{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T10:27:16Z","timestamp":1786789636258,"version":"build-2736575974"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":61,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007343","name":"Universit\u00e0 degli Studi di Brescia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007343","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Calcineurin inhibitor\u2013induced pain syndrome (CIPS) is a rare complication of immunosuppressive therapy, predominantly described in solid organ transplantation and only occasionally after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We report an atypical early presentation of CIPS in a 57-year-old woman with adverse-risk acute myeloid leukemia undergoing matched sibling donor allo-HSCT. GVHD prophylaxis included ciclosporin, methotrexate, and antithymocyte globulin. On day\u2009+\u20092, the patient developed severe, stabbing back pain refractory to opioids and partially responsive to pregabalin. Extensive cardiologic, neurologic, radiologic, and laboratory workup was negative except for mild alkaline phosphatase elevation; ciclosporin levels were therapeutic. After exclusion of alternative etiologies, CIPS was suspected (Naranjo score 7). Pain resolved rapidly following ciclosporin discontinuation and steroid introduction, with no recurrence during subsequent tacrolimus therapy.<\/jats:p>","DOI":"10.1007\/s00277-026-07079-w","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T04:44:57Z","timestamp":1779857097000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Calcineurin inhibitor\u2013induced pain syndrome: an uncommon side effect of immunosuppressive therapy after allogeneic hematopoietic stem cell transplant. a case report and review of the literature"],"prefix":"10.1007","volume":"105","author":[{"given":"Rachele","family":"De Domenico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Magliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Morello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Zanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Radici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Malagola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Avenoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"7079_CR1","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.2174\/0929867327666201006153202","volume":"28","author":"J Patocka","year":"2021","unstructured":"Patocka J, Nepovimova E, Kuca K, Wu W, Cyclosporine A (2021) Chemistry and Toxicity \u2013 A Review. CMC 28:3925\u20133934","journal-title":"CMC"},{"key":"7079_CR2","doi-asserted-by":"publisher","first-page":"269","DOI":"10.5301\/jn.5000174","volume":"25","author":"EJ Hoorn","year":"2012","unstructured":"Hoorn EJ et al (2012) Pathogenesis of calcineurin inhibitor\u2013induced hypertension. JN 25:269\u2013275","journal-title":"JN"},{"key":"7079_CR3","first-page":"753","volume":"56","author":"G Bouteiller","year":"1989","unstructured":"Bouteiller G, Lloveras JJ, Condouret J, Durroux R, Durand D (1989) [Painful polyarticular syndrome probably induced by cyclosporin in three patients with a kidney transplant and one with a heart transplant]. Rev Rhum Mal Osteoartic 56:753\u2013755","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"7079_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s001470000285","volume":"14","author":"WH Grotz","year":"2001","unstructured":"Grotz WH et al (2001) Calcineurin-inhibitor induced pain syndrome (CIPS): a severe disabling complication after organ transplantation. Transpl Int 14:16\u201323","journal-title":"Transpl Int"},{"key":"7079_CR5","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1182\/blood.2022016867","volume":"140","author":"H D\u00f6hner","year":"2022","unstructured":"D\u00f6hner H et al (2022) Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood 140:1345\u20131377","journal-title":"Blood"},{"key":"7079_CR6","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1016\/S2352-3026(19)30157-7","volume":"7","author":"DW Beelen","year":"2020","unstructured":"Beelen DW et al (2020) Treosulfan or busulfan plus fludarabine as conditioning treatment before allogeneic haemopoietic stem cell transplantation for older patients with acute myeloid leukaemia or myelodysplastic syndrome (MC-FludT.14\/L): a randomised, non-inferiority, phase 3 trial. Lancet Haematol 7:e28\u2013e39","journal-title":"Lancet Haematol"},{"key":"7079_CR7","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/clpt.1981.154","volume":"30","author":"CA Naranjo","year":"1981","unstructured":"Naranjo CA et al (1981) A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30:239\u2013245","journal-title":"Clin Pharmacol Ther"},{"key":"7079_CR8","doi-asserted-by":"publisher","first-page":"442","DOI":"10.12659\/AJCR.908886","volume":"19","author":"S Udomkarnjananun","year":"2018","unstructured":"Udomkarnjananun S, Townamchai N, Virojanawat M, Avihingsanon Y, Praditpornsilpa K (2018) An Unusual Manifestation of Calcineurin Inhibitor-Induced Pain Syndrome in Kidney Transplantation: A Case Report and Literature Review. Am J Case Rep 19:442\u2013446","journal-title":"Am J Case Rep"},{"key":"7079_CR9","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.pmrj.2017.08.442","volume":"10","author":"TK Mohideen","year":"2018","unstructured":"Mohideen TK, Wu H (2018) Immunosuppressant medication\u2013induced lower extremity pain after combined liver and kidney transplant: a case report. PM&R 10:309\u2013312","journal-title":"PM&amp;R"},{"key":"7079_CR10","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/bmt.2011.120","volume":"47","author":"K Kakihana","year":"2012","unstructured":"Kakihana K et al (2012) Clinical features of calcineurin inhibitor-induced pain syndrome after allo-SCT. Bone Marrow Transpl 47:593\u2013595","journal-title":"Bone Marrow Transpl"},{"key":"7079_CR11","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1365-2141.2004.05066.x","volume":"126","author":"A Kida","year":"2004","unstructured":"Kida A et al (2004) Calcineurin-inhibitor pain syndrome following haematopoietic stem cell transplantation. Br J Haematol 126:288\u2013288","journal-title":"Br J Haematol"},{"key":"7079_CR12","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1345\/aph.1L641","volume":"43","author":"SR Lavoratore","year":"2009","unstructured":"Lavoratore SR et al (2009) Cyclosporine-Induced Pain Syndrome in a Child Undergoing Hematopoietic Stem Cell Transplant. Ann Pharmacother 43:767\u2013771","journal-title":"Ann Pharmacother"},{"key":"7079_CR13","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1111\/j.1399-3046.2008.01009.x","volume":"13","author":"T Nishikawa","year":"2009","unstructured":"Nishikawa T et al (2009) Calcineurin-inhibitor\u2010induced pain syndrome after a second allogeneic bone marrow transplantation for a child with aplastic anemia. Pediatr Transplant 13:641\u2013644","journal-title":"Pediatr Transplant"},{"key":"7079_CR14","first-page":"753","volume":"56","author":"G Bouteiller","year":"1989","unstructured":"Bouteiller G, Lloveras JJ, Condouret J, Durroux R, Durand D (1989) [Painful polyarticular syndrome probably induced by cyclosporin in three patients with a kidney transplant and one with a heart transplant]. Rev Rhum Mal Osteoartic 56:753\u2013755","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"7079_CR15","first-page":"653","volume":"12","author":"E Naredo S\u00e1nchez","year":"1994","unstructured":"Naredo S\u00e1nchez E et al (1994) Leg bone pain syndrome due to cyclosporine in a renal transplant patient. Clin Exp Rheumatol 12:653\u2013656","journal-title":"Clin Exp Rheumatol"},{"key":"7079_CR16","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1136\/ard.58.10.653a","volume":"58","author":"V Villaverde","year":"1999","unstructured":"Villaverde V, Cantalejo M, Balsa A, Mola EM, Sanz A (1999) Leg bone pain syndrome in a kidney transplant patient treated with tacrolimus (FK506). Ann Rheum Dis 58:653\u2013654","journal-title":"Ann Rheum Dis"},{"key":"7079_CR17","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1034\/j.1399-3046.2002.02030.x","volume":"6","author":"GE Malat","year":"2002","unstructured":"Malat GE et al (2002) Tacrolimus-induced pain syndrome in a pediatric orthotopic liver transplant patient. Pediatr Transplant 6:435\u2013438","journal-title":"Pediatr Transplant"},{"key":"7079_CR18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S1297-319X(03)00095-2","volume":"71","author":"M Franco","year":"2004","unstructured":"Franco M et al (2004) Tacrolimus pain syndrome in renal transplant patients: report of two cases. Joint Bone Spine 71:157\u2013159","journal-title":"Joint Bone Spine"},{"key":"7079_CR19","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/BF03033761","volume":"10","author":"A Kida","year":"2004","unstructured":"Kida A et al (2004) Incapacitating lower limb pain syndrome in cord blood stem cell transplant recipients with calcineurin inhibitor. Pathol Oncol Res 10:204\u2013206","journal-title":"Pathol Oncol Res"},{"key":"7079_CR20","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/sj.ki.5001833","volume":"70","author":"A Collini","year":"2006","unstructured":"Collini A et al (2006) Calcineurin-inhibitor induced pain syndrome after organ transplantation. Kidney Int 70:1367\u20131370","journal-title":"Kidney Int"},{"key":"7079_CR21","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1532\/IJH97.05154","volume":"83","author":"N Fujii","year":"2006","unstructured":"Fujii N et al (2006) Calcineurin Inhibitor-Induced Irreversible Neuropathic Pain after Allogeneic Hematopoietic Stem Cell Transplantation. Int J Hematol 83:459\u2013461","journal-title":"Int J Hematol"},{"key":"7079_CR22","first-page":"1372","volume":"47","author":"S Takashima","year":"2006","unstructured":"Takashima S et al (2006) [Acute lymphoblastic leukemia presenting with calcineurin-inhibitor induced pain syndrome after a second allogeneic bone marrow transplantation]. Rinsho Ketsueki 47:1372\u20131376","journal-title":"Rinsho Ketsueki"},{"key":"7079_CR23","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00540-007-0574-2","volume":"22","author":"Y Noda","year":"2008","unstructured":"Noda Y, Kodama K, Yasuda T, Takahashi S (2008) Calcineurin-inhibitor-induced pain syndrome after bone marrow transplantation. J Anesth 22:61\u201363","journal-title":"J Anesth"},{"key":"7079_CR24","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1093\/ndtplus\/sfq172","volume":"4","author":"A Breitenstein","year":"2011","unstructured":"Breitenstein A, Stumpe KDM, Gnannt R, Fehr T, Etter C (2011) Calcineurin inhibitor-induced pain syndrome after kidney transplantation\u2013a rare but disabling condition. Clin Kidney J 4:63\u201366","journal-title":"Clin Kidney J"},{"key":"7079_CR25","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.1016\/j.transproceed.2012.07.138","volume":"44","author":"LC Prates","year":"2012","unstructured":"Prates LC et al (2012) Pain syndrome induced by calcineurin inhibitor and resolved by conversion to sirolimus in a child after kidney transplantation: a case report. Transpl Proc 44:2510\u20132511","journal-title":"Transpl Proc"},{"key":"7079_CR26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/ndtplus\/sfr156","volume":"5","author":"L Gurin","year":"2012","unstructured":"Gurin L, Gohh R, Evangelista P (2012) Pain syndrome with stress fractures in transplanted patients treated with calcineurin inhibitors. Clin Kidney J 5:13\u201316","journal-title":"Clin Kidney J"},{"key":"7079_CR27","doi-asserted-by":"publisher","first-page":"e71","DOI":"10.1111\/tri.12103","volume":"26","author":"S Sahay","year":"2013","unstructured":"Sahay S, McBennett K, Sheers T (2013) Calcineurin-inhibitor induced pain syndrome in a lung transplant patient. Transpl Int 26:e71\u2013e73","journal-title":"Transpl Int"},{"key":"7079_CR28","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1007\/s00256-013-1616-5","volume":"42","author":"RW Chapin","year":"2013","unstructured":"Chapin RW, Chua E, Simmons J, Bunke M (2013) Case report: imaging features in a renal transplant patient with calcineurin inhibitor-induced pain syndrome (CIPS). Skeletal Radiol 42:1311\u20131315","journal-title":"Skeletal Radiol"},{"key":"7079_CR29","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1007\/s00247-016-3644-5","volume":"46","author":"RS Ayyala","year":"2016","unstructured":"Ayyala RS, Arnold SD, Bhatia M, Dastgir J (2016) Imaging findings in a child with calcineurin inhibitor-induced pain syndrome after bone marrow transplant for beta thalassemia major. Pediatr Radiol 46:1618\u20131621","journal-title":"Pediatr Radiol"},{"key":"7079_CR30","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1177\/1526924816654832","volume":"26","author":"\u00d6 Ta\u015fo\u011flu","year":"2016","unstructured":"Ta\u015fo\u011flu \u00d6 et al (2016) Pregabalin: A New Adjunct in Calcineurin Inhibitor Pain Syndrome Treatment. Prog Transpl 26:224\u2013226","journal-title":"Prog Transpl"},{"key":"7079_CR31","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1007\/s00277-017-3019-5","volume":"96","author":"M Watanabe","year":"2017","unstructured":"Watanabe M, Koba Y, Tamekane A (2017) Successful treatment of calcineurin inhibitor-induced pain syndrome with acute graft versus host disease by switching calcineurin inhibitors followed by pregabalin. Ann Hematol 96:1207\u20131208","journal-title":"Ann Hematol"},{"key":"7079_CR32","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.transproceed.2016.11.007","volume":"49","author":"S Ishida","year":"2017","unstructured":"Ishida S et al (2017) Calcineurin Inhibitor\u2013Induced Pain Syndrome in ABO-Incompatible Living Kidney Transplantation: A Case Report. Transpl Proc 49:163\u2013166","journal-title":"Transpl Proc"},{"key":"7079_CR33","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.1016\/j.transproceed.2018.09.002","volume":"50","author":"X Wei","year":"2018","unstructured":"Wei X, Zhao M, Li Q, Xiao X, Zhu L (2018) Tacrolimus-Induced Pain Syndrome After Bone Marrow Transplantation: A Case Report and Literature Review. Transpl Proc 50:4090\u20134095","journal-title":"Transpl Proc"},{"key":"7079_CR34","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.clinimag.2018.10.022","volume":"53","author":"Y Chadha","year":"2019","unstructured":"Chadha Y, Brahme SK, Huang BK, Chang EY (2019) Calcineurin-inhibitor induced pain syndrome \u2013 Magnetic resonance imaging and scintigraphic findings illustrated through two cases. Clin Imaging 53:174\u2013178","journal-title":"Clin Imaging"},{"key":"7079_CR35","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1080\/10428194.2020.1765235","volume":"61","author":"A Varma","year":"2020","unstructured":"Varma A et al (2020) Calcineurin-inhibitor induced pain syndrome after stem cell transplant. Leuk Lymphoma 61:2230\u20132233","journal-title":"Leuk Lymphoma"},{"key":"7079_CR36","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.1016\/j.transproceed.2021.08.014","volume":"53","author":"OJ Ilonze","year":"2021","unstructured":"Ilonze OJ et al (2021) Calcineurin-Inhibitor Induced Pain Syndrome in a Heart Transplant Patient. Transpl Proc 53:2630\u20132635","journal-title":"Transpl Proc"},{"key":"7079_CR37","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s40001-025-02357-1","volume":"30","author":"T Abdul-Rahman","year":"2025","unstructured":"Abdul-Rahman T et al (2025) A comprehensive review of the clinical presentation, diagnosis, and treatment of calcineurin inhibitor-induced pain syndrome. Eur J Med Res 30:177","journal-title":"Eur J Med Res"},{"key":"7079_CR38","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/S0041-1345(00)02300-9","volume":"33","author":"W Grotz","year":"2001","unstructured":"Grotz W, Breitenfeldt K, Cybulla M (2001) Immunosuppression and skeletal disorders. Transpl Proc 33:992\u2013993","journal-title":"Transpl Proc"},{"key":"7079_CR39","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/j.1432-2277.2008.00668.x","volume":"21","author":"F-P Tillmann","year":"2008","unstructured":"Tillmann F-P et al (2008) Post-transplant distal limb syndrome: clinical diagnosis and long-term outcome in 37 renal transplant recipients. Transpl Int 21:547\u2013553","journal-title":"Transpl Int"},{"key":"7079_CR40","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1007\/s00247-016-3644-5","volume":"46","author":"RS Ayyala","year":"2016","unstructured":"Ayyala RS, Arnold SD, Bhatia M, Dastgir J (2016) Imaging findings in a child with calcineurin inhibitor-induced pain syndrome after bone marrow transplant for beta thalassemia major. Pediatr Radiol 46:1618\u20131621","journal-title":"Pediatr Radiol"},{"key":"7079_CR41","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0002-9343(81)90407-1","volume":"70","author":"F Kozin","year":"1981","unstructured":"Kozin F, Ryan LM, Carerra GF, Soin JS, Wortmann RL (1981) The reflex sympathetic dystrophy syndrome (RSDS). Am J Med 70:23\u201330","journal-title":"Am J Med"},{"key":"7079_CR42","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/BF00336653","volume":"6","author":"VA Briner","year":"1993","unstructured":"Briner VA, Landmann J, Brunner FP, Thiel G (1993) Cyclosporin A-induced transient rise in plasma alkaline phosphatase in kidney transplant patients. Transpl Int 6:99\u2013107","journal-title":"Transpl Int"},{"key":"7079_CR43","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1002\/nop2.489","volume":"7","author":"M Dalvindt","year":"2020","unstructured":"Dalvindt M, Kisch A, Nozohoor S, Lennerling A, Forsberg A (2020) Chronic pain 1\u20135 years after heart transplantation\u2014A nationwide cross-sectional cohort study. Nurs Open 7:1146\u20131156","journal-title":"Nurs Open"},{"key":"7079_CR44","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1097\/00007890-199404270-00016","volume":"57","author":"M Cvetkovic","year":"1994","unstructured":"Cvetkovic M et al (1994) THE DELETERIOUS EFFECTS OF LONG-TERM CYCLOSPORINE A, CYCLOSPORINE G, AND FK506 ON BONE MINERAL METABOLISM IN VIVO. Transplantation 57:1231\u20131237","journal-title":"Transplantation"},{"key":"7079_CR45","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1210\/endo-123-5-2571","volume":"123","author":"C Movsowitz","year":"1988","unstructured":"Movsowitz C, Epstein S, Fallon M, Ismail F, Thomas S (1988) Cyclosporin-A in Vivo Produces Severe Osteopenia in the Rat: Effect of Dose and Duration of Administration*. Endocrinology 123:2571\u20132577","journal-title":"Endocrinology"},{"key":"7079_CR46","doi-asserted-by":"publisher","first-page":"3707","DOI":"10.1523\/JNEUROSCI.0282-20.2020","volume":"40","author":"Y Huang","year":"2020","unstructured":"Huang Y, Chen S-R, Chen H, Luo Y, Pan H-L (2020) Calcineurin Inhibition Causes \u03b12\u03b4-1\u2013Mediated Tonic Activation of Synaptic NMDA Receptors and Pain Hypersensitivity. J Neurosci 40:3707\u20133719","journal-title":"J Neurosci"},{"key":"7079_CR47","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1113\/jphysiol.2013.263814","volume":"592","author":"S Chen","year":"2014","unstructured":"Chen S, Hu Y, Chen H, Pan H (2014) Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords. J Physiol 592:215\u2013227","journal-title":"J Physiol"},{"key":"7079_CR48","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1016\/j.celrep.2018.02.021","volume":"22","author":"J Chen","year":"2018","unstructured":"Chen J et al (2018) The \u03b12\u03b4-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Rep 22:2307\u20132321","journal-title":"Cell Rep"},{"key":"7079_CR49","doi-asserted-by":"publisher","first-page":"E309","DOI":"10.36076\/ppj.2009\/12\/E09","volume":"12","author":"HS Smith","year":"2009","unstructured":"Smith HS (2009) Calcineurin as a nociceptor modulator. Pain Physician 12:E309\u2013318","journal-title":"Pain Physician"},{"key":"7079_CR50","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1097\/AJP.0b013e31823a67f1","volume":"28","author":"E Prommer","year":"2012","unstructured":"Prommer E (2012) Calcineurin-inhibitor Pain Syndrome. Clin J Pain 28:556\u2013559","journal-title":"Clin J Pain"},{"key":"7079_CR51","doi-asserted-by":"publisher","first-page":"863","DOI":"10.7326\/0003-4819-121-11-199412010-00007","volume":"121","author":"VJ Gauthier","year":"1994","unstructured":"Gauthier VJ, Barbosa LM (1994) Bone Pain in Transplant Recipients Responsive to Calcium Channel Blockers. Ann Intern Med 121:863\u2013865","journal-title":"Ann Intern Med"},{"key":"7079_CR52","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1111\/j.1440-1797.2006.00708.x","volume":"11","author":"GJ Elder","year":"2006","unstructured":"Elder GJ (2006) From marrow oedema to osteonecrosis: Common paths in the development of post-transplant bone pain (Review Article). Nephrology 11:560\u2013567","journal-title":"Nephrology"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-07079-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-07079-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-07079-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T10:02:22Z","timestamp":1786788142000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00277-026-07079-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":52,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["7079"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-07079-w","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]},"assertion":[{"value":"6 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The patient provided written informed consent for publication of the clinical details included in this manuscript.","order":2,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"345"}}