{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:51:43Z","timestamp":1776408703986,"version":"3.51.2"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Key Research and Development Plan of Jining City","award":["2023YXNS227"],"award-info":[{"award-number":["2023YXNS227"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-026-06975-5","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:28:34Z","timestamp":1774963714000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of CBC-derived inflammatory biomarkers with overall anemia in U.S. youth: NHANES study"],"prefix":"10.1007","volume":"105","author":[{"given":"Menmei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huabin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruihan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"issue":"6","key":"6975_CR1","first-page":"612","volume":"110","author":"MF Raleigh","year":"2024","unstructured":"Raleigh MF, Yano AS, Shaffer NE (2024) Anemia in infants and children: evaluation and treatment. Am Fam Physician 110(6):612\u2013620","journal-title":"Am Fam Physician"},{"key":"6975_CR2","unstructured":"The Lancet New study reveals global anemia cases remain persistently high among women and children. Anemia rates decline for men. | Institute for Health Metrics and Evaluation [Internet]. [cited 2025 Aug 20]. Available from: https:\/\/www.healthdata.org\/news-events\/newsroom\/news-releases\/lancet-new-study-reveals-global-anemia-cases-remain-persistently"},{"key":"6975_CR3","unstructured":"Anaemia [Internet] [cited 2025 Aug 20]. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/anaemia"},{"key":"6975_CR4","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1016\/j.tjnut.2023.07.018","volume":"153","author":"GM Brittenham","year":"2023","unstructured":"Brittenham GM, Moir-Meyer G, Abuga KM, Datta-Mitra A, Cerami C, Green R et al (2023) Biology of Anemia: A Public Health Perspective. J Nutr 153:S7\u201328. https:\/\/doi.org\/10.1016\/j.tjnut.2023.07.018","journal-title":"J Nutr"},{"issue":"10","key":"6975_CR5","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1080\/01635581.2023.2272800","volume":"75","author":"Z Luo","year":"2023","unstructured":"Luo Z, Wang W, Xiang L, Jin T (2023) Association between the systemic immune-inflammation index and prostate cancer. Nutr Cancer 75(10):1918\u20131925. https:\/\/doi.org\/10.1080\/01635581.2023.2272800","journal-title":"Nutr Cancer"},{"issue":"5","key":"6975_CR6","doi-asserted-by":"publisher","first-page":"103781","DOI":"10.1016\/j.numecd.2024.10.019","volume":"35","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Zhang W, Liu Z, Ou J, Sun Y, Zhang L et al (2025) Association between systemic inflammation markers and cardiovascular mortality in adults with metabolic dysfunction-associated steatotic liver disease. Nutr Metab Cardiovasc Dis: NMCD 35(5):103781. https:\/\/doi.org\/10.1016\/j.numecd.2024.10.019","journal-title":"Nutr Metab Cardiovasc Dis: NMCD"},{"issue":"9","key":"6975_CR7","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.3390\/medicina59091592","volume":"59","author":"Y Alshuweishi","year":"2023","unstructured":"Alshuweishi Y, Alfaifi M, Almoghrabi Y, Al-Sheikh YA, Alfhili MA (2023) A retrospective analysis of the association of neutrophil-lymphocyte ratio (NLR) with anemia in the saudi population. Med (kaunas Lith) 59(9):1592. https:\/\/doi.org\/10.3390\/medicina59091592","journal-title":"Med (kaunas Lith)"},{"issue":"6","key":"6975_CR8","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3390\/geriatrics9060146","volume":"9","author":"K Yuenyongchaiwat","year":"2024","unstructured":"Yuenyongchaiwat K, Akekawatchai C, Changsri K (2024) The prevalence of malnutrition and sarcopenia and the relationship with inflammation and anemia among community-dwelling older adults: a preliminary cross-sectional study. Geriatr (basel Switz) 9(6):146. https:\/\/doi.org\/10.3390\/geriatrics9060146","journal-title":"Geriatr (basel Switz)"},{"issue":"23","key":"6975_CR9","doi-asserted-by":"publisher","first-page":"7248","DOI":"10.3390\/jcm12237248","volume":"12","author":"M Carrillo-Palau","year":"2023","unstructured":"Carrillo-Palau M, Vera-Santana B, Morant-Dom\u00ednguez A, Hern\u00e1ndez-Camba A, Ramos L, Alonso-Abreu I et al (2023) Hematological composite scores in patients with inflammatory bowel disease. J Clin Med 12(23):7248. https:\/\/doi.org\/10.3390\/jcm12237248","journal-title":"J Clin Med"},{"key":"6975_CR10","doi-asserted-by":"publisher","first-page":"1467683","DOI":"10.3389\/fendo.2024.1467683","volume":"15","author":"M Yan","year":"2024","unstructured":"Yan M, Gong P, Li X, Huang H, Wei H (2024) Non-diabetic elderly populations: SIRI as a risk factor and PIV as a protective factor against bone abnormalities. Front Endocrinol (Lausanne) 15:1467683. https:\/\/doi.org\/10.3389\/fendo.2024.1467683","journal-title":"Front Endocrinol (Lausanne)"},{"key":"6975_CR11","doi-asserted-by":"publisher","first-page":"1426404","DOI":"10.3389\/fendo.2024.1426404","volume":"15","author":"L Luo","year":"2024","unstructured":"Luo L, Chen L, Song J, Ma X, Wang X (2024) Association between systemic immune-inflammatory index and systemic inflammatory response index with body mass index in children and adolescents: a population-based study based on the national health and nutrition examination survey 2017\u20132020. Front Endocrinol 15:1426404. https:\/\/doi.org\/10.3389\/fendo.2024.1426404","journal-title":"Front Endocrinol"},{"key":"6975_CR12","unstructured":"NHANES survey methods and analytic guidelines | CDC [Internet]. [cited 2024 Dec 7]. Available from: https:\/\/www.cdc.gov\/Nchs\/Nhanes\/AnalyticGuideli"},{"issue":"56","key":"6975_CR13","first-page":"1","volume":"1","author":"G Zipf","year":"2013","unstructured":"Zipf G, Chiappa M, Porter KS, Ostchega Y, Lewis BG, Dostal J (2013) National health and nutrition examination survey: plan and operations, 1999\u20132010. Vital Health Stat 1(56):1\u201337","journal-title":"Vital Health Stat"},{"key":"6975_CR14","unstructured":"US Department of Health & Human Services (2022) Office of Extramural Research. [Internet]. [cited 2025 Aug 21]. Available from: https:\/\/grants.nih.gov\/grants\/policy\/hs\/hs_policies.htm(accessedon1March"},{"key":"6975_CR15","unstructured":"NHANES survey methods and analytic guidelines [Internet]. [cited 2025 Mar 12]. Available from: https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/analyticguidelines.aspx"},{"key":"6975_CR16","unstructured":"Nutrition and food safety [Internet]. [cited 2025 Aug 21]. Available from: https:\/\/www.who.int\/teams\/nutrition-and-food-safety\/monitoring-nutritional-status-and-food-safety-and-events\/global-anaemia-estimates\/methodology-for-the-global-anaemia-estimates"},{"issue":"1","key":"6975_CR17","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1001\/jamapediatrics.2015.3065","volume":"170","author":"KE Drury","year":"2016","unstructured":"Drury KE, Schaeffer M, Silverberg JI (2016) Association between atopic disease and anemia in US children. JAMA Pediatr 170(1):29\u201334. https:\/\/doi.org\/10.1001\/jamapediatrics.2015.3065","journal-title":"JAMA Pediatr"},{"key":"6975_CR18","doi-asserted-by":"publisher","first-page":"1205687","DOI":"10.3389\/fimmu.2023.1205687","volume":"14","author":"J Ke","year":"2023","unstructured":"Ke J, Qiu F, Fan W, Wei S (2023) Associations of complete blood cell count-derived inflammatory biomarkers with asthma and mortality in adults: a population-based study. Front Immunol 14:1205687. https:\/\/doi.org\/10.3389\/fimmu.2023.1205687","journal-title":"Front Immunol"},{"key":"6975_CR19","unstructured":"National Health and Nutrition Examination Survey (NHANES) (2022) MEC In-Person Dietary Interviewers Procedures Manual. Available online: [Internet]. [cited 2025 Aug 21]. Available from: https:\/\/www.ars.usda.gov\/page-not-found\/?aspxerrorpath=\/ba\/bhnrc\/fsrg(accessedon12March"},{"issue":"15","key":"6975_CR20","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.3390\/nu14153052","volume":"14","author":"H Liu","year":"2022","unstructured":"Liu H, Wang L, Chen C, Dong Z, Yu S (2022) Association between dietary niacin intake and migraine among american adults: national health and nutrition examination survey. Nutrients 14(15):3052. https:\/\/doi.org\/10.3390\/nu14153052","journal-title":"Nutrients"},{"key":"6975_CR21","unstructured":"Mcq_i [Internet] [cited 2025 Aug 21]. Available from: https:\/\/wwwn.cdc.gov\/Nchs\/Data\/Nhanes\/Public\/2015\/DataFiles\/MCQ_I.htm"},{"issue":"1","key":"6975_CR22","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12933-023-01794-8","volume":"22","author":"Y Cheng","year":"2023","unstructured":"Cheng Y, Fang Z, Zhang X, Wen Y, Lu J, He S et al (2023) Association between triglyceride glucose-body mass index and cardiovascular outcomes in patients undergoing percutaneous coronary intervention: a retrospective study. Cardiovasc Diabetol 22(1):75. https:\/\/doi.org\/10.1186\/s12933-023-01794-8","journal-title":"Cardiovasc Diabetol"},{"issue":"11","key":"6975_CR23","doi-asserted-by":"publisher","first-page":"3732","DOI":"10.3390\/nu13113732","volume":"13","author":"L Lanser","year":"2021","unstructured":"Lanser L, Fuchs D, Kurz K, Weiss G (2021) Physiology and inflammation driven pathophysiology of iron homeostasis\u2014mechanistic insights into anemia of inflammation and its treatment. Nutrients 13(11):3732. https:\/\/doi.org\/10.3390\/nu13113732","journal-title":"Nutrients"},{"issue":"5704","key":"6975_CR24","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1126\/science.1104742","volume":"306","author":"E Nemeth","year":"2004","unstructured":"Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM et al (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306(5704):2090\u20132093. https:\/\/doi.org\/10.1126\/science.1104742","journal-title":"Science"},{"issue":"Suppl 3","key":"6975_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1365-2362.2005.01525.x","volume":"35","author":"KU Eckardt","year":"2005","unstructured":"Eckardt KU, Kurtz A (2005) Regulation of erythropoietin production. Eur J Clin Invest 35(Suppl 3):13\u201319. https:\/\/doi.org\/10.1111\/j.1365-2362.2005.01525.x","journal-title":"Eur J Clin Invest"},{"key":"6975_CR26","doi-asserted-by":"publisher","unstructured":"Lt GW (2005) Anemia of chronic disease. N Engl J Med 352(10). https:\/\/doi.org\/10.1056\/NEJMra041809","DOI":"10.1056\/NEJMra041809"},{"key":"6975_CR27","doi-asserted-by":"publisher","unstructured":"Eh K, H T, Hl W, Dw S (2008) Hepcidin: from discovery to differential diagnosis. Haematologica 93(1). https:\/\/doi.org\/10.3324\/haematol.11705","DOI":"10.3324\/haematol.11705"},{"key":"6975_CR28","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1146\/annurev-med-050109-142444","volume":"62","author":"T Ganz","year":"2011","unstructured":"Ganz T, Nemeth E (2011) Hepcidin and disorders of iron metabolism. Annu Rev Med 62:347\u2013360. https:\/\/doi.org\/10.1146\/annurev-med-050109-142444","journal-title":"Annu Rev Med"},{"issue":"31","key":"6975_CR29","doi-asserted-by":"publisher","first-page":"e34357","DOI":"10.1097\/MD.0000000000034357","volume":"102","author":"MLT Nguyen","year":"2023","unstructured":"Nguyen MLT, Pham C, Le QV, Nham PLT, Tran DH, Le TS et al (2023) The diagnostic and prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on gastric cancer patients. Med (Baltim) 102(31):e34357. https:\/\/doi.org\/10.1097\/MD.0000000000034357","journal-title":"Med (Baltim)"},{"issue":"1","key":"6975_CR30","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1159\/000489807","volume":"47","author":"H Fu","year":"2018","unstructured":"Fu H, Zheng J, Cai J, Zeng K, Yao J, Chen L et al (2018) Systemic immune-inflammation index (SII) is useful to predict survival outcomes in patients after liver transplantation for hepatocellular carcinoma within hangzhou criteria. Cell Physiol Biochem: Int J Exp Cell Physiol Biochem Pharmacol 47(1):293\u2013301. https:\/\/doi.org\/10.1159\/000489807","journal-title":"Cell Physiol Biochem: Int J Exp Cell Physiol Biochem Pharmacol"},{"issue":"6","key":"6975_CR31","doi-asserted-by":"publisher","first-page":"dju124","DOI":"10.1093\/jnci\/dju124","volume":"106","author":"AJ Templeton","year":"2014","unstructured":"Templeton AJ, McNamara MG, \u0160eruga B, Vera-Badillo FE, Aneja P, Oca\u00f1a A et al (2014) Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst 106(6):dju124. https:\/\/doi.org\/10.1093\/jnci\/dju124","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"6975_CR32","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12967-023-03924-y","volume":"21","author":"L Meng","year":"2023","unstructured":"Meng L, Yang Y, Hu X, Zhang R, Li X (2023) Prognostic value of the pretreatment systemic immune-inflammation index in patients with prostate cancer: a systematic review and meta-analysis. J Transl Med 21(1):79. https:\/\/doi.org\/10.1186\/s12967-023-03924-y","journal-title":"J Transl Med"},{"key":"6975_CR33","doi-asserted-by":"publisher","first-page":"1370516","DOI":"10.3389\/fimmu.2024.1370516","volume":"15","author":"C Jin","year":"2024","unstructured":"Jin C, Li X, Luo Y, Zhang C, Zuo D (2024) Associations between pan-immune-inflammation value and abdominal aortic calcification: a cross-sectional study. Front Immunol 15:1370516. https:\/\/doi.org\/10.3389\/fimmu.2024.1370516","journal-title":"Front Immunol"},{"key":"6975_CR34","doi-asserted-by":"publisher","first-page":"1408700","DOI":"10.3389\/fimmu.2024.1408700","volume":"15","author":"S Tan","year":"2024","unstructured":"Tan S, Zheng Q, Zhang W, Zhou M, Xia C, Feng W (2024) Prognostic value of inflammatory markers NLR, PLR, and LMR in gastric cancer patients treated with immune checkpoint inhibitors: a meta-analysis and systematic review. Front Immunol 15:1408700. https:\/\/doi.org\/10.3389\/fimmu.2024.1408700","journal-title":"Front Immunol"},{"key":"6975_CR35","doi-asserted-by":"publisher","unstructured":"Vn HP, Djf Y, Is S, Agd N, Bsag S (2022) The preoperative neutrophil-to-lymphocyte ratio predictive value for survival in patients with brain metastasis. Arq Neuropsiquiatr 80(9). https:\/\/doi.org\/10.1055\/s-0042-1755324","DOI":"10.1055\/s-0042-1755324"},{"issue":"1","key":"6975_CR36","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41408-024-01176-7","volume":"14","author":"T Barbui","year":"2024","unstructured":"Barbui T, Carobbio A, Ghirardi A, Fenili F, Finazzi MC, Castelli M et al (2024) Neutrophil-to-lymphocyte ratio as a prognostic indicator of mortality in polycythemia vera: insights from a prospective cohort analysis. Blood Cancer J 14(1):195. https:\/\/doi.org\/10.1038\/s41408-024-01176-7","journal-title":"Blood Cancer J"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06975-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-06975-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06975-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:59:42Z","timestamp":1776405582000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-06975-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["6975"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-06975-5","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"assertion":[{"value":"16 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The studies involving human participants were reviewed and approved by The National Center for Health Statistics (NCHS) Research Ethics Review Board. The patients\/participants provided their written informed consent to participate in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The manuscript has been reviewed and approved for publication by all authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"217"}}