{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:14:09Z","timestamp":1778753649962,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100010725","name":"An-Najah National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-026-07037-6","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:17:43Z","timestamp":1777605463000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A combined hematological and molecular study of Hodgkin lymphoma in Palestine: insights into subtype-specific prognosis and the role of Claudin-6\/GATA-4"],"prefix":"10.1007","volume":"105","author":[{"given":"Mohammad","family":"Asees","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Amer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayoub","family":"Rezeq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Salhab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toleen","family":"Abdalhaq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"7037_CR1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"SH Swerdlow","year":"2017","unstructured":"Swerdlow SH, Campo E, Harris NL et al (2017) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. IARC, Lyon","edition":"4"},{"key":"7037_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s13045-019-0799-1","volume":"12","author":"L Zhou","year":"2019","unstructured":"Zhou L, Deng Y, Li N et al (2019) Global, regional, and national burden of Hodgkin lymphoma from 1990 to 2017: estimates from the Global Burden of Disease Study 2017. J Hematol Oncol 12:107","journal-title":"J Hematol Oncol"},{"issue":"2","key":"7037_CR3","first-page":"116","volume":"68","author":"S Shanbhag","year":"2018","unstructured":"Shanbhag S, Ambinder RF (2018) Hodgkin lymphoma: A review and update on recent progress. CA Cancer J Clin 68(2):116\u2013132","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"7037_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/nrc2542","volume":"9","author":"R K\u00fcppers","year":"2009","unstructured":"K\u00fcppers R (2009) The biology of Hodgkin lymphoma. Nat Rev Cancer 9(1):15\u201327","journal-title":"Nat Rev Cancer"},{"issue":"23","key":"7037_CR5","doi-asserted-by":"publisher","first-page":"3815","DOI":"10.1200\/JCO.2008.20.5138","volume":"27","author":"A Diepstra","year":"2009","unstructured":"Diepstra A, van Imhoff GW, Schaapveld M et al (2009) Latent Epstein\u2013Barr virus infection of tumor cells in classical Hodgkin lymphoma predicts adverse outcome in older adults. J Clin Oncol 27(23):3815\u20133821","journal-title":"J Clin Oncol"},{"issue":"1","key":"7037_CR6","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1182\/asheducation-2014.1.144","volume":"2014","author":"DW Scott","year":"2014","unstructured":"Scott DW, Steidl C (2014) The classical Hodgkin lymphoma tumor microenvironment: macrophages and gene expression-based modeling. Hematol Am Soc Hematol Educ Program 2014(1):144\u2013150","journal-title":"Hematol Am Soc Hematol Educ Program"},{"issue":"3","key":"7037_CR7","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3892\/mmr.2021.12316","volume":"24","author":"H Du","year":"2021","unstructured":"Du H, Yang X, Fan J, Du X (2021) Claudin-6: therapeutic prospects for tumors and mechanisms of expression and regulation. Mol Med Rep 24(3):677","journal-title":"Mol Med Rep"},{"issue":"7","key":"7037_CR8","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","volume":"36","author":"R Alaggio","year":"2022","unstructured":"Alaggio R, Amador C, Anagnostopoulos I et al (2022) WHO classification of haematolymphoid tumours: 5th edition. Leukemia 36(7):1720\u20131748","journal-title":"Leukemia"},{"key":"7037_CR9","unstructured":"Aggarwal P, Limaiem F (2025) Reed\u2013Sternberg cells. StatPearls"},{"issue":"1","key":"7037_CR10","doi-asserted-by":"publisher","first-page":"e2014040","DOI":"10.4084\/mjhid.2014.040","volume":"6","author":"C Agostinelli","year":"2014","unstructured":"Agostinelli C, Pileri S (2014) Pathobiology of Hodgkin lymphoma. Mediterr J Hematol Infect Dis 6(1):e2014040","journal-title":"Mediterr J Hematol Infect Dis"},{"issue":"6","key":"7037_CR11","first-page":"1189","volume":"26","author":"B MacMahon","year":"1966","unstructured":"MacMahon B (1966) Epidemiology of Hodgkin\u2019s disease. Cancer Res 26(6):1189\u20131201","journal-title":"Cancer Res"},{"issue":"2","key":"7037_CR12","first-page":"256","volume":"186","author":"G Guillet","year":"1990","unstructured":"Guillet G, Guillet C, Le Gall F (1990) Epidemiology of Hodgkin disease: a 30-year study. Pathol Res Pract 186(2):256\u2013260","journal-title":"Pathol Res Pract"},{"issue":"1","key":"7037_CR13","doi-asserted-by":"publisher","first-page":"e2014022","DOI":"10.4084\/mjhid.2014.048","volume":"6","author":"M Salati","year":"2014","unstructured":"Salati M, Zinzani PL, Baccarani M (2014) Epidemiology of Hodgkin lymphoma. Mediterr J Hematol Infect Dis 6(1):e2014022","journal-title":"Mediterr J Hematol Infect Dis"},{"issue":"1","key":"7037_CR14","first-page":"7","volume":"67","author":"RL Siegel","year":"2017","unstructured":"Siegel RL, Miller KD, Jemal A (2017) Cancer statistics, 2017. CA Cancer J Clin 67(1):7\u201330","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"7037_CR15","first-page":"e35848","volume":"15","author":"S Munir","year":"2023","unstructured":"Munir S, Tandon M, Ali A, Jamil MO (2023) Nodular lymphocyte-predominant Hodgkin lymphoma: review. Cureus 15(3):e35848","journal-title":"Cureus"},{"issue":"1","key":"7037_CR16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00428-023-03553-2","volume":"483","author":"S Hartmann","year":"2023","unstructured":"Hartmann S, Fend F (2023) Hodgkin lymphoma. Virchows Arch 483(1):3\u201314","journal-title":"Virchows Arch"},{"issue":"12","key":"7037_CR17","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.15537\/1658-3175.2725","volume":"25","author":"NM Almasri","year":"2004","unstructured":"Almasri NM (2004) Hodgkin lymphoma in North Jordan. Saudi Med J 25(12):1917\u20131921","journal-title":"Saudi Med J"},{"issue":"1","key":"7037_CR18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.4103\/0971-5851.177038","volume":"37","author":"K Konkay","year":"2016","unstructured":"Konkay K, Paul TR, Uppin SG, Rao DR (2016) Hodgkin lymphoma: clinicopathological and immunophenotypic study. Indian J Med Paediatr Oncol 37(1):59\u201365","journal-title":"Indian J Med Paediatr Oncol"},{"issue":"3","key":"7037_CR19","doi-asserted-by":"publisher","first-page":"498","DOI":"10.5114\/aoms.2014.43744","volume":"10","author":"MF Law","year":"2014","unstructured":"Law MF, Ng TY, Chan HN et al (2014) Clinical features and treatment outcomes of Hodgkin lymphoma in Hong Kong Chinese. Arch Med Sci 10(3):498\u2013504","journal-title":"Arch Med Sci"},{"issue":"1","key":"7037_CR20","doi-asserted-by":"crossref","first-page":"101446","DOI":"10.1016\/j.beha.2023.101446","volume":"36","author":"T Tousseyn","year":"2023","unstructured":"Tousseyn T, de Leval L, Pilet G (2023) Hodgkin lymphoma: morphological and clinical update. Best Pract Res Clin Haematol 36(1):101446","journal-title":"Best Pract Res Clin Haematol"},{"issue":"12","key":"7037_CR21","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1158\/1055-9965.EPI-14-0683","volume":"23","author":"K Kushekhar","year":"2014","unstructured":"Kushekhar K, van den Berg A, Nolte I et al (2014) Genetic associations in classical Hodgkin lymphoma: systematic review. Cancer Epidemiol Biomarkers Prev 23(12):2737\u20132747","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"7037_CR22","first-page":"125","volume":"50","author":"G Mata","year":"2017","unstructured":"Mata G, Calaminici M, de la Cruz A et al (2017) Molecular biology of Hodgkin lymphoma: recent insights. Rev Esp Patol 50(2):125\u2013134","journal-title":"Rev Esp Patol"},{"key":"7037_CR23","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1182\/asheducation-2009.1.491","volume":"2009","author":"R K\u00fcppers","year":"2009","unstructured":"K\u00fcppers R (2009) Molecular biology of Hodgkin lymphoma. Hematol Am Soc Hematol Educ Program 2009:491\u2013496","journal-title":"Hematol Am Soc Hematol Educ Program"},{"issue":"10","key":"7037_CR24","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1172\/JCI61245","volume":"122","author":"R K\u00fcppers","year":"2012","unstructured":"K\u00fcppers R, Engert A, Hansmann ML (2012) Hodgkin lymphoma. J Clin Invest 122(10):3439\u20133447","journal-title":"J Clin Invest"},{"key":"7037_CR25","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1186\/s12967-023-04433-8","volume":"21","author":"AG Simon","year":"2023","unstructured":"Simon AG, Lyu SI, Laible M et al (2023) Claudin-6 as a therapeutic target in adenocarcinoma. J Transl Med 21:552","journal-title":"J Transl Med"},{"issue":"1","key":"7037_CR26","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s00424-016-1919-1","volume":"469","author":"AB Singh","year":"2017","unstructured":"Singh AB, Uppada SB, Dhawan P (2017) Claudin proteins and carcinogenesis. Pflugers Arch 469(1):69\u201375","journal-title":"Pflugers Arch"},{"issue":"1","key":"7037_CR27","doi-asserted-by":"publisher","first-page":"20","DOI":"10.4048\/jbc.2011.14.1.20","volume":"14","author":"Y Liu","year":"2011","unstructured":"Liu Y, Wang W, Ren Y et al (2011) Estrogen receptor regulation of Claudin-6 in breast cancer. J Breast Cancer 14(1):20\u201327","journal-title":"J Breast Cancer"},{"issue":"16","key":"7037_CR28","doi-asserted-by":"crossref","first-page":"12799","DOI":"10.3390\/ijms241612799","volume":"24","author":"Y Wang","year":"2023","unstructured":"Wang Y, Li T, Liu Z (2023) Claudin family as therapeutic targets in colorectal cancer. Int J Mol Sci 24(16):12799","journal-title":"Int J Mol Sci"},{"issue":"1","key":"7037_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/07357907.2010.512594","volume":"29","author":"VE Zavala-Zendejas","year":"2011","unstructured":"Zavala-Zendejas VE, Torres-Martinez AC, Salas-Morales B et al (2011) Claudin overexpression in gastric adenocarcinoma. Cancer Invest 29(1):1\u201311","journal-title":"Cancer Invest"},{"key":"7037_CR30","first-page":"101567","volume":"29","author":"A Ullah","year":"2023","unstructured":"Ullah A, Ganaie M, Ashraf S (2023) Advances in Hodgkin lymphoma treatment. Transl Oncol 29:101567","journal-title":"Transl Oncol"},{"issue":"1","key":"7037_CR31","first-page":"11","volume":"26","author":"A El-Nawawy","year":"2014","unstructured":"El-Nawawy A, Kamel M, El-Sabbagh A, El-Khashab Y (2014) Hodgkin lymphoma in Egypt. J Egypt Natl Canc Inst 26(1):11\u201318","journal-title":"J Egypt Natl Canc Inst"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-07037-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-07037-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-07037-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:22:47Z","timestamp":1778750567000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-07037-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["7037"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-07037-6","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"25 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"279"}}