{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:58:25Z","timestamp":1781643505795,"version":"3.54.5"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Occult hematologic malignancies can initially present with cutaneous manifestations. We describe a 53-year-old woman with chronic hepatitis C and intravenous drug use presenting with a painful, progressive leg rash and worsening bicytopenias. A skin punch biopsy revealed neutrophilic dermatosis morphologically compatible with Sweet syndrome (SS), along with rare CD117+\/CD34\u2009\u2212\u2009blastoid cells. Subsequent bone marrow studies revealed acute myeloid leukemia with mutated\n                    <jats:italic>NPM1<\/jats:italic>\n                    . This case highlights the diagnostic challenge of distinguishing SS from leukemia cutis (LC) when skin biopsies demonstrate mixed neutrophilic with rare blastoid cells. LC represents cutaneous infiltration of leukemic blasts, whereas SS represents a non-neoplastic, cytokine-driven process. Prompt immunophenotypic evaluation and genomic testing of myeloid dermatoses, particularly those with blastoid cells, can be critical in distinguishing SS from LC to provide significant insight on prognosis and therapeutic options. This case highlights the clinical and histopathologic spectrum of myeloid dermatoses and further emphasizes the relevance of skin biopsies in the diagnosis of cutaneous involvement by hematologic malignancies, such as myeloid neoplasms.\n                  <\/jats:p>","DOI":"10.1007\/s00277-026-06949-7","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:11:18Z","timestamp":1774253478000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myeloid dermatosis with features of sweet syndrome and leukemia cutis: a case report"],"prefix":"10.1007","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6332-7789","authenticated-orcid":false,"given":"Evani","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Beach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Morrissette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Caponetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"issue":"4","key":"6949_CR1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/s0190-9622(94)70215-2","volume":"31","author":"D Von Driesch","year":"1994","unstructured":"Von Driesch D, P (1994) Sweet\u2019s syndrome (acute febrile neutrophilic dermatosis). JAAD 31(4):535\u2013556. https:\/\/doi.org\/10.1016\/s0190-9622(94)70215-2","journal-title":"JAAD"},{"issue":"3","key":"6949_CR2","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s40257-022-00673-4","volume":"23","author":"TP Joshi","year":"2022","unstructured":"Joshi TP, Friske SK, Hsiou DA, Duvic M (2022) New practical aspects of Sweet syndrome. Am J Clin Dermatol 23(3):301\u2013318. https:\/\/doi.org\/10.1007\/s40257-022-00673-4","journal-title":"Am J Clin Dermatol"},{"issue":"4","key":"6949_CR3","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1053\/j.seminhematol.2021.10.007","volume":"58","author":"N Patel","year":"2021","unstructured":"Patel N, Dulau-Florea A, Calvo KR (2021) Characteristic bone marrow findings in patients with UBA1 somatic mutations and VEXAS syndrome. Semin Hematol Vol 58(4):204\u2013211. https:\/\/doi.org\/10.1053\/j.seminhematol.2021.10.007","journal-title":"Semin Hematol Vol"},{"key":"6949_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fmed.2020.00020","volume":"7","author":"S Zheng","year":"2020","unstructured":"Zheng S, Li S, Tang S, Pan Y, Ding Y, Qiao J, Fang H (2020) Insights into the characteristics of sweet syndrome in patients with and without hematologic malignancy. Front Med 7:20. https:\/\/doi.org\/10.3389\/fmed.2020.00020","journal-title":"Front Med"},{"issue":"2","key":"6949_CR5","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S0733-8635(18)30190-6","volume":"12","author":"KV Ratnam","year":"1994","unstructured":"Ratnam KV, Khor CJ, Su WD (1994) Leukemia cutis. Dermatol Clin 12(2):419\u2013431","journal-title":"Dermatol Clin"},{"issue":"2","key":"6949_CR6","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/ajcp\/106.2.192","volume":"106","author":"SJ Wells","year":"1996","unstructured":"Wells SJ, Bray RA, Stempora LL, Farhi DC (1996) CD117\/CD34 expression in leukemic blasts. Am J Clin Pathol 106(2):192\u2013195. https:\/\/doi.org\/10.1093\/ajcp\/106.2.192","journal-title":"Am J Clin Pathol"},{"issue":"9","key":"6949_CR7","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1002\/ajh.26989","volume":"98","author":"B Falini","year":"2023","unstructured":"Falini B (2023) NPM1-mutated acute myeloid leukemia: new pathogenetic and therapeutic insights and open questions. Am J Hematol 98(9):1452\u20131464. https:\/\/doi.org\/10.1002\/ajh.26989","journal-title":"Am J Hematol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06949-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-06949-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06949-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:41:19Z","timestamp":1781642479000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-06949-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["6949"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-06949-7","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"4 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research did not require Institutional Review Board approval because A case report for 1-3 patients does not require IRB review.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent from the patient was unable to be obtained as the patient deceased prior to production of this manuscript. Next of kin were sought and untraceable. All information from this manuscript is de-identified and made anonymous to the authors\u2019 best abilities.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"194"}}