{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:49:29Z","timestamp":1792162169149,"version":"4.4.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":87,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Care for Rare Foundation (Munich, Germany)."},{"DOI":"10.13039\/501100004351","name":"Sultan Qaboos University","doi-asserted-by":"publisher","award":["CL\/SQU-CFRF\/MRC\/24\/01"],"award-info":[{"award-number":["CL\/SQU-CFRF\/MRC\/24\/01"]}],"id":[{"id":"10.13039\/501100004351","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Hematol"],"DOI":"10.1007\/s00277-026-07185-9","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:54:58Z","timestamp":1784645698000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Between scarcity and surfeit: a familial tale of contradictory iron disorders (\u03b2 -thalassemia and iron-refractory iron deficiency anemia)"],"prefix":"10.1007","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4217-5813","authenticated-orcid":false,"given":"Maha","family":"AlRiyami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-2420","authenticated-orcid":false,"given":"A.","family":"AlSayegh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"ALRawahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Balasuburamanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rohlfs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-0445","authenticated-orcid":false,"given":"C.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4275-4524","authenticated-orcid":false,"given":"Y.","family":"Wali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"issue":"5","key":"7185_CR1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1600-0609.2011.01687.x","volume":"87","author":"S Al Zadjali","year":"2011","unstructured":"Al Zadjali S, Wali Y, Al Lawatiya F, Gravell D, Alkindi S, Al Falahi K, Krishnamoorthy R, Daar S (2011) The beta-globin promoter\u2009\u2013\u200971 C\u2009>\u2009T mutation is a beta+ thalassemic allele. Eur J Haematol 87(5):457\u2013460. https:\/\/doi.org\/10.1111\/j.1600-0609.2011.01687.x","journal-title":"Eur J Haematol"},{"key":"7185_CR2","doi-asserted-by":"publisher","unstructured":"Hassan SM, Alrawas A, Al Khanbashi L, Wali Y. (2023). Homozygous mild beta-thalassaemia promoter transversion\u2009\u2212\u200971 C\u2009>\u2009T HBB:c.-121 C\u2009>\u2009T. BMJ Case Rep. 16(4). https:\/\/doi.org\/10.1136\/bcr-2022-254416","DOI":"10.1136\/bcr-2022-254416"},{"issue":"5","key":"7185_CR3","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/ng.130","volume":"40","author":"KE Finberg","year":"2008","unstructured":"Finberg KE, Heeney MM, Campagna DR, Aydinok Y, Pearson HA, Hartman KR, Mayo MM, Samuel SM, Strouse JJ, Markianos K, Andrews NC, Fleming MD (2008) Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet 40(5):569\u2013571. https:\/\/doi.org\/10.1038\/ng.130","journal-title":"Nat Genet"},{"issue":"4","key":"7185_CR4","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1111\/bjh.20030","volume":"206","author":"V Hoving","year":"2025","unstructured":"Hoving V, Donker AE, Schols SEM, Swinkels DW (2025) How I treat iron-refractory iron deficiency anaemia-An expert opinion-based treatment guidance for children and adults. Br J Haematol 206(4):1067\u20131076. https:\/\/doi.org\/10.1111\/bjh.20030","journal-title":"Br J Haematol"},{"issue":"2","key":"7185_CR5","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3109\/03630269.2015.1009632","volume":"39","author":"SM Hassan","year":"2015","unstructured":"Hassan SM, Harteveld CL, Bakker E, Giordano PC (2015) Broader spectrum of beta-thalassemia mutations in Oman: regional distribution and comparison with neighboring countries. Hemoglobin 39(2):107\u2013110. https:\/\/doi.org\/10.3109\/03630269.2015.1009632","journal-title":"Hemoglobin"},{"issue":"2","key":"7185_CR6","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1046\/j.1365-2141.2000.01870.x","volume":"108","author":"YT Liu","year":"2000","unstructured":"Liu YT, Old JM, Miles K, Fisher CA, Weatherall DJ, Clegg JB (2000) Rapid detection of alpha-thalassaemia deletions and alpha-globin gene triplication by multiplex polymerase chain reactions. Br J Haematol 108(2):295\u2013299. https:\/\/doi.org\/10.1046\/j.1365-2141.2000.01870.x","journal-title":"Br J Haematol"},{"key":"7185_CR7","doi-asserted-by":"publisher","unstructured":"Pinto VM, Forni GL. (2020). Management of Iron Overload in Beta-Thalassemia Patients: Clinical Practice Update Based on Case Series. Int J Mol Sci. 21(22). https:\/\/doi.org\/10.3390\/ijms21228771","DOI":"10.3390\/ijms21228771"},{"issue":"2","key":"7185_CR8","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/ejh.12136","volume":"91","author":"SS Alkindi","year":"2013","unstructured":"Alkindi SS, Alzadjali S, Daar S, Sindhuvi E, Wali Y, Pathare AV, Venugopal S, Lapoumeroulie C, Srivastava A, Krishnamoorthy R (2013) A stepwise alpha-thalassemia screening strategy in high-prevalence areas. Eur J Haematol 91(2):164\u2013169. https:\/\/doi.org\/10.1111\/ejh.12136","journal-title":"Eur J Haematol"},{"issue":"10","key":"7185_CR9","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.3324\/haematol.13342","volume":"93","author":"MA Melis","year":"2008","unstructured":"Melis MA, Cau M, Congiu R, Sole G, Barella S, Cao A, Westerman M, Cazzola M, Galanello R (2008) A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. Haematologica 93(10):1473\u20131479. https:\/\/doi.org\/10.3324\/haematol.13342","journal-title":"Haematologica"},{"issue":"6","key":"7185_CR10","doi-asserted-by":"publisher","first-page":"840","DOI":"10.3324\/haematol.2008.001867","volume":"94","author":"AJ Ramsay","year":"2009","unstructured":"Ramsay AJ, Hooper JD, Folgueras AR, Velasco G, Lopez-Otin C (2009) Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis. Haematologica 94(6):840\u2013849. https:\/\/doi.org\/10.3324\/haematol.2008.001867","journal-title":"Haematologica"}],"container-title":["Annals of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-07185-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-07185-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00277-026-07185-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:22:41Z","timestamp":1792160561000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00277-026-07185-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":10,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,11]]}},"alternative-id":["7185"],"URL":"https:\/\/doi.org\/10.1007\/s00277-026-07185-9","relation":{},"ISSN":["1432-0584"],"issn-type":[{"value":"1432-0584","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"5 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Medical Research Ethics Committee (MREC) of the College of Medicine and Health Sciences at Sultan Qaboos University (Ref. No. 3535, 31st of August 2023). Informed consent was obtained from all study participants.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Consent was obtained from parents and all participating family members.","order":2,"name":"Ethics","label":"Patient consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"459"}}