{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:52:09Z","timestamp":1776408729298,"version":"3.51.2"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Science and Technology Development Program of Jinan Municipal Health Commission","award":["2024304013"],"award-info":[{"award-number":["2024304013"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-026-06938-w","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:35:20Z","timestamp":1773387320000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of cystatin C in predicting the risk of hypermethotrexemia and kidney injury after high-dose methotrexate chemotherapy in childhood acute lymphoblastic leukemia"],"prefix":"10.1007","volume":"105","author":[{"given":"Wenting","family":"Pei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-an","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muyuan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Mou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luping","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"issue":"1","key":"6938_CR1","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1080\/0886022X.2022.2039193","volume":"44","author":"C Hong","year":"2022","unstructured":"Hong C, Zhu Q, Li Y, Tang S (2022) Acute kidney injury defined by cystatin C may be superior for predicting the outcomes of liver cirrhosis with acute gastrointestinal bleeding. Ren Fail 44(1):398\u2013406. https:\/\/doi.org\/10.1080\/0886022X.2022.2039193","journal-title":"Ren Fail"},{"issue":"10","key":"6938_CR2","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1182\/blood.V78.10.2514.2514","volume":"78","author":"CM Niemeyer","year":"1991","unstructured":"Niemeyer CM, Gelber RD, Tarbell NJ (1991) Low-dose versus high-dose methotrexate during remission induction in childhood acute lymphoblastic leukemia (Protocol 81\u2009\u2013\u200901 update). Blood 78(10):2514\u20132519. https:\/\/doi.org\/10.1182\/blood.V78.10.2514.2514","journal-title":"Blood"},{"issue":"9","key":"6938_CR3","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1182\/blood-2004-04-1616","volume":"104","author":"CH Pui","year":"2004","unstructured":"Pui CH, Sandlund JT, Pei D (2004) Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children\u2019s Research Hospital. Blood 104(9):2690\u20132696. https:\/\/doi.org\/10.1182\/blood-2004-04-1616","journal-title":"Blood"},{"issue":"12","key":"6938_CR4","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1634\/theoncologist.2015-0164","volume":"21","author":"SC Howard","year":"2016","unstructured":"Howard SC, McCormick J, Pui CH (2016) Preventing and managing toxicities of high-dose methotrexate. Oncologist 21(12):1471\u20131482. https:\/\/doi.org\/10.1634\/theoncologist.2015-0164","journal-title":"Oncologist"},{"issue":"4","key":"6938_CR5","doi-asserted-by":"publisher","first-page":"c179","DOI":"10.1159\/000339789","volume":"120","author":"A Khwaja","year":"2012","unstructured":"Khwaja A (2012) KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract 120(4):c179\u2013184. https:\/\/doi.org\/10.1159\/000339789","journal-title":"Nephron Clin Pract"},{"issue":"6","key":"6938_CR6","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1038\/s41390-022-02015-w","volume":"92","author":"AAS Mahmoud","year":"2022","unstructured":"Mahmoud AAS, Elsalam HBA, El-Deeb SM (2022) Evaluation of kidney dysfunction in childhood cancer survivors. Pediatr Res 92(6):1689\u20131694. https:\/\/doi.org\/10.1038\/s41390-022-02015-w","journal-title":"Pediatr Res"},{"issue":"7","key":"6938_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28387","volume":"67","author":"S Khera","year":"2020","unstructured":"Khera S, Kapoor R, Pramanik SK (2020) Solitary serum methotrexate level 36 hours post high-dose methotrexate: a safe, efficacious, and cost-effective strategy to monitor methotrexate toxicities in childhood leukemia in resource-limited centers. Pediatr Blood Cancer 67(7):e28387. https:\/\/doi.org\/10.1002\/pbc.28387","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"6938_CR8","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s12885-021-09145-0","volume":"22","author":"E Daetwyler","year":"2022","unstructured":"Daetwyler E, Bargetzi M, Otth M, Scheinemann K (2022) Late effects of high-dose methotrexate treatment in childhood cancer survivors-a systematic review. BMC Cancer 22(1):267. https:\/\/doi.org\/10.1186\/s12885-021-09145-0","journal-title":"BMC Cancer"},{"key":"6938_CR9","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5914593","volume":"2022","author":"FL Qin","year":"2022","unstructured":"Qin FL, Sang GY, Zou XQ, Cheng DH (2022) Drug-induced liver injury during consolidation therapy in childhood acute lymphoblastic leukemia as assessed for causality using the updated RUCAM. Can J Gastroenterol Hepatol 2022:5914593. https:\/\/doi.org\/10.1155\/2022\/5914593","journal-title":"Can J Gastroenterol Hepatol"},{"issue":"3","key":"6938_CR10","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s00280-020-04197-8","volume":"87","author":"A Al-Sheikh","year":"2021","unstructured":"Al-Sheikh A, Yousef AM, Alshamaseen D, Farhad R (2021) Effects of thymidylate synthase polymorphisms on toxicities associated with high-dose methotrexate in childhood acute lymphoblastic leukemia. Cancer Chemother Pharmacol 87(3):379\u2013385. https:\/\/doi.org\/10.1007\/s00280-020-04197-8","journal-title":"Cancer Chemother Pharmacol"},{"issue":"11","key":"6938_CR11","doi-asserted-by":"publisher","first-page":"6243","DOI":"10.1007\/s00520-021-06199-5","volume":"29","author":"M Curra","year":"2021","unstructured":"Curra M, Gabriel AF, Ferreira MBC, Martins MAT, Brunetto AT, Gregianin LJ, Martins MD (2021) Incidence and risk factors for oral mucositis in pediatric patients receiving chemotherapy. Support Care Cancer 29(11):6243\u20136251. https:\/\/doi.org\/10.1007\/s00520-021-06199-5","journal-title":"Support Care Cancer"},{"issue":"3","key":"6938_CR12","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s12288-019-01245-z","volume":"36","author":"P Mandal","year":"2020","unstructured":"Mandal P, Samaddar S, Chandra J, Parakh N, Goel M (2020) Adverse effects with intravenous methotrexate in children with acute lymphoblastic leukemia\/lymphoma: a retrospective study. Indian J Hematol Blood Transfus 36(3):498\u2013504. https:\/\/doi.org\/10.1007\/s12288-019-01245-z","journal-title":"Indian J Hematol Blood Transfus"},{"issue":"12","key":"6938_CR13","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1002\/pbc.25137","volume":"61","author":"E Ylinen","year":"2014","unstructured":"Ylinen E, Jahnukainen K, Saarinen-Pihkala UM (2014) Assessment of renal function during high-dose methotrexate treatment in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 61(12):2199\u20132202. https:\/\/doi.org\/10.1002\/pbc.25137","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"6938_CR14","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/cts.13125","volume":"15","author":"JN Barreto","year":"2022","unstructured":"Barreto JN, Reid JM, Thompson CA (2022) Prospective evaluation of high-dose methotrexate pharmacokinetics in adult patients with lymphoma using novel determinants of kidney function. Clin Transl Sci 15(1):105\u2013117. https:\/\/doi.org\/10.1111\/cts.13125","journal-title":"Clin Transl Sci"},{"key":"6938_CR15","first-page":"779","volume":"61","author":"A Nirenberg","year":"1977","unstructured":"Nirenberg A, Mosende C, Mehta BM, Gisolfi AL, Rosen G (1977) High-dose methotrexate with citrovorum factor rescue: predictive value of serum methotrexate concentrations and corrective measures to avert toxicity. Cancer Treat Rep 61:779\u2013783","journal-title":"Cancer Treat Rep"},{"key":"6938_CR16","first-page":"709","volume":"61","author":"HM Pinedo","year":"1977","unstructured":"Pinedo HM, Chabner BA (1977) Role of drug concentration, duration of exposure, and endogenous metabolites in determining methotrexate cytotoxicity. Cancer Treat Rep 61:709\u2013715","journal-title":"Cancer Treat Rep"},{"key":"6938_CR17","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1056\/NEJM197709222971203","volume":"297","author":"RG Stoller","year":"1977","unstructured":"Stoller RG, Hande KR, Jacobs SA, Rosenberg SA, Chabner BA (1977) Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity. N Engl J Med 297:630\u2013634. https:\/\/doi.org\/10.1056\/NEJM197709222971203","journal-title":"N Engl J Med"},{"key":"6938_CR18","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7169897","volume":"2018","author":"JN Barreto","year":"2018","unstructured":"Barreto JN, McClanahan AL, Rule AD, Thompson CA, Frazee E (2018) Incorporating cystatin C to predict methotrexate elimination in patients with CNS lymphoma and suspicious renal function. Case Rep Hematol 2018:7169897. https:\/\/doi.org\/10.1155\/2018\/7169897","journal-title":"Case Rep Hematol"},{"key":"6938_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.751299","volume":"8","author":"S Al-Amodih","year":"2021","unstructured":"Al-Amodih S, Abdelsattar S, Kasemy ZA, Bedair HM, Elbarbary HS, Kamel HFM (2021) Potential value of TNF-alpha (-376 G\/A) polymorphism and cystatin C (CysC) in the diagnosis of sepsis associated acute kidney injury (S-AK I) and prediction of mortality in critically ill patients. Front Mol Biosci 8:751299. https:\/\/doi.org\/10.3389\/fmolb.2021.751299","journal-title":"Front Mol Biosci"},{"issue":"1","key":"6938_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-00693-5","volume":"10","author":"S Valade","year":"2020","unstructured":"Valade S, Mariotte E, Azoulay E, Darmon M (2020) High-dose methotrexate in ICU patients: a retrospective study. Ann Intensive Care 10(1):81. https:\/\/doi.org\/10.1186\/s13613-020-00693-5","journal-title":"Ann Intensive Care"},{"issue":"10","key":"6938_CR21","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1080\/10428194.2022.2074987","volume":"63","author":"J Wight","year":"2022","unstructured":"Wight J, Ku M, Garwood M, Carradice D, Lasica M, Keamy L, Hawkes EA, Grigg A (2022) Toxicity associated with high-dose intravenous methotrexate for hematological malignancies. Leuk Lymphoma 63(10):2375\u20132382. https:\/\/doi.org\/10.1080\/10428194.2022.2074987","journal-title":"Leuk Lymphoma"},{"key":"6938_CR22","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1586\/14737175.6.5.635","volume":"6","author":"MR Green","year":"2006","unstructured":"Green MR, Chowdhary S, Lombardi KM, Chalmers LM, Chamberlain M (2006) Clinical utility and pharmacology of high-dose methotrexate in the treatment of primary CNS lymphoma. Expert Rev Neurother 6:635\u2013652. https:\/\/doi.org\/10.1586\/14737175.6.5.635","journal-title":"Expert Rev Neurother"},{"issue":"10","key":"6938_CR23","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1080\/14737159.2020.1768849","volume":"20","author":"SW Benoit","year":"2020","unstructured":"Benoit SW, Ciccia EA, Devarajan P (2020) Cystatin C as a biomarker of chronic kidney disease: latest developments. Expert Rev Mol Diagn 20(10):1019\u20131026. https:\/\/doi.org\/10.1080\/14737159.2020.1768849","journal-title":"Expert Rev Mol Diagn"},{"issue":"3","key":"6938_CR24","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jped.2021.08.005","volume":"98","author":"H Yang","year":"2022","unstructured":"Yang H, Lin C, Zhuang C, Chen J, Jia Y, Shi H, Zhuang C (2022) Serum cystatin C as a predictor of acute kidney injury in neonates: a meta-analysis. J Pediatr (Rio J) 98(3):230\u2013240. https:\/\/doi.org\/10.1016\/j.jped.2021.08.005","journal-title":"J Pediatr (Rio J)"},{"key":"6938_CR25","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00280-002-0552-1","volume":"51","author":"T Ska\u00a8rby","year":"2003","unstructured":"Ska\u00a8rby T, Jo\u00a8nsson P, Hjorth L, Behrentz M, Bj\u00f6rk O, Forestier E, Jarfelt M, L\u00f6nnerholm G, H\u00f6glund P (2003) High dose methotrexate: on the relationship of methotrexate elimination time vs renal function and serum methotrexate levels in 1164 courses in 246 Swedish children with acute lymphoblastic leukaemia (ALL). Cancer Chemother Pharmacol 51:311\u2013320. https:\/\/doi.org\/10.1007\/s00280-002-0552-1","journal-title":"Cancer Chemother Pharmacol"},{"key":"6938_CR26","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1007\/s00467-005-1839-3","volume":"20","author":"M Krawczuk-Rybak","year":"2005","unstructured":"Krawczuk-Rybak M, Kuzmicz M, Wysocka J (2005) Renal function during and after treatment for acute lymphoblastic leukemia in children. Pediatr Nephrol 20:782\u2013785. https:\/\/doi.org\/10.1007\/s00467-005-1839-3","journal-title":"Pediatr Nephrol"},{"key":"6938_CR27","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.2215\/CJN.02040310","volume":"5","author":"CD Krawczeski","year":"2010","unstructured":"Krawczeski CD, Vandevoorde RG, Kathman T, Bennett MR, Woo JG, Wang Y, Griffiths RE, Devarajan P (2010) Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass. Clin J Am Soc Nephrol 5:1552\u20131557. https:\/\/doi.org\/10.2215\/CJN.02040310","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06938-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-06938-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06938-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:00:03Z","timestamp":1776405603000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-06938-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["6938"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-06938-w","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]},"assertion":[{"value":"30 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"176"}}