{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T04:39:01Z","timestamp":1774413541849,"version":"3.50.1"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Traditional Chinese Medicine Innovation Core Talent Training Program, the Hematological Diseases Program of the Chinese Association of Traditional Chinese Medicine","award":["202169-004"],"award-info":[{"award-number":["202169-004"]}]},{"name":"National Natural Science Foundation Youth Foundation","award":["No.82305338"],"award-info":[{"award-number":["No.82305338"]}]},{"DOI":"10.13039\/501100007956","name":"Natural Science Foundation of Nanjing University of Chinese Medicine","doi-asserted-by":"crossref","award":["XZR2021017"],"award-info":[{"award-number":["XZR2021017"]}],"id":[{"id":"10.13039\/501100007956","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-025-06691-6","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:27:41Z","timestamp":1760948861000},"page":"5947-5958","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lactic acidosis as the initial presentation of lymphoma: A case report and integrated analysis of clinical characteristics and prognostic factors"],"prefix":"10.1007","volume":"104","author":[{"given":"Weiguang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuqiong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deli","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjin","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingbin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"issue":"1","key":"6691_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-018-0160-y","volume":"5","author":"Y Wang","year":"2018","unstructured":"Wang Y, Huang Y, Yang J, Zhou FQ, Zhao L, Zhou H (2018) Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis. Mil Med Res 5(1):13. https:\/\/doi.org\/10.1186\/s40779-018-0160-y","journal-title":"Mil Med Res"},{"issue":"1","key":"6691_CR2","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211067749","volume":"50","author":"C Wang","year":"2022","unstructured":"Wang C, Lv Z, Zhang Y (2022) Type B lactic acidosis associated with diffuse large B-cell lymphoma and the Warburg effect. J Int Med Res 50(1):3000605211067749. https:\/\/doi.org\/10.1177\/03000605211067749","journal-title":"J Int Med Res"},{"issue":"24","key":"6691_CR3","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1056\/NEJMra1309483","volume":"371","author":"JA Kraut","year":"2014","unstructured":"Kraut JA, Madias NE (2014) Lactic acidosis. N Engl J Med 371(24):2309\u20132319. https:\/\/doi.org\/10.1056\/NEJMra1309483","journal-title":"N Engl J Med"},{"issue":"10","key":"6691_CR4","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.2169\/internalmedicine.4450-24","volume":"64","author":"S Yamazaki","year":"2025","unstructured":"Yamazaki S, Watanabe Y, Takahashi K, Tominaga K, Ikarashi S, Yokoo T, Kamimura H, Tsuchiya A, Terai S (2025) Diffuse large B-cell lymphoma with severe lactic acidosis and liver failure: a case report and literature review. Intern Med 64(10):1534\u20131541. https:\/\/doi.org\/10.2169\/internalmedicine.4450-24","journal-title":"Intern Med"},{"issue":"5","key":"6691_CR5","doi-asserted-by":"publisher","first-page":"e60985","DOI":"10.7759\/cureus.60985","volume":"16","author":"P Khanal","year":"2024","unstructured":"Khanal P, Pokharel A, Bastola S (2024) Severe lactic acidosis and hypoglycemia associated with Burkitt lymphoma and the Warburg effect. Cureus 16(5):e60985. https:\/\/doi.org\/10.7759\/cureus.60985","journal-title":"Cureus"},{"issue":"2","key":"6691_CR6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1080\/10428190400016723","volume":"46","author":"JJ Glasheen","year":"2005","unstructured":"Glasheen JJ, Sorensen MD (2005) Burkitt\u2019s lymphoma presenting with lactic acidosis and hypoglycemia - a case presentation. Leuk Lymphoma 46(2):281\u2013283. https:\/\/doi.org\/10.1080\/10428190400016723","journal-title":"Leuk Lymphoma"},{"issue":"6","key":"6691_CR7","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-241067","volume":"14","author":"P Englert","year":"2021","unstructured":"Englert P, Levy S, Vekemans M, De Wilde V (2021) Intravascular lymphoma presenting with hypoxaemia, platypnoea and lactic acidosis. BMJ Case Rep 14(6):e241067. https:\/\/doi.org\/10.1136\/bcr-2020-241067","journal-title":"BMJ Case Rep"},{"key":"6691_CR8","doi-asserted-by":"publisher","DOI":"10.1177\/23247096211034040","volume":"9","author":"KH Chan","year":"2021","unstructured":"Chan KH, Prabhakar L, Al-Radideh O, Okwesili B, Are G, Shaaban H (2021) A rare case of severe lactic acidosis in a patient with mantle cell lymphoma. J Invest Med High Impact Case Rep 9:23247096211034040. https:\/\/doi.org\/10.1177\/23247096211034040","journal-title":"J Invest Med High Impact Case Rep"},{"key":"6691_CR9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.5414\/CNCS110123","volume":"9","author":"JD Salcedo Betancourt","year":"2021","unstructured":"Salcedo Betancourt JD, Garcia Valencia OA, Becerra-Gonzales VG, Carias Martinez KG, Chapman J, Yanchenko N, Ladino MA (2021) Severe type-B lactic acidosis in a patient with bilateral renal Burkitt\u2019s lymphoma. Clin Nephrol Case Stud 9:49\u201353. https:\/\/doi.org\/10.5414\/CNCS110123","journal-title":"Clinical Nephrology \u2013 Case Studies"},{"issue":"2","key":"6691_CR10","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1159\/000509510","volume":"13","author":"T Hamada","year":"2020","unstructured":"Hamada T, Kaku T, Mitsu S, Morita Y, Ohno N, Yamaguchi H (2020) Lactic acidosis and hypoglycemia in a patient with gastric diffuse large B-cell lymphoma due to the Warburg effect. Case Rep Oncol 13(2):1047\u20131052. https:\/\/doi.org\/10.1159\/000509510","journal-title":"Case Rep Oncol"},{"issue":"2","key":"6691_CR11","doi-asserted-by":"publisher","first-page":"e35521","DOI":"10.7759\/cureus.35521","volume":"15","author":"AK Abbas","year":"2023","unstructured":"Abbas AK, Osman AY (2023) Atypical presentation of Burkitt lymphoma with isolated peritoneal involvement and association with refractory type B lactic acidosis and hypoglycemia secondary to the Warburg effect. Cureus 15(2):e35521. https:\/\/doi.org\/10.7759\/cureus.35521","journal-title":"Cureus"},{"key":"6691_CR12","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3704309","volume":"2017","author":"SY Golhar","year":"2017","unstructured":"Golhar SY, Green MS, Guy S (2017) Unusual case of severe lactic acidosis in a liver transplant patient. Case Rep Transplant 2017:3704309. https:\/\/doi.org\/10.1155\/2017\/3704309","journal-title":"Case Rep Transplant"},{"issue":"8","key":"6691_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e18968","volume":"9","author":"D Yu","year":"2023","unstructured":"Yu D, Tang X, Xue H, Ao Y, Xie Y, Li X (2023) Paraneoplastic syndrome in malignant lymphoma: a case report. Heliyon 9(8):e18968. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e18968","journal-title":"Heliyon"},{"key":"6691_CR14","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.941270","volume":"24","author":"P Weeraddana","year":"2023","unstructured":"Weeraddana P, Odujoko O, Bal S, Mannapperuma N, Maslak D, Gupta G (2023) An elusive diagnosis: diffuse large B-cell lymphoma masquerading as acute liver failure with persistent lactic acidosis. Am J Case Rep 24:e941270. https:\/\/doi.org\/10.12659\/AJCR.941270","journal-title":"Am J Case Rep"},{"issue":"1","key":"6691_CR15","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4103\/0971-5851.133728","volume":"35","author":"A Kumar","year":"2014","unstructured":"Kumar A, Raina V (2014) Non-Hodgkins lymphoma with lactic acidosis at presentation: a case report of a rare oncologic emergency. Indian J Med Paediatr Oncol 35(1):83\u201385. https:\/\/doi.org\/10.4103\/0971-5851.133728","journal-title":"Indian J Med Paediatr Oncol"},{"issue":"2","key":"6691_CR16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1097\/MAJ.0b013e3181c3fdeb","volume":"339","author":"BC Keller","year":"2010","unstructured":"Keller BC, Nussensveig D, Dowell JE (2010) Diffuse large B-cell lymphoma in a hepatitis C virus-infected patient presenting with lactic acidosis and hypoglycemia. Am J Med Sci 339(2):202\u2013204. https:\/\/doi.org\/10.1097\/MAJ.0b013e3181c3fdeb","journal-title":"Am J Med Sci"},{"issue":"5","key":"6691_CR17","doi-asserted-by":"publisher","first-page":"e2561","DOI":"10.7759\/cureus.2561","volume":"10","author":"H Arif","year":"2018","unstructured":"Arif H, Zahid S, Kaura A (2018) Persistent lactic acidosis: thinking outside the box. Cureus 10(5):e2561. https:\/\/doi.org\/10.7759\/cureus.2561","journal-title":"Cureus"},{"issue":"2","key":"6691_CR18","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1159\/000517658","volume":"14","author":"Z Al Maqrashi","year":"2021","unstructured":"Al Maqrashi Z, Sedarous M, Pandey A, Ross C, Wyne A (2021) Refractory hyperlactatemia and hypoglycemia in an adult with Non-Hodgkin\u2019s lymphoma: a case report and review of the Warburg effect. Case Rep Oncol 14(2):1159\u20131167. https:\/\/doi.org\/10.1159\/000517658","journal-title":"Case Rep Oncol"},{"issue":"2","key":"6691_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.6948","volume":"11","author":"N Nakagawa","year":"2023","unstructured":"Nakagawa N, Yamazaki M (2023) Leukemic phase as the initial presentation of ALK-positive anaplastic large\u2010cell lymphoma complicated by lactic acidosis. Clin Case Rep 11(2):e6948. https:\/\/doi.org\/10.1002\/ccr3.6948","journal-title":"Clin Case Rep"},{"issue":"Pt 2","key":"6691_CR20","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1258\/acb.2012.012125","volume":"50","author":"D Hoogwerf","year":"2013","unstructured":"Hoogwerf D, van Doorn J, Maartense E (2013) The insulin-like growth factor-system in a patient with diffuse large B-cell non-Hodgkin\u2019s lymphoma and lactic acidosis. Ann Clin Biochem 50(Pt 2):169\u2013172. https:\/\/doi.org\/10.1258\/acb.2012.012125","journal-title":"Ann Clin Biochem"},{"key":"6691_CR21","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-205044","volume":"2014","author":"S Yun","year":"2014","unstructured":"Yun S, Walker CN, Vincelette ND, Anwer F (2014) Acute renal failure and type B lactic acidosis as first manifestation of extranodal T-cell lymphoblastic lymphoma. BMJ Case Rep 2014:bcr2014205044. https:\/\/doi.org\/10.1136\/bcr-2014-205044","journal-title":"BMJ Case Rep"},{"issue":"3","key":"6691_CR22","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1007\/s12185-010-0534-8","volume":"91","author":"K Kulkarni","year":"2010","unstructured":"Kulkarni K, Kaur S, Sibal A, Jerath N, Arya LS (2010) Severe lactic acidosis, hypertriglyceridemia, and extensive axial skeleton involvement in a case of disseminated Burkitt\u2019s lymphoma. Int J Hematol 91(3):546\u2013548. https:\/\/doi.org\/10.1007\/s12185-010-0534-8","journal-title":"Int J Hematol"},{"issue":"11","key":"6691_CR23","doi-asserted-by":"publisher","first-page":"e73084","DOI":"10.7759\/cureus.73084","volume":"16","author":"A Figueiredo","year":"2024","unstructured":"Figueiredo A, Pimentel J, Figueira M, Neves A (2024) Spontaneous tumor Lysis syndrome in a thoracic Burkitt lymphoma: A case report. Cureus 16(11):e73084. https:\/\/doi.org\/10.7759\/cureus.73084","journal-title":"Cureus"},{"issue":"1","key":"6691_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-023-04079-6","volume":"17","author":"Y Cao","year":"2023","unstructured":"Cao Y, Liu MC, Hanlon EL, Chen Y, Afzal MZ, Hayes CA, Hill JM (2023) Clinical presentation of Warburg effect in aggressive lymphoma: a case report. J Med Case Rep 17(1):380. https:\/\/doi.org\/10.1186\/s13256-023-04079-6","journal-title":"J Med Case Rep"},{"issue":"1","key":"6691_CR25","doi-asserted-by":"publisher","first-page":"e20927","DOI":"10.7759\/cureus.20927","volume":"14","author":"A Gkoufa","year":"2022","unstructured":"Gkoufa A, Georgakopoulou VE, Lakiotaki E, Cholongitas E (2022) An unusual presentation of diffuse large B-Cell lymphoma. Cureus 14(1):e20927. https:\/\/doi.org\/10.7759\/cureus.20927","journal-title":"Cureus"},{"issue":"4","key":"6691_CR26","doi-asserted-by":"publisher","first-page":"30","DOI":"10.4322\/acr.2017.034","volume":"7","author":"FMH Ronny","year":"2017","unstructured":"Ronny FMH, Black MA, Arbini AA (2017) Intravascular large B-cell lymphoma with multi-organ failure presenting as a pancreatic mass: a case with atypical presentation and definite diagnosis postmortem. Autops Case Rep 7(4):30\u201336. https:\/\/doi.org\/10.4322\/acr.2017.034","journal-title":"Autops Case Rep"},{"issue":"3","key":"6691_CR27","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1159\/000525843","volume":"15","author":"J Dong","year":"2022","unstructured":"Dong J, Barnett D, Adjei-Kyeremeh N, Bartz H (2022) Diagnosing intravascular large B-cell lymphoma: a tale of hide and seek. Case Rep Oncol 15(3):936\u2013941. https:\/\/doi.org\/10.1159\/000525843","journal-title":"Case Rep Oncol"},{"issue":"1","key":"6691_CR28","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvaa182","volume":"5","author":"I Goyal","year":"2020","unstructured":"Goyal I, Ogbuah C, Chaudhuri A, Quinn T, Sharma R (2020) Confirmed hypoglycemia without Whipple triad: a rare case of Hyper-Warburgism. J Endocr Soc 5(1):bvaa182. https:\/\/doi.org\/10.1210\/jendso\/bvaa182","journal-title":"J Endocr Soc"},{"key":"6691_CR29","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9093623","volume":"2018","author":"M Mejia","year":"2018","unstructured":"Mejia M, Perez A, Watson H, Sanchez D, Parellada J, Madruga M, Carlan SJ (2018) Successful treatment of severe type B lactic acidosis in a patient with HIV\/AIDS-associated high-grade NHL. Case Reports Immunol 2018:9093623. https:\/\/doi.org\/10.1155\/2018\/9093623","journal-title":"Case Reports Immunol"},{"key":"6691_CR30","doi-asserted-by":"publisher","first-page":"177","DOI":"10.7754\/Clin.Lab.2018.180726","volume":"65","author":"L Zhang","year":"2019","unstructured":"Zhang L, Feng Y, Cheng N, Zou Q, Lai W, Liu JJ (2019) A case of renal involvement in B lymphoblastic lymphoma leukemia. Clin Lab 65:177\u2013180. https:\/\/doi.org\/10.7754\/Clin.Lab.2018.180726","journal-title":"Clin Lab"},{"issue":"11","key":"6691_CR31","doi-asserted-by":"publisher","first-page":"e229814","DOI":"10.1136\/bcr-2019-229814","volume":"12","author":"J Albano","year":"2019","unstructured":"Albano J, Patarroyo Aponte GD, Mahmood E (2019) Case of acute hepatic injury and elevated ethanol levels in a non-alcoholic adult. BMJ Case Rep 12(11):e229814. https:\/\/doi.org\/10.1136\/bcr-2019-229814","journal-title":"BMJ Case Rep"},{"key":"6691_CR32","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4642925","volume":"2019","author":"JH Scott","year":"2019","unstructured":"Scott JH, Bains APS, Lindsay TD, Zhao X, Bromberg ME (2019) Severe type B lactic acidosis in a rare and aggressive HIV-related lymphoma. Case Rep Crit Care 2019:4642925. https:\/\/doi.org\/10.1155\/2019\/4642925","journal-title":"Case Rep Crit Care"},{"key":"6691_CR33","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/214970","volume":"2014","author":"M Ijaz","year":"2014","unstructured":"Ijaz M, Tariq H, Niazi M, Lvovsky D (2014) Complete heart block and persistent lactic acidosis as an initial presentation of non-Hodgkin lymphoma in a critically ill newly diagnosed AIDS patient. Case Rep Crit Care 2014:214970. https:\/\/doi.org\/10.1155\/2014\/214970","journal-title":"Case Rep Crit Care"},{"issue":"12","key":"6691_CR34","doi-asserted-by":"publisher","first-page":"4311","DOI":"10.1210\/jc.2012-2327","volume":"97","author":"GC Elhomsy","year":"2012","unstructured":"Elhomsy GC, Eranki V, Albert SG, Fesler MJ, Parker SM, Michael AG, Griffing GT (2012) \"Hyper-warburgism,\" a cause of asymptomatic hypoglycemia with lactic acidosis in a patient with non-Hodgkin\u2019s lymphoma. J Clin Endocrinol Metab 97(12):4311\u20134316. https:\/\/doi.org\/10.1210\/jc.2012-2327","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"6691_CR35","doi-asserted-by":"publisher","first-page":"E49","DOI":"10.1002\/ajh.23904","volume":"90","author":"M Garg","year":"2015","unstructured":"Garg M, Lee BE, McGarry K, Mangray S, Castillo JJ (2015) CD20-negative diffuse large B\u2010cell lymphoma presenting with lactic acidosis. Am J Hematol 90(3):E49\u201350. https:\/\/doi.org\/10.1002\/ajh.23904","journal-title":"Am J Hematol"},{"issue":"2","key":"6691_CR36","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1080\/15384047.2017.1394550","volume":"19","author":"A Wahab","year":"2018","unstructured":"Wahab A, Kesari K, J Smith S, Liu Y, Barta SK (2018) Type B lactic acidosis, an uncommon paraneoplastic syndrome. Cancer Biol Ther 19(2):101\u2013104. https:\/\/doi.org\/10.1080\/15384047.2017.1394550","journal-title":"Cancer Biol Ther"},{"issue":"8","key":"6691_CR37","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.kjms.2013.10.001","volume":"30","author":"CY Kuo","year":"2014","unstructured":"Kuo CY, Yeh ST, Huang CT, Lin SF (2014) Diffuse large B-cell lymphoma presenting with type B lactic acidosis and hemophagocytic syndrome. Kaohsiung J Med Sci 30(8):428\u2013429. https:\/\/doi.org\/10.1016\/j.kjms.2013.10.001","journal-title":"Kaohsiung J Med Sci"},{"issue":"3","key":"6691_CR38","first-page":"416","volume":"43","author":"T Yatabe","year":"2015","unstructured":"Yatabe T, Taniguchi Y, Nishiyama M, Inoue K, Ikezoe T, Fujimoto S, Terada Y, Yokoyama M (2015) Lactic acidosis and asymptomatic hypoglycaemia due to plasmablastic lymphoma. Anaesth Intensive Care 43(3):416\u2013417","journal-title":"Anaesth Intensive Care"},{"key":"6691_CR39","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2021.324","volume":"11","author":"MH Storandt","year":"2021","unstructured":"Storandt MH, Koponen MA (2021) Intravascular large B-cell lymphoma presenting with fever and refractory acidosis. Autops Case Rep 11:e2021324. https:\/\/doi.org\/10.4322\/acr.2021.324","journal-title":"Autops Case Rep"},{"issue":"5","key":"6691_CR40","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1177\/1545109710377803","volume":"9","author":"MH Kestler","year":"2010","unstructured":"Kestler MH, Gardner EM, Cohn DL (2010) Hepatic non-Hodgkin\u2019s lymphoma with lactic acidosis in HIV-infected patients: report of 2 cases. J Int Assoc Physicians AIDS Care (Chic) 9(5):301\u2013305. https:\/\/doi.org\/10.1177\/1545109710377803","journal-title":"J Int Assoc Physicians AIDS Care (Chic)"},{"key":"6691_CR41","doi-asserted-by":"publisher","first-page":"S1243","DOI":"10.14309\/00000434-201810001-02175","volume":"113","author":"M Espinoza","year":"2018","unstructured":"Espinoza M, MunaAguon P, Patel N, Zhou W, Hsiehchen D (2018) A fatal case of severe lactic acidosis and acute liver failure in a patient with primary hepatic lymphoma. Am J Gastroenterol 113:S1243","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"6691_CR42","doi-asserted-by":"publisher","first-page":"319A","DOI":"10.1016\/j.chest.2017.08.345","volume":"152","author":"V Reddy","year":"2017","unstructured":"Reddy V, Black M, Mitchell O, Rivera P, Rapkiewicz A, Gunther I (2017) Invisible assassin: fatal refractory lactic acidosis due to intravascular lymphoma. Chest 152(4):319A. https:\/\/doi.org\/10.1016\/j.chest.2017.08.345","journal-title":"Chest"},{"issue":"4","key":"6691_CR43","doi-asserted-by":"publisher","first-page":"261A","DOI":"10.1378\/chest.2260897","volume":"148","author":"BM SIVASAMBU","year":"2015","unstructured":"SIVASAMBU BM, Yogarajah M (2015) Unusual cause of lactic acidosis and hypoglycemia: burkitt\u2019s lymphoma. Chest 148(4):261A. https:\/\/doi.org\/10.1378\/chest.2260897","journal-title":"Chest"},{"issue":"1","key":"6691_CR44","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/01.ccm.0000528581.60916.c9","volume":"46","author":"G Phadke","year":"2018","unstructured":"Phadke G, Guerrero D, Nagpal A, Khan H, Kherallah M, Hoskote S, Velgersdyk J (2018) Intravascular large B cell lymphoma presenting as hemophagocytic syndrome and type b lactic acidosis. Crit Care Med 46(1):267. https:\/\/doi.org\/10.1097\/01.ccm.0000528581.60916.c9","journal-title":"Crit Care Med"},{"issue":"Suppl 2","key":"6691_CR45","first-page":"S556","volume":"32","author":"S Korzan","year":"2017","unstructured":"Korzan S, Nankani R, Thompson M, Herath S (2017) Ouch my leg! Atypical presentation of Burkitt lymphoma with persistent lactic acidosis and hypoglycemia. J Gen Intern Med 32(Suppl 2):S556\u2013S557","journal-title":"J Gen Intern Med"},{"issue":"4","key":"6691_CR46","doi-asserted-by":"publisher","first-page":"1535A","DOI":"10.1016\/j.chest.2023.07.1054","volume":"164","author":"M Rahim","year":"2023","unstructured":"Rahim M, Zolotov E, Mohammed A, Hochfeld U, Hong SH, Hazaveh S, Pradhan A, Feldman T, De S, Barmaimon G (2023) Refractory type B lactic acidosis with multiorgan failure as the initial presentation of diffuse large B cell lymphoma. Chest 164(4):1535A\u20131536A. https:\/\/doi.org\/10.1016\/j.chest.2023.07.1054","journal-title":"Chest"},{"key":"6691_CR47","first-page":"A1963","volume":"193","author":"T Jain","year":"2016","unstructured":"Jain T, Sanchez JR, Sengupta R, Huda N, Ouellette D (2016) Persistent type B lactic acidosis and hypoglycemia as A complication of burkitt\u2019s lymphoma without hepatic involvement: A rare presentation. Am J Respir Crit Care Med 193:A1963","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"6691_CR48","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1080\/08998280.2017.11929534","volume":"30","author":"U Masood","year":"2017","unstructured":"Masood U, Sharma A, Nijjar S, Sitaraman K (2017) B-cell lymphoma, thiamine deficiency, and lactic acidosis. Proc (Bayl Univ Med Cent) 30(1):69\u201370. https:\/\/doi.org\/10.1080\/08998280.2017.11929534","journal-title":"Proc (Bayl Univ Med Cent)"},{"issue":"6","key":"6691_CR49","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1309\/AJCPAY9ZIS1XEPRO","volume":"143","author":"V Podduturi","year":"2015","unstructured":"Podduturi V, Guileyardo JM, Soto LR, Krause JR (2015) A case series of clinically undiagnosed hematopoietic neoplasms discovered at autopsy. Am J Clin Pathol 143(6):854\u2013860. https:\/\/doi.org\/10.1309\/AJCPAY9ZIS1XEPRO","journal-title":"Am J Clin Pathol"},{"issue":"3","key":"6691_CR50","doi-asserted-by":"publisher","first-page":"e7446","DOI":"10.7759\/cureus.7446","volume":"12","author":"D Griffin","year":"2020","unstructured":"Griffin D, Myadam R, Patel P (2020) Steroid-induced lactic acidosis in diffuse large B-cell lymphoma. Cureus 12(3):e7446. https:\/\/doi.org\/10.7759\/cureus.7446","journal-title":"Cureus"},{"issue":"10","key":"6691_CR51","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1097\/RLU.0b013e3181ef0978","volume":"35","author":"L Huo","year":"2010","unstructured":"Huo L, Luo Y, Zhang T, Zhu Z, Li F, Zhao Y (2010) Unexpected primary osseous lymphoma as the cause of lactic acidosis in a patient suffering from pancreatitis. Clin Nucl Med 35(10):790\u2013793. https:\/\/doi.org\/10.1097\/RLU.0b013e3181ef0978","journal-title":"Clin Nucl Med"},{"issue":"7","key":"6691_CR52","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1111\/j.1572-0241.2003.07536.x","volume":"98","author":"CJ Lettieri","year":"2003","unstructured":"Lettieri CJ, Berg BW (2003) Clinical features of non-Hodgkins lymphoma presenting with acute liver failure: a report of five cases and review of published experience. Am J Gastroenterol 98(7):1641\u20131646. https:\/\/doi.org\/10.1111\/j.1572-0241.2003.07536.x","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"6691_CR53","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.218","volume":"4","author":"S Nong","year":"2023","unstructured":"Nong S, Han X, Xiang Y, Qian Y, Wei Y, Zhang T, Tian K, Shen K, Yang J, Ma X (2023) Metabolic reprogramming in cancer: mechanisms and therapeutics. MedComm 4(2):e218. https:\/\/doi.org\/10.1002\/mco2.218","journal-title":"MedComm"},{"issue":"1","key":"6691_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08964-1","volume":"7","author":"TJ Kim","year":"2017","unstructured":"Kim TJ, Kim ER, Hong SN, Kim YH, Chang DK, Ji J, Kim JE, Kim HS, Kim K, Son HJ (2017) Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia. Sci Rep 7(1):9011. https:\/\/doi.org\/10.1038\/s41598-017-08964-1","journal-title":"Sci Rep"},{"issue":"3","key":"6691_CR55","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1093\/annonc\/mdq403","volume":"22","author":"M Picardi","year":"2011","unstructured":"Picardi M, Soricelli A, Grimaldi F, Nicolai E, Gallamini A, Pane F (2011) Fused FDG\u2013PET\/contrast-enhanced CT detects occult subdiaphragmatic involvement of Hodgkin\u2019s lymphoma thereby identifying patients requiring six cycles of anthracycline-containing chemotherapy and consolidation radiation of spleen. Ann Oncol 22(3):671\u2013680. https:\/\/doi.org\/10.1093\/annonc\/mdq403","journal-title":"Ann Oncol"},{"issue":"4","key":"6691_CR56","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s00277-017-2926-9","volume":"96","author":"N Pugliese","year":"2017","unstructured":"Pugliese N, Di Perna M, Cozzolino I, Ciancia G, Pettinato G, Zeppa P, Varone V, Masone S, Cerchione C, Della Pepa R, Simeone L, Giordano C, Martinelli V, Salvatore C, Pane F, Picardi M (2017) Randomized comparison of power doppler ultrasonography-guided core-needle biopsy with open surgical biopsy for the characterization of lymphadenopathies in patients with suspected lymphoma. Ann Hematol 96(4):627\u2013637. https:\/\/doi.org\/10.1007\/s00277-017-2926-9","journal-title":"Ann Hematol"},{"issue":"5","key":"6691_CR57","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1002\/hon.3204","volume":"41","author":"M Picardi","year":"2023","unstructured":"Picardi M, Giordano C, Vigliar E, Zeppa P, Cozzolino I, Pugliese N, Della Pepa R, Esposito M, Abagnale DP, Ciriello M, Muccioli Casadei G, Troncone G, Russo D, Mascolo M, Varricchio S, Accarino R, Persico M, Pane F (2023) Ultrasonography-guided core\u2010needle biopsy of lymphadenopathies suspected of lymphoma: analysis on diagnostic efficacy and safety of 1000 front\u2010line biopsies in a multicenter Italian study. Hematol Oncol 41(5):817\u2013827. https:\/\/doi.org\/10.1002\/hon.3204","journal-title":"Hematol Oncol"},{"key":"6691_CR58","doi-asserted-by":"publisher","unstructured":"Picardi M, Giordano C, Vincenzi A, Pugliese N, Scarpa A, Mascolo M, Vigliar E, Troncone G, Salvatore C, Pane F (2025) Ultrasonography-guided core\u2010needle biopsy for newly diagnosed large b-cell lymphomas: analysis on diagnostic efficacy and safety in an italian retrospective study. Acta Haematol 1\u201316. https:\/\/doi.org\/10.1159\/000544794","DOI":"10.1159\/000544794"},{"issue":"6","key":"6691_CR59","first-page":"652","volume":"87","author":"M Picardi","year":"2002","unstructured":"Picardi M, Muretto P, De Rosa G, Selleri C, De Renzo A, Persico M, Rotoli B (2002) Color ultrasound-guided fine needle cutting biopsy for the characterization of diffuse liver damage in critical bone marrow transplanted patients. Haematologica 87(6):652\u2013657","journal-title":"Haematologica"},{"issue":"6","key":"6691_CR60","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/sj.bmt.1701390","volume":"22","author":"M Picardi","year":"1998","unstructured":"Picardi M, De Rosa G, Muretto P, Pezzullo L, Raiola A, Rotoli B (1998) Ultrasound-guided fine needle cutting biopsy for the characterization of diffuse liver diseases in bone marrow transplant patients. Bone Marrow Transplant 22(6):571\u2013573. https:\/\/doi.org\/10.1038\/sj.bmt.1701390","journal-title":"Bone Marrow Transplant"},{"issue":"11","key":"6691_CR61","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1177\/0885066619854355","volume":"35","author":"RB Chebl","year":"2020","unstructured":"Chebl RB, Tamim H, Dagher GA, Sadat M, Enezi FA, Arabi YM (2020) Serum lactate as an independent predictor of in-hospital mortality in intensive care patients. J Intensive Care Med 35(11):1257\u20131264. https:\/\/doi.org\/10.1177\/0885066619854355","journal-title":"J Intensive Care Med"},{"issue":"4","key":"6691_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.retram.2024.103451","volume":"72","author":"SMK Bozgul","year":"2024","unstructured":"Bozgul SMK, Kurtulmus IA, Gunes A, Koymen G, Bozkurt D, Karaman ZT, Islamoglu K, Ozkilic B, Barutcuoglu B, Cilli FF, Soyer NA (2024) Lactate level is an independent predictor of mortality in patients with hematologic malignancy receiving urgent chemotherapy in intensive care unit. Curr Res Transl Med 72(4):103451. https:\/\/doi.org\/10.1016\/j.retram.2024.103451","journal-title":"Curr Res Transl Med"},{"issue":"6","key":"6691_CR63","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20160385","volume":"36","author":"MM Adeva-Andany","year":"2016","unstructured":"Adeva-Andany MM, P\u00e9rez-Felpete N, Fern\u00e1ndez-Fern\u00e1ndez C, Donapetry-Garc\u00eda C, Pazos-Garc\u00eda C (2016) Liver glucose metabolism in humans. Biosci Rep 36(6):e00416. https:\/\/doi.org\/10.1042\/BSR20160385","journal-title":"Biosci Rep"},{"issue":"7964","key":"6691_CR64","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/s41586-023-06114-4","volume":"618","author":"G Wang","year":"2023","unstructured":"Wang G, Li J, Bojmar L, Chen H, Li Z, Tobias GC, Hu M, Homan EA, Lucotti S, Zhao F, Posada V, Oxley PR, Cioffi M, Kim HS, Wang H, Lauritzen P, Boudreau N, Shi Z, Burd CE, Zippin JH, Lo JC, Pitt GS, Hernandez J, Zambirinis CP, Hollingsworth MA, Grandgenett PM, Jain M, Batra SK, DiMaio DJ, Grem JL, Klute KA, Trippett TM, Egeblad M, Paul D, Bromberg J, Kelsen D, Rajasekhar VK, Healey JH, Matei IR, Jarnagin WR, Schwartz RE, Zhang H, Lyden D (2023) Tumour extracellular vesicles and particles induce liver metabolic dysfunction. Nature 618(7964):374\u2013382. https:\/\/doi.org\/10.1038\/s41586-023-06114-4","journal-title":"Nature"},{"issue":"2","key":"6691_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2022.100675","volume":"27","author":"P Katopodis","year":"2022","unstructured":"Katopodis P, Pappas EM, Katopodis KP (2022) Acid-base abnormalities and liver dysfunction. Ann Hepatol 27(2):100675. https:\/\/doi.org\/10.1016\/j.aohep.2022.100675","journal-title":"Ann Hepatol"},{"issue":"17","key":"6691_CR66","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231710037","volume":"23","author":"A Fukushi","year":"2022","unstructured":"Fukushi A, Kim HD, Chang YC, Kim CH (2022) Revisited metabolic control and reprogramming cancers by means of the Warburg effect in tumor cells. Int J Mol Sci 23(17):10037. https:\/\/doi.org\/10.3390\/ijms231710037","journal-title":"Int J Mol Sci"},{"issue":"41","key":"6691_CR67","doi-asserted-by":"publisher","first-page":"15947","DOI":"10.1074\/jbc.RA118.004180","volume":"293","author":"M \u017ddralevi\u0107","year":"2018","unstructured":"\u017ddralevi\u0107 M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, Peter K, Schnell A, Bruss C, Decking S, Koehl G, Felipe-Abrio B, Durivault J, Bayer P, Evangelista M, O\u2019Brien T, Oefner PJ, Renner K, Pouyss\u00e9gur J, Kreutz M (2018) Double genetic disruption of lactate dehydrogenases A and B is required to ablate the \"Warburg effect\" restricting tumor growth to oxidative metabolism. J Biol Chem 293(41):15947\u201315961. https:\/\/doi.org\/10.1074\/jbc.RA118.004180","journal-title":"J Biol Chem"},{"key":"6691_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216459","volume":"578","author":"N Kumar","year":"2023","unstructured":"Kumar N, Sethi G (2023) Telomerase and hallmarks of cancer: an intricate interplay governing cancer cell evolution. Cancer Lett 578:216459. https:\/\/doi.org\/10.1016\/j.canlet.2023.216459","journal-title":"Cancer Lett"},{"issue":"1","key":"6691_CR69","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-024-00519-1","volume":"13","author":"Z Shi","year":"2024","unstructured":"Shi Z, Hu C, Zheng X, Sun C, Li Q (2024) Feedback loop between hypoxia and energy metabolic reprogramming aggravates the radioresistance of cancer cells. Exp Hematol Oncol 13(1):55. https:\/\/doi.org\/10.1186\/s40164-024-00519-1","journal-title":"Exp Hematol Oncol"},{"issue":"20","key":"6691_CR70","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12206453","volume":"12","author":"G Wang","year":"2023","unstructured":"Wang G, Lian H, Zhang H, Wang X (2023) Microcirculation and mitochondria: the critical unit. J Clin Med 12(20):6453. https:\/\/doi.org\/10.3390\/jcm12206453","journal-title":"J Clin Med"},{"key":"6691_CR71","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1257651","volume":"11","author":"J Purhonen","year":"2023","unstructured":"Purhonen J, Klefstr\u00f6m J, Kallij\u00e4rvi J (2023) MYC\u2014an emerging player in mitochondrial diseases. Front Cell Dev Biol 11:1257651. https:\/\/doi.org\/10.3389\/fcell.2023.1257651","journal-title":"Front Cell Dev Biol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06691-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-025-06691-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-025-06691-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T02:31:06Z","timestamp":1764729066000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-025-06691-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":71,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["6691"],"URL":"https:\/\/doi.org\/10.1007\/s00277-025-06691-6","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]},"assertion":[{"value":"11 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board of the Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine) (protocol code 2024NL-146-02).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Ethical approval"}},{"value":"All authors review the manuscript and agree to its publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}