occlusion, compared to 75% without parenteral nutrition,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007. Platelet count and T-TAS AUC were significantly higher one hour after platelet transfusion. T-TAS AUC but not platelet count 12\u201324\u00a0h after transfusion was lower in patients requiring next transfusion within &lt;\u20095 days compared to those with later transfusions. Our data suggest that occlusion in T-TAS HD-Chip in patients with myeloid neoplasia does not occur in patients with platelet counts \u226420\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    per liter. Parenteral nutrition seems to interfere with the occlusion of T-TAS HD chip. T-TAS may be able to predict the need for further platelet transfusions.\n                  <\/jats:p>","DOI":"10.1007\/s00277-025-06679-2","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T06:57:31Z","timestamp":1760511451000},"page":"5453-5461","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Total thrombus formation analysis in patients with myeloid neoplasia and thrombocytopenia"],"prefix":"10.1007","volume":"104","author":[{"given":"Katharina","family":"Freitag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg-Nikolaus","family":"Franke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Weise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Herling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan","family":"Kl\u00f6ter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Herling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelie","family":"Siegemund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madlen","family":"Jentzsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirak","family":"Petros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Henschler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus H.","family":"Metzeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0485-7402","authenticated-orcid":false,"given":"Christian","family":"Pfrepper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"6679_CR1","doi-asserted-by":"publisher","first-page":"895","DOI":"10.14670\/HH-11-976","volume":"33","author":"S Shahrabi","year":"2018","unstructured":"Shahrabi S, Behzad MM, Jaseb K, Saki N (2018) Thrombocytopenia in leukemia: pathogenesis and prognosis. 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