{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:18:18Z","timestamp":1789154298366,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Clinical Research Fund Project of Qiqihar Academy of Medical Sciences","award":["QMSI2024L-10"],"award-info":[{"award-number":["QMSI2024L-10"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-026-06777-9","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T01:14:14Z","timestamp":1768612454000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lycorine inhibits the proliferation of acute myeloid leukemia cells by upregulating the expression of THBS1"],"prefix":"10.1007","volume":"105","author":[{"given":"Lunbi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enliang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangxu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiyu","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,17]]},"reference":[{"key":"6777_CR1","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1001\/jamaoncol.2024.266","volume":"10","author":"A Sangeetha Venugopal, Mikkael","year":"2024","unstructured":"Sangeetha Venugopal, Mikkael A, Sekeres (2024) Contemporary management of acute myeloid leukemia: A Review[J]. JAMA Oncol 10:1417\u20131425. https:\/\/doi.org\/10.1001\/jamaoncol.2024.266","journal-title":"JAMA Oncol"},{"key":"6777_CR2","doi-asserted-by":"publisher","first-page":"154266","DOI":"10.1016\/j.phymed.2022.154266","volume":"104","author":"X Haoxiang Xiao","year":"2022","unstructured":"Haoxiang Xiao X, Xu L, Du X, Li H, Zhao Z, Wang L, Zhao Z, Yang S, Zhang Y, Yang C, Wang (2022) Lycorine and organ protection: review of its potential effects and molecular mechanisms[J]. Phytomedicine 104:154266. https:\/\/doi.org\/10.1016\/j.phymed.2022.154266","journal-title":"Phytomedicine"},{"key":"6777_CR3","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1158\/1535-7163.MCT-17-0498","volume":"16","author":"Y Haiyang","year":"2017","unstructured":"Haiyang Y, Qiu Y, Pang X, Li J, Wu S, Yin S, Han L, Zhang Y, Jin C, Gao X (2017) Lycorine promotes autophagy and apoptosis via TCRP1\/Akt\/mTOR axis inactivation in human hepatocellular Carcinoma[J]. Mol Cancer Ther 16:2711\u20132723. https:\/\/doi.org\/10.1158\/1535-7163.MCT-17-0498","journal-title":"Mol Cancer Ther"},{"key":"6777_CR4","doi-asserted-by":"publisher","first-page":"138","DOI":"10.18632\/aging.102606","volume":"12","author":"H Man","year":"2020","unstructured":"Man H, Mei ZYP, Li J, Luo D, Zhang H, Zhou M, Liang F, Chen R (2020) Lycorine induces autophagy-associated apoptosis by targeting MEK2 and enhances Vemurafenib activity in colorectal cancer[J]. Aging 12:138\u2013155. https:\/\/doi.org\/10.18632\/aging.102606","journal-title":"Aging"},{"key":"6777_CR5","doi-asserted-by":"publisher","first-page":"479","DOI":"10.19852\/j.cnki.jtcm.20220408.003","volume":"42","author":"J Wu","year":"2022","unstructured":"Wu J, Zhang F, Li Z, Jin W, Shi Y (2022) Integration strategy of network Pharmacology in traditional Chinese medicine: a narrative review[J]. J Tradit Chin Med 42:479\u2013486. https:\/\/doi.org\/10.19852\/j.cnki.jtcm.20220408.003","journal-title":"J Tradit Chin Med"},{"key":"6777_CR6","doi-asserted-by":"publisher","unstructured":"Fatima Noor MTU, Qamar UA, Ashfaq A, Albutti, Ameen SS, Alwashmi, Mohammad Abdullah Aljasir (2022) Network Pharmacology Approach for Medicinal Plant: Review and Assessment[J].Pharmaceuticals (Basel) 15:572. https:\/\/doi.org\/10.3390\/ph15050572","DOI":"10.3390\/ph15050572"},{"key":"6777_CR7","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s40364-024-00649-y","volume":"12","author":"G Yeming Zhou","year":"2024","unstructured":"Yeming Zhou G, Huang X, Cai Y, Liu B, Qian D, Li (2024) Global, regional, and National burden of acute myeloid leukemia, 1990\u20132021: a systematic analysis for the global burden of disease study 2021[J]. Biomark Res 12:101. https:\/\/doi.org\/10.1186\/s40364-024-00649-y","journal-title":"Biomark Res"},{"key":"6777_CR8","doi-asserted-by":"publisher","first-page":"1329529","DOI":"10.3389\/fpubh.2023.1329529","volume":"11","author":"P Chen","year":"2023","unstructured":"Chen P, Liu X, Zhao Y, Hu Y, Guo J, Wang H (2023) Global, national, and regional burden of acute myeloid leukemia among 60\u201389 years-old individuals: insights from a study covering the period 1990 to 2019[J]. Front Public Health 11:1329529. https:\/\/doi.org\/10.3389\/fpubh.2023.1329529","journal-title":"Front Public Health"},{"key":"6777_CR9","doi-asserted-by":"publisher","first-page":"1388903","DOI":"10.3389\/fphar.2024.1388903","volume":"15","author":"X Xinlong Gao","year":"2024","unstructured":"Xinlong Gao X, Zuo T, Min Y, Wan Y, He B, Jiang (2024) Traditional Chinese medicine for acute myelocytic leukemia therapy: exploiting epigenetic targets[J]. Front Pharmacol 15:1388903. https:\/\/doi.org\/10.3389\/fphar.2024.1388903","journal-title":"Front Pharmacol"},{"key":"6777_CR10","doi-asserted-by":"publisher","unstructured":"Zheng D, Zhou Y, Liu Y, Ma L (2022) Molecular mechanism investigation on monomer Kaempferol of the traditional medicine Dingqing tablet in promoting apoptosis of acute myeloid leukemia HL-60 Cells[J]. Evid Based Complement Alternat Med 8383315. https:\/\/doi.org\/10.1155\/2022\/8383315","DOI":"10.1155\/2022\/8383315"},{"key":"6777_CR11","doi-asserted-by":"publisher","first-page":"796757","DOI":"10.3389\/fcell.2021.796757","volume":"9","author":"X Guanfei Jia","year":"2021","unstructured":"Guanfei Jia X, Jiang Z, Li X, Ding L, Lei S, Xu, Ning Gao (2021) Decoding the mechanism of Shen Qi Sha Bai Decoction in treating acute myeloid leukemia based on network Pharmacology and molecular Docking[J]. Front Cell Dev Biol 9:796757. https:\/\/doi.org\/10.3389\/fcell.2021.796757","journal-title":"Front Cell Dev Biol"},{"key":"6777_CR12","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1177\/1078155211416530","volume":"18","author":"S Veena","year":"2012","unstructured":"Veena S, Ghalaut L, Sangwan K, Dahiya PS, Ghalaut R, Dhankhar R, Saharan (2012) Effect of Imatinib therapy with and without turmeric powder on nitric oxide levels in chronic myeloid leukemia[J]. J Oncol Pharm Pract 18:186\u2013190. https:\/\/doi.org\/10.1177\/1078155211416530","journal-title":"J Oncol Pharm Pract"},{"key":"6777_CR13","doi-asserted-by":"publisher","first-page":"897791","DOI":"10.3389\/fphar.2022.897791","volume":"13","author":"X Lai","year":"2022","unstructured":"Lai X, Sun Y, Zhang X, Wang D, Wang J, Wang H, Zhao Y, Liu X, Xu X, Song H, Ping W (2022) Yanli Sun, Zhenbo Hu. Honokiol induces ferroptosis by upregulating HMOX1 in acute myeloid leukemia Cells[J]. Front Pharmacol 13:897791. https:\/\/doi.org\/10.3389\/fphar.2022.897791","journal-title":"Front Pharmacol"},{"key":"6777_CR14","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.3390\/biomedicines11102619","volume":"11","author":"AD Sotto","year":"2023","unstructured":"Sotto AD, Valipour M, Azari A, Giacomo SD, Hamid Irannejad (2023) Benzoindolizidine alkaloids tylophorine and Lycorine and their analogues with Antiviral, Anti-Inflammatory, and anticancer properties: promises and Challenges[J]. Biomedicines 11:2619. https:\/\/doi.org\/10.3390\/biomedicines11102619","journal-title":"Biomedicines"},{"key":"6777_CR15","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.biopha.2018.07.147","volume":"107","author":"L Mridul Roy","year":"2018","unstructured":"Mridul Roy L, Liang X, Xiao P, Feng M, Ye J, Liu (2018) Lycorine: A prospective natural lead for anticancer drug discovery[J]. Biomed Pharmacother 107:615\u2013624. https:\/\/doi.org\/10.1016\/j.biopha.2018.07.147","journal-title":"Biomed Pharmacother"},{"key":"6777_CR16","doi-asserted-by":"publisher","first-page":"718","DOI":"10.3390\/cancers17050718","volume":"17","author":"L Jingyan Liu","year":"2025","unstructured":"Jingyan Liu L, Qiu J, Chen T, Zeng (2025) Lycorine hydrochloride suppresses the proliferation and invasion of esophageal cancer by targeting TRIM22 and inhibiting the JAK2\/STAT3 and Erk Pathways[J]. Cancers (Basel) 17:718. https:\/\/doi.org\/10.3390\/cancers17050718","journal-title":"Cancers (Basel)"},{"key":"6777_CR17","doi-asserted-by":"publisher","unstructured":"Xin Z, Guo Z, Liu S, Chen Z, Wang Y, Yang R, Li X (2024) Ketao Ma. Transcriptomics and molecular docking reveal the potential mechanism of lycorine against pancreatic cancer[J]. Phytomedicine. 122 155128. https:\/\/doi.org\/10.1016\/j.phymed.2023.155128","DOI":"10.1016\/j.phymed.2023.155128"},{"key":"6777_CR18","doi-asserted-by":"publisher","first-page":"216364","DOI":"10.1016\/j.canlet.2023.216364","volume":"573","author":"L FangFang Zhuo","year":"2023","unstructured":"FangFang Zhuo L, Li TT, Liu XM, Liang Z, Yang YZ, Zheng QW, Luo JH, Lu D, Liu (2023) KeWu Zeng, PengFei Tu. Lycorine promotes IDH1 acetylation to induce mitochondrial dynamics imbalance in colorectal cancer cells[J]. Cancer Lett 573:216364. https:\/\/doi.org\/10.1016\/j.canlet.2023.216364","journal-title":"Cancer Lett"},{"key":"6777_CR19","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.3390\/ijms25031782","volume":"25","author":"C Eleonora Corbella","year":"2024","unstructured":"Eleonora Corbella C, Fara F, Covarelli V, Porreca B, Palmisano G, Mignogna A, Corsi M, Riminucci B, Maras (2024) Carmine Mancone. THBS1 and THBS2 enhance the in vitro Proliferation, Adhesion, migration and invasion of intrahepatic cholangiocarcinoma Cells[J]. Int J Mol Sci 25:1782. https:\/\/doi.org\/10.3390\/ijms25031782","journal-title":"Int J Mol Sci"},{"key":"6777_CR20","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/s41418-024-01347-w","volume":"31","author":"R Polara","year":"2024","unstructured":"Polara R, Ganesan R, Pitson SM, Robinson N (2024) Cell autonomous functions of CD47 in regulating cellular plasticity and metabolic plasticity. Cell Death Differ 31:1255\u20131266. https:\/\/doi.org\/10.1038\/s41418-024-01347-w","journal-title":"Cell Death Differ"},{"key":"6777_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121185","volume":"279","author":"S Patwardhan","year":"2021","unstructured":"Patwardhan S, Mahadik P, Shetty O, Sen S (2021) ECM stiffness-tuned exosomes drive breast cancer motility through thrombospondin-1. Biomaterials 279:121185. https:\/\/doi.org\/10.1016\/j.biomaterials.2021.121185","journal-title":"Biomaterials"},{"key":"6777_CR22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI156967","volume":"132","author":"H Fu","year":"2022","unstructured":"Fu H, Siggs OM, Knight LS, Staffieri SE, Ruddle JB, Birsner AE, Collantes ER, Craig JE, Wiggs JL, D\u2019Amato RJ (2022) Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma. J Clin Invest 132:e156967. https:\/\/doi.org\/10.1172\/JCI156967","journal-title":"J Clin Invest"},{"key":"6777_CR23","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.semcancer.2022.09.006","volume":"86","author":"J Lawler","year":"2022","unstructured":"Lawler J (2022) Counter regulation of tumor angiogenesis by vascular endothelial growth factor and thrombospondin-1. Semin Cancer Biol 86:126\u2013135. https:\/\/doi.org\/10.1016\/j.semcancer.2022.09.006","journal-title":"Semin Cancer Biol"},{"key":"6777_CR24","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s00395-023-01021-1","volume":"119","author":"L Pei","year":"2024","unstructured":"Pei L, Ouyang Z, Zhang H, Huang S, Jiang R, Liu B, Tang Y, Feng M, Yuan M, Wang H, Yao S, Shi S, Yu Z, Xu D, Gong G, Wei K (2024) Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair. Basic Res Cardiol 119:169\u2013192. https:\/\/doi.org\/10.1007\/s00395-023-01021-1","journal-title":"Basic Res Cardiol"},{"key":"6777_CR25","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.matbio.2017.12.009","volume":"68","author":"JE Murphy-Ullrich","year":"2018","unstructured":"Murphy-Ullrich JE, Suto MJ (2018) Thrombospondin-1 regulation of latent TGF-\u03b2 activation: a therapeutic target for fibrotic disease. Matrix Biol 68:28\u201343. https:\/\/doi.org\/10.1016\/j.matbio.2017.12.009","journal-title":"Matrix Biol"},{"key":"6777_CR26","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1136\/gutjnl-2024-333213","volume":"74","author":"F Link","year":"2025","unstructured":"Link F, Li Y, Zhao J, Munker S, Fan W, Nwosu ZC, Yao Y, Wang S, Huang C, Liebe R, Hammad S, Liu H, Shao C, Gao C, Sun B, T\u00f6r\u00f6k NJ, Ding H, Ebert MP, Weng H, Ten Dijke P, Drasdo D, Dooley S, Wang S (2025) ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-\u03b21 activation. Gut 74:424\u2013439. https:\/\/doi.org\/10.1136\/gutjnl-2024-333213","journal-title":"Gut"},{"key":"6777_CR27","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1038\/s41467-023-36824-2","volume":"14","author":"FV Alexander","year":"2023","unstructured":"Alexander FV, Stein R, Rebollido-Rios A, Lukas M, Koch A, von Lom S, Reinartz D, Bachurski F, Rose K, Bozek AT, Abdallah V, Kohlhas J, Saggau R, Z\u00f6lzer Y, Zhao C, Bruns PJ, Br\u00f6ckelmann P, Lohneis R, B\u00fcttner Bj\u00f6rn, H\u00e4upl T, Oellerich (2023) Phuong-Hien Nguyen, Michael Hallek. LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1[J]. Nat Commun 14:1330. https:\/\/doi.org\/10.1038\/s41467-023-36824-2","journal-title":"Nat Commun"},{"key":"6777_CR28","doi-asserted-by":"publisher","first-page":"4722","DOI":"10.1002\/ptr.7942","volume":"37","author":"Z Zeng","year":"2023","unstructured":"Zeng Z, Lin C, Zhang M-C, Kossinna P, Wang P, Cao D, Wang J, Xu M, Wang X, Li Q, Xu X, Yang H, Zhu S, Liu G-R, Xie K, Yang J, Luo Y, Wang Y, Zhang X-H, Lin J, Chen H (2023) Shu-Lin Liu, Huidi Liu. Enterolactone and trabectedin suppress epithelial ovarian cancer synergistically via upregulating THBS1[J]. Phytother Res 37:4722\u20134739. https:\/\/doi.org\/10.1002\/ptr.7942","journal-title":"Phytother Res"},{"key":"6777_CR29","doi-asserted-by":"publisher","first-page":"e23591","DOI":"10.1096\/fj.202302422RR","volume":"38","author":"X Ma","year":"2024","unstructured":"Ma X, Xu L, Gong S, Wu N, Guo J, Feng X, Zhao M, Qiu S, Sun M, Zhang C, Zhang X, Ren Z (2024) Pengbo Zhang. hsa_circ_0007919 promotes pancreatic cancer metastasis by modulating Sp1-mediated THBS1 transcription[J]. FASEB J 38:e23591. https:\/\/doi.org\/10.1096\/fj.202302422RR","journal-title":"FASEB J"},{"key":"6777_CR30","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.canlet.2018.10.031","volume":"442","author":"W-T Huang","year":"2019","unstructured":"Huang W-T, Chong I-W, Chen H-L, Li C-Y, Hsieh C-C, Kuo H-F, Chang C-Y, Chen Y-H, Liu Y-P, Lu C-Y, Liu Y-R (2019) Po-Len Liu. Pigment epithelium-derived factor inhibits lung cancer migration and invasion by upregulating Exosomal thrombospondin 1[J]. Cancer Lett 442:287\u2013298. https:\/\/doi.org\/10.1016\/j.canlet.2018.10.031","journal-title":"Cancer Lett"},{"key":"6777_CR31","doi-asserted-by":"publisher","first-page":"1489210","DOI":"10.3389\/fphar.2025.1489210","volume":"16","author":"Q Tang","year":"2025","unstructured":"Tang Q, Dong J, Zhang F, Zhao D, Yang Q, Wen J, Sun Y, Wei J, Zhixian Liu (2025) Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-\u03b2 signaling pathways[J]. Front Pharmacol 16:1489210. https:\/\/doi.org\/10.3389\/fphar.2025.1489210","journal-title":"Front Pharmacol"},{"key":"6777_CR32","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.jare.2024.06.023","volume":"71","author":"J Shen","year":"2025","unstructured":"Shen J, Zhou L, Ye K, Gong J, Wu F, Mo K, Zhu Y, Chen C, Zhan R (2025) The role of SPI1\/VSIG4\/THBS1 on glioblastoma progression through modulation of the PI3K\/AKT pathway[J]. J Adv Res 71:487\u2013500. https:\/\/doi.org\/10.1016\/j.jare.2024.06.023","journal-title":"J Adv Res"},{"key":"6777_CR33","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41419-021-03532-y","volume":"12","author":"Z Xu Chen","year":"2021","unstructured":"Xu Chen Z, Guo D, Cao Y, Chen J, Chen (2021) MYC-mediated upregulation of PNO1 promotes glioma tumorigenesis by activating THBS1\/FAK\/Akt signaling[J]. Cell Death Dis 12:244. https:\/\/doi.org\/10.1038\/s41419-021-03532-y","journal-title":"Cell Death Dis"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06777-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-06777-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06777-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T03:33:10Z","timestamp":1770262390000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-06777-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,17]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["6777"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-06777-9","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,17]]},"assertion":[{"value":"26 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors confirm that there are no conflicts of interest regarding the publication of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study has obtained informed consent from all participants. The Ethics Committee of Qiqihar Medical College\u2019s Second Affiliated Hospital provided ethical permission for this study (Scientific Research 2023-03-003).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}}],"article-number":"24"}}