{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:58:57Z","timestamp":1771952337164,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province","award":["20210027"],"award-info":[{"award-number":["20210027"]}]},{"name":"Research Project Plan of the Shanxi Provincial Health Commission","award":["2021056"],"award-info":[{"award-number":["2021056"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-026-06877-6","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:34:48Z","timestamp":1770773688000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic lymphocytic leukemia with IGH\/BCL2 fusion and clonal heterogeneity: phenotypic and molecular profiling analysis of a rare case"],"prefix":"10.1007","volume":"105","author":[{"given":"Ting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanggang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianbian","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaofang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"issue":"1","key":"6877_CR1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41591-022-02113-6","volume":"29","author":"EM Parry","year":"2023","unstructured":"Parry EM, Leshchiner I, Gui\u00e8ze R, Johnson C, Tausch E, Parikh SA, Lemvigh C, Bros\u00e9us J, Hergalant S, Messer C, Utro F, Levovitz C, Rhrissorrakrai K, Li L, Rosebrock D, Yin S, Deng S, Slowik K, Jacobs R, Huang T, Li S, Fell G, Redd R, Lin Z, Knisbacher BA, Livitz D, Schneider C, Ruthen N, Elagina L, Taylor-Weiner A, Persaud B, Martinez A, Fernandes SM, Purroy N, Anandappa AJ, Ma J, Hess J, Rassenti LZ, Kipps TJ, Jain N, Wierda W, Cymbalista F, Feugier P, Kay NE, Livak KJ, Danysh BP, Stewart C, Neuberg D, Davids MS, Brown JR, Parida L, Stilgenbauer S, Getz G, Wu CJ (2023) Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome. Nat Med 29(1):158\u2013169. https:\/\/doi.org\/10.1038\/s41591-022-02113-6","journal-title":"Nat Med"},{"issue":"10","key":"6877_CR2","doi-asserted-by":"publisher","first-page":"e435","DOI":"10.1016\/S1470-2045(14)70153-6","volume":"15","author":"U Ralf K\u00fcppers","year":"2014","unstructured":"Ralf K\u00fcppers U, D\u00fchrsen M-L (2014) Hansmann. Pathogenesis, diagnosis, and treatment of composite lymphomas. Lancet Oncol 15(10):e435-46. https:\/\/doi.org\/10.1016\/S1470-2045(14)70153-6","journal-title":"Lancet Oncol"},{"issue":"6","key":"6877_CR3","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/ajh.20850","volume":"82","author":"P DelvilleJP, Heimann","year":"2007","unstructured":"DelvilleJP,Heimann P, Housni HE, Boutriaux M, Jeronnez A, Remmelink M, Lasudry J, Pradier O, Kentos A (2007) Biclonal low grade B-cell lymphoma confirmed by both flow cytometry and karyotypic analysis, in spite of a normal kappa\/lambda Ig light chain ratio. Am J Hematol 82(6):473\u2013480 https:\/\/doi.org\/10.1002\/ajh.20850","journal-title":"Am J Hematol"},{"issue":"18","key":"6877_CR4","doi-asserted-by":"publisher","first-page":"4427","DOI":"10.3390\/cancers15184427","volume":"15","author":"T Robak","year":"2023","unstructured":"Robak T, Krawczy\u0144ska A, Cebula-Obrzut B, Urbaniak M, Iskierka-Ja\u017cd\u017cewska E P Robak (2023) Atypical chronic lymphocytic Leukemia-The current status. Cancers (Basel) 15(18):4427 https:\/\/doi.org\/10.3390\/cancers15184427","journal-title":"Cancers (Basel)"},{"issue":"3","key":"6877_CR5","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/bjh.13859","volume":"172","author":"ID Giudice","year":"2016","unstructured":"Giudice ID, Wang MMJ, Bonina S, Chiaretti MMS, Ilari C, Cafforio L (2016) Francesca Romana Mauro, Valeria Di Maio, Maria Stefania de Propris, Mauro Nanni, Carmela Ciardullo, Davide Rossi, Gianluca Gaidano, Anna Guarini, Raul Rabadan, robin Fo\u00e0. Inter- and intra-patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidences from Circulating and lymph nodal compartments. Br J Haematol 172(3):371\u2013383. https:\/\/doi.org\/10.1111\/bjh.13859","journal-title":"Br J Haematol"},{"issue":"20","key":"6877_CR6","doi-asserted-by":"publisher","first-page":"4117","DOI":"10.1182\/blood-2012-09-452805","volume":"120","author":"W CatherineJ","year":"2012","unstructured":"CatherineJW (2012) CLL clonal heterogeneity: an ecology of competing subpopulations. Blood 120(20):4117\u20134118 https:\/\/doi.org\/10.1182\/blood-2012-09-452805","journal-title":"Blood"},{"issue":"4","key":"6877_CR7","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/j.1365-2141.2012.09178.x","volume":"158","author":"L Baseggio","year":"2012","unstructured":"BaseggioL, Geay M-O, Gazzo S, Berger F, Traverse-Glehen A, Ffrench M, Hayette S, Callet-Bauchu E, Verney A, Morel D, Jallades L, Magaud J-P, Salles G, Felman P (2012) In non-follicular lymphoproliferative disorders, IGH\/BCL2-fusion is not restricted to chronic lymphocytic leukaemia. Br J Haematol 158(4):489\u2013498 https:\/\/doi.org\/10.1111\/j.1365-2141.2012.09178.x","journal-title":"Br J Haematol"},{"issue":"29","key":"6877_CR8","doi-asserted-by":"publisher","first-page":"4473","DOI":"10.1200\/JCO.2009.27.8762","volume":"28","author":"B ThorstenZenz","year":"2010","unstructured":"ThorstenZenzB, Eichhorst R, Busch T, Denzel S, H\u00e4be D, Winkler A, B\u00fchler J, Edelmann M, Bergmann G, Hopfinger M, Hensel M, Hallek H, D\u00f6hner S (2010) Stilgenbauer. TP53 mutation and survival in chronic lymphocytic leukemia. J Clin Oncol 28(29):4473\u20134479 https:\/\/doi.org\/10.1200\/JCO.2009.27.8762","journal-title":"J Clin Oncol"},{"issue":"7574","key":"6877_CR9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nature15395","volume":"526","author":"TE LandauDA","year":"2015","unstructured":"LandauDATE, Taylor-Weiner AN, Stewart C, Reiter JG, Bahlo J, Kluth S, Bozic I, Lawrence M, B\u00f6ttcher S, Carter SL, Cibulskis K, Sougnez DMCL, Rosenberg M, Hess JM, Edelmann J, Kless S, Kneba M, Ritgen M, Fink A, Fischer K, Gabriel S, Lander ES, Nowak MA, D\u00f6hner H, Hallek M, Neuberg D, Getz G, Stilgenbauer S, Wu CJ (2015) Mutations driving CLL and their evolution in progression and relapse. Nature 526(7574):525\u2013530 https:\/\/doi.org\/10.1038\/nature15395","journal-title":"Nature"},{"issue":"8","key":"6877_CR10","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1038\/s41375-021-01124-5","volume":"35","author":"Y Shuhua Yi","year":"2021","unstructured":"Shuhua Yi Y, Jin YM, Xiong W, Yu Z, Yu Y, Cui R, Wang J, Wang Y, Lin Y, Jia Y, Zhang D, Wang T, Lv R, Liu W, Sui W, Huang W, Fu M, Xu Y, Deng S, An G, Zou D, Li Z, Shi J, Wang ZXJ (2021) Tao Cheng, Robert Peter Gale, Lili Wang, Lugui Qiu. High incidence of MYD88 and KMT2D mutations in Chinese with chronic lymphocytic leukemia. Leukemia 35(8):2412\u20132415. https:\/\/doi.org\/10.1038\/s41375-021-01124-5","journal-title":"Leukemia"},{"issue":"7","key":"6877_CR11","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1002\/ijc.25497","volume":"128","author":"C Philipp","year":"2011","unstructured":"Philipp C, Edelmann J, B\u00fchler A, Winkler D, Stilgenbauer S, K\u00fcppers R (2011) Mutation analysis of the TNFAIP3 (A20) tumor suppressor gene in CLL. Int J Cancer 128(7):1747\u20131750. https:\/\/doi.org\/10.1002\/ijc.25497","journal-title":"Int J Cancer"},{"issue":"8","key":"6877_CR12","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/gcc.22542","volume":"57","author":"H TeradaK, Yamaguchi","year":"2018","unstructured":"TeradaK,Yamaguchi H, Ueki T, Usuki K, Kobayashi Y, Tajika K, Gomi S, Kurosawa S, Saito R, Furuta Y, Miyadera K, Tokura T, Marumo A, Omori I, Sakaguchi M, Fujiwara Y, Yui S, Ryotokuji T, Arai K, Kitano T, Wakita S, Fukuda T, Inokuchi K (2018) Usefulness of BCOR gene mutation as a prognostic factor in acute myeloid leukemia with intermediate cytogenetic prognosis. Genes Chromosomes Cancer 57(8):401\u2013408 https:\/\/doi.org\/10.1002\/gcc.22542","journal-title":"Genes Chromosomes Cancer"},{"issue":"1","key":"6877_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41392-020-00437-8","volume":"6","author":"Y-H Huang","year":"2021","unstructured":"Huang Y-H, Xu KCP-P, Wang L, Huang C-X, Fang Y, Cheng S, Sun X-J, Huang FLJ-Y (2021) CREBBP\/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2\/CSF1 axis. Signal Transduct Target Ther 6(1):10. https:\/\/doi.org\/10.1038\/s41392-020-00437-8","journal-title":"Signal Transduct Target Ther"},{"key":"6877_CR14","doi-asserted-by":"publisher","unstructured":"Pozzo F, Bittolo T, Tissino E, Zucchetto A, Bomben R, Polcik L, Prosseda SD, Hartmann TN, Gattei V (2022) Mechanisms of NOTCH1 Activation in Chronic Lymphocytic Leukemia: NOTCH1 Mutations and Beyond Cancers (Basel). 14(12):2997 https:\/\/doi.org\/10.3390\/cancers14122997","DOI":"10.3390\/cancers14122997"},{"issue":"11","key":"6877_CR15","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/s41419-020-03144-y","volume":"11","author":"J KapoorI, Bodo","year":"2020","unstructured":"KapoorI,Bodo J, Hill BT, Hsi ED, Almasan A (2020) Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance. Cell Death Dis 11(11):941 https:\/\/doi.org\/10.1038\/s41419-020-03144-y","journal-title":"Cell Death Dis"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06877-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-06877-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06877-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:04:40Z","timestamp":1771949080000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-06877-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["6877"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-06877-6","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]},"assertion":[{"value":"22 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"this study received approval from the ethics committee of our hospital, and obtained the written informed consent of the legal guardian.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"105"}}