{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:11:55Z","timestamp":1783977115546,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-026-07064-3","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T02:54:29Z","timestamp":1778295269000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful use of ruxolitinib in steroid-refractory chronic GvHD affecting central nervous system: a case report"],"prefix":"10.1007","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-5041","authenticated-orcid":false,"given":"Ewa","family":"Karakulska-Prystupiuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Zakrzewska-Pniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Tomaszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ha\u0142aburda-Rola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wies\u0142aw Wiktor","family":"J\u0119drzejczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz W\u0142adys\u0142aw","family":"Basak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"7064_CR1","doi-asserted-by":"publisher","unstructured":"Lee SJ, Williams KM, Sarantopoulos S, Kitko CL, Cutler C, Pidala J, Hill GR, DeFilipp Z, Greinix HT, Wolff D, Paczesny S, Cuvelier GDE, Schultz KR, Pavletic SZ (2025) NIH Chronic Graft-Versus-Host Disease Consensus Conference 2025 Update. Transplant Cell Ther. 31(9):678.e1-678.e16. https:\/\/doi.org\/10.1016\/j.jtct.2025.05.016","DOI":"10.1016\/j.jtct.2025.05.016"},{"issue":"8","key":"7064_CR2","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.jtct.2022.05.038","volume":"28","author":"GDE Cuvelier","year":"2022","unstructured":"Cuvelier GDE, Schoettler M, Buxbaum NP, Pinal-Fernandez I, Schmalzing M, Distler JHW, Penack O, Santomasso BD, Zeiser R, Angstwurm K, MacDonald KPA, Kimberly WT, Taylor N, Bilic E, Banas B, Buettner-Herold M, Sinha N, Greinix HT, Pidala J, Schultz KR, Williams KM, Inamoto Y, Cutler C, Griffith LM, Lee SJ, Sarantopoulos S, Pavletic SZ, Wolff D (2022) Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force. Transpl Cell Ther 28(8):426\u2013445. https:\/\/doi.org\/10.1016\/j.jtct.2022.05.038","journal-title":"Transpl Cell Ther"},{"key":"7064_CR3","doi-asserted-by":"publisher","unstructured":"Chen BJ (2022) Chronic GVHD of the CNS. Blood. ;139(9):1271\u20131272. https:\/\/doi.org\/10.1182\/blood.2021014079","DOI":"10.1182\/blood.2021014079"},{"key":"7064_CR4","doi-asserted-by":"publisher","unstructured":"Penack O, Marchetti M, Aljurf M, Arat M, Bonifazi F, Duarte RF, Giebel S, Greinix H, Hazenberg MD, Kr\u00f6ger N, Mielke S, Mohty M, Nagler A, Passweg J, Patriarca F, Ruutu T, Schoemans H, Solano C, Vrhovac R, Wolff D, Zeiser R, Sureda A, Peric Z (2024) Prophylaxis and management of graft-versus-host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation. Lancet Haematol. ;11(2):e147-e159. https:\/\/doi.org\/10.1016\/S2352-3026(23)00342-3","DOI":"10.1016\/S2352-3026(23)00342-3"},{"key":"7064_CR5","doi-asserted-by":"crossref","unstructured":"Harris AC, Young R, Devine S, Hogan WJ, Ayuk F, Bunworasate U, Chanswangphuwana C, Efebera YA, Holler E, Litzow M, Ordemann R, Qayed M, Renteria AS, Reshef R, W\u00f6lfl M, Chen YB, Goldstein S, Jagasia M, Locatelli F, Mielke S, Porter D, Schechter T, Shekhovtsova Z, Ferrara JL, Levine JE (2016) Multicenter Standardization of Acute Graft-versus-Host Disease Clinical Data Collection: A Report from the Mount Sinai Acute GVHD International Consortium. Biol Blood Marrow Transpl 22(1):4\u201310","DOI":"10.1016\/j.bbmt.2015.09.001"},{"issue":"11","key":"7064_CR6","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1038\/s41409-018-0204-7","volume":"53","author":"HM Schoemans","year":"2018","unstructured":"Schoemans HM, Lee SJ, Ferrara JL, Wolff D, Levine JE, Schultz KR, Shaw BE, Flowers ME, Ruutu T, Greinix H, Holler E, Basak G, Duarte RF, Pavletic SZ (2018) EBMT (European Society for Blood and Marrow Transplantation) Transplant Complications Working Party and the EBMT\u2009\u2013\u2009NIH (National Institutes of Health)\u2013CIBMTR (Center for International Blood and Marrow Transplant Research) GvHD Task Force. EBMT-NIH-CIBMTR Task Force position statement on standardized terminology & guidance for graft-versus-host disease assessment. Bone Marrow Transpl 53(11):1401\u20131415. https:\/\/doi.org\/10.1038\/s41409-018-0204-7","journal-title":"Bone Marrow Transpl"},{"issue":"7","key":"7064_CR7","first-page":"545","volume":"27","author":"CL Kitko","year":"2021","unstructured":"Kitko CL, Pidala J, Schoemans HM, Lawitschka A, Flowers ME, Cowen EW, Tkaczyk E, Farhadfar N, Jain S, Steven P, Luo ZK, Ogawa Y, Stern M, Yanik GA, Cuvelier GDE, Cheng GS, Holtan SG, Schultz KR, Martin PJ, Lee SJ, Pavletic SZ, Wolff D, Paczesny S, Blazar BR, Sarantopoulos S, Socie G, Greinix H, Cutler C (2021) National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report. Transpl Cell Ther 27(7):545\u2013557","journal-title":"Transpl Cell Ther"},{"key":"7064_CR8","doi-asserted-by":"publisher","unstructured":"Stohlman SA, Hinton DR (2001 Jan) Viral induced demyelination. Brain Pathol 11(1):92\u2013106. https:\/\/doi.org\/10.1111\/j.1750-3639.2001.tb00384.x","DOI":"10.1111\/j.1750-3639.2001.tb00384.x"},{"key":"7064_CR9","doi-asserted-by":"publisher","unstructured":"GrauerO, Wolff D, Bertz H, Greinix H, K\u00fchl JS, Lawitschka A, Lee SJ, Pavletic SZ, Holler E, Kleiter I (2010) Neurological manifestations of chronic graft-versus-host disease after allogeneic haematopoietic stem cell transplantation: report from the Consensus Conference on Clinical Practice in chronic graft-versus-host disease. Brain. 133(10):2852\u201365. https:\/\/doi.org\/10.1093\/brain\/awq245","DOI":"10.1093\/brain\/awq245"},{"issue":"4","key":"7064_CR10","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1093\/brain\/awae340","volume":"148","author":"N Lambert","year":"2025","unstructured":"Lambert N, Forte F, El Moussaoui M, Monseur J, Raus N, Polushin A, Michonneau D, Shultz C, Hogan WJ, Balaguer-Rosell\u00f3 A, Gil-Perot\u00edn S, Brijs J, Chauvet P, Gavriilaki M, Carre M, Dulamea AO, Chalandon Y, Salmenniemi U, Duminuco A, Ram R, Garc\u00eda-Cadenas I, Porto G, Nguyen S, Smallbone P, Gonz\u00e1lez-Vicent M, Santoro JD, Willems E, Baron F, Servais S, Beguin Y, Maquet P, CNS-GvHD Study Group (2025) CNS manifestations in acute and chronic graft-versus-host disease. Brain 148(4):1122\u20131133. https:\/\/doi.org\/10.1093\/brain\/awae340","journal-title":"Brain"},{"key":"7064_CR11","doi-asserted-by":"publisher","unstructured":"BuxbaumNP, Pavletic SZ (2020) Autoimmunity Following Allogeneic Hematopoietic Stem Cell Transplantation. Front Immunol. 11:2017. https:\/\/doi.org\/10.3389\/fimmu.2020.02017","DOI":"10.3389\/fimmu.2020.02017"},{"key":"7064_CR12","doi-asserted-by":"publisher","first-page":"621392","DOI":"10.3389\/fneur.2021.621392","volume":"12","author":"M Li","year":"2021","unstructured":"Li M, Zhang Y, Guan Y, Zhang Z, Dong H, Zhao Y, Deng H (2021) A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review. Front Neurol 12:621392","journal-title":"Front Neurol"},{"issue":"42","key":"7064_CR13","doi-asserted-by":"publisher","first-page":"e8303","DOI":"10.1097\/MD.0000000000008303","volume":"96","author":"M Ruggiu","year":"2017","unstructured":"Ruggiu M, Cuccuini W, Mokhtari K, Meignin V, Peffault de Latour R, Robin M, Fontbrune FS, Xhaard A, Soci\u00e9 G, Michonneau D (2017) Case report: Central nervous system involvement of human graft versus host disease: Report of 7 cases and a review of literature. Med (Baltim) 96(42):e8303. https:\/\/doi.org\/10.1097\/MD.0000000000008303","journal-title":"Med (Baltim)"},{"issue":"12","key":"7064_CR14","first-page":"772","volume":"29","author":"J Doering","year":"2023","unstructured":"Doering J, Perl M, Weber D, Banas B, Schulz C, Hamer OW, Angstwurm K, Holler E, Herr W, Edinger M, Wolff D, Fante MA (2023) Incidence and Outcome of Atypical Manifestations of Chronic Graft-versus-Host Disease: Results From a Retrospective Single-Center Analysis. Transpl Cell Ther 29(12):772. e1-772.e10Epub 2023 Sep 28. PMID: 37777112","journal-title":"Transpl Cell Ther"},{"key":"7064_CR15","doi-asserted-by":"publisher","unstructured":"ZeiserR, Polverelli N, Ram R, Hashmi SK, Chakraverty R, Middeke JM, Musso M, Giebel S, Uzay A, Langmuir P, Hollaender N, Gowda M, Stefanelli T, Lee SJ, Teshima T, Locatelli F (2021) REACH3 Investigators. Ruxolitinib for Glucocorticoid-Refractory Chronic Graft-versus-Host Disease. N Engl J Med. 385(3):228\u2013238. https:\/\/doi.org\/10.1056\/NEJMoa2033122","DOI":"10.1056\/NEJMoa2033122"},{"issue":"17","key":"7064_CR16","doi-asserted-by":"publisher","first-page":"4886","DOI":"10.1182\/bloodadvances.2022007611","volume":"7","author":"NP Buxbaum","year":"2023","unstructured":"Buxbaum NP, Soci\u00e9 G, Hill GR, MacDonald KPA, Tkachev V, Teshima T, Lee SJ, Ritz J, Sarantopoulos S, Luznik L, Zeng D, Paczesny S, Martin PJ, Pavletic SZ, Schultz KR, Blazar BR (2023) Chronic GvHD NIH Consensus Project Biology Task Force: evolving path to personalized treatment of chronic GvHD. Blood Adv 7(17):4886\u20134902. https:\/\/doi.org\/10.1182\/bloodadvances.2022007611","journal-title":"Blood Adv"},{"key":"7064_CR17","doi-asserted-by":"publisher","unstructured":"WolffD (2020) A few steps on the long road toward biomarkers in GVHD. Blood. 135(15):1196\u20131197. https:\/\/doi.org\/10.1182\/blood.2020005116","DOI":"10.1182\/blood.2020005116"},{"issue":"9","key":"7064_CR18","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1182\/blood.2021011671","volume":"139","author":"RC Adams","year":"2022","unstructured":"Adams RC, Carter-Cusack D, Shaikh SN, Llanes GT, Johnston RL, Quaife-Ryan G, Boyle G, Koufariotis LT, M\u00f6ller A, Blazar BR, Vukovic J, MacDonald KPA (2022) Donor bone marrow-derived macrophage MHC II drives neuroinflammation and altered behavior during chronic GVHD in mice. Blood 139(9):1389\u20131408. https:\/\/doi.org\/10.1182\/blood.2021011671","journal-title":"Blood"},{"key":"7064_CR19","doi-asserted-by":"publisher","first-page":"119395","DOI":"10.1016\/j.lfs.2021.119395","volume":"276","author":"A Hosseini","year":"2021","unstructured":"Hosseini A, Gharibi T, Mohammadzadeh A, Ebrahimi-Kalan A, Jadidi-Niaragh F, Babaloo Z, Shanehbandi D, Baghbani E, Baradaran B (2021) Ruxolitinib attenuates experimental autoimmune encephalomyelitis (EAE) development as animal models of multiple sclerosis (MS). Life Sci 276:119395","journal-title":"Life Sci"},{"key":"7064_CR20","doi-asserted-by":"publisher","unstructured":"ZeiserR, Teshima T (2021) Nonclassical manifestations of acute GVHD. Blood. 138(22):2165\u20132172. https:\/\/doi.org\/10.1182\/blood.2021012431","DOI":"10.1182\/blood.2021012431"},{"issue":"3","key":"7064_CR21","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1172\/JCI130272","volume":"130","author":"NR Mathew","year":"2020","unstructured":"Mathew NR, Vinnakota JM, Apostolova P, Erny D, Hamarsheh S, Andrieux G, Kim JS, Hanke K, Goldmann T, Chappell-Maor L, El-Khawanky N, Ihorst G, Schmidt D, Duyster J, Finke J, Blank T, Boerries M, Blazar BR, Jung S, Prinz M, Zeiser R (2020) Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia. J Clin Invest 130(3):1315\u20131329. https:\/\/doi.org\/10.1172\/JCI130272","journal-title":"J Clin Invest"},{"key":"7064_CR22","doi-asserted-by":"publisher","unstructured":"Schwartz DM, Kanno Y, Villarino A, Ward M, Gadina M, O\u2019Shea JJ (2017) JAK inhibition as a therapeutic strategy for immune and inflammatory diseases. Nat Rev Drug Discov. ;16(12):843\u2013862. https:\/\/doi.org\/10.1038\/nrd.2017.201","DOI":"10.1038\/nrd.2017.201"},{"key":"7064_CR23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.neuro.2024.08.004","volume":"105","author":"CW Lim","year":"2024","unstructured":"Lim CW, Hamanaka G, Liang AC, Chan SJ, Ling KH, Lo EH, Arai K, Cheah PS (2024) In vitro cytotoxicity assessment of ruxolitinib on oligodendrocyte precursor cell and neural stem\/progenitor cell populations. Neurotoxicology 105:10\u201320","journal-title":"Neurotoxicology"},{"issue":"12","key":"7064_CR24","doi-asserted-by":"publisher","first-page":"eadi9885","DOI":"10.1126\/sciadv.adi9885","volume":"11","author":"JC Hargarten","year":"2025","unstructured":"Hargarten JC, Ssebambulidde K, Anjum SH, Vaughan MJ, Xu J, Ganguly A, Dulek B, Otaizo-Carrasquero F, Song B, Tao S, Park YD, Scott TL, H\u00f6ltermann TA, Schinazi RF, Chittiboina P, Billioux BJ, Hammoud DA, Olszewski MA, Williamson PR (2025) Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome. Sci Adv 11(12):eadi9885. https:\/\/doi.org\/10.1126\/sciadv.adi9885","journal-title":"Sci Adv"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-07064-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-07064-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-07064-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:02:32Z","timestamp":1783976552000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-07064-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,9]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["7064"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-07064-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8745448\/v1","asserted-by":"object"}]},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,9]]},"assertion":[{"value":"31 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The ethical consent was approved by Medical University of Warsaw, Bioethical Commission.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"This is a retrospective analysis of anonymous data contained in medical records.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Written consent for publication was obtained from the patient.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Authors declare no financial interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial interests"}}],"article-number":"310"}}