{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:38:05Z","timestamp":1789767485901,"version":"4.0.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This retrospective cohort study investigated the diagnostic performance of cerebrospinal fluid (CSF) \u03b22-microglobulin (\u03b22-M) in patients with central nervous system lymphoma (CNSL). Between January 2018 and August 2024, 1,349 hospitalized patients with CSF \u03b22-M in our center were categorized into lymphoma, leukemia, solid tumor, and other disease cohorts, with additional stratification by central nervous system involvement. CSF \u03b22-M concentrations were markedly elevated in CNSL relative to all other comparator groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). A cut-off value of 1.85\u00a0mg\/L discriminated CNSL from non-CNS-involved lymphoma with high diagnostic accuracy, yielding 85.7% sensitivity and 89.7% specificity. Longitudinal assessment further demonstrated that dynamic CSF \u03b22-M trajectories correlated with therapeutic response and relapse risk. Collectively, these findings establish CSF \u03b22-microglobulin as a reliable, accessible, and cost-effective diagnostic biomarker for CNSL.\n                  <\/jats:p>","DOI":"10.1007\/s00277-025-06719-x","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:49:41Z","timestamp":1762760981000},"page":"5711-5718","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebrospinal fluid \u03b22-microglobulin as a diagnostic biomarker in central nervous system lymphoma: a single-center retrospective analysis"],"prefix":"10.1007","volume":"104","author":[{"given":"Yijun","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouzhou","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunzong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"6719_CR1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/nop\/npz015","volume":"6","author":"AA Morell","year":"2019","unstructured":"Morell AA, Shah AH, Cavallo C et al (2019) Diagnosis of primary central nervous system lymphoma: a systematic review of the utility of CSF screening and the role of early brain biopsy. 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