{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:45:36Z","timestamp":1789469136868,"version":"build-2803163510"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":67,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100014064","name":"Universidad de Salamanca","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014064","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vitreoretinal Lymphoma (VRL) is a rare ocular malignancy often presenting with atypical retinal findings, which can lead to misdiagnosis. We report the case of a patient with bilateral intraocular lesions and reduced visual acuity. Diagnosis was confirmed by multimodal imaging and molecular analysis of aqueous humor. Treatment consisted of intravitreal methotrexate and rituximab, followed by systemic chemotherapy, achieving partial resolution of the ocular lesions but subsequent ocular and systemic recurrence. After rescue treatment, patient achieved sustained complete remission. Early diagnosis and a multidisciplinary approach are essential, and multimodal imaging combined with molecular diagnostics is key in confirming the diagnosis.<\/jats:p>","DOI":"10.1007\/s00277-026-07122-w","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:53:49Z","timestamp":1781232829000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitreoretinal Lymphoma: a clinical case highlighting the diagnostic and therapeutic challenge and the need for a multidisciplinary management"],"prefix":"10.1007","volume":"105","author":[{"given":"Mar\u00eda Sanchidri\u00e1n","family":"Mayo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena Cabero","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Cacharro","family":"Moras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Alonso","family":"Castronu\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Garc\u00eda","family":"\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar Javier Blanco","family":"Mu\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro Mart\u00edn Garc\u00eda","family":"Sancho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora Carmen","family":"Guti\u00e9rrez Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"issue":"2","key":"7122_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/eye.2012.250","volume":"27","author":"JL Davis","year":"2013","unstructured":"Davis JL (2013) Intraocular lymphoma: a clinical perspective. 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Trans Vis Sci Technol 1:1","journal-title":"Trans Vis Sci Technol"},{"issue":"1","key":"7122_CR8","doi-asserted-by":"publisher","DOI":"10.2217\/cns-2019-0022","volume":"9","author":"T Low","year":"2020","unstructured":"Low T, Peters B (2020) Ibrutinib in primary central nervous system diffuse large B-cell lymphoma. CNS Oncol 9(1):CNS51","journal-title":"CNS Oncol"},{"issue":"4","key":"7122_CR9","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1093\/annonc\/mdz032","volume":"30","author":"H Ghesquieres","year":"2019","unstructured":"Ghesquieres H, Chevrier M, Laadhari Mea et al (2019) Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed\/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective \u2018proof of concept\u2019 phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA). 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