{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:19:17Z","timestamp":1793272757218,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100013114","name":"Yunnan Key Research and Development Program","doi-asserted-by":"publisher","award":["202403AC100005"],"award-info":[{"award-number":["202403AC100005"]}],"id":[{"id":"10.13039\/501100013114","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-026-07055-4","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T02:04:14Z","timestamp":1778292254000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of platelet-rich plasma injection for hemophilic chronic synovitis and arthropathy: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"105","author":[{"given":"Shaoyu","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"7055_CR1","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.phrs.2016.11.032","volume":"115","author":"AE Pulles","year":"2017","unstructured":"Pulles AE, Mastbergen SC, Schutgens REG, Lafeber FPJG, van Vulpen LFD (2017) Pathophysiology of hemophilic arthropathy and potential targets for therapy. Pharmacol Res 115:192\u2013199. https:\/\/doi.org\/10.1016\/j.phrs.2016.11.032","journal-title":"Pharmacol Res"},{"key":"7055_CR2","doi-asserted-by":"publisher","first-page":"S74","DOI":"10.1097\/PHM.0b013e31823d4f35","volume":"91","author":"M Krasuska","year":"2012","unstructured":"Krasuska M, Riva S, Fava L, von Mackensen S, Bullinger M (2012) Linking quality-of-life measures using the International Classification of Functioning, Disability and Health and the International Classification of Functioning, Disability and Health-Children and Youth Version in chronic health conditions: the example of young people with hemophilia. Am J Phys Med Rehabil 91:S74\u201383. https:\/\/doi.org\/10.1097\/PHM.0b013e31823d4f35","journal-title":"Am J Phys Med Rehabil"},{"key":"7055_CR3","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1007\/s00167-012-1896-7","volume":"20","author":"PO Zingg","year":"2012","unstructured":"Zingg PO, Fucentese SF, Lutz W, Brand B, Mamisch N, Koch PP (2012) Haemophilic knee arthropathy: long-term outcome after total knee replacement. Knee Surg Sports Traumatol Arthrosc 20:2465\u20132470. https:\/\/doi.org\/10.1007\/s00167-012-1896-7","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"7055_CR4","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1097\/01.scs.0000186454.07097.bf","volume":"16","author":"WS Pietrzak","year":"2005","unstructured":"Pietrzak WS, Eppley BL (2005) Platelet rich plasma: biology and new technology. J Craniofac Surg 16:1043\u20131054. https:\/\/doi.org\/10.1097\/01.scs.0000186454.07097.bf","journal-title":"J Craniofac Surg"},{"key":"7055_CR5","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1186\/s40001-025-03253-4","volume":"30","author":"C Wang","year":"2025","unstructured":"Wang C, Yao B (2025) Efficacy and safety of platelet-rich plasma injections for the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Eur J Med Res 30:992. https:\/\/doi.org\/10.1186\/s40001-025-03253-4","journal-title":"Eur J Med Res"},{"key":"7055_CR6","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13075-020-02155-6","volume":"22","author":"Y Xue","year":"2020","unstructured":"Xue Y, Su X, Jiang M, Yu Z, Yang H, Qin L et al (2020) Pure platelet-rich plasma facilitates the repair of damaged cartilage and synovium in a rabbit hemorrhagic arthritis knee model. Arthritis Res Ther 22:68. https:\/\/doi.org\/10.1186\/s13075-020-02155-6","journal-title":"Arthritis Res Ther"},{"key":"7055_CR7","doi-asserted-by":"publisher","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","volume":"151","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151:264\u2013269. https:\/\/doi.org\/10.7326\/0003-4819-151-4-200908180-00135","journal-title":"Ann Intern Med"},{"issue":"Suppl 11","key":"7055_CR8","doi-asserted-by":"publisher","first-page":"S240","DOI":"10.1002\/acr.20543","volume":"63","author":"GA Hawker","year":"2011","unstructured":"Hawker GA, Mian S, Kendzerska T, French M (2011) Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP). Arthritis Care Res (Hoboken) 63(Suppl 11):S240\u2013252. https:\/\/doi.org\/10.1002\/acr.20543","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"7055_CR9","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1111\/hae.12197","volume":"19","author":"K Fischer","year":"2013","unstructured":"Fischer K, de Kleijn P (2013) Using the Haemophilia Joint Health Score for assessment of teenagers and young adults: exploring reliability and validity. Haemophilia 19:944\u2013950. https:\/\/doi.org\/10.1111\/hae.12197","journal-title":"Haemophilia"},{"key":"7055_CR10","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/1529-0131(200110)45:5<453::aid-art365>3.0.co;2-w","volume":"45","author":"S McConnell","year":"2001","unstructured":"McConnell S, Kolopack P, Davis AM (2001) The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC): a review of its utility and measurement properties. Arthritis Rheum 45:453\u2013461. https:\/\/doi.org\/10.1002\/1529-0131(200110)45:5%3C453::aid-art365%3E3.0.co;2-w","journal-title":"Arthritis Rheum"},{"key":"7055_CR11","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1055\/s-0035-1564798","volume":"41","author":"SN Keshava","year":"2015","unstructured":"Keshava SN, Gibikote S, Doria AS (2015) Imaging evaluation of hemophilia: musculoskeletal approach. Semin Thromb Hemost 41:880\u2013893. https:\/\/doi.org\/10.1055\/s-0035-1564798","journal-title":"Semin Thromb Hemost"},{"key":"7055_CR12","doi-asserted-by":"publisher","first-page":"e028777","DOI":"10.1136\/bmjopen-2018-028777","volume":"9","author":"Q Hao","year":"2019","unstructured":"Hao Q, Devji T, Zeraatkar D, Wang Y, Qasim A, Siemieniuk RAC et al (2019) Minimal important differences for improvement in shoulder condition patient-reported outcomes: a systematic review to inform a BMJ Rapid Recommendation. BMJ Open 9:e028777. https:\/\/doi.org\/10.1136\/bmjopen-2018-028777","journal-title":"BMJ Open"},{"key":"7055_CR13","doi-asserted-by":"publisher","first-page":"c4675","DOI":"10.1136\/bmj.c4675","volume":"341","author":"S Wandel","year":"2010","unstructured":"Wandel S, J\u00fcni P, Tendal B, N\u00fcesch E, Villiger PM, Welton NJ et al (2010) Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. BMJ 341:c4675. https:\/\/doi.org\/10.1136\/bmj.c4675","journal-title":"BMJ"},{"key":"7055_CR14","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1002\/art.24646","volume":"61","author":"M Backhaus","year":"2009","unstructured":"Backhaus M, Ohrndorf S, Kellner H, Strunk J, Backhaus TM, Hartung W et al (2009) Evaluation of a novel 7-joint ultrasound score in daily rheumatologic practice: a pilot project. Arthritis Rheum 61:1194\u20131201. https:\/\/doi.org\/10.1002\/art.24646","journal-title":"Arthritis Rheum"},{"key":"7055_CR15","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.jclinepi.2004.12.008","volume":"58","author":"CLK Lam","year":"2005","unstructured":"Lam CLK, Tse EYY, Gandek B, Fong DYT (2005) The SF-36 summary scales were valid, reliable, and equivalent in a Chinese population. J Clin Epidemiol 58:815\u2013822. https:\/\/doi.org\/10.1016\/j.jclinepi.2004.12.008","journal-title":"J Clin Epidemiol"},{"key":"7055_CR16","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898. https:\/\/doi.org\/10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"7055_CR17","doi-asserted-by":"publisher","first-page":"i4919","DOI":"10.1136\/bmj.i4919","volume":"355","author":"JA Sterne","year":"2016","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC, Savovi\u0107 J, Berkman ND, Viswanathan M et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ 355:i4919. https:\/\/doi.org\/10.1136\/bmj.i4919","journal-title":"BMJ"},{"key":"7055_CR18","doi-asserted-by":"publisher","unstructured":"Je M, Em B, Ab F (2016) Introduction to systematic reviews and meta-analysis. Respirol (Carlton Vic) 21. https:\/\/doi.org\/10.1111\/resp.12783","DOI":"10.1111\/resp.12783"},{"key":"7055_CR19","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jclinepi.2016.01.032","volume":"76","author":"HJ Sch\u00fcnemann","year":"2016","unstructured":"Sch\u00fcnemann HJ, Mustafa R, Brozek J, Santesso N, Alonso-Coello P, Guyatt G et al (2016) GRADE Guidelines: 16. GRADE evidence to decision frameworks for tests in clinical practice and public health. J Clin Epidemiol 76:89\u201398. https:\/\/doi.org\/10.1016\/j.jclinepi.2016.01.032","journal-title":"J Clin Epidemiol"},{"key":"7055_CR20","first-page":"11","volume":"80","author":"P Teyssler","year":"2014","unstructured":"Teyssler P, Kolostova K, Bobek V (2014) The impact of platelet-rich plasma on chronic synovitis in hemophilia. Acta Orthop Belg 80:11\u201317","journal-title":"Acta Orthop Belg"},{"key":"7055_CR21","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/hae.13212","volume":"23","author":"H Caviglia","year":"2017","unstructured":"Caviglia H, Landro ME, Daffunchio C, Galatro G, Douglas Price AL, Salgado P et al (2017) Platelet Rich Plasma for Chronic Synovitis Treatment in Patients with Haemophilia. Haemophilia 23:613\u2013619. https:\/\/doi.org\/10.1111\/hae.13212","journal-title":"Haemophilia"},{"key":"7055_CR22","doi-asserted-by":"publisher","first-page":"9140","DOI":"10.3390\/ijms25179140","volume":"25","author":"H Caviglia","year":"2024","unstructured":"Caviglia H, Landro ME, Oneto P, Cambiaggi G, Galatro G, Berni M et al (2024) Treatment of Chronic Haemophilic Synovitis with PRP: Clinical and In Vitro Studies. Int J Mol Sci 25:9140. https:\/\/doi.org\/10.3390\/ijms25179140","journal-title":"Int J Mol Sci"},{"key":"7055_CR23","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/hae.13711","volume":"25","author":"T-Y Li","year":"2019","unstructured":"Li T-Y, Wu Y-T, Chen L-C, Cheng S-N, Pan R-Y, Chen Y-C (2019) An exploratory comparison of single intra-articular injection of platelet-rich plasma vs hyaluronic acid in treatment of haemophilic arthropathy of the knee. Haemophilia 25:484\u2013492. https:\/\/doi.org\/10.1111\/hae.13711","journal-title":"Haemophilia"},{"key":"7055_CR24","doi-asserted-by":"publisher","first-page":"705","DOI":"10.52628\/87.4.15","volume":"87","author":"ME Landro","year":"2021","unstructured":"Landro ME, Daffunchio C, Cambiaggi G, Galatro GG, Caviglia H (2021) Platelet-rich plasma vs platelet-rich plasma plus hyaluronic acid for haemophilic knee arthropathy treatment. Acta Orthop Belg 87:705\u2013712. https:\/\/doi.org\/10.52628\/87.4.15","journal-title":"Acta Orthop Belg"},{"key":"7055_CR25","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1097\/CORR.0000000000002264","volume":"480","author":"W Duan","year":"2022","unstructured":"Duan W, Su X, Yu Z, Jiang M, Zhao L, Giannoudis PV et al (2022) No Benefit to Platelet-rich Plasma Over Placebo Injections in Terms of Pain or Function in Patients with Hemophilic Knee Arthritis: A Randomized Trial. Clin Orthop Relat Res 480:2361\u20132370. https:\/\/doi.org\/10.1097\/CORR.0000000000002264","journal-title":"Clin Orthop Relat Res"},{"key":"7055_CR26","doi-asserted-by":"publisher","first-page":"e187","DOI":"10.1111\/hae.14075","volume":"26","author":"H Caviglia","year":"2020","unstructured":"Caviglia H, Daffunchio C, Galatro G, Cambiaggi G, Oneto P, Douglas Price AL et al (2020) Inhibition of Fenton reaction is a novel mechanism to explain the therapeutic effect of intra-articular injection of PRP in patients with chronic haemophilic synovitis. Haemophilia 26:e187\u2013e193. https:\/\/doi.org\/10.1111\/hae.14075","journal-title":"Haemophilia"},{"key":"7055_CR27","doi-asserted-by":"publisher","first-page":"10616","DOI":"10.3390\/ijms262110616","volume":"26","author":"P Oneto","year":"2025","unstructured":"Oneto P, Landro ME, Ledesma MM, Etulain J, Daffunchio C, Cambiaggi G et al (2025) Platelet Releasate Reprograms Synovial Macrophages In Vitro: A New Approach in the Treatment of Hemophilic Synovitis. Int J Mol Sci 26:10616. https:\/\/doi.org\/10.3390\/ijms262110616","journal-title":"Int J Mol Sci"},{"key":"7055_CR28","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1080\/17474086.2023.2166922","volume":"16","author":"EC Rodriguez-Merchan","year":"2023","unstructured":"Rodriguez-Merchan EC (2023) Intra-articular injection of platelet-rich plasma in patients with hemophilia and painful knee joint cartilage degeneration. Expert Rev Hematol 16:407\u2013416. https:\/\/doi.org\/10.1080\/17474086.2023.2166922","journal-title":"Expert Rev Hematol"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-07055-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-07055-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-07055-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:02:23Z","timestamp":1783976543000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-07055-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,9]]},"references-count":28,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["7055"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-07055-4","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,9]]},"assertion":[{"value":"14 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"308"}}