{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:51:05Z","timestamp":1790628665072,"version":"4.1.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-026-06856-x","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T03:57:12Z","timestamp":1770177432000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Many faces of non\u2011deletional \u03b1\u2011thalassaemia variants in neonate and early childhood"],"prefix":"10.1007","volume":"105","author":[{"given":"Patcharee","family":"Komvilaisak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Napat","family":"Laoaroon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pongsatorn","family":"Paopongsawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Jirapradittha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pakaphan","family":"Kiatchoosakun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunanya","family":"Suwannaying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratana","family":"Komwilaisak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Worrawalan","family":"Lerttham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"6856_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3109\/03630268709036587","volume":"11","author":"S Fucharoen","year":"1987","unstructured":"Fucharoen S, Winichagoon P (1987) Hemoglobinopathies in Southeast Asia. Hemoglobin 11:65\u201388","journal-title":"Hemoglobin"},{"key":"6856_CR2","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/BF00208939","volume":"84","author":"M Laig","year":"1990","unstructured":"Laig M, Pape M, Hundrieser J et al (1990) The distribution of the Hb constant spring gene in Southeast Asian populations. Hum Genet 84:188\u2013190","journal-title":"Hum Genet"},{"key":"6856_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145230","volume":"10","author":"W Jomoui","year":"2015","unstructured":"Jomoui W, Fucharoen G, Sanchaisuriya K et al (2015) Hemoglobin constant spring among Southeast Asian populations: haplotypic heterogeneities and phylogenetic analysis. PLoS One 10:e0145230","journal-title":"PLoS One"},{"key":"6856_CR4","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1159\/000096857","volume":"117","author":"N Sae-ung","year":"2007","unstructured":"Sae-ung N, Fucharoen G, Sanchaisuriya K et al (2007) \u03b10-thalassemia and related disorders in northeast Thailand: a molecular and hematological characterization. Acta Haematol 117:78\u201382","journal-title":"Acta Haematol"},{"key":"6856_CR5","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/pd.2514","volume":"30","author":"S Yamsri","year":"2010","unstructured":"Yamsri S, Sanchaisuriya K, Fucharoen G et al (2010) Prevention of severe thalassemia in northeast Thailand: 16 years of experience at a single university center. Prenat Diagn 30:540\u2013546","journal-title":"Prenat Diagn"},{"key":"6856_CR6","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1172\/JCI111374","volume":"73","author":"S Derry","year":"1984","unstructured":"Derry S, Wood WG, Pippard M, Clegg JB, Weatherall DJ, Wickramasinghe NS, Darley J, Fucharoen S, Wasi P (1984) Hematologic and biosynthetic studies in homozygous hemoglobin constant spring. J Clin Invest 73:1673\u201382","journal-title":"J Clin Invest"},{"key":"6856_CR7","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1097\/01.mph.0000243662.56432.37","volume":"28","author":"P Charoenkwan","year":"2006","unstructured":"Charoenkwan P, Sirichotiyakul S, Chanprapaph P et al (2006) Anemia and hydrops in a fetus with homozygous hemoglobin constant spring. J Pediatr Hematol Oncol 28:827\u2013830","journal-title":"J Pediatr Hematol Oncol"},{"issue":"5","key":"6856_CR8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1097\/MPH.0000000000001051","volume":"40","author":"P Komvilaisak","year":"2018","unstructured":"Komvilaisak P, Komvilaisak R, Jetsrisuparb A, Wiangnon S, Jirapradittha J, Kiatchoosakun P, Fucharoen G (2018) Fetal anemia causing hydrops fetalis from an Alpha-globin variant: homozygous hemoglobin constant spring. J Pediatr Hematol Oncol 40(5):405\u2013408","journal-title":"J Pediatr Hematol Oncol"},{"issue":"5","key":"6856_CR9","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/MPH.0000000000001160","volume":"40","author":"P Komvilaisak","year":"2018","unstructured":"Komvilaisak P, Jetsrisuparb A, Fucharoen G, Komwilaisak R, Jirapradittha J, Kiatchoosakun P (2018) Clinical course of homozygous hemoglobin constant spring in pediatric patients. J Pediatr Hematol Oncol 40(5):409\u2013412","journal-title":"J Pediatr Hematol Oncol"},{"issue":"7","key":"6856_CR10","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/s41372-019-0397-7","volume":"39","author":"S Sirilert","year":"2019","unstructured":"Sirilert S, Charoenkwan P, Sirichotiyakul S, Tongprasert F, Srisupundit K, Luewan S, Tongsong T (2019) Prenatal diagnosis and management of homozygous hemoglobin constant spring disease. J Perinatol 39(7):927\u2013933","journal-title":"J Perinatol"},{"key":"6856_CR11","doi-asserted-by":"publisher","first-page":"e413","DOI":"10.1097\/MPH.0000000000001406","volume":"41","author":"P Komvilaisak","year":"2019","unstructured":"Komvilaisak P, Jetsrisuparb A, Fucharoen G, Komwilaisak R, Jirapradittha J, Kiatchoosakun P (2019) Presentation of compound heterozygous hemoglobin constant spring and hemoglobin Pakse in neonates. J Pediatr Hematol Oncol 41:e413\u2013e415","journal-title":"J Pediatr Hematol Oncol"},{"issue":"2","key":"6856_CR12","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/bjh.19869","volume":"206","author":"D DuantidaSongdej","year":"2025","unstructured":"DuantidaSongdej D, Teawtrakul N, Laoaroon N, Komvilaisak P, Sripornsawan P, Surapolchai P et al (2025) Impact of HbE mutation on the clinical severity of HbH disease: a multicentre study from Thailand. Br J Haematol 206(2):703\u2013712","journal-title":"Br J Haematol"},{"issue":"8","key":"6856_CR13","volume":"16","author":"SF Embong","year":"2024","unstructured":"Embong SF, Daud A, Nordin MH, Adzahar S (2024) Detection of hemoglobin constant spring: a comparison of capillary electrophoresis versus high-performance liquid chromatography. Cureus 16(8):e67228","journal-title":"Cureus"},{"issue":"5","key":"6856_CR14","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2024.96","volume":"39","author":"S Adzahar","year":"2024","unstructured":"Adzahar S, Rameli N, Hussin S, Fatma Fairuz N, Mohd Hassan N, Norhasanah W, Yusoff W, Yusoff SM, Bahar R (2024) Detection of hemoglobin constant spring by capillary electrophoresis and high-performance liquid chromatography: a study in Kelantan, Malay: a study in Kelantan, Malay. Oman Med J 39(5):e669","journal-title":"Oman Med J"},{"issue":"1","key":"6856_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02197-w","volume":"17","author":"K Singha","year":"2022","unstructured":"Singha K, Yamsri S, Chaibunruang A, Srivorakun H, Sanchaisuriya K, Fucharoen G, Fucharoen S (2022) Diagnostic value of fetal hemoglobin Bart\u2019s for evaluation of fetal \u03b1-thalassemia syndromes: application to prenatal characterization of fetal anemia caused by undiagnosed \u03b1-hemoglobinopathy. Orphanet J Rare Dis 17(1):45","journal-title":"Orphanet J Rare Dis"},{"issue":"7","key":"6856_CR16","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1080\/00365513.2021.1972332","volume":"81","author":"P Wichian","year":"2021","unstructured":"Wichian P, Yamsrib S, Chaibunruangb A, KerdKaew C, Thongsee D, Srivorakunb H, Fucharoen S (2021) Direct PCR assays without DNA extraction for rapid detection of hemoglobin constant spring and Pakse\u2019 genes: application for carrier screening and prenatal diagnosis. Scand J Clin Lab Invest 81(7):557\u2013563","journal-title":"Scand J Clin Lab Invest"},{"issue":"1","key":"6856_CR17","volume":"10","author":"A Chaibunruang","year":"2018","unstructured":"Chaibunruang A, Sornkayasit K, Chewasateanchai M et al (2018) Prevalence of thalassemia among newborns: a re-visited after 20 years of a prevention and control program in northeast. Thailand. Mediterr J Hematol Infect Dis 10(1):e201805","journal-title":"Mediterr J Hematol Infect Dis"},{"issue":"10","key":"6856_CR18","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s00277-005-1091-8","volume":"84","author":"WY Au","year":"2005","unstructured":"Au WY, Cheung WC, Hu WH, Chan GCF, Ha SY, Khong PL, Ma SK, Liang R (2005) Hyperbilirubinemia and cholelithiasis in Chinese patients with hemoglobin H disease. Ann Hematol 84(10):671\u2013674","journal-title":"Ann Hematol"},{"issue":"4","key":"6856_CR19","first-page":"205","volume":"25","author":"P Chen","year":"2004","unstructured":"Chen P, Long G-F, Lin W-X, Li S-Q (2004) Homozygous hemoglobin constant spring in Guangxi province. Zhonghua Xue Ye Xue Za Zhi 25(4):205\u2013208","journal-title":"Zhonghua Xue Ye Xue Za Zhi"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06856-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-06856-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06856-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:05:10Z","timestamp":1771949110000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-06856-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["6856"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-06856-x","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]},"assertion":[{"value":"17 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study protocol was reviewed and approved by the Khon Kaen University ethics committee No HE681561. Written informed consent was obtained from participants and from parents\/legal guardians for all participants aged under 18 to participate in this study\n                      .","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent for publication Written informed consent for publication was obtained from parents.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"80"}}