{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:28:45Z","timestamp":1786786125136,"version":"build-2736575974"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005690","name":"Universit\u00e4t des Saarlandes","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005690","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute lymphoblastic leukemia is the most common pediatric hematological disease representing less than 1% of hematological diseases in adults. The prognosis of ALL improved significantly in the last decades. Almost all patients require a therapy at the time of diagnosis. Rare cases of spontaneous remission of ALL have been described. We report a case of B-ALL that underwent spontaneous remission after an episode of infection and describe the cytogenetic changes associated with this uncommon clinical presentation of B-ALL.<\/jats:p>","DOI":"10.1007\/s00277-026-06825-4","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:46:14Z","timestamp":1785498374000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous regression of B-cell acute lymphoblastic leukemia with PAX5 alterations at relapse: a case report"],"prefix":"10.1007","volume":"105","author":[{"given":"Vadim","family":"Lesan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Bittenbring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Altmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"6825_CR1","doi-asserted-by":"crossref","unstructured":"Sasaki K, Jabbour E, Short NJ, Jain N, Ravandi F, Pui CH et al (2021) Acute lymphoblastic leukemia: a population-based study of outcome in the United States based on the surveillance, epidemiology, and end results (SEER) database, 1980\u20132017. Am J Hematol [Internet]. [cited 2025 Feb 2];96(6):650. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9517941\/","DOI":"10.1002\/ajh.26156"},{"key":"6825_CR2","doi-asserted-by":"crossref","unstructured":"Yi M, Zhou L, Li A, Luo S, Wu K (2020) Global burden and trend of acute lymphoblastic leukemia from 1990 to 2017. Aging (Albany NY) [Internet]. [cited 2025 Feb 2];12(22):22869. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7746341\/","DOI":"10.18632\/aging.103982"},{"key":"6825_CR3","doi-asserted-by":"publisher","unstructured":"H\u00f6res T, Wendelin K, Schaefer-Eckart K (2018) Spontaneous remission of acute lymphoblastic leukemia: a case report. Oncol Lett [Internet]. [cited 2025 Feb 2];15(1):115\u201320. 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