{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:56:02Z","timestamp":1792443362817,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-026-06763-1","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:20:17Z","timestamp":1768454417000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neutrophil to lymphocyte ratio at diagnosis predicts venous thrombosis in prefibrotic primary myelofibrosis: results from a multicenter cooperative study"],"prefix":"10.1007","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5819-9476","authenticated-orcid":false,"given":"Fabrizio","family":"Cavalca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Latagliata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Novella","family":"Pugliese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Alberto","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Polverelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pellegrino","family":"Musto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Benevolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Branzanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra","family":"Di Veroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia Accorsi","family":"Buttini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Ripamonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Civettini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Montelisciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Antolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Gambacorti-Passerini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Palandri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Maria","family":"Elli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"issue":"7","key":"6763_CR1","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1080\/17474086.2018.1484280","volume":"11","author":"E Rumi","year":"2018","unstructured":"Rumi E, Sant\u2019Antonio E, Boveri E, Pietra D, Cavalloni C, Roncoroni E et al (2018) Diagnosis and management of prefibrotic myelofibrosis. Expert Rev Hematol 11(7):537\u2013545","journal-title":"Expert Rev Hematol"},{"issue":"23","key":"6763_CR2","doi-asserted-by":"publisher","first-page":"3179","DOI":"10.1200\/JCO.2010.34.5298","volume":"29","author":"T Barbui","year":"2011","unstructured":"Barbui T, Thiele J, Passamonti F, Rumi E, Boveri E, Ruggeri M et al (2011) Survival and disease progression in Essential Thrombocythemia are significantly influenced by accurate morphologic diagnosis: an International Study. J Clin Oncol 29(23):3179\u201384","journal-title":"J Clin Oncol"},{"issue":"2","key":"6763_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-0289-2","volume":"10","author":"P Guglielmelli","year":"2020","unstructured":"Guglielmelli P, Carobbio A, Rumi E, De Stefano V, Mannelli L, Mannelli F et al (2020) Validation of the IPSET score for thrombosis in patients with prefibrotic myelofibrosis. Blood Cancer J 10(2):21","journal-title":"Blood Cancer J"},{"key":"6763_CR4","doi-asserted-by":"crossref","unstructured":"Gleitz HFE, Benabid A, Schneider RK (2021) Still a burning question: The interplay between inflammation and fibrosis in myeloproliferative neoplasms. Curr Opin Hematol [Internet]. [cited 2022 Sep 21];28(5):364\u2013371. Available from: https:\/\/journals.lww.com\/co-hematology\/Fulltext\/2021\/09000\/Still_a_burning_question__the_interplay_between.13.aspx","DOI":"10.1097\/MOH.0000000000000669"},{"key":"6763_CR5","doi-asserted-by":"crossref","unstructured":"Barbui T, Carobbio A, Finazzi G, Vannucchi AM, Barosi G, Antonioli E et al (2011) Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3. Haematologica [Internet]. [cited 2022 Sep 18];96(2):315\u20138. Available from: https:\/\/haematologica.org\/article\/view\/5881","DOI":"10.3324\/haematol.2010.031070"},{"key":"6763_CR6","doi-asserted-by":"crossref","unstructured":"Barbui T, Finazzi G, Falanga A (2013) Myeloproliferative neoplasms and thrombosis. Blood [Internet]. [cited 2022 Sep 6];122(13):2176\u20132184. Available from: https:\/\/ashpublications.org\/blood\/article\/122\/13\/2176\/31711\/Myeloproliferative-neoplasms-and-thrombosis","DOI":"10.1182\/blood-2013-03-460154"},{"key":"6763_CR7","doi-asserted-by":"crossref","unstructured":"Guy A, Garcia G, Gourdou-Latyszenok V, Wolff-Trombini L, Josserand L, Kimmerlin Q et al (2024) Platelets and neutrophils cooperate to induce increased neutrophil extracellular trap formation in JAK2V617F myeloproliferative neoplasms. Journal of Thrombosis and Haemostasis [Internet]. [cited 2025 Oct 28];22(1):172\u2013187. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/37678548\/","DOI":"10.1016\/j.jtha.2023.08.028"},{"key":"6763_CR8","doi-asserted-by":"crossref","unstructured":"Lucijanic M, Krecak I, Soric E, Sabljic A, Galusic D, Holik H et al (2024) Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis. Life (Basel) [Internet]. [cited 2024 Oct 13];14(4). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/38672793\/","DOI":"10.3390\/life14040523"},{"key":"6763_CR9","doi-asserted-by":"crossref","unstructured":"Lucijanic M, Cicic D, Stoos-Veic T, Pejsa V, Lucijanic J, Dzankic AF et al (2018) Elevated Neutrophil-to-Lymphocyte-ratio and Platelet-to-Lymphocyte Ratio in Myelofibrosis: Inflammatory Biomarkers or Representatives of Myeloproliferation Itself? Anticancer Res [Internet]. [cited 2022 Oct 20];38(5):3157\u20133163. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/29715157\/","DOI":"10.21873\/anticanres.12579"},{"issue":"Supplement 1","key":"6763_CR10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-116418","volume":"132","author":"A Romano","year":"2018","unstructured":"Romano A, Palandri F, Masarova L, Bonifacio M, Polverelli N, Elli EM et al (2018) Prognostic role of neutrophil to lymphocyte ratio (NLR) in Myelofibrosis patients treated with Ruxolitinib: a multi-center experience. Blood 132(Supplement 1):4303","journal-title":"Blood"},{"key":"6763_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01373","volume":"10","author":"CP Marin Oyarz\u00fan","year":"2019","unstructured":"Marin Oyarz\u00fan CP, Heller PG (2019) Platelets as mediators of thromboinflammation in chronic myeloproliferative neoplasms. Front Immunol 10:465282","journal-title":"Front Immunol"},{"key":"6763_CR12","doi-asserted-by":"publisher","unstructured":"Azab B, Chainani V, Shah N, McGinn JT (2012) Neutrophil\u2013Lymphocyte Ratio as a Predictor of Major Adverse Cardiac Events Among Diabetic Population. https:\/\/doi.org\/10.1177\/0003319712455216 [Internet]. [cited 2023 Sep 26];64(6):456\u201365. Available from: https:\/\/journals.sagepub.com\/doi\/10.1177\/0003319712455216","DOI":"10.1177\/0003319712455216"},{"key":"6763_CR13","doi-asserted-by":"crossref","unstructured":"Carobbio A, Vannucchi AM, De Stefano V, Masciulli A, Guglielmelli P, Loscocco GG et al (2022) Neutrophil-to-lymphocyte ratio is a novel predictor of venous thrombosis in polycythemia vera. Blood Cancer J [Internet]. [cited 2022 Oct 16];12(2). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/35145055\/","DOI":"10.1038\/s41408-022-00625-5"},{"key":"6763_CR14","doi-asserted-by":"crossref","unstructured":"Ripamonti A, Cavalca F, Montelisciani L, Antolini L, Gambacorti-Passerini C, Elli EM (2025) Neutrophil-to-lymphocyte ratio (NLR) at diagnosis in essential thrombocythemia: A new promising predictor of thrombotic events. Cancer [Internet]. [cited 2025 Jan 16];131(1):e35638. Available from: https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/cncr.35638","DOI":"10.1002\/cncr.35638"},{"key":"6763_CR15","doi-asserted-by":"crossref","unstructured":"Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF et al (2022) The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic\/Dendritic Neoplasms. Leukemia 2022 36:7 [Internet]. [cited 2022 Oct 16];36(7):1703\u20131719. Available from: https:\/\/www.nature.com\/articles\/s41375-022-01613-1","DOI":"10.1038\/s41375-022-01613-1"},{"key":"6763_CR16","unstructured":"Thiele J, Kvasnicka H, Facchetti F, Franco V, van der Walt JD, Orazi A (2005) European consensus on grading bone marrow fibrosis and assessment of cellularity. Haematologica"},{"key":"6763_CR17","doi-asserted-by":"crossref","unstructured":"Cervantes F, Dupriez B, Pereira A, Passamonti F, Reilly JT, Morra E et al (2009) New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood [Internet]. [cited 2024 May 19];113(13):2895\u20132901. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/18988864\/","DOI":"10.1182\/blood-2008-07-170449"},{"key":"6763_CR18","doi-asserted-by":"crossref","unstructured":"Barbui T, Finazzi G, Carobbio A, Thiele J, Passamonti F, Rumi E et al (2012) Development and validation of an International Prognostic Score of thrombosis in World Health Organization\u2013essential thrombocythemia (IPSET-thrombosis). Blood [Internet]. [cited 2022 Sep 15];120(26):5128\u20135133. Available from: https:\/\/ashpublications.org\/blood\/article\/120\/26\/5128\/30914\/Development-and-validation-of-an-International","DOI":"10.1182\/blood-2012-07-444067"},{"key":"6763_CR19","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3389\/fped.2018.00142","volume":"6","author":"BR Branchford","year":"2018","unstructured":"Branchford BR, Carpenter SL (2018) The role of inflammation in venous thromboembolism. Front Pediatr 6:142","journal-title":"Front Pediatr"},{"key":"6763_CR20","doi-asserted-by":"crossref","unstructured":"Marin Oyarz\u00fan CP, Heller PG (2019) Platelets as mediators of thromboinflammation in chronic myeloproliferative neoplasms. Front Immunol [Internet]. [cited 2024 Apr 6];10(JUN):465282. Available from: www.frontiersin.org","DOI":"10.3389\/fimmu.2019.01373"},{"key":"6763_CR21","doi-asserted-by":"crossref","unstructured":"Jackson SP, Darbousset R, Schoenwaelder SM (2019) Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms. Blood [Internet]. [cited 2022 Oct 20];133(9):906\u2013918. Available from: https:\/\/ashpublications.org\/blood\/article\/133\/9\/906\/260659\/Thromboinflammation-challenges-of-therapeutically","DOI":"10.1182\/blood-2018-11-882993"},{"issue":"1","key":"6763_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01176-7","volume":"14","author":"T Barbui","year":"2024","unstructured":"Barbui T, Carobbio A, Ghirardi A, Fenili F, Finazzi MC, Castelli M et al (2024) Neutrophil-to-lymphocyte ratio as a prognostic indicator of mortality in Polycythemia Vera: insights from a prospective cohort analysis. Blood Cancer J 14(1):195","journal-title":"Blood Cancer J"},{"key":"6763_CR23","doi-asserted-by":"publisher","unstructured":"Lagan\u00e0 A, Passucci M, Pepe S, Scalzulli E, Carmosino I, Costa A et al (2024) Neutrophil to lymphocyte ratio in myelofibrosis patients treated with ruxolitinib may predict prognosis and rate of discontinuation. Eur J Haematol [Internet]. [cited 2024 May 19];112(6):938\u2013943. Available from: https:\/\/onlinelibrary.wiley.com\/doi\/full\/https:\/\/doi.org\/10.1111\/ejh.14188","DOI":"10.1111\/ejh.14188"},{"key":"6763_CR24","doi-asserted-by":"crossref","unstructured":"Song M, Graubard BI, Rabkin CS, Engels EA (2021) Neutrophil-to-lymphocyte ratio and mortality in the United States general population. Scientific Reports 2021 11:1 [Internet]. [cited 2022 Sep 19];11(1):1\u20139. Available from: https:\/\/www.nature.com\/articles\/s41598-020-79431-7","DOI":"10.1038\/s41598-020-79431-7"},{"key":"6763_CR25","doi-asserted-by":"publisher","unstructured":"Navarrete S, Solar C, Tapia R, Pereira J, Fuentes E, Palomo I (2023) Pathophysiology of deep vein thrombosis. Clin Exp Med [Internet]. [cited 2024 Jul 7];23(3):645\u2013654. Available from: https:\/\/link.springer.com\/article\/https:\/\/doi.org\/10.1007\/s10238-022-00829-w","DOI":"10.1007\/s10238-022-00829-w"},{"issue":"6","key":"6763_CR26","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/joim.12296","volume":"276","author":"L Badimon","year":"2014","unstructured":"Badimon L, Vilahur G (2014) Thrombosis formation on atherosclerotic lesions and plaque rupture. J Intern Med 276(6):618\u2013632","journal-title":"J Intern Med"},{"key":"6763_CR27","doi-asserted-by":"crossref","unstructured":"Alvarez-Larr\u00e1n A, Cuevas B, Velez P, Noya S, Caballero-Navarro G, Ferrer-Mar\u00edn F et al (2023) Application of IPSET-thrombosis in 1366 Patients Prospectively Followed From the Spanish Registry of Essential Thrombocythemia. Hemasphere [Internet]. [cited 2025 Oct 28];7(8):e936. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10356121\/","DOI":"10.1097\/HS9.0000000000000936"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06763-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-06763-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06763-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T03:33:54Z","timestamp":1770262434000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-06763-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["6763"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-06763-1","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]},"assertion":[{"value":"23 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19"}}