{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:13:51Z","timestamp":1778753631187,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-026-06983-5","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T07:12:27Z","timestamp":1776496347000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PML::RARA\u2013negative APL-mimicking AML with a novel KMT2C::CREB3L2 fusion and RARA\/RXRA-mediated sensitivity to all-trans retinoic acid"],"prefix":"10.1007","volume":"105","author":[{"given":"Lina","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"6983_CR1","doi-asserted-by":"crossref","unstructured":"Liquori A, Ibanez M, Sargas C, Sanz MA, Barragan E, Cervera J (2020) Acute promyelocytic leukemia: a constellation of molecular events around a single PML-RARA fusion gene. Cancers (Basel) 12(3):624","DOI":"10.3390\/cancers12030624"},{"key":"6983_CR2","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/nrc2943","volume":"10","author":"H de Th\u00e9","year":"2010","unstructured":"de Th\u00e9 H, Chen Z (2010) Acute Promyelocytic Leukaemia: Novel Insights Into the Mechanisms of Cure. Nat Rev Cancer 10:775\u2013783","journal-title":"Nat Rev Cancer"},{"key":"6983_CR3","first-page":"33","volume":"9","author":"X Zhang","year":"2021","unstructured":"Zhang X, Sun J, Yu W, Jin (2021) J. Current views on the genetic landscape and management of variant acute promyelocytic leukemia.Biomark. Res 9:33","journal-title":"Res"},{"key":"6983_CR4","doi-asserted-by":"crossref","unstructured":"Alexandra G, Gabriel G (2023) Charting a course through the acute promyelocytic leukemia (APL)-like nebula: the enigmatic cousins of APL. Haematologica 108:2886\u20132888","DOI":"10.3324\/haematol.2023.283232"},{"key":"6983_CR5","doi-asserted-by":"crossref","unstructured":"Guarnera L (2022) Atypical rearrangements in APL-like acute myeloid leukemias: molecular characterization and prognosis. Front Oncol 12","DOI":"10.3389\/fonc.2022.871590"},{"key":"6983_CR6","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/ijlh.13357","volume":"43","author":"MJ Arana Rosainz","year":"2021","unstructured":"Arana Rosainz MJ, Nguyen N, Wahed A et al (2021) Acute myeloid leukemia with mutated NPM1 mimics acute promyelocytic leukemia presentation. Int J Lab Hematol 43:218\u2013226","journal-title":"Int J Lab Hematol"},{"key":"6983_CR7","doi-asserted-by":"crossref","unstructured":"Liu H, Liu GX, Liu FH, Wang SG (2025) Acute myeloid leukemia with DEK::NUP214 fusion resembling acute promyelocytic leukemia, initially presenting as sweet syndrome: a case report and literature review. J Int Med Res 53(3):3000605251327476.","DOI":"10.1177\/03000605251327476"},{"key":"6983_CR8","doi-asserted-by":"crossref","unstructured":"Ferrari A, Bussaglia E \u00fabeda (2012) Immunophenotype distinction between acute promyelocytic leukaemia and CD15- CD34- HLA-DR- acute myeloid leukaemia with nucleophosmin mutations [J]. Hematol Oncol 30(3):109\u2013114","DOI":"10.1002\/hon.1011"},{"key":"6983_CR9","doi-asserted-by":"crossref","unstructured":"Liu M, Weng XQ, Gong SL et al (2017) Flow cytometric analysis of CD64 expression pattern and density in the diagnosis of acute promyelocytic leukemia: a multi-center study in Shanghai, China. Oncotarget 8(46):80625\u201380637","DOI":"10.18632\/oncotarget.20814"},{"issue":"04","key":"6983_CR10","first-page":"272","volume":"42","author":"S Gao Weifeng","year":"2024","unstructured":"Gao Weifeng S, Zhijuan Y, Yiping et al (2024) Application of Immunophenotype in Differentiating Acute Promyelocytic Leukemia from HLA-DR Negative Acute Myeloid Leukemia [J]. Clin Lab J 42(04):272\u2013276","journal-title":"Clin Lab J"},{"issue":"1","key":"6983_CR11","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/emboj.2008.256","volume":"28","author":"N Bruck","year":"2009","unstructured":"Bruck N, Vitoux D, Ferry C et al (2009) A coordinated phosphorylation cascade initiated by p38MAPK\/MSK1 directs RARalpha to target promoters. EMBO J 28(1):34\u201347","journal-title":"EMBO J"},{"issue":"8","key":"6983_CR12","doi-asserted-by":"publisher","first-page":"611","DOI":"10.7150\/ijms.15374","volume":"13","author":"C Xiao","year":"2016","unstructured":"Xiao C, Zhong L, Shan Z, Xu T, Gan L, Song H, Yang R, Li L, Liu B (2016) NLS-RAR\u03b1 Inhibits the Effects of All-trans Retinoic Acid on NB4 Cells by Interacting with P38\u03b1 MAPK. Int J Med Sci 13(8):611\u2013619","journal-title":"Int J Med Sci"},{"key":"6983_CR13","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3389\/fncel.2018.00476","volume":"12","author":"S Bonney","year":"2018","unstructured":"Bonney S, Dennison BJC, Wendlandt M, Siegenthaler JA (2018) Retinoic Acid Regulates Endothelial \u03b2-catenin Expression and Pericyte Numbers in the Developing Brain Vasculature. Front Cell Neurosci 12:476 Published 2018 Dec 5","journal-title":"Front Cell Neurosci"},{"issue":"10","key":"6983_CR14","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1158\/2159-8290.CD-17-0399","volume":"7","author":"MR McKeown","year":"2017","unstructured":"McKeown MR, Corces MR, Eaton ML et al (2017) Superenhancer analysis defines novel epigenomic subtypes of non-APL AML including an RARa dependency targetable by SY-1425, a potent and selective RAR\u03b1 agonist. Cancer Discov 7(10):1136\u20131153","journal-title":"Cancer Discov"},{"key":"6983_CR15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.exphem.2017.04.007","volume":"52","author":"N Van Gils","year":"2017","unstructured":"Van Gils N, Verhagen HJMP, Smit L (2017) Reprogramming acute myeloid leukemiainto sensitivity for retinoic-acid-driven differentiation. Exp Hematol 52:12\u201323","journal-title":"Exp Hematol"},{"issue":"10","key":"6983_CR16","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1158\/2159-8290.CD-17-0399","volume":"7","author":"MR McKeown","year":"2017","unstructured":"McKeown MR, Corces MR, Eaton ML et al (2017) Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARa Dependency Targetable by SY-1425, a Potent and Selective RARa Agonist. Cancer Discov 7(10):1136\u20131153","journal-title":"Cancer Discov"},{"issue":"4","key":"6983_CR17","first-page":"575","volume":"17","author":"S Ji Mengmeng","year":"2013","unstructured":"Ji Mengmeng S, Zimin L, Huilan et al (2013) Detection and clinical significance of DN-MT3A gene mutation in adult acute myeloid leukemia[J]. Anhui Med 17(4):575\u2013577","journal-title":"Anhui Med"},{"key":"6983_CR18","doi-asserted-by":"crossref","unstructured":"Ribeiro AFT, Pratcorona M, Erpelinck-Verschueren C et al (2012) Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. Blood 119(24):5824\u20135831","DOI":"10.1182\/blood-2011-07-367961"},{"key":"6983_CR19","unstructured":"Qiao CS, Chao Z, Suhong X et al (2011) Study on DNMT3A genetic mutation in acute myeloid leukemia. Chin J Exp Hematol 19(2):303\u2013307"},{"key":"6983_CR20","doi-asserted-by":"crossref","unstructured":"Renneville A, Boissel N, Nibourel O et al (2012) Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association. Leukemia 26(6):1247\u20131254","DOI":"10.1038\/leu.2011.382"},{"key":"6983_CR21","doi-asserted-by":"crossref","unstructured":"Ley TJ, Ding L, Walter MJ et al (2010) DNMT3A mutations in acute myeloid leukemia. N Engl J Med 363(25):2424\u20132433","DOI":"10.1056\/NEJMoa1005143"},{"key":"6983_CR22","doi-asserted-by":"crossref","unstructured":"Hou HA, Kuo YY, Liu CY et al (2012) DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications. Blood 119(2):559\u2013568","DOI":"10.1182\/blood-2011-07-369934"},{"key":"6983_CR23","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.febslet.2012.02.052","volume":"586","author":"Z Niu","year":"2012","unstructured":"Niu Z, Jin W, Zhang L, Li X (2012) Tumor suppressor RBM5 directly interacts with the DExD\/H-box protein DHX15 and stimulates its helicase activity. FEBS Lett 586:977\u2013983","journal-title":"FEBS Lett"},{"key":"6983_CR24","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1017\/S1355838202021076","volume":"8","author":"MA Fouraux","year":"2002","unstructured":"Fouraux MA, Kolkman MJ, Van der Heijden A, De Jong AS, Van Venrooij WJ, Pruijn GJ (2002) The human La (SS-B) autoantigen interacts with DDX15\/hPrp43, a putative DEAH-box RNA helicase. RNA 8:1428\u20131443","journal-title":"RNA"},{"issue":"52","key":"6983_CR25","doi-asserted-by":"publisher","first-page":"89643","DOI":"10.18632\/oncotarget.20288","volume":"16","author":"L Pan","year":"2017","unstructured":"Pan L, Li Y, Zhang HY, Zheng Y, Liu XL, Hu Z, Wang Y, Wang J, Cai YH, Liu Q, Chen WL, Guo Y, Huang YM, Qian F, Jin L, Wang J, Wang SY (2017) DHX15 is associated with poor prognosis in acute myeloid leukemia (AML) and regulates cell apoptosis via the NF-kB signaling pathway. Oncotarget 16(52):89643\u201389654","journal-title":"Oncotarget"},{"key":"6983_CR26","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/s41586-021-03903-7","volume":"597","author":"B Shi","year":"2021","unstructured":"Shi B, Li W, Song Y, Wang Z, Ju R, Ulman A, Hu J, Palomba F, Zhao Y, Le JP et al (2021) UTX condensation underlies its tumour-suppressive activity. Nature 597:726\u2013731","journal-title":"Nature"},{"key":"6983_CR27","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/ng.349","volume":"41","author":"G van Haaften","year":"2009","unstructured":"van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C et al (2009) Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet 41:521\u2013523","journal-title":"Nat Genet"},{"key":"6983_CR28","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nature13605","volume":"514","author":"P Ntziachristos","year":"2014","unstructured":"Ntziachristos P, Tsirigos A, Welstead GG, Trimarchi T, Bakogianni S, Xu L et al (2014) Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia. Nature 514:513\u2013517","journal-title":"Nature"},{"key":"6983_CR29","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3324\/haematol.2014.113381","volume":"100","author":"N Bolli","year":"2015","unstructured":"Bolli N, Manes N, McKerrell T, Chi J, Park N, Gundem G et al (2015) Characterization of gene mutations and copy number changes in acute myeloid leukemia using a rapid target enrichment protocol. Haematologica 100:214\u2013222","journal-title":"Haematologica"},{"key":"6983_CR30","first-page":"1227","volume":"130","author":"L Tian","year":"2017","unstructured":"Tian L, Wartman LD (2017) The Role of Kdm6a in Malignant Hematopoiesis. Blood 130:1227","journal-title":"Blood"},{"key":"6983_CR31","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/s41375-023-01833-z","volume":"37","author":"LD Boila","year":"2023","unstructured":"Boila LD, Ghosh S, Bandyopadhyay SK, Jin L, Murison A, Zeng AGX, Shaikh W, Bhowmik S, Muddineni S, Biswas M et al (2023) KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition. Leukemia 37:751\u2013764","journal-title":"Leukemia"},{"issue":"1","key":"6983_CR32","first-page":"50","volume":"34","author":"MS Hanneforth","year":"2019","unstructured":"Hanneforth MS, Weser A, Mattes S, Carlet R, Liu M, Dom\u00ednguez WDM, Oettle H, M., Kempf J (2019) Loss of KDM6A confers drug resistance in acute myeloid leukemia. Leukemia 34(1):50\u201362","journal-title":"Leukemia"},{"issue":"13","key":"6983_CR33","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.3390\/cancers17132236","volume":"17","author":"Y Zhao","year":"2025","unstructured":"Zhao Y, Niu L, Yang S, Yu L, Zhao T, Jiang H, Xu L, Wang Y, Zhang X, Huang X (2025) KDM6A Variants Increased Relapse Risk in Adult Acute Myeloid Leukemia. Cancers 17(13):2236","journal-title":"Cancers"},{"issue":"5","key":"6983_CR34","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.ccr.2014.03.016","volume":"25","author":"C Chen","year":"2014","unstructured":"Chen C, Liu Y, Rappaport A, Kitzing T, Schultz N, Zhao Z, Shroff A, Dickins R, Vakoc C, Bradner J (2014) MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia. Cancer Cell 25(5):652\u2013665","journal-title":"Cancer Cell"},{"issue":"6","key":"6983_CR35","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1038\/s41375-018-0338-z","volume":"33","author":"J Zhao","year":"2019","unstructured":"Zhao J, Liang JW, Xue HL, Shen SH, Chen J, Tang YJ et al (2019) The genetics and clinical characteristics of children morphologically diagnosed as acute promyelocytic leukemia. Leukemia 33(6):1387\u20131399","journal-title":"Leukemia"},{"key":"6983_CR36","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1080\/10428194.2019.1607328","volume":"60","author":"X Zhang","year":"2019","unstructured":"Zhang X, Huang X, Xu H, Li J, Yu W (2019) MLL-rearrangement can resemble acute promyelocytic leukemia. Leuk Lymphoma 60:2841\u20132843","journal-title":"Leuk Lymphoma"},{"issue":"2","key":"6983_CR37","doi-asserted-by":"publisher","first-page":"354","DOI":"10.3324\/haematol.2021.279152","volume":"107","author":"F Qiu","year":"2021","unstructured":"Qiu F, De H (2021) An exciting RXRA mutant revives interest in retinoids for acute myeloid leukemia. Haematologica 107(2):354\u2013355","journal-title":"Haematologica"},{"issue":"2","key":"6983_CR38","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3324\/haematol.2021.278603","volume":"107","author":"RXRA DT448","year":"2021","unstructured":"RXRA DT448 (2021) \/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells. Haematologica 107(2):417\u2013426","journal-title":"Haematologica"},{"issue":"1","key":"6983_CR39","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.cell.2013.08.031","volume":"155","author":"S Pauklin","year":"2013","unstructured":"Pauklin S, Vallier L (2013) The Cell-Cycle State of Stem Cells Determines Cell Fate Propensity [published correction appears in 2014;156(6):1338]. Cell 155(1):135\u2013147","journal-title":"Cell"},{"issue":"18","key":"6983_CR40","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1182\/blood.2020010100","volume":"137","author":"MC Geoffroy","year":"2021","unstructured":"Geoffroy MC, Esnault C, de Th\u00e9 H (2021) Retinoids in hematology: a timelyrevival? Blood 137(18):2429\u20132437","journal-title":"Blood"}],"updated-by":[{"DOI":"10.1007\/s00277-026-07049-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000}}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06983-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-06983-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-06983-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:22:44Z","timestamp":1778750564000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-06983-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,18]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["6983"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-06983-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8640660\/v1","asserted-by":"object"}]},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,18]]},"assertion":[{"value":"19 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00277-026-07049-2","URL":"https:\/\/doi.org\/10.1007\/s00277-026-07049-2","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board\/Ethics Committee of Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine. Written informed consent was obtained from the guardian for publication of this case report and accompanying data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical"}},{"value":"Written informed consent was obtained from the patient for the publication of this case report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"254"}}