{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:39:17Z","timestamp":1785865157070,"version":"3.56.0"},"reference-count":144,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Platelet transfusion is a cornerstone of modern supportive care, yet its application is characterized by significant practice variation and uncertainty regarding optimal strategies. This comprehensive review synthesizes current evidence to delineate a more nuanced, physiologically informed approach to platelet therapy. A paradigm shift is underway, moving from uniform count-based triggers toward more restrictive, evidence-based practices; this includes prophylactic thresholds of &lt;\u200910\u2009\u00d7\u200910\u2079\/L in stable hematology-oncology patients and therapeutic-only strategies in select populations. In massive hemorrhage, fixed-ratio resuscitation protocols incorporating early platelet administration are critical for improving hemostasis. Conversely, high-quality evidence now defines populations where transfusion may be harmful, including in thrombotic microangiopathies like TTP, heparin-induced thrombocytopenia, and spontaneous intracerebral hemorrhage in patients on antiplatelet agents. The utility of viscoelastic assays in guiding goal-directed therapy and the potential of novel products such as pathogen-reduced, cold-stored, and cryopreserved platelets to mitigate the limitations of conventional storage are also critically examined. This review provides clinicians with a framework to navigate these complexities, emphasizing a context-dependent strategy that balances hemostatic benefit against potential harm to optimize patient outcomes and steward a precious resource.<\/jats:p>","DOI":"10.1007\/s00277-026-06758-y","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:51:14Z","timestamp":1768441874000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The evolving landscape of platelet therapy: risks, innovations, and clinical judgment"],"prefix":"10.1007","volume":"105","author":[{"given":"Ali","family":"Mushtaq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moises","family":"Salgado de la Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al-Homam","family":"Dabaliz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaher","family":"Otrock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Tolich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moises","family":"Auron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"6758_CR1","doi-asserted-by":"crossref","unstructured":"Trochanowska-Pauk N, Walski T, Bohara R, Mikolas J, Kubica K (2024) Platelet storage-problems, improvements, and new perspectives. Int J Mol Sci 25(14)","DOI":"10.3390\/ijms25147779"},{"issue":"8","key":"6758_CR2","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/vox.12917","volume":"115","author":"MH Yazer","year":"2020","unstructured":"Yazer MH, Shaz B, Seheult JN et al (2020) Trends in platelet distributions from 2008 to 2017: a survey of twelve National and regional blood collectors. Vox Sang 115(8):703\u2013711","journal-title":"Vox Sang"},{"issue":"9","key":"6758_CR3","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1111\/trf.13676","volume":"56","author":"B Whitaker","year":"2016","unstructured":"Whitaker B, Rajbhandary S, Kleinman S, Harris A, Kamani N (2016) Trends in united States blood collection and transfusion: results from the 2013 AABB blood Collection, Utilization, and patient blood management survey. Transfusion 56(9):2173\u20132183","journal-title":"Transfusion"},{"key":"6758_CR4","doi-asserted-by":"crossref","unstructured":"Metcalf RA, Nahirniak S, Guyatt G et al (2025) Platelet transfusion: 2025 AABB and ICTMG international clinical practice guidelines. JAMA","DOI":"10.1001\/jama.2025.7529"},{"issue":"8","key":"6758_CR5","doi-asserted-by":"publisher","first-page":"3433","DOI":"10.1007\/s00431-023-05031-y","volume":"182","author":"HS Ribeiro","year":"2023","unstructured":"Ribeiro HS, Assuncao A, Vieira RJ, Soares P, Guimaraes H, Flor-de-Lima F (2023) Platelet transfusions in preterm infants: current concepts and controversies-a systematic review and meta-analysis. Eur J Pediatr 182(8):3433\u20133443","journal-title":"Eur J Pediatr"},{"issue":"46","key":"6758_CR6","doi-asserted-by":"publisher","first-page":"e36072","DOI":"10.1097\/MD.0000000000036072","volume":"102","author":"Y Lin","year":"2023","unstructured":"Lin Y, Liu Y, Liu L et al (2023) Platelet transfusion for spontaneous intracerebral hemorrhage with prior antiplatelet: A systematic review and meta-analysis. Med (Baltim) 102(46):e36072","journal-title":"Med (Baltim)"},{"issue":"18","key":"6758_CR7","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1182\/blood.2022016558","volume":"140","author":"SJ Stanworth","year":"2022","unstructured":"Stanworth SJ, Shah A (2022) How I use platelet transfusions. Blood 140(18):1925\u20131936","journal-title":"Blood"},{"issue":"26","key":"6758_CR8","doi-asserted-by":"publisher","first-page":"3688","DOI":"10.1182\/blood.2021014889","volume":"139","author":"VJ Kogler","year":"2022","unstructured":"Kogler VJ, Stolla M (2022) There and back again: the once and current developments in donor-derived platelet products for hemostatic therapy. Blood 139(26):3688\u20133698","journal-title":"Blood"},{"issue":"1","key":"6758_CR9","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/MOH.0000000000000843","volume":"32","author":"A Mo","year":"2025","unstructured":"Mo A, Wood E, McQuilten Z (2025) Platelet transfusion. Curr Opin Hematol 32(1):14\u201321","journal-title":"Curr Opin Hematol"},{"issue":"5","key":"6758_CR10","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/j.1365-2141.2006.06215.x","volume":"134","author":"VR Deutsch","year":"2006","unstructured":"Deutsch VR, Tomer A (2006) Megakaryocyte development and platelet production. Br J Haematol 134(5):453\u2013466","journal-title":"Br J Haematol"},{"key":"6758_CR11","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1196\/annals.1349.018","volume":"1044","author":"K Kaushansky","year":"2005","unstructured":"Kaushansky K (2005) Thrombopoietin and the hematopoietic stem cell. Ann N Y Acad Sci 1044:139\u2013141","journal-title":"Ann N Y Acad Sci"},{"issue":"19","key":"6758_CR12","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1056\/NEJMra052706","volume":"354","author":"K Kaushansky","year":"2006","unstructured":"Kaushansky K (2006) Lineage-specific hematopoietic growth factors. N Engl J Med 354(19):2034\u20132045","journal-title":"N Engl J Med"},{"issue":"3","key":"6758_CR13","first-page":"192","volume":"35","author":"MW Long","year":"1998","unstructured":"Long MW (1998) Megakaryocyte differentiation events. Semin Hematol 35(3):192\u2013199","journal-title":"Semin Hematol"},{"issue":"12","key":"6758_CR14","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1172\/JCI26674","volume":"115","author":"K Kaushansky","year":"2005","unstructured":"Kaushansky K (2005) The molecular mechanisms that control thrombopoiesis. J Clin Invest 115(12):3339\u20133347","journal-title":"J Clin Invest"},{"issue":"3","key":"6758_CR15","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1055\/s-0035-1564835","volume":"42","author":"T Gremmel","year":"2016","unstructured":"Gremmel T, Frelinger AL 3rd, Michelson AD (2016) Platelet physiology. Semin Thromb Hemost 42(3):191\u2013204","journal-title":"Semin Thromb Hemost"},{"issue":"1","key":"6758_CR16","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1161\/01.ATV.0000193624.28251.83","volume":"26","author":"DM Monroe","year":"2006","unstructured":"Monroe DM, Hoffman M (2006) What does it take to make the perfect clot? Arterioscler Thromb Vasc Biol 26(1):41\u201348","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"6758_CR17","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.ccell.2013.08.003","volume":"25","author":"EM Greenberg","year":"2013","unstructured":"Greenberg EM, Kaled ES (2013) Thrombocytopenia. Crit Care Nurs Clin North Am 25(4):427\u2013434","journal-title":"Crit Care Nurs Clin North Am"},{"issue":"6","key":"6758_CR18","first-page":"612","volume":"85","author":"RL Gauer","year":"2012","unstructured":"Gauer RL, Braun MM (2012) Thrombocytopenia. Am Fam Physician 85(6):612\u2013622","journal-title":"Am Fam Physician"},{"issue":"1","key":"6758_CR19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1080\/17474086.2017.1271319","volume":"10","author":"M Franchini","year":"2017","unstructured":"Franchini M, Veneri D, Lippi G (2017) Thrombocytopenia and infections. Expert Rev Hematol 10(1):99\u2013106","journal-title":"Expert Rev Hematol"},{"issue":"3","key":"6758_CR20","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1055\/s-0039-1697930","volume":"46","author":"E Danese","year":"2020","unstructured":"Danese E, Montagnana M, Favaloro EJ, Lippi G (2020) Drug-induced thrombocytopenia: mechanisms and laboratory diagnostics. Semin Thromb Hemost 46(3):264\u2013274","journal-title":"Semin Thromb Hemost"},{"key":"6758_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.alcohol.2020.02.166","volume":"86","author":"A Silczuk","year":"2020","unstructured":"Silczuk A, Habrat B (2020) Alcohol-induced thrombocytopenia: current review. Alcohol 86:9\u201316","journal-title":"Alcohol"},{"issue":"10","key":"6758_CR22","doi-asserted-by":"publisher","first-page":"342","DOI":"10.31083\/j.fbl2910342","volume":"29","author":"Z Tariq","year":"2024","unstructured":"Tariq Z, Qadeer MI, Zahid K, Cherepkova EV, Olzhayev ST (2024) Immune thrombocytopenia: immune dysregulation and genetic perturbations Deciphering the fate of platelets. Front Biosci (Landmark Ed) 29(10):342","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"6","key":"6758_CR23","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.hoc.2017.08.010","volume":"31","author":"S Kappler","year":"2017","unstructured":"Kappler S, Ronan-Bentle S, Graham A (2017) Thrombotic microangiopathies (TTP, HUS, HELLP). Hematol Oncol Clin North Am 31(6):1081\u20131103","journal-title":"Hematol Oncol Clin North Am"},{"issue":"1","key":"6758_CR24","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1038\/s41598-018-38086-1","volume":"9","author":"M Grodzielski","year":"2019","unstructured":"Grodzielski M, Goette NP, Glembotsky AC et al (2019) Multiple concomitant mechanisms contribute to low platelet count in patients with immune thrombocytopenia. Sci Rep 9(1):2208","journal-title":"Sci Rep"},{"issue":"1","key":"6758_CR25","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1182\/hematology.2023000465","volume":"2023","author":"R Jesudas","year":"2023","unstructured":"Jesudas R, Takemoto CM (2023) Where have all the platelets gone? HIT, DIC, or something else? Hematol Am Soc Hematol Educ Program 2023(1):43\u201350","journal-title":"Hematol Am Soc Hematol Educ Program"},{"issue":"3","key":"6758_CR26","first-page":"229","volume":"23","author":"M Mah\u00e9vas","year":"2006","unstructured":"Mah\u00e9vas M, Le Page L, Salle V et al (2006) Thrombocytopenia in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 23(3):229\u2013235","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"issue":"1","key":"6758_CR27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s10067-024-07235-5","volume":"44","author":"Z Zheng","year":"2025","unstructured":"Zheng Z, Liu J, Yun M et al (2025) Immune thrombocytopenia in patients with systemic lupus erythematosus. Clin Rheumatol 44(1):97\u2013104","journal-title":"Clin Rheumatol"},{"issue":"7","key":"6758_CR28","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1177\/1535370217693113","volume":"242","author":"Y Lv","year":"2017","unstructured":"Lv Y, Yee Lau W, Wu H et al (2017) Causes of peripheral cytopenia in hepatitic cirrhosis and portal hypertensive splenomegaly. Exp Biol Med (Maywood) 242(7):744\u2013749","journal-title":"Exp Biol Med (Maywood)"},{"issue":"3","key":"6758_CR29","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.3892\/mmr.2015.3971","volume":"12","author":"JC Yang","year":"2015","unstructured":"Yang JC, Sun Y, Xu CX et al (2015) Coagulation defects associated with massive blood transfusion: A large multicenter study. Mol Med Rep 12(3):4179\u20134186","journal-title":"Mol Med Rep"},{"issue":"6","key":"6758_CR30","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1111\/j.1572-0241.2005.41543.x","volume":"100","author":"R Rios","year":"2005","unstructured":"Rios R, Sangro B, Herrero I, Quiroga J, Prieto J (2005) The role of thrombopoietin in the thrombocytopenia of patients with liver cirrhosis. Am J Gastroenterol 100(6):1311\u20131316","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"6758_CR31","first-page":"829","volume":"60","author":"MO Padden","year":"1999","unstructured":"Padden MO (1999) HELLP syndrome: recognition and perinatal management. Am Fam Physician 60(3):829\u2013836","journal-title":"Am Fam Physician"},{"issue":"12","key":"6758_CR32","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1182\/blood-2010-03-276691","volume":"116","author":"JA Reese","year":"2010","unstructured":"Reese JA, Li X, Hauben M et al (2010) Identifying drugs that cause acute thrombocytopenia: an analysis using 3 distinct methods. Blood 116(12):2127\u20132133","journal-title":"Blood"},{"key":"6758_CR33","doi-asserted-by":"crossref","unstructured":"Vayne C, Guery EA, Rollin J, Baglo T, Petermann R, Gruel Y (2020) Pathophysiology and diagnosis of drug-induced immune thrombocytopenia. J Clin Med 9(7)","DOI":"10.3390\/jcm9072212"},{"issue":"4","key":"6758_CR34","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/jcph.2389","volume":"64","author":"L Kunyu","year":"2024","unstructured":"Kunyu L, Shuping S, Chang S et al (2024) An updated comprehensive pharmacovigilance study of Drug-Induced thrombocytopenia based on FDA adverse event reporting system data. J Clin Pharmacol 64(4):478\u2013489","journal-title":"J Clin Pharmacol"},{"key":"6758_CR35","doi-asserted-by":"crossref","unstructured":"George JN, Sadler JE, L\u00e4mmle B (2002) Platelets: thrombotic thrombocytopenic purpura. Hematol Am Soc Hematol Educ Program 315\u2013334","DOI":"10.1182\/asheducation-2002.1.315"},{"issue":"1","key":"6758_CR36","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.1038\/s41598-023-27824-9","volume":"13","author":"S Zhou","year":"2023","unstructured":"Zhou S, Song B, Li C et al (2023) The predictive model for risk of chemotherapy-induced thrombocytopenia based on antineoplastic drugs for solid tumors in Eastern China. Sci Rep 13(1):3185","journal-title":"Sci Rep"},{"issue":"6","key":"6758_CR37","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.3324\/haematol.2021.279512","volume":"107","author":"DJ Kuter","year":"2022","unstructured":"Kuter DJ (2022) Treatment of chemotherapy-induced thrombocytopenia in patients with non-hematologic malignancies. Haematologica 107(6):1243\u20131263","journal-title":"Haematologica"},{"key":"6758_CR38","doi-asserted-by":"publisher","first-page":"1549214","DOI":"10.3389\/fphar.2025.1549214","volume":"16","author":"H Yang","year":"2025","unstructured":"Yang H, Xu X, Tan M et al (2025) Efficacy and safety of different treatments in chemotherapy-induced thrombocytopenia: a systematic review and network meta-analysis. Front Pharmacol 16:1549214","journal-title":"Front Pharmacol"},{"issue":"6","key":"6758_CR39","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s12185-017-2319-9","volume":"106","author":"ES Winer","year":"2017","unstructured":"Winer ES, Safran H, Karaszewska B et al (2017) Eltrombopag for thrombocytopenia in patients with advanced solid tumors receiving gemcitabine-based chemotherapy: a randomized, placebo-controlled phase 2 study. Int J Hematol 106(6):765\u2013776","journal-title":"Int J Hematol"},{"issue":"15","key":"6758_CR40","doi-asserted-by":"publisher","first-page":"e7429","DOI":"10.1002\/cam4.7429","volume":"13","author":"GA Soff","year":"2024","unstructured":"Soff GA, Al-Samkari H, Leader A, Eisen M, Saad H (2024) Romiplostim in chemotherapy-induced thrombocytopenia: A review of the literature. Cancer Med 13(15):e7429","journal-title":"Cancer Med"},{"key":"6758_CR41","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.thromres.2019.06.009","volume":"196","author":"Y Brennan","year":"2020","unstructured":"Brennan Y, Levade M, Ward CM (2020) Acquired platelet function disorders. Thromb Res 196:561\u2013568","journal-title":"Thromb Res"},{"key":"6758_CR42","doi-asserted-by":"crossref","unstructured":"Boggio F, Giannotta JA, Lecchi A (2025) Automation in platelet function testing: current challenges and future directions. Semin Thromb Hemost","DOI":"10.1055\/a-2622-3545"},{"issue":"8","key":"6758_CR43","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1055\/s-0032-1328881","volume":"38","author":"RE Scharf","year":"2012","unstructured":"Scharf RE (2012) Drugs that affect platelet function. Semin Thromb Hemost 38(8):865\u2013883","journal-title":"Semin Thromb Hemost"},{"key":"6758_CR44","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1182\/asheducation-2011.1.391","volume":"2011","author":"BA Konkle","year":"2011","unstructured":"Konkle BA (2011) Acquired disorders of platelet function. Hematol Am Soc Hematol Educ Program 2011:391\u2013396","journal-title":"Hematol Am Soc Hematol Educ Program"},{"issue":"10","key":"6758_CR45","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1056\/NEJMcp1810479","volume":"381","author":"N Cooper","year":"2019","unstructured":"Cooper N, Ghanima W (2019) Immune thrombocytopenia. N Engl J Med 381(10):945\u2013955","journal-title":"N Engl J Med"},{"issue":"13","key":"6758_CR46","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1182\/blood.2020007208","volume":"139","author":"NI Popescu","year":"2022","unstructured":"Popescu NI, Lupu C, Lupu F (2022) Disseminated intravascular coagulation and its immune mechanisms. Blood 139(13):1973\u20131986","journal-title":"Blood"},{"issue":"3","key":"6758_CR47","doi-asserted-by":"publisher","first-page":"205","DOI":"10.7326\/M14-1589","volume":"162","author":"RM Kaufman","year":"2015","unstructured":"Kaufman RM, Djulbegovic B, Gernsheimer T et al (2015) Platelet transfusion: a clinical practice guideline from the AABB. Ann Intern Med 162(3):205\u2013213","journal-title":"Ann Intern Med"},{"issue":"2","key":"6758_CR48","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1200\/JOP.2017.028902","volume":"14","author":"CA Schiffer","year":"2018","unstructured":"Schiffer CA, Bohlke K, Anderson KC (2018) Platelet transfusion for patients with cancer: American society of clinical oncology clinical practice guideline update summary. J Oncol Pract 14(2):129\u2013133","journal-title":"J Oncol Pract"},{"issue":"4","key":"6758_CR49","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.cll.2021.07.005","volume":"41","author":"S Yuan","year":"2021","unstructured":"Yuan S, Otrock ZK (2021) Platelet transfusion: an update on indications and guidelines. Clin Lab Med 41(4):621\u2013634","journal-title":"Clin Lab Med"},{"issue":"7","key":"6758_CR50","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1056\/NEJMoa0904084","volume":"362","author":"SJ Slichter","year":"2010","unstructured":"Slichter SJ, Kaufman RM, Assmann SF et al (2010) Dose of prophylactic platelet transfusions and prevention of hemorrhage. N Engl J Med 362(7):600\u2013613","journal-title":"N Engl J Med"},{"issue":"2","key":"6758_CR51","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.transci.2013.02.004","volume":"48","author":"PF van der Meer","year":"2013","unstructured":"van der Meer PF (2013) Platelet concentrates, from whole blood or collected by apheresis? Transfus Apher Sci 48(2):129\u2013131","journal-title":"Transfus Apher Sci"},{"key":"6758_CR52","doi-asserted-by":"crossref","unstructured":"Capraru A, Jalowiec KA, Medri C, Daskalakis M, Zeerleder SS, Mansouri Taleghani B (2021) Platelet Transfusion-Insights from current practice to future development. J Clin Med 10(9)","DOI":"10.3390\/jcm10091990"},{"issue":"1","key":"6758_CR53","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1046\/j.1365-3148.1997.d01-73.x","volume":"7","author":"NA Anderson","year":"1997","unstructured":"Anderson NA, Gray S, Copplestone JA et al (1997) A prospective randomized study of three types of platelet concentrates in patients with haematological malignancy: corrected platelet count increments and frequency of nonhaemolytic febrile transfusion reactions. Transfus Med 7(1):33\u201339","journal-title":"Transfus Med"},{"issue":"12","key":"6758_CR54","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1111\/j.1537-2995.2009.02338.x","volume":"49","author":"EC Vamvakas","year":"2009","unstructured":"Vamvakas EC (2009) Relative safety of pooled whole blood-derived versus single-donor (apheresis) platelets in the united states: a systematic review of disparate risks. Transfusion 49(12):2743\u20132758","journal-title":"Transfusion"},{"issue":"23","key":"6758_CR55","doi-asserted-by":"publisher","first-page":"5553","DOI":"10.1182\/blood-2011-11-393165","volume":"119","author":"DJ Triulzi","year":"2012","unstructured":"Triulzi DJ, Assmann SF, Strauss RG et al (2012) The impact of platelet transfusion characteristics on posttransfusion platelet increments and clinical bleeding in patients with hypoproliferative thrombocytopenia. Blood 119(23):5553\u20135562","journal-title":"Blood"},{"issue":"7","key":"6758_CR56","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1111\/j.1537-2995.2008.01731.x","volume":"48","author":"NM Heddle","year":"2008","unstructured":"Heddle NM, Arnold DM, Boye D, Webert KE, Resz I, Dumont LJ (2008) Comparing the efficacy and safety of apheresis and whole blood-derived platelet transfusions: a systematic review. Transfusion 48(7):1447\u20131458","journal-title":"Transfusion"},{"issue":"2","key":"6758_CR57","first-page":"109","volume":"14","author":"O Garraud","year":"2016","unstructured":"Garraud O, Cognasse F, Tissot JD et al (2016) Improving platelet transfusion safety: biomedical and technical considerations. Blood Transfus 14(2):109\u2013122","journal-title":"Blood Transfus"},{"issue":"2","key":"6758_CR58","first-page":"143","volume":"12","author":"EC Vamvakas","year":"2014","unstructured":"Vamvakas EC (2014) The abandoned controversy surrounding universal white blood cell reduction. Blood Transfus 12(2):143\u2013145","journal-title":"Blood Transfus"},{"issue":"6","key":"6758_CR59","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/00062752-200111000-00013","volume":"8","author":"PM Ness","year":"2001","unstructured":"Ness PM, Campbell-Lee SA (2001) Single donor versus pooled random donor platelet concentrates. Curr Opin Hematol 8(6):392\u2013396","journal-title":"Curr Opin Hematol"},{"issue":"5","key":"6758_CR60","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1111\/bjh.17015","volume":"191","author":"T Foukaneli","year":"2020","unstructured":"Foukaneli T, Kerr P, Bolton-Maggs PHB et al (2020) Guidelines on the use of irradiated blood components. Br J Haematol 191(5):704\u2013724","journal-title":"Br J Haematol"},{"issue":"3","key":"6758_CR61","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1182\/blood-2015-01-620872","volume":"126","author":"I Kopolovic","year":"2015","unstructured":"Kopolovic I, Ostro J, Tsubota H et al (2015) A systematic review of transfusion-associated graft-versus-host disease. Blood 126(3):406\u2013414","journal-title":"Blood"},{"issue":"4","key":"6758_CR62","doi-asserted-by":"publisher","first-page":"150840","DOI":"10.1016\/j.tmrv.2024.150840","volume":"38","author":"L Cain","year":"2024","unstructured":"Cain L, Geneen LJ, Wiltshire M et al (2024) Universal irradiation of platelets: does irradiation affect the quality, effectiveness, and safety of platelets for transfusion? Transfus Med Rev 38(4):150840","journal-title":"Transfus Med Rev"},{"issue":"3","key":"6758_CR63","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tracli.2018.07.001","volume":"25","author":"O Garraud","year":"2018","unstructured":"Garraud O, Lozano M (2018) Pathogen inactivation\/reduction technologies for platelet transfusion: where do we stand? Transfus Clin Biol 25(3):165\u2013171","journal-title":"Transfus Clin Biol"},{"issue":"1","key":"6758_CR64","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/09537104.2017.1306046","volume":"29","author":"A Magron","year":"2018","unstructured":"Magron A, Laugier J, Provost P, Boilard E (2018) Pathogen reduction technologies: the pros and cons for platelet transfusion. Platelets 29(1):2\u20138","journal-title":"Platelets"},{"issue":"7","key":"6758_CR65","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/vox.12558","volume":"112","author":"J Cid","year":"2017","unstructured":"Cid J (2017) Prevention of transfusion-associated graft-versus-host disease with pathogen-reduced platelets with Amotosalen and ultraviolet A light: a review. Vox Sang 112(7):607\u2013613","journal-title":"Vox Sang"},{"issue":"3","key":"6758_CR66","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.transci.2011.03.002","volume":"44","author":"H Azuma","year":"2011","unstructured":"Azuma H, Hirayama J, Akino M, Ikeda H (2011) Platelet additive solution - electrolytes. Transfus Apher Sci 44(3):277\u2013281","journal-title":"Transfus Apher Sci"},{"issue":"2","key":"6758_CR67","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1159\/000487513","volume":"45","author":"PF van der Meer","year":"2018","unstructured":"van der Meer PF, de Korte D (2018) Platelet additive solutions: a review of the latest developments and their clinical implications. Transfus Med Hemother 45(2):98\u2013102","journal-title":"Transfus Med Hemother"},{"issue":"2","key":"6758_CR68","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tmrv.2005.11.003","volume":"20","author":"J Ringwald","year":"2006","unstructured":"Ringwald J, Zimmermann R, Eckstein R (2006) The new generation of platelet additive solution for storage at 22 degrees C: development and current experience. Transfus Med Rev 20(2):158\u2013164","journal-title":"Transfus Med Rev"},{"issue":"S2","key":"6758_CR69","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1111\/trf.15255","volume":"59","author":"PM Ketter","year":"2019","unstructured":"Ketter PM, Kamucheka R, Arulanandam B, Akers K, Cap AP (2019) Platelet enhancement of bacterial growth during room temperature storage: mitigation through refrigeration. Transfusion 59(S2):1479\u20131489","journal-title":"Transfusion"},{"issue":"7","key":"6758_CR70","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/vox.13640","volume":"119","author":"S Ramirez-Arcos","year":"2024","unstructured":"Ramirez-Arcos S, Kumaran D, Cap A et al (2024) Proliferation of psychrotrophic bacteria in cold-stored platelet concentrates. Vox Sang 119(7):693\u2013701","journal-title":"Vox Sang"},{"issue":"4","key":"6758_CR71","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/trf.12918","volume":"55","author":"AR Harvey","year":"2015","unstructured":"Harvey AR, Basavaraju SV, Chung KW, Kuehnert MJ (2015) Transfusion-related adverse reactions reported to the National healthcare safety network hemovigilance Module, united States, 2010 to 2012. Transfusion 55(4):709\u2013718","journal-title":"Transfusion"},{"issue":"2","key":"6758_CR72","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.tracli.2018.03.002","volume":"25","author":"O Garraud","year":"2018","unstructured":"Garraud O, Sut C, Haddad A et al (2018) Transfusion-associated hazards: A revisit of their presentation. Transfus Clin Biol 25(2):118\u2013135","journal-title":"Transfus Clin Biol"},{"issue":"2","key":"6758_CR73","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/vox.12262","volume":"109","author":"KG Badami","year":"2015","unstructured":"Badami KG, Joliffe E, Stephens M (2015) Transfusion-associated dyspnea\u2013shadow or substance? Vox Sang 109(2):197\u2013200","journal-title":"Vox Sang"},{"issue":"4","key":"6758_CR74","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.tracli.2021.07.001","volume":"28","author":"M Raturi","year":"2021","unstructured":"Raturi M, Jain A, Kusum A, Sahrawat A (2021) Reporting an abrupt-onset persistent hypotensive transfusion reaction in an Indian female patient. Transfus Clin Biol 28(4):420\u2013422","journal-title":"Transfus Clin Biol"},{"issue":"10","key":"6758_CR75","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1053\/bbmt.2002.v8.pm12434952","volume":"8","author":"MS Zumberg","year":"2002","unstructured":"Zumberg MS, del Rosario ML, Nejame CF et al (2002) A prospective randomized trial of prophylactic platelet transfusion and bleeding incidence in hematopoietic stem cell transplant recipients: 10,000\/L versus 20,000\/microL trigger. Biol Blood Marrow Transpl 8(10):569\u2013576","journal-title":"Biol Blood Marrow Transpl"},{"issue":"10","key":"6758_CR76","first-page":"CD010984","volume":"2015","author":"LJ Estcourt","year":"2015","unstructured":"Estcourt LJ, Stanworth S, Doree C et al (2015) Different doses of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation. Cochrane Database Syst Rev 2015(10):CD010984","journal-title":"Cochrane Database Syst Rev"},{"issue":"19","key":"6758_CR77","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1056\/NEJMoa1212772","volume":"368","author":"SJ Stanworth","year":"2013","unstructured":"Stanworth SJ, Estcourt LJ, Powter G et al (2013) A no-prophylaxis platelet-transfusion strategy for hematologic cancers. N Engl J Med 368(19):1771\u20131780","journal-title":"N Engl J Med"},{"issue":"21","key":"6758_CR78","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1056\/NEJMoa2214322","volume":"388","author":"FLF van Baarle","year":"2023","unstructured":"van Baarle FLF, van de Weerdt EK, van der Velden W et al (2023) Platelet transfusion before CVC placement in patients with thrombocytopenia. N Engl J Med 388(21):1956\u20131965","journal-title":"N Engl J Med"},{"issue":"8","key":"6758_CR79","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.jvir.2019.04.016","volume":"30","author":"JC Davidson","year":"2019","unstructured":"Davidson JC, Rahim S, Hanks SE et al (2019) Society of interventional radiology consensus guidelines for the periprocedural management of thrombotic and bleeding risk in patients undergoing percutaneous Image-Guided Interventions-Part I: review of anticoagulation agents and clinical considerations: endorsed by the Canadian association for interventional radiology and the cardiovascular and interventional radiological society of Europe. J Vasc Interv Radiol 30(8):1155\u20131167","journal-title":"J Vasc Interv Radiol"},{"issue":"8","key":"6758_CR80","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1016\/j.jvir.2019.04.017","volume":"30","author":"IJ Patel","year":"2019","unstructured":"Patel IJ, Rahim S, Davidson JC et al (2019) Society of interventional radiology consensus guidelines for the periprocedural management of thrombotic and bleeding risk in patients undergoing percutaneous Image-Guided Interventions-Part II: recommendations: endorsed by the Canadian association for interventional radiology and the cardiovascular and interventional radiological society of Europe. J Vasc Interv Radiol 30(8):1168\u20131184e1161","journal-title":"J Vasc Interv Radiol"},{"issue":"21","key":"6758_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1182\/blood.V120.21.1.1","volume":"120","author":"SJ Stanworth","year":"2012","unstructured":"Stanworth SJ, Estcourt L, Powter G et al (2012) The effect of a No-Prophylactic versus prophylactic platelet transfusion strategy on bleeding in patients with hematological malignancies and severe thrombocytopenia (TOPPS trial). A randomized Controlled, Non-Inferiority trial. Blood 120(21):1\u20131","journal-title":"Blood"},{"issue":"9850","key":"6758_CR82","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/S0140-6736(12)60689-8","volume":"380","author":"H Wandt","year":"2012","unstructured":"Wandt H, Schaefer-Eckart K, Wendelin K et al (2012) Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study. Lancet 380(9850):1309\u20131316","journal-title":"Lancet"},{"issue":"1","key":"6758_CR83","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1186\/s13054-023-04650-z","volume":"27","author":"F Reizine","year":"2023","unstructured":"Reizine F, Le Marec S, Le Meur A et al (2023) Prophylactic platelet transfusion response in critically ill patients: a prospective multicentre observational study. Crit Care 27(1):373","journal-title":"Crit Care"},{"issue":"8","key":"6758_CR84","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1111\/aas.14467","volume":"68","author":"CT Anthon","year":"2024","unstructured":"Anthon CT, P\u00e8ne F, Perner A et al (2024) Platelet transfusions in adult ICU patients with thrombocytopenia: A sub-study of the PLOT-ICU inception cohort study. Acta Anaesthesiol Scand 68(8):1018\u20131030","journal-title":"Acta Anaesthesiol Scand"},{"issue":"3","key":"6758_CR85","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1056\/NEJMoa1807320","volume":"380","author":"A Curley","year":"2019","unstructured":"Curley A, Stanworth SJ, Willoughby K et al (2019) Randomized trial of Platelet-Transfusion thresholds in neonates. N Engl J Med 380(3):242\u2013251","journal-title":"N Engl J Med"},{"issue":"8","key":"6758_CR86","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1111\/trf.17844","volume":"64","author":"LE Heeger","year":"2024","unstructured":"Heeger LE, Houben NAM, Caram-Deelder C, Fustolo-Gunnink SF, van der Bom JG, Lopriore E (2024) Impact of restrictive platelet transfusion strategies on transfusion rates: A cohort study in very preterm infants. Transfusion 64(8):1421\u20131427","journal-title":"Transfusion"},{"issue":"3","key":"6758_CR87","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1097\/MS9.0000000000001751","volume":"86","author":"MA Shafique","year":"2024","unstructured":"Shafique MA, Abbas SQ, Habiba U, Mughal A, Fadlalla Ahmad TK, Munir Chaudhary A (2024) Transfusion strategies for neonates: current perspectives. Ann Med Surg (Lond) 86(3):1550\u20131562","journal-title":"Ann Med Surg (Lond)"},{"issue":"5","key":"6758_CR88","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1001\/jama.2015.12","volume":"313","author":"JB Holcomb","year":"2015","unstructured":"Holcomb JB, Tilley BC, Baraniuk S et al (2015) Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA 313(5):471\u2013482","journal-title":"JAMA"},{"issue":"4","key":"6758_CR89","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1097\/TA.0000000000003323","volume":"91","author":"TWH Rijnhout","year":"2021","unstructured":"Rijnhout TWH, Duijst J, Noorman F et al (2021) Platelet to erythrocyte transfusion ratio and mortality in massively transfused trauma patients. A systematic review and meta-analysis. J Trauma Acute Care Surg 91(4):759\u2013771","journal-title":"J Trauma Acute Care Surg"},{"issue":"3","key":"6758_CR90","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1097\/TA.0000000000001333","volume":"82","author":"JW Cannon","year":"2017","unstructured":"Cannon JW, Khan MA, Raja AS et al (2017) Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern association for the surgery of trauma. J Trauma Acute Care Surg 82(3):605\u2013617","journal-title":"J Trauma Acute Care Surg"},{"issue":"9","key":"6758_CR91","first-page":"CD012779","volume":"9","author":"LJ Estcourt","year":"2018","unstructured":"Estcourt LJ, Malouf R, Doree C, Trivella M, Hopewell S, Birchall J (2018) Prophylactic platelet transfusions prior to surgery for people with a low platelet count. Cochrane Database Syst Rev 9(9):CD012779","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"6758_CR92","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1182\/blood.V91.10.3601","volume":"91","author":"H Wandt","year":"1998","unstructured":"Wandt H, Frank M, Ehninger G et al (1998) Safety and cost effectiveness of a 10 x 10(9)\/L trigger for prophylactic platelet transfusions compared with the traditional 20 x 10(9)\/L trigger: a prospective comparative trial in 105 patients with acute myeloid leukemia. Blood 91(10):3601\u20133606","journal-title":"Blood"},{"issue":"11","key":"6758_CR93","doi-asserted-by":"publisher","first-page":"3536","DOI":"10.1111\/trf.15526","volume":"59","author":"S Thorn","year":"2019","unstructured":"Thorn S, Guting H, Mathes T, Schafer N, Maegele M (2019) The effect of platelet transfusion in patients with traumatic brain injury and concomitant antiplatelet use: a systematic review and meta-analysis. Transfusion 59(11):3536\u20133544","journal-title":"Transfusion"},{"key":"6758_CR94","first-page":"12","volume":"2015","author":"LJ Estcourt","year":"2015","unstructured":"Estcourt LJ, Ingram C, Doree C, Hopewell S, Trivella M, Stanworth SJ (2015) Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in people with thrombocytopenia. Cochrane Database Syst Rev 2015:12","journal-title":"Cochrane Database Syst Rev"},{"issue":"10038","key":"6758_CR95","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1016\/S0140-6736(16)30392-0","volume":"387","author":"MI Baharoglu","year":"2016","unstructured":"Baharoglu MI, Cordonnier C, Al-Shahi Salman R et al (2016) Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial. Lancet 387(10038):2605\u20132613","journal-title":"Lancet"},{"issue":"8","key":"6758_CR96","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1182\/blood-2017-10-804096","volume":"131","author":"M Levi","year":"2018","unstructured":"Levi M, Scully M (2018) How I treat disseminated intravascular coagulation. Blood 131(8):845\u2013854","journal-title":"Blood"},{"issue":"9","key":"6758_CR97","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1182\/blood-2014-10-605493","volume":"125","author":"R Goel","year":"2015","unstructured":"Goel R, Ness PM, Takemoto CM, Krishnamurti L, King KE, Tobian AA (2015) Platelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in-hospital mortality. Blood 125(9):1470\u20131476","journal-title":"Blood"},{"issue":"5","key":"6758_CR98","first-page":"835","volume":"116","author":"A Cuker","year":"2016","unstructured":"Cuker A (2016) Management of the multiple phases of heparin-induced thrombocytopenia. Thromb Haemost 116(5):835\u2013842","journal-title":"Thromb Haemost"},{"issue":"5","key":"6758_CR99","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1111\/bjh.15409","volume":"182","author":"JD Grainger","year":"2018","unstructured":"Grainger JD, Thachil J, Will AM (2018) How we treat the platelet glycoprotein defects; Glanzmann thrombasthenia and Bernard soulier syndrome in children and adults. Br J Haematol 182(5):621\u2013632","journal-title":"Br J Haematol"},{"key":"6758_CR100","doi-asserted-by":"crossref","unstructured":"Palma-Barqueros V, Revilla N, S\u00e1nchez A et al (2021) Inherited platelet disorders: an updated overview. Int J Mol Sci 22(9)","DOI":"10.3390\/ijms22094521"},{"issue":"1","key":"6758_CR101","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1182\/asheducation-2016.1.251","volume":"2016","author":"MP Lambert","year":"2016","unstructured":"Lambert MP (2016) Platelets in liver and renal disease. Hematol Am Soc Hematol Educ Program 2016(1):251\u2013255","journal-title":"Hematol Am Soc Hematol Educ Program"},{"issue":"1","key":"6758_CR102","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/ejh.13342","volume":"104","author":"P Liu","year":"2020","unstructured":"Liu P, Hum J, Jou J, Scanlan RM, Shatzel J (2020) Transfusion strategies in patients with cirrhosis. Eur J Haematol 104(1):15\u201325","journal-title":"Eur J Haematol"},{"key":"6758_CR103","doi-asserted-by":"crossref","unstructured":"Szmit S, Kepski J, Lech-Maranda E, Kowalski DM, Krzakowski M, Zaborowska-Szmit M (2025) Anticoagulant therapy in patients with cancer and thrombocytopenia. J Thromb Thrombolysis","DOI":"10.1007\/s11239-025-03188-x"},{"issue":"8","key":"6758_CR104","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1111\/jth.15748","volume":"20","author":"S Booth","year":"2022","unstructured":"Booth S, Haem SN, Desborough M, Curry N, Stanworth S (2022) Platelet transfusion and anticoagulation in hematological cancer-associated thrombosis and thrombocytopenia: the caveat multicenter prospective cohort. J Thromb Haemost 20(8):1830\u20131838","journal-title":"J Thromb Haemost"},{"issue":"20","key":"6758_CR105","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1182\/blood.2023022883","volume":"145","author":"S Nahirniak","year":"2025","unstructured":"Nahirniak S, Nadarajan V, Stanworth SJ (2025) How I treat patients who are refractory to platelet transfusions. Blood 145(20):2293\u20132302","journal-title":"Blood"},{"issue":"26","key":"6758_CR106","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1056\/NEJM199712253372601","volume":"337","author":"Leukocyte reduction","year":"1997","unstructured":"Leukocyte reduction (1997) Ultraviolet B irradiation of platelets to prevent alloimmunization and refractoriness to platelet transfusions. N Engl J Med 337(26):1861\u20131869","journal-title":"N Engl J Med"},{"key":"6758_CR107","doi-asserted-by":"publisher","first-page":"101135","DOI":"10.1016\/j.blre.2023.101135","volume":"62","author":"SR Panch","year":"2023","unstructured":"Panch SR, Guo L, Vassallo R (2023) Platelet transfusion refractoriness due to HLA alloimmunization: evolving paradigms in mechanisms and management. Blood Rev 62:101135","journal-title":"Blood Rev"},{"issue":"10","key":"6758_CR108","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1182\/blood-2003-08-2724","volume":"105","author":"SJ Slichter","year":"2005","unstructured":"Slichter SJ, Davis K, Enright H et al (2005) Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients. Blood 105(10):4106\u20134114","journal-title":"Blood"},{"issue":"1","key":"6758_CR109","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1182\/hematology.2020000137","volume":"2020","author":"CS Cohn","year":"2020","unstructured":"Cohn CS (2020) Platelet transfusion refractoriness: how do I diagnose and manage? Hematol Am Soc Hematol Educ Program 2020(1):527\u2013532","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"6758_CR110","doi-asserted-by":"publisher","first-page":"1125367","DOI":"10.3389\/fimmu.2023.1125367","volume":"14","author":"A Couvidou","year":"2023","unstructured":"Couvidou A, Rojas-Jim\u00e9nez G, Dupuis A, Ma\u00eetre B (2023) Anti-HLA class I alloantibodies in platelet transfusion refractoriness: from mechanisms and determinants to therapeutic prospects. Front Immunol 14:1125367","journal-title":"Front Immunol"},{"issue":"3","key":"6758_CR111","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/bjh.14338","volume":"175","author":"MJ Desborough","year":"2016","unstructured":"Desborough MJ, Smethurst PA, Estcourt LJ, Stanworth SJ (2016) Alternatives to allogeneic platelet transfusion. Br J Haematol 175(3):381\u2013392","journal-title":"Br J Haematol"},{"issue":"11","key":"6758_CR112","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1182\/blood.2022016308","volume":"140","author":"TB Gernsheimer","year":"2022","unstructured":"Gernsheimer TB, Brown SP, Triulzi DJ et al (2022) Prophylactic Tranexamic acid in patients with hematologic malignancy: a placebo-controlled, randomized clinical trial. Blood 140(11):1254\u20131262","journal-title":"Blood"},{"issue":"1","key":"6758_CR113","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.1016\/S2352-3026(24)00317-X","volume":"12","author":"Tranexamic acid versus","year":"2025","unstructured":"Tranexamic acid versus (2025) Placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial. Lancet Haematol 12(1):e14\u2013e22","journal-title":"Lancet Haematol"},{"issue":"4","key":"6758_CR114","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1111\/trf.17285","volume":"63","author":"JP Pitman","year":"2023","unstructured":"Pitman JP, Payrat JM, Park MS, Liu K, Corash L, Benjamin RJ (2023) Longitudinal analysis of annual National hemovigilance data to assess pathogen reduced platelet transfusion trends during conversion to routine universal clinical use and 7-day storage. Transfusion 63(4):711\u2013723","journal-title":"Transfusion"},{"issue":"1","key":"6758_CR115","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/09537104.2021.1935838","volume":"33","author":"J Cid","year":"2022","unstructured":"Cid J, Lozano M (2022) Pathogen inactivation of platelets for transfusion. Platelets 33(1):23\u201326","journal-title":"Platelets"},{"issue":"3","key":"6758_CR116","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/vox.13573","volume":"119","author":"J Cid","year":"2024","unstructured":"Cid J, Charry P, Lozano M (2024) Therapeutic efficacy and safety of pathogen-reduced platelet components: results of a meta-analysis of randomized controlled trials. Vox Sang 119(3):203\u2013211","journal-title":"Vox Sang"},{"issue":"3","key":"6758_CR117","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/bjh.16187","volume":"188","author":"B Bahar","year":"2020","unstructured":"Bahar B, Schulz WL, Gokhale A, Spencer BR, Gehrie EA, Snyder EL (2020) Blood utilisation and transfusion reactions in adult patients transfused with conventional or pathogen-reduced platelets. Br J Haematol 188(3):465\u2013472","journal-title":"Br J Haematol"},{"issue":"4","key":"6758_CR118","first-page":"1086","volume":"106","author":"V Brixner","year":"2021","unstructured":"Brixner V, Bug G, Pohler P et al (2021) Efficacy of UVC-treated, pathogen-reduced platelets versus untreated platelets: a randomized controlled non-inferiority trial. Haematologica 106(4):1086\u20131096","journal-title":"Haematologica"},{"issue":"2","key":"6758_CR119","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1182\/blood-2018-02-831289","volume":"132","author":"PF van der Meer","year":"2018","unstructured":"van der Meer PF, Ypma PF, van Geloven N et al (2018) Hemostatic efficacy of pathogen-inactivated vs untreated platelets: a randomized controlled trial. Blood 132(2):223\u2013231","journal-title":"Blood"},{"key":"6758_CR120","doi-asserted-by":"crossref","unstructured":"Pati I, Masiello F, Pupella S, Cruciani M, De Angelis V (2022) Efficacy and safety of Pathogen-Reduced platelets compared with standard apheresis platelets: a systematic review of RCTs. Pathogens 11(6)","DOI":"10.3390\/pathogens11060639"},{"issue":"5","key":"6758_CR121","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1055\/s-0042-1757897","volume":"49","author":"S Tsalas","year":"2023","unstructured":"Tsalas S, Petrou E, Tsantes AG et al (2023) Pathogen reduction technologies and their impact on metabolic and functional properties of treated platelet concentrates: A systematic review. Semin Thromb Hemost 49(5):523\u2013541","journal-title":"Semin Thromb Hemost"},{"issue":"1","key":"6758_CR122","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/trf.16747","volume":"62","author":"G Escolar","year":"2022","unstructured":"Escolar G, Diaz-Ricart M, McCullough J (2022) Impact of different pathogen reduction technologies on the biochemistry, function, and clinical effectiveness of platelet concentrates: an updated view during a pandemic. Transfusion 62(1):227\u2013246","journal-title":"Transfusion"},{"issue":"2","key":"6758_CR123","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1537-2995.1973.tb05442.x","volume":"13","author":"GA Becker","year":"1973","unstructured":"Becker GA, Tuccelli M, Kunicki T, Chalos MK, Aster RH (1973) Studies of platelet concentrates stored at 22\u00a0C Nad 4\u00a0C. Transfusion 13(2):61\u201368","journal-title":"Transfusion"},{"key":"6758_CR124","doi-asserted-by":"crossref","unstructured":"Zhao H, Devine DV (2022) The missing pieces to the Cold-Stored platelet puzzle. Int J Mol Sci 23(3)","DOI":"10.3390\/ijms23031100"},{"issue":"6","key":"6758_CR125","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1111\/trf.15302","volume":"59","author":"SJ Slichter","year":"2019","unstructured":"Slichter SJ, Fitzpatrick L, Osborne B et al (2019) Platelets stored in whole blood at 4\u00b0C: in vivo posttransfusion platelet recoveries and survivals and in vitro hemostatic function. Transfusion 59(6):2084\u20132092","journal-title":"Transfusion"},{"issue":"1","key":"6758_CR126","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/trf.16148","volume":"61","author":"MA Warner","year":"2021","unstructured":"Warner MA, Kurian EB, Hammel SA, van Buskirk CM, Kor DJ, Stubbs JR (2021) Transition from room temperature to cold-stored platelets for the preservation of blood inventories during the COVID-19 pandemic. Transfusion 61(1):72\u201377","journal-title":"Transfusion"},{"issue":"10","key":"6758_CR127","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1007\/s12630-023-02561-9","volume":"70","author":"J Lu","year":"2023","unstructured":"Lu J, Karkouti K, Peer M et al (2023) Cold-stored platelets for acute bleeding in cardiac surgical patients: a narrative review. Can J Anaesth 70(10):1682\u20131700","journal-title":"Can J Anaesth"},{"issue":"4","key":"6758_CR128","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/j.jtha.2023.11.025","volume":"22","author":"SM Shea","year":"2024","unstructured":"Shea SM, Reisz JA, Mihalko EP et al (2024) Cold-stored platelet hemostatic capacity is maintained for three weeks of storage and associated with taurine metabolism. J Thromb Haemost 22(4):1154\u20131166","journal-title":"J Thromb Haemost"},{"issue":"Suppl 1","key":"6758_CR129","first-page":"S68","volume":"61","author":"PM Nair","year":"2021","unstructured":"Nair PM, Meledeo MA, Wells AR et al (2021) Cold-stored platelets have better preserved contractile function in comparison with room temperature-stored platelets over 21 days. Transfusion 61(Suppl 1):S68\u2013s79","journal-title":"Transfusion"},{"issue":"1","key":"6758_CR130","doi-asserted-by":"publisher","first-page":"2188969","DOI":"10.1080\/09537104.2023.2188969","volume":"34","author":"CE George","year":"2023","unstructured":"George CE, Saunders CV, Morrison A, Scorer T, Jones S, Dempsey NC (2023) Cold stored platelets in the management of bleeding: is it about bioenergetics? Platelets 34(1):2188969","journal-title":"Platelets"},{"issue":"2","key":"6758_CR131","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1097\/ALN.0000000000004605","volume":"139","author":"AM Klompas","year":"2023","unstructured":"Klompas AM, Zec S, Hanson AC et al (2023) Postoperative transfusions after administration of delayed Cold-stored platelets versus room temperature platelets in cardiac surgery: A retrospective cohort study. Anesthesiology 139(2):153\u2013163","journal-title":"Anesthesiology"},{"issue":"4","key":"6758_CR132","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.tmrv.2020.08.003","volume":"34","author":"JP Mack","year":"2020","unstructured":"Mack JP, Miles J, Stolla M (2020) Cold-stored platelets: review of studies in humans. Transfus Med Rev 34(4):221\u2013226","journal-title":"Transfus Med Rev"},{"issue":"4","key":"6758_CR133","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.tmrv.2020.09.008","volume":"34","author":"K Kelly","year":"2020","unstructured":"Kelly K, Cancelas JA, Szczepiorkowski ZM, Dumont DF, Rugg N, Dumont LJ (2020) Frozen Platelets-Development and future directions. Transfus Med Rev 34(4):286\u2013293","journal-title":"Transfus Med Rev"},{"issue":"1","key":"6758_CR134","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1182\/blood.V43.1.131.131","volume":"43","author":"CR Valeri","year":"1974","unstructured":"Valeri CR, Feingold H, Marchionni LD (1974) A simple method for freezing human platelets using 6 per cent dimethylsulfoxide and storage at -80 degrees C. Blood 43(1):131\u2013136","journal-title":"Blood"},{"issue":"12","key":"6758_CR135","doi-asserted-by":"publisher","first-page":"e0168401","DOI":"10.1371\/journal.pone.0168401","volume":"11","author":"F Noorman","year":"2016","unstructured":"Noorman F, van Dongen TT, Plat MJ, Badloe JF, Hess JR, Hoencamp R (2016) Transfusion: -80\u00b0C frozen blood products are safe and effective in military casualty care. PLoS ONE 11(12):e0168401","journal-title":"PLoS ONE"},{"key":"6758_CR136","doi-asserted-by":"crossref","unstructured":"Six KR, Compernolle V, Feys HB (2020) Platelet biochemistry and morphology after cryopreservation. Int J Mol Sci 21(3)","DOI":"10.3390\/ijms21030935"},{"issue":"4","key":"6758_CR137","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1111\/trf.12915","volume":"55","author":"L Johnson","year":"2015","unstructured":"Johnson L, Reade MC, Hyland RA, Tan S, Marks DC (2015) In vitro comparison of cryopreserved and liquid platelets: potential clinical implications. Transfusion 55(4):838\u2013847","journal-title":"Transfusion"},{"issue":"6","key":"6758_CR138","doi-asserted-by":"publisher","first-page":"102666","DOI":"10.1016\/j.transci.2019.10.008","volume":"58","author":"M Napolitano","year":"2019","unstructured":"Napolitano M, Mancuso S, Raso S et al (2019) Buffy coat-derived platelets cryopreserved using a new method: results from a pivotal clinical trial on thrombocytopenic patients with acute leukaemia. Transfus Apher Sci 58(6):102666","journal-title":"Transfus Apher Sci"},{"issue":"3","key":"6758_CR139","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/vox.13203","volume":"117","author":"S McGuinness","year":"2022","unstructured":"McGuinness S, Charlewood R, Gilder E et al (2022) A pilot randomized clinical trial of cryopreserved versus liquid-stored platelet transfusion for bleeding in cardiac surgery: the cryopreserved versus liquid platelet-New Zealand pilot trial. Vox Sang 117(3):337\u2013345","journal-title":"Vox Sang"},{"issue":"3","key":"6758_CR140","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.jtha.2023.11.022","volume":"22","author":"BJ Kuhn","year":"2024","unstructured":"Kuhn BJ, Swanson A, Cherupalla AS et al (2024) Mechanisms of action of an investigational new freeze-dried platelet-derived hemostatic product. J Thromb Haemost 22(3):686\u2013699","journal-title":"J Thromb Haemost"},{"issue":"7","key":"6758_CR141","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1021\/acs.bioconjchem.8b00271","volume":"29","author":"J Fernandez-Moure","year":"2018","unstructured":"Fernandez-Moure J, Maisha N, Lavik EB, Cannon JW (2018) The chemistry of lyophilized blood products. Bioconjug Chem 29(7):2150\u20132160","journal-title":"Bioconjug Chem"},{"issue":"S2","key":"6758_CR142","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1111\/trf.15167","volume":"59","author":"JA Bynum","year":"2019","unstructured":"Bynum JA, Meledeo MA, Peltier GC et al (2019) Evaluation of a lyophilized platelet-derived hemostatic product. Transfusion 59(S2):1490\u20131498","journal-title":"Transfusion"},{"key":"6758_CR143","doi-asserted-by":"publisher","first-page":"941817","DOI":"10.3389\/fbioe.2022.941817","volume":"10","author":"B Schnoor","year":"2022","unstructured":"Schnoor B, Papa AL (2022) Lyophilized platelets inhibit platelet aggregation with simultaneous Paradoxical promotion of platelet adhesion. Front Bioeng Biotechnol 10:941817","journal-title":"Front Bioeng Biotechnol"},{"issue":"1","key":"6758_CR144","first-page":"176","volume":"108","author":"NV Joshi","year":"2012","unstructured":"Joshi NV, Raftis JB, Lucking AJ et al (2012) Lyophilised reconstituted human platelets increase thrombus formation in a clinical ex vivo model of deep arterial injury. Thromb Haemost 108(1):176\u2013182","journal-title":"Thromb Haemost"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06758-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-06758-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06758-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:03:07Z","timestamp":1770267787000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-06758-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":144,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["6758"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-06758-y","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]},"assertion":[{"value":"3 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14"}}